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Protein-coding gene in the species Homo sapiens
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103
Integrin_alpha_E
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
Mammalian protein found in Homo sapiens
known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein
Integrin_alpha_X
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Mammalian protein found in Homo sapiens
is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family
Integrin_alpha_4
Mammalian protein found in Homo sapiens
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans
Integrin_alpha_L
Mammalian protein found in Homo sapiens
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are
Integrin_alpha_6
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7
Integrin_alpha_7
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Mammalian protein found in Homo sapiens
CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane
Integrin_alpha_2
Protein
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins
Integrin_alpha_5
Protein-coding gene in the species Homo sapiens
Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_D
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Protein found in humans
Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of
Integrin_alpha_10
Mammalian protein found in Homo sapiens
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains
Integrin_beta_2
In cell biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte
CD11
It consists of two components, integrin alpha V and integrin beta 5. Sheppard D (October 2002). "Endothelial integrins and angiogenesis: not so simple
Alpha-v_beta-5
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits
Integrin_beta_4
Mammalian protein found in Homo sapiens
with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to
Integrin_beta_1
Mammalian protein found in Homo sapiens
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given
Integrin_beta_3
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_8
Protein-coding gene in the species Homo sapiens
Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins
Integrin_alpha_9
Integrin complex found on platelets
medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a transmembrane receptor
Glycoprotein_IIb/IIIa
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Protein-coding gene in the species Homo sapiens
Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral
Integrin_alpha_11
Contrast agent for cancer imaging
(68Ga). 68Ga-Trivehexin targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous
Ga-68-Trivehexin
Protein-coding gene in the species Homo sapiens
subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is
Integrin_beta_5
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
American immunologist
adhesion molecules of the immune system, the first relationships among integrins—between LFA-1 and Mac-1—and the three-step model for leukocyte emigration
Timothy_A._Springer
(or integrin αMβ2 or macrophage integrin or Mac-1) is an integrin complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2)
Macrophage-1_antigen
Subunit of a protein
receptor, the fibrinogen alpha chain, the integrin alpha chain, Hemoglobin, alpha 1 It should be distinguished from the term alpha helix, which refers to
Alpha_chain
Protein found in humans
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are
Integrin-linked_kinase
Pharmaceutical compound
(MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used
Vitaxin
Protein in the extracellular matrix
includes the brain and muscle fibers. In muscle, it binds to alpha-dystroglycan and integrin alpha7—beta1 via the G domain, and via the other end, it binds
Laminin
Mammalian protein found in Homo sapiens
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7).
Alpha-actinin-3
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
Enzyme found in humans
Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as
Serine/threonine kinase haspin
Serine/threonine_kinase_haspin
Mammalian protein found in humans
ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration
Collagen,_type_XVII,_alpha_1
Subset of cell adhesion proteins
survival, and transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits
Cell_adhesion_molecule
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Protein-coding gene in the species Homo sapiens
Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. Cell Biol. 111 (2): 721–9. doi:10
Alpha-actinin-4
Protein found in humans
(MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like
Addressin
J. F.; Kaminski, N.; Garat, C.; Matthay, M. A.; et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
TGF_beta_activation
Protein-coding gene in humans
protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). CIB1 is a small
CIB1
Mammalian protein found in Homo sapiens
expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus
ICAM-1
Protein-coding gene in the species Homo sapiens
Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling". Hum. Mol
PARVB
Protein-coding gene in humans
and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't
CD47
α5β1, also known as the fibronectin receptor, is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. It
Alpha-5_beta-1
Human protein-encoding gene
Robertson C, McNicol A (January 2001). "CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets". Thrombosis
CD9
Protein found in humans
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7):
Alpha-actinin-2
Protein-coding gene in the species Homo sapiens
Schaffner-Reckinger E, Landrieu I, Lippens G, Lin M, Zhang J, Kieffer N (Aug 2008). "The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic
TLN1
Pharmaceutical compound
Vatelizumab is an immunomodulator. It binds to integrin alpha 2. It was withdrawn from Phase II trials for inflammatory bowel disease due to a lack of
Vatelizumab
migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes
Lymph_node_stromal_cell
Chemical compound
known as iRGD, is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. It also binds and activates neuropilin-1, leading to a
Arginylglycylaspartic_acid
Protein-coding gene in the species Homo sapiens
inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200
Alpha-1B_adrenergic_receptor
Protein-coding gene in the species Homo sapiens
This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular
Integrin_beta_8
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Medical condition neuromuscular disorders
namely integrin-α7β1 and α-dystroglycan. In LAMA2-CMD the laminin alpha2 deficiency results in malfunctioning or down regulation of integrin-α7β1 and
LAMA2 related congenital muscular dystrophy
LAMA2_related_congenital_muscular_dystrophy
Structures which transmit force and signals between a cell and the extracellular matrix
DGEA and GFOGER motifs found in collagen. Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present in
Focal_adhesion
Mammalian protein found in humans
β1 integrins. Collagen XXIII interacts in an ion-and conformation-dependent manner with integrin α2β1. Integrin α2β1 is a collagen-binding integrin present
Collagen,_type_XXIII,_alpha_1
Hemorrhagic fever caused by ebolaviruses
to specific cell-surface receptors such as C-type lectins, DC-SIGN, or integrins, which is followed by fusion of the viral envelope with cellular membranes
Ebola
Protein-coding gene in humans
WA (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". The Journal of Biological Chemistry
PTK2
Protein-coding gene in the species Homo sapiens
the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells
Periostin
Class of enzymes
In enzymology, a lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) is an enzyme that catalyzes the chemical reaction CMP-N-acetylneuraminate
Lactosylceramide alpha-2,3-sialyltransferase
Lactosylceramide_alpha-2,3-sialyltransferase
Protein-coding gene in humans
altering the molecule's conformation. Modification of integrin's conformation serves to dissociate alpha and beta subunits by disrupting their interactions
FERMT3
Movement of white blood cells out of blood vessels and towards the inflamed site
the body (e.g. the skin). At the same time, chemokines released by macrophages activate the rolling leukocytes and cause surface integrin molecules to
Leukocyte_extravasation
Cytokine
Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
Transforming growth factor beta
Transforming_growth_factor_beta
Type of chemical bond
integrin alpha L beta 2 and intercellular adhesion molecule 1 (ICAM-1), integrin alpha 4 beta 1 with vascular adhesion molecule 1, integrin alpha M
Catch_bond
Protein found in humans
Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene. This gene encodes the alpha chain of type XVI collagen, a member
Collagen,_type_XVI,_alpha_1
Protein factor that regulates the length of R-actin
the connection between the actin cytoskeleton within the cell and the integrins that directly interact with the stromal ECM. Additionally, it can sense
Actinin
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Protein Domain
"Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10277–81. Bibcode:1995PNAS
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Mammalian protein
(monomers), each called an alpha 1 chain of type III collagen. Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded
Collagen,_type_III,_alpha_1
Component of striated muscle cells
dystrophin-glycoprotein complex (DGC) and the integrin-vinculin-talin complex. The sarcoglycans of the DGC and the integrins of the integrin-vinculin-talin complex attach
Costamere
Protein found in humans
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_1
Protein-coding gene in the species Homo sapiens
Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific
PKC_alpha
Human protein-coding gene
Hogg J, Balmes J, Sheppard D (May 1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin
Tenascin_C
Protein-coding gene in the species Homo sapiens
Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene. Laminins are basement membrane components thought to mediate the attachment
Laminin,_alpha_3
Human protein-coding gene
regulating beta1 integrin function". J. Cell Sci. 116 (Pt 19): 3893–904. doi:10.1242/jcs.00699. PMID 12915587. Mori S, Tanaka M, Nanba D, Nishiwaki E, Ishiguro
ADAM12
Medical condition
chromosome 21. This subunit is involved in the formation of the β-2 integrins (LFA-1, integrin alphaXbeta2/CR4/p150,95, and Mac-1/CR3) by dimerization with different
Leukocyte_adhesion_deficiency
Protein found in humans
αE-catenin, also known as Catenin alpha-1, is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly expressed in cardiac muscle
Catenin_alpha-1
Protein-coding gene in humans
Sheppard D, Engvall E, Takada Y (May 2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications
ADAM2
Protein-coding gene in the species Homo sapiens
2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal
Laminin,_alpha_5
Mammalian protein found in humans
Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. This protein is an alpha chain of type VI collagen that aids in
Collagen,_type_VI,_alpha_3
Macrophage found in the lungs
in the suppression of IFNγ and TNF-alpha suppression. Integrins are dimeric cell-surface receptors composed of alpha and beta subunits, which activates
Alveolar_macrophage
Protein found in humans
costamerogenesis is that in cultured, undifferentiated myoblasts, alpha-5 integrin, vinculin and paxillin are in complex and located primarily at focal
Paxillin
Virus of the herpes family
BMRF-2 interacts with cellular β1 integrins. Then, viral protein gH/gL interacts with cellular αvβ6/αvβ8 integrins. This triggers fusion of the viral
Epstein–Barr_virus
Mammalian protein found in Homo sapiens
immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through
ICAM3
Protein-coding gene in the species Homo sapiens
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse
Alpha-actinin-1
Protein-coding gene in the species Homo sapiens
activity and regulates alpha-synuclein phosphorylation. It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal
SKAP2
Overview of and topical guide to immunology
/ CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late antigen receptor: Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1
Outline_of_immunology
Monoclonal antibody
Intetumumab is a human monoclonal antibody targeting integrins that was being studied for the treatment of solid tumors. Intetumumab was developed by
Intetumumab
Type of proteins
heterotrimeric G protein complexes. The latter class of complexes is made up of alpha (Gα), beta (Gβ) and gamma (Gγ) subunits. In addition, the beta and gamma
G_protein
Chemical compound
disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the
Etrolizumab
Protein found in humans
Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of proteins that play a role in
Collagen,_type_VI,_alpha_1
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INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
Boy/Male
Korean
Eastern integrity.
Male
African
(ox); the first letter of the Greek alphabet.
Boy/Male
Hindu
First letter of the greek alphabet
Boy/Male
Afghan, Arabic, Bengali, Indian, Malayalam, Muslim, Pashtun, Punjabi, Sikh, Telugu
Conscience; Integrity
Girl/Female
Muslim
Integrity and virtuous
Girl/Female
Greek American
Firstbom.' The first letter of the Greek alphabet.
Boy/Male
Korean
Integrity returns.
Girl/Female
Indian
Little
Girl/Female
Indian
Trust; Integrity
Boy/Male
Arabic, Muslim
Soundness; Integrity
Boy/Male
Muslim
Soundness. Integrity.
Girl/Female
Arabic
Respectable
Girl/Female
Indian
Loving
Girl/Female
American, British, English, Greek
Healer; With Healing Power
Boy/Male
Korean
Integrity lasts.
Girl/Female
English American
Healer.
Boy/Male
Muslim/Islamic
Soundness integrity
Boy/Male
Arabic
Soundness; Integrity
Boy/Male
African, Australian, Chinese, French, Latin, Swedish
First Letter of the Greek Alphabet; Leader
Girl/Female
Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Sanskrit, Tamil, Telugu
Little; Collection of Many Small Things
INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
INTEGRIN ALPHA-E
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