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Protein found in humans
abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in
Collagen,_type_V,_alpha_1
Mammalian protein found in humans
Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. COL1A1 encodes the major component
Collagen,_type_I,_alpha_1
Mammalian protein
Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each called an alpha 1 chain of type III collagen
Collagen,_type_III,_alpha_1
Protein found in humans
abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in
Collagen,_type_V,_alpha_2
Protein found in humans
Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene. This gene encodes the alpha chain of type XII collagen, a member
Collagen,_type_XII,_alpha_1
Mammalian protein found in humans
It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. Collagen XVII is a structural
Collagen,_type_XVII,_alpha_1
Protein found in humans
Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene. COL27A1 is a type XXVII collagen. It was discovered
Collagen,_type_XXVII,_alpha_1
II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen
Alpha_collagen
Protein found in humans
Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen binding and cell-cell adhesion
Collagen,_type_XIV,_alpha_1
Protein found in humans
Collagen alpha-1(X) chain is a protein that in humans is a member of the collagen family encoded by the COL10A1 gene. This gene encodes the alpha chain
Collagen,_type_X,_alpha_1
containing type I collagen. Type V collagen is a part of the family of collagen proteins consisting of Collagen I – Collagen XXVIII. Collagen proteins are
Type_V_collagen
Protein found in humans
Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues
Collagen,_type_IV,_alpha_1
Protein found in humans
Collagen alpha-1(IX) chain is a protein that in humans is encoded by the COL9A1 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_1
Protein found in humans
Collagen alpha-2(I) chain is a protein that in humans is encoded by the COL1A2 gene. This gene encodes one of the chains for type I collagen, the fibrillar
Collagen,_type_I,_alpha_2
Protein found in humans
Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene. This gene encodes one of the two alpha chains of type VIII collagen
Collagen,_type_VIII,_alpha_1
Protein found in humans
Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene. This gene encodes the alpha chain of type XVI collagen, a member
Collagen,_type_XVI,_alpha_1
Protein-coding gene in humans
Collagen alpha-5(IV) chain is a protein that in humans is encoded by the COL4A5 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_5
Protein-coding gene in the species Homo sapiens
COL20A1 is a collagen gene. GRCh38: Ensembl release 89: ENSG00000101203 – Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000016356 – Ensembl, May
Collagen,_type_XX,_alpha_1
Protein found in humans
Collagen alpha-4(IV) chain is a protein that in humans is encoded by the COL4A4 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_4
Protein found in humans
abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in
Collagen,_type_V,_alpha_3
Protein found in humans
Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene. This gene encodes the alpha chain of type XIX collagen, a member
Collagen,_type_XIX,_alpha_1
Protein found in humans
Collagen alpha-1(XIII) chain is a protein that in humans is encoded by the COL13A1 gene. This gene encodes the alpha chain of one of the nonfibrillar collagens
Collagen,_type_XIII,_alpha_1
Protein found in humans
Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene. COL25A1 is a brain-specific membrane-bound collagen. Proteolytic
Collagen,_type_XXV,_alpha_1
Protein found in humans
Biotechnology Information, U.S. National Library of Medicine. "COL22A1 collagen type XXII alpha 1 chain". NCBI. 25 May 2017. Retrieved 18 September 2017. v t e
Collagen,_type_XXII,_alpha_1
Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_2
Basis for articular and hyaline cartilage in animals
collagen, type II, alpha 1 chains. It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage. Type II collagen is organised
Type_II_collagen
Mammalian protein found in humans
Collagen alpha-6(IV) chain is a protein that in humans is encoded by the COL4A6 gene. This gene encodes one of the six subunits of type IV collagen, the
Collagen,_type_IV,_alpha_6
Protein found in humans
Collagen alpha-3(IX) chain is a protein that in humans is encoded by the COL9A3 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_3
Protein found in humans
Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. The collagens are a superfamily of proteins that play a role in
Collagen,_type_VI,_alpha_1
Protein found in humans
Collagen alpha-1(XV) chain is a protein that in humans is encoded by the COL15A1 gene. This gene encodes the alpha chain of type XV collagen, a member
Collagen,_type_XV,_alpha_1
Protein found in humans
Collagen, type XXVIII, alpha 1 also known as COL28A1 is a protein that in humans is encoded by the COL28A1 gene. This protein belongs to a class of collagens
Collagen, type XXVIII, alpha 1
Collagen,_type_XXVIII,_alpha_1
Protein found in humans
Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene. This gene encodes the alpha chain of type XVIII collagen. This
Collagen,_type_XVIII,_alpha_1
Mammalian protein found in humans
Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. This protein is an alpha chain of type VI collagen that aids in microfibril
Collagen,_type_VI,_alpha_3
Non-fibrillar collagen found in the structure of basement membranes
Collagen IV (ColIV, Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational
Type_IV_collagen
IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Protein found in humans
Collagen alpha-2(IX) chain is a protein that in humans is encoded by the COL9A2 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_2
Type of collagen protein
Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI maintains regularity in muscle
Type_VI_collagen
Most abundant structural protein in animals
of the types contain at least one triple helix. Over 90% of the collagen in humans is Type I and Type III collagen. Fibrillar (type I, II, III, V, XI) Non-fibrillar
Collagen
Protein found in humans
PMID 11689488. "Entrez Gene: COL8A2 collagen, type VIII, alpha 2". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 (10):
Collagen,_type_VIII,_alpha_2
Type XXVII collagen is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his colleagues at the University
Type_XXVII_collagen
Protein found in humans
Collagen alpha-2(VI) chain is a protein that in humans is encoded by the COL6A2 gene. This gene encodes one of the three alpha chains of type VI collagen
Collagen,_type_VI,_alpha_2
Protein found in humans
Collagen alpha-5(VI) chain also known as von Willebrand factor A domain-containing protein 4 is a protein that in humans is encoded by the COL6A5 gene
Collagen,_type_VI,_alpha_5
Group of genetic disorders resulting in fragile bones
problem with connective tissue due to a lack of, or poorly formed, type I collagen. In more than 90% of cases, OI occurs due to mutations in the COL1A1
Osteogenesis_imperfecta
Chemical compound
component of the protein collagen, comprising roughly 13.5% of mammalian collagen. Hydroxyproline and proline play key roles for collagen stability. They permit
Hydroxyproline
Protein in the extracellular matrix
place. Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. The proteins also
Laminin
Rare autoimmune disease
glomerulonephritis, and kidney failure. It is thought to attack the alpha-3 subunit of type IV collagen, which has therefore been referred to as Goodpasture's antigen
Goodpasture_syndrome
Fibers obtained from natural sources
applications. Collagen is a structural protein, often referred to as "the steel of biological materials". There are multiple types of collagen: Type I (comprising
Natural_fiber
Mammalian protein involved in blood clotting
this day. Von Willebrand Factor has been shown to interact with Collagen, type I, alpha 1. Recently, It has been reported that the cooperation and interactions
Von_Willebrand_factor
Protein-coding gene in the species Homo sapiens
Interleukin-1 alpha (IL-1 alpha or IL-1α) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that is encoded by the IL1A gene in humans
Interleukin_1-alpha
Mammalian protein found in Homo sapiens
"Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins"
Integrin_alpha-1
Mammalian protein found in Homo sapiens
"Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". The Journal
Integrin_alpha_2
Medical condition
When vWF comes into contact with exposed collagen it uncoils and binds to the collagen. Circulating platelets bind to vWF using their GpIb-alpha surface
Von_Willebrand_disease
Protein-coding gene in humans
Collagen, type XXIV, alpha 1 is a protein that in humans is encoded by the COL24A1 gene. GRCm38: Ensembl release 89: ENSMUSG00000028197 – Ensembl, May
COL24A1
Medical condition
Metaphyseal chondrodysplasia Schmid type is a type of chondrodysplasia associated with a deficiency of collagen, type X, alpha 1. Unlike other "rickets syndromes"
Metaphyseal chondrodysplasia Schmid type
Metaphyseal_chondrodysplasia_Schmid_type
Surface glycoproteins involved in hemostasis
"Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein-coding gene in the species Homo sapiens
protein can bind to fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet
Thrombospondin_1
Protein-coding gene in the species Homo sapiens
myofibrillar actin filaments. Alpha-actinin-1 has been shown to interact with: CDK5R1, CDK5R2, Collagen, type XVII, alpha 1, GIPC1, PDLIM1, Protein kinase
Alpha-actinin-1
Human chromosome
CDKN2BAS: CDKN2B antisense RNA 1 or antisense non-coding RNA in the INK4 locus (ANRIL) COL5A1: collagen, type V, alpha 1 DDX31: DEAD box polypeptide 31
Chromosome_9
Connective tissue cell which produces reticular fibers
In cellular biology, a reticular cell is a type of fibroblast that synthesizes collagen alpha-1(III) and uses it to produce extracellular reticular fibers
Reticular_cell
Mammalian protein found in humans
Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1
Alpha-1_antitrypsin
Enzyme in humans
(SP), and B-type natriuretic peptide (BNP), human fibroblast growth factor 21 (FGF-21), human alpha2 antiplasmin and denatured collagen I and III. NPY
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Organic compounds containing amine and carboxylic groups
groups (alpha- (α-), beta- (β-), gamma- (γ-) amino acids, etc.); other categories relate to polarity, ionization, and side-chain group type (aliphatic
Amino_acid
hydroxylase, and human alpha(I)-collagen). ErEN cleavage site V -cccaacgggcccu—ccucccc—ucc/u alpha globin (HBA1 or HBA2, NM_000517.1) cccca-----cccu—cuuccccaa
C-rich_stability_element
Protein domain
1 (CHRDL1) Chordin-like 2 (CHRDL2) Brorin (VWC2) Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1)
Von Willebrand factor type C domain
Von_Willebrand_factor_type_C_domain
Protein found in humans
a human chaperone protein for collagen. HSP47 contains 3 beta sheets and 9 alpha helices. After binding with collagen no conformation change is observed
Serpin_H1
Protein found in humans
(VISTA) is a protein that in humans is encoded by the gene VSIR. It is a type I transmembrane protein that functions as an immune checkpoint. VISTA is
V-set immunoregulatory receptor
V-set_immunoregulatory_receptor
Medical condition
maintaining the human body's integrity of various tissues. Alpha 1 subunit of type VI collagen is the encoded protein. In terms of the genetics of UCMD2
Ullrich congenital muscular dystrophy
Ullrich_congenital_muscular_dystrophy
Protein factor that regulates the length of R-actin
(January 2005). "Spectrin, alpha-actinin, and dystrophin". Advances in Protein Chemistry. Fibrous Proteins: Coiled-Coils, Collagen and Elastomers. 70. Academic
Actinin
Hollow cavity found in the lungs
alveolar septum that separates the alveoli in the alveolar sac contains some collagen fibers and elastic fibers. The septa also house the enmeshed capillary
Pulmonary_alveolus
Immune system messenger protein which induces inflammation
contributors of liver fibrosis. On the other hand, TNF suppresses alpha-1 type-1 collagen expression and HSC proliferation in vitro, which should inhibit
Tumor_necrosis_factor
Mammalian protein found in Homo sapiens
Collagen alpha-1(XXVI) chain is a protein that in humans is encoded by the EMID2 gene. GRCh38: Ensembl release 89: ENSG00000160963 – Ensembl, May 2017
EMID2
Mammalian protein found in Homo sapiens
N-glycanase and site-directed mutagenesis on structure and binding of type V collagen". The Journal of Biological Chemistry. 270 (39): 23212–7. doi:10.1074/jbc
Osteonectin
Space curve that winds around a line
in Wiktionary, the free dictionary. Alpha helix Arc spring Boerdijk–Coxeter helix Circular polarization Collagen helix Helical symmetry Helicity Helix
Helix
Protein-coding gene in the species Homo sapiens
extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens and other extracellular matrix proteins. Studies in rhesus monkeys
MMP9
Series of events that restore integrity to damaged tissue after an injury
construction attach to, grow and differentiate on the collagen matrix laid down by fibroblasts. Type III collagen and fibronectin generally begin to be produced
Wound_healing
Protein found in humans
signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in
Integrin_alpha_10
Protein-coding gene in the species Homo sapiens
subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis
P4HA1
Human chromosome
syndrome type IV, autosomal dominant) COL4A3: collagen, type IV, alpha 3 (Goodpasture antigen) COL4A4: collagen, type IV, alpha 4 COL5A2: collagen, type V, alpha
Chromosome_2
Signaling glycoprotein regulating cell proliferation
kinase (RTK), a type of cell surface receptor. Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs. The alpha type binds to PDGF-AA
Platelet-derived growth factor
Platelet-derived_growth_factor
Gene therapy
with dystrophic epidermolysis bullosa with mutation(s) in the collagen type VII alpha 1 chain (COL7A1) gene. The safety and effectiveness of beremagene
Beremagene_geperpavec
Dog breed
resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV". Proceedings of the National Academy of Sciences. 91 (9):
Samoyed_dog
Proteins found on the outer membrane of Gram-negative bacteria
then adheres to an element of the host extracellular matrix, for example, collagen, fibronectin, etc. Most TAAs have a similar protein structure. When observed
Trimeric autotransporter adhesin
Trimeric_autotransporter_adhesin
Large plasma protein found in the blood
α2-Macroglobulin (α2M) or alpha-2-macroglobulin is a large (720 KDa) plasma protein found in the blood. It is mainly produced by the liver, and also locally
Alpha-2-Macroglobulin
Protein-coding gene in the species Homo sapiens
Genetics. 40 (1): 145–148. doi:10.1007/BF01874078. PMID 7780165. Arora PD, McCulloch CA (April 1994). "Dependence of collagen remodelling on alpha-smooth muscle
ACTA2
Component of blood aiding in coagulation
store vWF in their alpha granules. When the endothelial layer is disrupted, collagen and VWF anchor platelets to the subendothelium. Platelet GP1b-IX-V receptor
Platelet
Protein Domain
clan). The vWA domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
Type of protein
higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened levels of collagen helped facilitate adhesions
Catenin
Structural fibrous protein
two types: the primitive, softer forms found in all vertebrates and the harder, derived forms found only among sauropsids (reptiles and birds). Alpha-keratins
Keratin
Rigid organs of the skeleton of vertebrates
substance. These cells synthesise collagen alpha polypeptide chains and then secrete collagen molecules. The collagen molecules associate with their neighbors
Bone
Protein-coding gene in humans
extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays
MMP2
Injury healing process
clinical burden. Collagen, for instance, is abnormally organised in scar tissue; collagen in scars is arranged in parallel bundles of collagen fibers, whilst
Scar_free_healing
Medical condition
Glutaric acidemia type 1 (GA1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine and
Glutaric_aciduria_type_1
Medical condition
inherited defect in type IV collagen—a structural material needed for the normal function of different body parts. Since type IV collagen is found in the
Alport_syndrome
Medical condition
observed to have increased GLUT-1 and decreased pro-collagen mRNA. A predominance of Type 1 collagen is observed in PL. Type 1 is associated with early phase
Necrobiosis_lipoidica
Group of autoimmune diseases resulting in abnormal growth of connective tissue
affected persons. Scleroderma is characterised by increased synthesis of collagen (leading to the sclerosis), damage to small blood vessels, activation of
Scleroderma
Class of compounds
and to fibrous matrix proteins, such as collagen. [citation needed] The combination of proteoglycans and collagen form cartilage, a sturdy tissue that is
Proteoglycan
Mammalian protein found in Homo sapiens
alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin
Integrin_beta_1
Protein-coding gene in the species Homo sapiens
deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being
Platelet_glycoprotein_VI
Protein-coding gene in the species Homo sapiens
glomerulosclerosis. Alpha-actinin-4 has been shown to interact with PDLIM1, Sodium-hydrogen exchange regulatory cofactor 2, Collagen, type XVII, alpha 1, CAMK2A,
Alpha-actinin-4
Species of bacterium
this alpha-toxin. The beta-toxin of H. histolytica is a group of seven collagenases. Collagenases are zinc metalloproteases that cleave collagen and gelatin
Hathewaya_histolytica
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COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
COLLAGEN TYPE-V-ALPHA-1
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