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Subunit of a protein
The term alpha chain is normally used to indicate one of the subunits of a multi-subunit protein. The term "chain" is a general term given to any peptide
Alpha_chain
Hemoglobin variant
mutation in the alpha globin gene produces an alpha globin chain that is abnormally long. It is the most common nondeletional alpha-thalassemia mutation
Hemoglobin_Constant_Spring
Protein
membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational
Integrin_alpha_5
Protein and coding gene in humans
Inhibin alpha chain, also known as INHA, is a protein which in humans is encoded by the INHA gene. The inhibin alpha chain subunit joins either the beta
Inhibin_alpha_chain
Mammalian protein found in Homo sapiens
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2
IL2RA
Mammalian protein found in Homo sapiens
composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join
Integrin_alpha_2b
Mammalian protein found in Homo sapiens
the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes
Integrin_alpha_3
Protein-coding gene in the species Homo sapiens
Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha component of fibrinogen,
Fibrinogen_alpha_chain
Normal human hemoglobin in adults
globin chains that have heme groups combine to form hemoglobin. One of the chains is an alpha chain and the other is a non-alpha chain. Non-alpha chain nature
Hemoglobin_A
Protein in the extracellular matrix
different alpha-, beta-, and gamma-chains. Five alpha-chain paralogs: LAMA1, LAMA2, LAMA3 (which has three splice forms), LAMA4, LAMA5 Four beta-chain paralogs:
Laminin
Mammalian protein found in Homo sapiens
Normal adult human HbA is a heterotetramer consisting of two alpha chains and two beta chains. β-globin is encoded by the HBB gene on human chromosome 11
Hemoglobin_subunit_beta
Soluble protein complex in blood plasma and involved in clot formation
chains, the fibrinogen alpha chain (also termed the Aα or α chain) encoded by the FGA gene, the fibrinogen beta chain (also termed the Bβ or β chain)
Fibrinogen
Human hemoglobin protein
untranslated regions. The human alpha polypeptide chain contains 141 amino acids. Two alpha chains plus two beta chains constitute an HbA protein molecule
Hemoglobin_subunit_alpha
Mammalian protein found in Homo sapiens
Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein. Integrins
Integrin_alpha_X
Mammalian protein found in Homo sapiens
Hemoglobin, alpha 2 also known as HBA2 is a gene that in humans codes for the alpha globin chain of hemoglobin. The human alpha globin gene cluster is
Hemoglobin,_alpha_2
Protein found in humans
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_1
10th and 11th episodes of the 6th season of Star Trek: The Next Generation
related to Chain of Command. "Chain of Command, Part I" at IMDb "Chain of Command, Part II" at IMDb Chain Of Command, Part I at Memory Alpha Chain Of Command
Chain of Command (Star Trek: The Next Generation)
Chain_of_Command_(Star_Trek:_The_Next_Generation)
Protein-coding gene in the species Homo sapiens
DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other
HLA-DRA
Protein-coding gene in the species Homo sapiens
Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene. Tubulin alpha-1A chain is a type of alpha-tubulin involved in the formation
Tubulin_alpha-1A_chain
Medical condition
the alpha chain and 92 in the beta chain. Distal histidine (E7) is designated as position 58 in the alpha chain and position 63 in the beta chain. At
Hemoglobin_M_disease
Series of radioactive decays
gives the chain the isotope will follow in its decay. There are other decay modes, but they invariably occur at a lower probability than alpha or beta decay
Decay_chain
Protein-coding gene in the species Homo sapiens
common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor). This gene encodes the alpha chain of the interleukin-4
Interleukin-4_receptor
Supermarket chain
Alpha Beta was a chain of supermarkets in the Southwestern United States. Stores under this brand existed between 1917 and 1995. Former Alpha Beta stores
Alpha_Beta
Isotope of uranium
is an alpha emitter, producing thorium-231. Uranium-235 is the main progenitor of the actinium series, one of the principal actinide decay chains, as it
Uranium-235
Antibody that plays a crucial role in the immune function of mucous membranes
molecule of the J chain (joining chain) inside the B cell prior to secretion as a J chain-coupled polymeric IgA molecule. The J chain is a polypeptide
Immunoglobulin_A
Glycoprotein polypeptide hormones
peptide chains, an alpha chain and a beta chain. LH and FSH share nearly identical alpha chains (about 100 amino acids long), whereas the beta chain provides
Gonadotropin
Multienzyme complex
enzyme complex catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids. BCKDC is a member of the mitochondrial α-ketoacid dehydrogenase
Branched-chain alpha-keto acid dehydrogenase complex
Branched-chain_alpha-keto_acid_dehydrogenase_complex
Protein-coding gene in the species Homo sapiens
Platelet glycoprotein Ib alpha chain, also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein
GP1BA
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
Serotype that covers a broad range of HLA-DQ haplotypes
range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1 (later DQ1, and split into
HLA-DQ1
Protein-coding gene in the species Homo sapiens
T-cell receptor alpha locus is a protein that in humans is encoded by the TRA gene, also known as TCRA or TRA@. It contributes the alpha chain to the larger
TRA_(gene)
Protein-coding gene in humans
T-cell surface glycoprotein CD8 alpha chain (Cluster of Differentiation 8a), is a protein encoded by CD8A gene. The CD8 protein is a cell surface glycoprotein
CD8A
Chemical compound
The genes that produce the alpha chains are located together in a cluster on chromosome 16 and the genes for beta chains form from a separate cluster
Embryonic_hemoglobin
Japanese immunologist and Nobel laureate (born 1942)
IL-4 and IL-5 cytokines involved in class switching and IL-2 receptor alpha chain in 1986, and went on further to discover AID in 2000, demonstrating its
Tasuku_Honjo
Protein-coding gene in the species Homo sapiens
to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored
Major histocompatibility complex, class II, DQ alpha 1
Major_histocompatibility_complex,_class_II,_DQ_alpha_1
Random process independent of past history
In probability theory and statistics, a Markov chain or Markov process is a stochastic process describing a sequence of possible events in which the probability
Markov_chain
a number of DQA1 (DQ alpha chain) genes, producing in cis-haplotype form, a large number of DQ αβ isoforms. These DQ alpha chains are also known to form
HLA-DQ7
Meerut India shows the mutation of 120th alanine to glutamic acid on alpha chain. Hemoglobin J was also reported from Chhattisgarh, Central India as revealed
Hemoglobin_J
Mammalian protein found in Homo sapiens
proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an
Integrin_alpha_4
Nomenclature for the clinical laboratory sciences
Concentration of 'Glycoprotein hormones alpha chain' in patient blood plasma NPU28109 Plasma—Glycoprotein hormones alpha chain; mass concentration = ? microgram
NPU_terminology
Protein-coding gene in the species Homo sapiens
protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer
Complement_component_4B
Mammalian protein found in Homo sapiens
beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains, CD18
Integrin_beta_2
Protein-coding gene in the species Homo sapiens
histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene. HLA-DMA belongs to the HLA class II alpha chain paralogues. This
HLA-DMA
Mammalian protein found in Homo sapiens
are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein
Glycoprotein hormones, alpha polypeptide
Glycoprotein_hormones,_alpha_polypeptide
Protein found in humans
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene
FCER1A
Protein complex involved in the complement system
seven branching alpha-chains. The main form of C4BP in human blood is composed of 7 identical alpha-chains and one unique beta-chain, which in turn binds
C4b-binding_protein
Protein found in humans
Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_2
Mammalian protein found in Homo sapiens
encodes the integrin alpha-2 (CD49b) protein. This is a type I transmembrane Glycoprotein that belongs to the integrin alpha chain family. The mature α2
Integrin_alpha_2
Protein-coding gene in the species Homo sapiens
GTP, one at an exchangeable site on the beta-chain and one at a non-exchangeable site on the alpha-chain. TUBB4A is preferentially and highly expressed
Tubulin_beta-4A_chain
Mammalian protein found in humans
Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. This protein is an alpha chain of type VI collagen that aids in
Collagen,_type_VI,_alpha_3
Type of white blood cell
create a functional beta chain, testing it against a 'mock' alpha chain. Then they attempt to create a functional alpha chain. Once a working TCR has been
T_cell
Medical condition
light chain. There are four forms: alpha chain disease (Seligmann's disease) gamma chain disease (Franklin's disease) mu chain disease delta chain disease
Heavy_chain_disease
Monoclonal antibody
the brand name Fasenra, is a monoclonal antibody directed against the alpha chain of the interleukin-5 receptor (CD125). It was developed by MedImmune
Benralizumab
Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. The protein encoded by this gene is a type I membrane
IFNAR1
Group of connective tissue conditions
three copies of the alpha chain made by the COL2A1 gene. Type XI collagen, on the other hand, is composed of three different alpha chains: the products of
Collagenopathy, types II and XI
Collagenopathy,_types_II_and_XI
Medical condition
congenital mutations in the fibrinogen alpha chain and classified as a dysfibrinogenemia (see Hereditary Fibrinogen Aα-Chain Amyloidosis). and, less commonly
Familial_renal_amyloidosis
Protein-coding gene in the species Homo sapiens
HLA class I histocompatibility antigen, alpha chain E (HLA-E) also known as MHC class I antigen E is a protein that in humans is encoded by the HLA-E
HLA-E
Protein found in humans
Collagen alpha-3(V) chain is a protein that in humans is encoded by the COL5A3 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_3
Mammalian protein found in Homo sapiens
integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin
Integrin_alpha_L
Type of radioactive decay
Alpha decay or α-decay is a type of radioactive decay in which an atomic nucleus emits an alpha particle (helium nucleus). The parent nucleus transforms
Alpha_decay
Mammalian protein found in Homo sapiens
is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit. The gene for the alpha subunit is 40 kilobases long and
Interleukin-3_receptor
Adaptive immunity variety-generation process
reactivity. Most T cell receptors are composed of a variable alpha chain and a beta chain. The T cell receptor genes are similar to immunoglobulin genes
V(D)J_recombination
Human leukocyte antigen serotype
chains can pair with trans to other alpha chain. However, there is no precedence in cis isoforms for DQ2, 4, 7, 8, or 9 binding DQ1 (DQA1*01) alpha chains
HLA-DQ2
Protein found in humans
Collagen alpha-1(XIII) chain is a protein that in humans is encoded by the COL13A1 gene. This gene encodes the alpha chain of one of the nonfibrillar
Collagen,_type_XIII,_alpha_1
Protein-coding gene in the species Homo sapiens
vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble
Laminin,_alpha_4
Protein-coding gene in the species Homo sapiens
separate biological effects. This may be due to effects of the respective alpha chains, which are unique to each receptor, the kinetics and affinity of cytokine-cytokine
Interleukin 15 receptor, alpha subunit
Interleukin_15_receptor,_alpha_subunit
Mammalian protein found in Homo sapiens
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are
Integrin_alpha_6
chemical reaction Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in alpha-chain of fibrinogen This enzyme is present in the venom of the
Fibrolase
heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha-7 integrin undergoes post-translational cleavage within the
Integrin_alpha_7
Rare, severe disease of lysosomal storage
Ashkenazi Jews with Tay–Sachs disease is an insertion in the gene for the alpha-chain of beta-hexosaminidase". Journal of Biological Chemistry. 263 (35): 18587–18589
Tay–Sachs_disease
Additionally, within one of the mutated alpha chains, there are substitutes at 114 and 118, two points on the amino acid chain. This mutation can cause sickle
Hemoglobin_Hopkins-2
Protein-coding gene in humans
CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded
CD79A
Protein family
complex-associated protein alpha chain (CD79A/Igα) and the B-cell antigen receptor complex-associated protein beta chain (CD79B/Igβ). The CD79 complex
CD79
Greek gastroenterologist (1931–2021)
Lumsden: 762–763. doi:10.1136/bmj.3.5568.762. PMC 1843266. PMID 6039646. "Alpha-chain Disease with Clinical, Immunological, and Histological Recovery". O.
Orestes_Manousos
Mammalian protein found in humans
receptor, a complex consisting of three chains, termed alpha (CD25), beta (CD122) and gamma (CD132). The gamma chain is common to all family members. The
Interleukin_2
Chemical group attached to backbone
acid residues, the side chains are attached to the alpha-carbon atoms of the amide backbone. The side chain connected to the alpha-carbon is specific for
Side_chain
Isotope of polonium
Po-210, historically radium F) is an isotope of polonium. It undergoes alpha decay to stable 206Pb with a half-life of 138.376 days (about 4+1⁄2 months)
Polonium-210
Protein complex on the surface of T cells that recognizes antigens
different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by
T-cell_receptor
Protein-coding gene in the species Homo sapiens
are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue
Integrin_alpha_11
fusion protein that preferentially binds the high-affinity IL-2 receptor alpha chain (CD25) to selectively promote Treg expansion". It is developed to treat
Efavaleukin_alfa
Protein-coding gene in the species Homo sapiens
paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role
HLA-DPB1
Medical condition
Roifman CM (1997). "Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor". Proc Natl Acad Sci U S A. 94 (7): 3168–71
CD25_deficiency
Topics referred to by the same term
Arts and Sciences Fellow of the Gemmological Association Fibrinogen alpha chain, encoded by the FGA gene Field and Game Australia Fit/gap analysis First
FGA
a channel. Each channel consist of two alpha chain, one beta, one gamma and one delta chain. These five chains assemble together (along with certain receptors
Pentameric_protein
Alkenes with CnH2n
Straight-chain terminal alkenes, also called linear alpha olefins (LAO) or normal alpha olefins (NAO), are alkenes (olefins) having a chemical formula
Straight-chain terminal alkene
Straight-chain_terminal_alkene
Most abundant structural protein in animals
residues occurs. Triple alpha helical structure is formed inside the endoplasmic reticulum from two alpha-1 chains and one alpha-2 chain. Procollagen is shipped
Collagen
Protein-coding gene in humans
Stilo R, Liguoro D, di Jeso B, Leonardi A, Vito P (April 2003). "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates
NACA_(gene)
Protein found in humans
Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene. Type IV collagen, the major structural component of basement membranes
Collagen,_type_IV,_alpha_3
Protein found in humans
Collagen alpha-1(XIX) chain is a protein that in humans is encoded by the COL19A1 gene. This gene encodes the alpha chain of type XIX collagen, a member
Collagen,_type_XIX,_alpha_1
Protein-coding gene in the species Homo sapiens
the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty
HADHA
Lymphocyte receptor specific for Interleukin-2
different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called
IL-2_receptor
Protein-coding gene in humans
(October 1992). "Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region". Genomics. 14 (2):
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Part of the human genome
α7 subset of HLA-Cw α-chains. For the serotype Cw7, the alpha chain are encoded by the HLA-Cw*07 allele group and the β-chain are encoded by B2M locus
HLA-Cw7
Hematological malignancy
leukemia: "variant" cases express the interleukin-2 receptor beta chain, but not the alpha chain (CD25)". Blood. 82 (2): 528–35. doi:10.1182/blood.V82.2.528
Hairy_cell_leukemia
Human gene
divergence) trendline was very similar to that of the fibrinogen alpha chain. Fibrinogen alpha chain sequence has a fast rate of change over time, which indicates
C5orf52
Hydrocarbon compounds with a C=C bond at the alpha carbon
of linear alpha-olefins and those with branches on the fourth carbon number and further from the start of the chain. Examples of linear alpha-olefins are
Terminal_alkene
Human leukocyte antigen serotype
α4 subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus
HLA-Cw4
Protein-coding gene in the species Homo sapiens
Spectrin alpha chain, erythrocyte is a protein that in humans is encoded by the SPTA1 gene. Spectrin is an actin crosslinking and molecular scaffold protein
Spectrin,_alpha_1
Pathognomic of Granulosa cell tumor ovary (Sex Cord Tumor)
chains, as well as type IV collagen alpha chains 1 and 2. However, the focimatrix also contains the additional proteins nidogen-1 and perlecan. Alpha
Call–Exner_bodies
Protein found in humans
Collagen alpha-2(IX) chain is a protein that in humans is encoded by the COL9A2 gene. This gene encodes one of the three alpha chains of type IX collagen
Collagen,_type_IX,_alpha_2
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ALPHA CHAIN
ALPHA CHAIN
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ALPHA CHAIN
ALPHA CHAIN
ALPHA CHAIN
ALPHA CHAIN
ALPHA CHAIN
ALPHA CHAIN
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