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Mammalian protein found in Homo sapiens
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin
Integrin_beta_1
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Mammalian protein found in Homo sapiens
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. The
Integrin_beta_3
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Mammalian protein found in Homo sapiens
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one
Integrin_beta_2
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta
Integrin_beta_4
Mammalian protein found in Homo sapiens
collagen. ITGA1 noncovalently associates with the Beta-1 (β1) integrin subunit to form the α1β1 integrin heterodimer, which is a cell-surface receptor also
Integrin_alpha-1
Protein-coding gene in the species Homo sapiens
subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is a receptor
Integrin_beta_5
Protein-coding gene in the species Homo sapiens
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain family and encodes a single-pass
Integrin_beta_8
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Mammalian protein found in Homo sapiens
protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain
Integrin_alpha_X
Protein-coding gene in the species Homo sapiens
Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin-related protein that is a member
Integrin_subunit_beta_like_1
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Protein complex
Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently
LPAM-1
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Protein
chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain
Integrin_alpha_5
Mammalian protein found in Homo sapiens
common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved
Integrin_alpha_2
Protein-coding gene in the species Homo sapiens
encoded by the ITGAE gene. CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name
Integrin_alpha_E
Mammalian protein found in Homo sapiens
alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha
Integrin_alpha_4
biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte adhesion
CD11
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Mammalian protein found in humans
Non-small-cell lung carcinoma Prostate cancer Homotrimer Lipid raft Integrin, beta 1 GRCh38: Ensembl release 89: ENSG00000050767 – Ensembl, May 2017 GRCm38:
Collagen,_type_XXIII,_alpha_1
Protein-coding gene in the species Homo sapiens
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for
ITGB1BP1
Mammalian protein found in Homo sapiens
alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion
Integrin_alpha_6
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Mammalian protein found in Homo sapiens
beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains
Integrin_alpha_V
beta 1 to form an integrin that binds to the extracellular matrix protein laminin-1. The primary binding partners of alpha-7 integrin are laminin-1
Integrin_alpha_7
Protein-coding gene in the species Homo sapiens
soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to
Integrin_alpha_8
Protein-coding gene in the species Homo sapiens
encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell
Integrin_alpha_9
Mammalian protein found in Homo sapiens
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and
Interleukin_1_beta
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
condensates in the cytosol composed of proteins and RNA that assemble into 0.1–2 μm membraneless organelles when the cell is under stress. The mRNA molecules
Stress_granule
Mammalian protein found in Homo sapiens
containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed
Integrin_alpha_L
Protein-coding gene in the species Homo sapiens
with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. TAR syndrome 1q21.1 deletion syndrome
Integrin_alpha_10
Protein-coding gene in the species Homo sapiens
of a novel gene-encoding a human beta 2-integrin alpha subunit". Gene. 171 (2): 291–4. doi:10.1016/0378-1119(95)00869-1. PMID 8666289. Shelley CS, Da Silva
Integrin_alpha_D
Protein found in humans
catalytic domain. Integrins lack enzymatic activity and depend on adapters to signal proteins. ILK is linked to beta-1 and beta-3 integrin cytoplasmic domains
Integrin-linked_kinase
not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein-coding gene in the species Homo sapiens
an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears
Integrin_alpha_11
Topics referred to by the same term
the Power Rangers franchise Integrin alpha-5, a protein encoded by the ITGA5 gen in humans Alpha-5 beta-1 (α5β1), an integrin that binds to matrix macromolecules
Alpha_5
Protein-coding gene in the species Homo sapiens
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted
TGF_beta_1
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Cytokine
Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation
Transforming growth factor beta
Transforming_growth_factor_beta
Monoclonal antibody
antibody, which binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7) on T lymphocytes
Cedelizumab
α5β1, also known as the fibronectin receptor, is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. It
Alpha-5_beta-1
Mammalian protein found in Homo sapiens
to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium. ICAM-1 is
ICAM-1
Garat, C.; Matthay, M. A.; et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation
TGF_beta_Activation
Protein-coding gene in the species Homo sapiens
Medicine. Li J, Mayne R, Wu C (Feb 2000). "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation". J
ITGB1BP3
Protein found in humans
eight-cysteine domains homologous with latent TGF-beta binding protein, and a proline-rich region. The FBN-1 gene is involved in a variety of embryonic developmental
Fibrillin-1
Type of proteins
alpha (Gα), beta (Gβ) and gamma (Gγ) subunits. In addition, the beta and gamma subunits can form a stable dimeric complex referred to as the beta-gamma complex
G_protein
Protein-coding gene in the species Homo sapiens
"The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking". Traffic. 1 (9): 713–23. doi:10.1034/j.1600-0854.2000.010904
TGOLN2
Mammalian protein found in humans
intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes". Biochemical and
Collagen,_type_XVII,_alpha_1
Protein-coding gene in the species Homo sapiens
(2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". J. Cell
Laminin,_beta_1
Contrast agent for cancer imaging
(LAP) in its complex with transforming growth factor beta 1 (TGF-β1). Binding of αvβ6-integrin to LAP releases and thus, activates TGF-β1. In early-stage
Ga-68-Trivehexin
Pharmaceutical compound
(MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used in
Vitaxin
Cell cycle regulation pathway
many known factors that enhance the PI3K/AKT pathway including EGF, shh, IGF-1, insulin, and calmodulin. Both leptin and insulin recruit PI3K signalling
PI3K/AKT/mTOR_pathway
Protein-coding gene in humans
affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits". The Journal of Cell Biology. 156 (2): 361–376. doi:10.1083/jcb
Filamin-A
Conversion of mechanical stimulus of a cell into electrochemical activity
extracellular matrix ligands, integrins are also receptive to autocrine and paracrine signals such as growth factors in the TGF-beta family. Chondrocytes have
Mechanotransduction
Protein-coding gene in the species Homo sapiens
Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during
TGF_beta_2
Surface glycoproteins involved in hemostasis
Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208 (4):
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein found in humans
structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences".
Addressin
Subset of cell adhesion proteins
transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits, which
Cell_adhesion_molecule
mediates cell survival in vitro via interaction with integrin beta 1 and activation of integrin-linked kinase. J. Biol. Chem. doi:10.1074/jbc.M706563200
Photo-reactive amino acid analog
Photo-reactive_amino_acid_analog
Protein domain
structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10
Adhesion molecule (immunoglobulin-like)
Adhesion_molecule_(immunoglobulin-like)
Protein-coding gene in humans
evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta". Chemistry & Biology. 6 (1): 1–10. doi:10.1016/S1074-5521(99)80015-5
ADAM2
American immunologist
(16 July 1993). "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1". Cell. 74 (1): 185–195. doi:10.1016/0092-8674(93)90305-A
Timothy_A._Springer
Protein-coding gene in the species Homo sapiens
2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal
Laminin,_beta_2
Protein-coding gene in the species Homo sapiens
cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered
TLN1
Protein-coding gene in the species Homo sapiens
(December 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J Cell
ITGB3BP
Substance that forms a complex with a biomolecule
1982). "Narcotic antagonistic potency of bivalent ligands which contain beta-naltrexamine. Evidence for bridging between proximal recognition sites".
Ligand_(biochemistry)
Protein-coding gene in the species Homo sapiens
"Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". The Journal of Biological Chemistry. 273 (4): 2379–83. doi:10
Receptor for activated C kinase 1
Receptor_for_activated_C_kinase_1
Peptides released by neurons as intercellular messengers
VIP Substance P Dopamine Cholecystokinin Neurotensin Glucagon-like peptide-1 (in the nucleus accumbens) Epinephrine (adrenaline) Neuropeptide Y Neurotensin
Neuropeptide
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Protein family
factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. TGF-beta-1 is a
Transforming growth factor beta superfamily
Transforming_growth_factor_beta_superfamily
Proteins from viper venom inhibiting platelets aggregation
clumping of platelets. They interact with the beta-1 and -3 families of integrins receptors. Integrins are cell receptors involved in cell–cell and cell–extracellular
Disintegrin
Protein-coding gene in humans
(ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc
ADAM9
Subunit of a protein
the T-cell receptor, the fibrinogen alpha chain, the integrin alpha chain, Hemoglobin, alpha 1 It should be distinguished from the term alpha helix,
Alpha_chain
Protein found in humans
Serine 612 by PI3K of IRS-1 protein is due to hyper-activation of Akt/PKB pathway in LNCaP. IRS-1 interacts with integrin α5β1, activating an alternative
Insulin_receptor_substrate_1
Protein found in humans
Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61
CCN_family_member_2
Mammalian protein
centers on preventing and treating arterial and organ complications. The beta-blocker celiprolol is the most studied preventive therapy: in a prospective
Collagen,_type_III,_alpha_1
Cascade of intracellular and molecular events for transmission/amplification of signals
PMID 17084981. Gilcrease MZ (March 2007). "Integrin signaling in epithelial cells". Cancer Letters. 247 (1): 1–25. doi:10.1016/j.canlet.2006.03.031. PMID 16725254
Signal_transduction
Protein in the extracellular matrix
secreted by Schwann cells. Neurons of the peripheral nervous system express integrin receptors that attach to laminins and promote neuroregeneration after injury
Laminin
Protein-coding gene in the species Homo sapiens
and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. The thrombospondin-1 protein
Thrombospondin_1
Protein found in humans
Ginsberg MH (1995). "Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit". J. Biol. Chem. 270 (44): 26146–51. doi:10.1074/jbc.270.44
Calpain-1_catalytic_subunit
Medical condition
subunit is involved in the formation of the β-2 integrins (LFA-1, integrin alphaXbeta2/CR4/p150,95, and Mac-1/CR3) by dimerization with different CD11 subunits
Leukocyte_adhesion_deficiency
Signaling pathway involving transforming growth factor beta proteins
The transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo
TGF_beta_signaling_pathway
Chemical compound
disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the
Etrolizumab
Protein-coding gene in the species Homo sapiens
affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits". J. Cell Biol. 156 (2). United States: 361–76. doi:10.1083/jcb
Filamin-B
Protein-coding gene in the species Homo sapiens
glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. ILKAP has been shown to interact with Integrin-linked kinase. GRCh38:
ILKAP
Exocrine gland in humans and other mammals
differentiation sub-locally. Important players include beta-1 integrin, epidermal growth factor receptor (EGFR), laminin-1/5, collagen-IV, matrix metalloproteinase
Mammary_gland
Protein-coding gene in the species Homo sapiens
laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". J. Cell Sci. 113. ( Pt 5) (5): 869–76. doi:10.1242/jcs
Laminin_subunit_gamma-1
Mammalian protein found in humans
"Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology
CD63
Protein-coding gene in the species Homo sapiens
β(2) integrin function depend on both cell type (Natural killer cell or Leukocytes) and the integrin activation stimulus. The prevention of the beta-3 activation
FERMT3
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Enzyme
Dib K (March 2003). "Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils"
Tyrosine-protein_kinase_SYK
Series of molecular signals
redundant Notch homologs, glp-1 and lin-12. During C. elegans, GLP-1, the C. elegans Notch homolog, interacts with APX-1, the C. elegans Delta homolog
Notch_signaling_pathway
Protein found in humans
presumed through a direct association with the cytoplasmic tail of beta-integrin. The N-terminal region of paxillin is rich in protein–protein interaction
Paxillin
Human protein-coding gene
J, Balmes J, Sheppard D (May 1995). "Distribution of integrins alpha v beta 6 and alpha 9 beta 1 and their known ligands, fibronectin and tenascin, in
Tenascin_C
Chemical compound
"Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins". Journal of Medicinal Chemistry. 45 (5): 1045–51
Cilengitide
Protein of the mucin family
chains: mucin-1 subunit alpha (MUC1-NT; MUC1-alpha) and mucin-1 subunit beta (MUC-CT; MUC1-beta). These subunits differ in size due to proteolytic cleavage
Mucin-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1
INTEGRIN BETA-1