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Mammalian protein found in Homo sapiens
Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a transmembrane protein which in humans is encoded by the CD49b gene. The CD49b protein
Integrin_alpha_2
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
Mammalian protein found in Homo sapiens
known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein
Integrin_alpha_X
Protein
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins
Integrin_alpha_5
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Protein-coding gene in the species Homo sapiens
Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_D
Mammalian protein found in Homo sapiens
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are
Integrin_alpha_6
Mammalian protein found in Homo sapiens
is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family
Integrin_alpha_4
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7
Integrin_alpha_7
Mammalian protein found in Homo sapiens
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans
Integrin_alpha_L
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Mammalian protein found in Homo sapiens
with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to
Integrin_beta_1
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_8
Protein-coding gene in the species Homo sapiens
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103
Integrin_alpha_E
Protein-coding gene in the species Homo sapiens
Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral
Integrin_alpha_11
Protein-coding gene in the species Homo sapiens
Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins
Integrin_alpha_9
Mammalian protein found in Homo sapiens
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains
Integrin_beta_2
Protein found in humans
Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of
Integrin_alpha_10
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Protein complex
Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently
LPAM-1
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
Pharmaceutical compound
Vatelizumab is an immunomodulator. It binds to integrin alpha 2. It was withdrawn from Phase II trials for inflammatory bowel disease due to a lack of
Vatelizumab
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits
Integrin_beta_4
Integrin complex found on platelets
"Signaling through platelet integrin alpha IIb beta 3: inside-out, outside-in, and sideways". Thrombosis and Haemostasis. 82 (2): 318–25. doi:10.1055/s-0037-1615849
Glycoprotein_IIb/IIIa
Mammalian protein found in Homo sapiens
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given
Integrin_beta_3
Protein-coding gene in the species Homo sapiens
subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is
Integrin_beta_5
Medical condition neuromuscular disorders
namely integrin-α7β1 and α-dystroglycan. In LAMA2-CMD the laminin alpha2 deficiency results in malfunctioning or down regulation of integrin-α7β1 and
LAMA2 related congenital muscular dystrophy
LAMA2_related_congenital_muscular_dystrophy
Subunit of a protein
receptor, the fibrinogen alpha chain, the integrin alpha chain, Hemoglobin, alpha 1 It should be distinguished from the term alpha helix, which refers to
Alpha_chain
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
(or integrin αMβ2 or macrophage integrin or Mac-1) is an integrin complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2)
Macrophage-1_antigen
Protein found in humans
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are
Integrin-linked_kinase
Protein-coding gene in the species Homo sapiens
This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular
Integrin_beta_8
Mammalian protein found in Homo sapiens
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7).
Alpha-actinin-3
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Mammalian protein found in humans
ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration
Collagen,_type_XVII,_alpha_1
Protein found in humans
Alpha-actinin-2 is a protein which in humans is encoded by the ACTN2 gene. This gene encodes an alpha-actinin isoform that is expressed in both skeletal
Alpha-actinin-2
migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes
Lymph_node_stromal_cell
Mammalian protein
(monomers), each called an alpha 1 chain of type III collagen. Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded
Collagen,_type_III,_alpha_1
American immunologist
; Weissman, I. L.; Hamann, A.; Butcher, E. C. (16 July 1993). "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1"
Timothy_A._Springer
Contrast agent for cancer imaging
targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous (i.v.) application
Ga-68-Trivehexin
Chemical compound
known as iRGD, is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. It also binds and activates neuropilin-1, leading to a
Arginylglycylaspartic_acid
Enzyme in humans
Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Surface glycoproteins involved in hemostasis
(link) Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Pharmaceutical compound
(MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used
Vitaxin
Protein found in humans
Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61
CCN_family_member_2
Protein found in humans
Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene. This gene encodes the alpha chain of type XVI collagen, a member
Collagen,_type_XVI,_alpha_1
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Protein-coding gene in the species Homo sapiens
1242/jcs.101.2.403. PMID 1629252. Otey CA, Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro"
Alpha-actinin-4
Protein found in humans
"Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens
Collagen,_type_V,_alpha_1
Chemical compound
disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the
Etrolizumab
Protein-coding gene in the species Homo sapiens
function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35):
Alpha-1B_adrenergic_receptor
Protein-coding gene in humans
and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't
CD47
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
Protein-coding gene in the species Homo sapiens
Zhang J, Kieffer N (Aug 2008). "The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing
TLN1
Human protein-encoding gene
Robertson C, McNicol A (January 2001). "CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets". Thrombosis
CD9
Protein-coding gene in humans
protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). CIB1 is a small
CIB1
Cytokine
Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
Transforming growth factor beta
Transforming_growth_factor_beta
Subset of cell adhesion proteins
survival, and transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits
Cell_adhesion_molecule
Mammalian protein found in Homo sapiens
expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus
ICAM-1
not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein in the extracellular matrix
includes the brain and muscle fibers. In muscle, it binds to alpha-dystroglycan and integrin alpha7—beta1 via the G domain, and via the other end, it binds
Laminin
Protein factor that regulates the length of R-actin
the connection between the actin cytoskeleton within the cell and the integrins that directly interact with the stromal ECM. Additionally, it can sense
Actinin
Protein-coding gene in the species Homo sapiens
Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific
PKC_alpha
Protein found in humans
(MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like
Addressin
Structures which transmit force and signals between a cell and the extracellular matrix
DGEA and GFOGER motifs found in collagen. Integrins are heterodimers which are formed from one beta and one alpha subunit. These subunits are present in
Focal_adhesion
Medical condition
chromosome 21. This subunit is involved in the formation of the β-2 integrins (LFA-1, integrin alphaXbeta2/CR4/p150,95, and Mac-1/CR3) by dimerization with different
Leukocyte_adhesion_deficiency
Macrophage found in the lungs
thus inducing the expression of the αvβ6 integrin. Integrins are dimeric cell-surface receptors composed of alpha and beta subunits, which activates TGF-β
Alveolar_macrophage
Protein-coding gene in the species Homo sapiens
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for
ITGB1BP1
Medical treatment
proinflammatory cytokines. The alpha 4 integrin on inflammatory cells interacts with these adhesion molecules to allow for migration. Integrin receptor antagonists
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
Protein family
LM, Hickey MJ, Wright MD, Jackson DE (2006). "Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice". Blood
Tetraspanin
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Mammalian protein found in humans
β1 integrins. Collagen XXIII interacts in an ion-and conformation-dependent manner with integrin α2β1. Integrin α2β1 is a collagen-binding integrin present
Collagen,_type_XXIII,_alpha_1
Protein-coding gene in the species Homo sapiens
OSF-2) is a protein that in humans is encoded by the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support
Periostin
Human protein-coding gene
attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins". Journal of Cell Science. 105 (4): 1001–1012. doi:10
Tenascin_C
Protein-coding gene in humans
WA (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". The Journal of Biological Chemistry
PTK2
J. F.; Kaminski, N.; Garat, C.; Matthay, M. A.; et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
TGF_beta_Activation
Protein domain
structures of 4-disulfide EGF-domains have been solved from the laminin and integrin proteins.[citation needed] The main structure of EGF-like domains is a
EGF-like_domain
Mammalian protein found in Homo sapiens
immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through
ICAM3
Protein Domain
"Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10277–81. Bibcode:1995PNAS
Von Willebrand factor type A domain
Von_Willebrand_factor_type_A_domain
Class of enzymes
In enzymology, a lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) is an enzyme that catalyzes the chemical reaction CMP-N-acetylneuraminate
Lactosylceramide alpha-2,3-sialyltransferase
Lactosylceramide_alpha-2,3-sialyltransferase
Protein
bone. In humans it is encoded by the VTN gene. Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. It also inhibits
Vitronectin
Overview of and topical guide to immunology
/ CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late antigen receptor: Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha3beta1
Outline_of_immunology
Protein found in humans
composed of three alpha subunits; this gene encodes the alpha 3 subunit. These subunits are encoded by six different genes, alpha 1 through alpha 6, each of
Collagen,_type_IV,_alpha_3
Protein-coding gene in the species Homo sapiens
2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal
Laminin,_beta_2
Protein-coding gene in humans
subcellular distribution, and determine binding to integrin [beta] subunits". The Journal of Cell Biology. 156 (2): 361–376. doi:10.1083/jcb.200103037. PMC 2199218
Filamin-A
Protein-coding gene in the species Homo sapiens
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse
Alpha-actinin-1
Protein-coding gene in the species Homo sapiens
Altered syndecan-2 expression has been detected in several different tumor types. SDC2 has been shown to interact with: CASK, Laminin, alpha 3, and EZR GRCh38:
Syndecan-2
Aggregation of platelets formed during early stage of coagulation
adhesion. This process will then be mediated by integrins, such as β1 (α2β1, α5β1) and β3 (αIIbβ3) integrins. In addition, platelets are activated, they will
Platelet_plug
Type of chemical bond
integrin alpha L beta 2 and intercellular adhesion molecule 1 (ICAM-1), integrin alpha 4 beta 1 with vascular adhesion molecule 1, integrin alpha M
Catch_bond
Protein-coding gene in the species Homo sapiens
altering the molecule's conformation. Modification of integrin's conformation serves to dissociate alpha and beta subunits by disrupting their interactions
FERMT3
Protein-coding gene in humans
"Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions"
ADAM2
Protein-coding gene in the species Homo sapiens
α3β1 Integrin, and Mitogen-activated Protein Kinase Can Regulate Epithelial Cell Proliferation". Mol. Biol. Cell. 10 (2): 259–70. doi:10.1091/mbc.10.2.259
Laminin,_alpha_3
Protein-coding gene in the species Homo sapiens
2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal
Laminin,_alpha_5
Mammalian protein found in Homo sapiens
chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues"
EMID2
Protein involved in cell adhesion, cell growth, cell migration and differentiation
extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as
Fibronectin
Component of striated muscle cells
dystrophin-glycoprotein complex (DGC) and the integrin-vinculin-talin complex. The sarcoglycans of the DGC and the integrins of the integrin-vinculin-talin complex attach
Costamere
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INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
INTEGRIN ALPHA-2
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