AI & ChatGPT searches , social queries for INTEGRIN ALPHA-8
Search references for INTEGRIN ALPHA-8. Phrases containing INTEGRIN ALPHA-8
See searches and references containing INTEGRIN ALPHA-8!
Search references for INTEGRIN ALPHA-8. Phrases containing INTEGRIN ALPHA-8
See searches and references containing INTEGRIN ALPHA-8!INTEGRIN ALPHA-8
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_8
Mammalian protein found in Homo sapiens
known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein
Integrin_alpha_X
Mammalian protein found in Homo sapiens
is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain family
Integrin_alpha_4
Protein
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins
Integrin_alpha_5
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Mammalian protein found in Homo sapiens
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans
Integrin_alpha_L
Mammalian protein found in Homo sapiens
CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane
Integrin_alpha_2
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7
Integrin_alpha_7
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Protein-coding gene in the species Homo sapiens
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103
Integrin_alpha_E
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Protein-coding gene in the species Homo sapiens
Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins
Integrin_alpha_9
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Mammalian protein found in Homo sapiens
CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one of a number of alpha chains
Integrin_beta_2
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
Protein-coding gene in the species Homo sapiens
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain family and encodes a single-pass
Integrin_beta_8
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Protein-coding gene in the species Homo sapiens
Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of
Integrin_alpha_10
Mammalian protein found in Homo sapiens
with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to
Integrin_beta_1
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta subunits
Integrin_beta_4
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Mammalian protein found in Homo sapiens
ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given
Integrin_beta_3
Protein-coding gene in the species Homo sapiens
subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is
Integrin_beta_5
Human protein-coding gene
Klimanskaya IV, Sheppard D, Pytela R (September 1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin"
Tenascin_C
Chemical compound
known as iRGD, is a cyclic peptide that homes to tumors via binding to integrin alpha V receptors. It also binds and activates neuropilin-1, leading to a
Arginylglycylaspartic_acid
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes
Lymph_node_stromal_cell
American immunologist
; Weissman, I. L.; Hamann, A.; Butcher, E. C. (16 July 1993). "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1"
Timothy_A._Springer
Surface glycoproteins involved in hemostasis
(link) Calvete JJ (1995). "On the structure and function of platelet integrin alpha IIb beta 3, the fibrinogen receptor". Proc. Soc. Exp. Biol. Med. 208
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein found in humans
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one of the low abundance fibrillar
Collagen,_type_V,_alpha_1
Mammalian protein found in humans
ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration
Collagen,_type_XVII,_alpha_1
Protein-coding gene in humans
and partners with membrane integrins and also binds the ligands thrombospondin 1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't
CD47
Protein-coding gene in the species Homo sapiens
laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins". J. Biol. Chem. 276 (20): 17550–8. doi:10.1074/jbc
Laminin,_alpha_3
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
Human protein-encoding gene
Robertson C, McNicol A (January 2001). "CD63 associates with the alphaIIb beta3 integrin-CD9 complex on the surface of activated platelets". Thrombosis
CD9
Protein found in humans
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are
Integrin-linked_kinase
Protein-coding gene in humans
regulates the reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and secondary messengers. At least
Filamin-A
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Protein found in humans
to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". Journal of Immunology. 156 (8): 2851–7
Addressin
Protein-coding gene in the species Homo sapiens
mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been
TLN1
Mammalian protein found in Homo sapiens
expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus
ICAM-1
Protein found in humans
Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene. This gene encodes the alpha chain of type XVI collagen, a member
Collagen,_type_XVI,_alpha_1
Protein in the extracellular matrix
includes the brain and muscle fibers. In muscle, it binds to alpha-dystroglycan and integrin alpha7—beta1 via the G domain, and via the other end, it binds
Laminin
Medical treatment
proinflammatory cytokines. The alpha 4 integrin on inflammatory cells interacts with these adhesion molecules to allow for migration. Integrin receptor antagonists
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
Dog breed
Chondrodysplasia Caused by a Truncating Mutation in Collagen-Binding Integrin Alpha Subunit 10". PLoS ONE. 8 (9) e75621. Public Library of Science (PLoS). doi:10.1371/journal
Karelian_Bear_Dog
Mammalian protein found in Homo sapiens
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7).
Alpha-actinin-3
Protein-coding gene in the species Homo sapiens
inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits". J. Biol. Chem. 279 (35): 36593–600. doi:10.1074/jbc.M402084200
Alpha-1B_adrenergic_receptor
Cytokine
Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. (February 1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
Transforming growth factor beta
Transforming_growth_factor_beta
Subset of cell adhesion proteins
transcription. Integrins are heterodimeric, as they consist of an alpha and beta subunit. There are currently 18 alpha subunits and 8 beta subunits, which
Cell_adhesion_molecule
Medical condition neuromuscular disorders
namely integrin-α7β1 and α-dystroglycan. In LAMA2-CMD the laminin alpha2 deficiency results in malfunctioning or down regulation of integrin-α7β1 and
LAMA2 related congenital muscular dystrophy
LAMA2_related_congenital_muscular_dystrophy
Protein-coding gene in the species Homo sapiens
2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha 6 beta 4 integrins". Journal
Laminin,_alpha_5
Protein-coding gene in humans
WA (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". The Journal of Biological Chemistry
PTK2
α5β1, also known as the fibronectin receptor, is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis. It
Alpha-5_beta-1
Chemical compound
disease. It is a humanized monoclonal antibody against the β7 subunit of integrins α4β7 and αEβ7. Etrolizumab was developed by Genentech by engineering the
Etrolizumab
Type of chemical bond
integrin alpha L beta 2 and intercellular adhesion molecule 1 (ICAM-1), integrin alpha 4 beta 1 with vascular adhesion molecule 1, integrin alpha M
Catch_bond
Protein family
"Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice". Blood. 108 (6): 1911–8. doi:10.1182/blood-2006-02-004267
Tetraspanin
Contrast agent for cancer imaging
targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous (i.v.) application
Ga-68-Trivehexin
Macrophage found in the lungs
thus inducing the expression of the αvβ6 integrin. Integrins are dimeric cell-surface receptors composed of alpha and beta subunits, which activates TGF-β
Alveolar_macrophage
Protein-coding gene in humans
(ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc
ADAM9
Protein factor that regulates the length of R-actin
the connection between the actin cytoskeleton within the cell and the integrins that directly interact with the stromal ECM. Additionally, it can sense
Actinin
Protein-coding gene in the species Homo sapiens
sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol
GIPC1
Protein-coding gene in the species Homo sapiens
the POSTN gene. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells
Periostin
not listed on hcdm Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3. J Clin Invest 2005; 115:3363-9. "FITC Anti-human CD51 Antibody
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein found in humans
involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. Galectin-8, interacts
Galectin-8
Protein-coding gene in the species Homo sapiens
neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin". Journal of Immunology. 151 (7):
Alpha-actinin-2
Human protein-coding gene
adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading". J. Cell Biol. 149 (5): 1143–56. doi:10.1083/jcb
ADAM12
Protein-coding gene in humans
protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). CIB1 is a small
CIB1
Mammalian protein found in humans
neutrophil stimulates the neutrophils to upregulate their expression of the integrin, LFA-1 (Lymphocyte function-associated antigen 1), which takes part in
Interleukin_8
J. F.; Kaminski, N.; Garat, C.; Matthay, M. A.; et al. (1999). "The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating
TGF_beta_Activation
Medical condition
chromosome 21. This subunit is involved in the formation of the β-2 integrins (LFA-1, integrin alphaXbeta2/CR4/p150,95, and Mac-1/CR3) by dimerization with different
Leukocyte_adhesion_deficiency
Protein-coding gene in the species Homo sapiens
Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of serine- and threonine-specific
PKC_alpha
Mammalian protein
(monomers), each called an alpha 1 chain of type III collagen. Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded
Collagen,_type_III,_alpha_1
Movement of white blood cells out of blood vessels and towards the inflamed site
juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In the activated state, integrins bind tightly to complementary
Leukocyte_extravasation
Protein-coding gene in the species Homo sapiens
endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. VCAM-1 expression has also been observed in other
VCAM-1
Protein-coding gene in the species Homo sapiens
Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol. 24 (24): 10923–32. doi:10
PRAM1
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Protein-coding gene in the species Homo sapiens
altering the molecule's conformation. Modification of integrin's conformation serves to dissociate alpha and beta subunits by disrupting their interactions
FERMT3
Protein found in humans
costamerogenesis is that in cultured, undifferentiated myoblasts, alpha-5 integrin, vinculin and paxillin are in complex and located primarily at focal
Paxillin
Enzyme in humans
Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Protein involved in cell adhesion, cell growth, cell migration and differentiation
extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as
Fibronectin
Chemical compound
Matzku S, DeNardo GL (August 2002). "Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy
Cilengitide
Protein-coding gene in humans
"Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions"
ADAM2
Protein-coding gene in the species Homo sapiens
Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. Cell Biol. 111 (2): 721–9. doi:10
Alpha-actinin-4
Mammalian protein found in Homo sapiens
immune system. ICAM3 mediates adhesion between cells by binding to specific integrin receptors. It plays an important role in the immune cell response through
ICAM3
Mammalian protein found in humans
proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology. 157 (5): 2039–47. doi:10
CD63
Protein-coding gene in the species Homo sapiens
22719. PMID 9712903. Jiang P, Lagenaur CF, Narayanan V (January 1999). "Integrin-associated protein is a ligand for the P84 neural adhesion molecule". The
Signal-regulatory protein alpha
Signal-regulatory_protein_alpha
Protein-coding gene in the species Homo sapiens
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for
ITGB1BP1
Protein-coding gene in the species Homo sapiens
possibly by limiting the expression of alpha-5 integrin. NISCH has been shown to interact with IRS4, Integrin alpha 5, and small GTPases Rac1, Rab4a, Rab9a
NISCH
Protein-coding gene in the species Homo sapiens
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse
Alpha-actinin-1
Protein found in humans
Ugarova TP, Ye RD, Lau LF, Lam SC (June 2002). "Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for
CCN_family_member_2
Protein-coding gene in humans
PMID 10652535. Takagi J (2002). "[First atomic view of alpha V beta 3 integrin extracellular domain]". Tanpakushitsu Kakusan Koso. 47 (2): 153–9
ADAM15
Protein-coding gene in the species Homo sapiens
Opinion in Cell Biology. 8 (5): 618–624. doi:10.1016/S0955-0674(96)80102-5. PMID 8939648. Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins"
Laminin_subunit_alpha-2
Protein-coding gene in humans
2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". The
RAC3
Protein-coding gene in the species Homo sapiens
interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. doi:10.1016/S0014-5793(99)00151-9
REV1
matrix metalloproteinase-9 (MMP) at the alpha chain on the collagen strand. Tumstatin interacts with the αvβ3 integrin found in the apoptosis pathway. There
Tumstatin
– tacrolimus binding protein 1a MeSH D12.776.543.750.705.408.100 – integrin alpha chains MeSH D12.776.543.750.705.408.100.100 – antigens, cd11a MeSH D12
List of MeSH codes (D12.776.543)
List_of_MeSH_codes_(D12.776.543)
Protein-coding gene in humans
sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling
AUP1
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8
INTEGRIN ALPHA-8