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Biological process
near-perfect fidelity for DNA replication. DNA replication usually begins at specific locations known as origins of replication which are scattered across
DNA_replication
DNA replication in eukaryotic organisms
Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA is central
Eukaryotic_DNA_replication
DNA replication in prokaryotes
Prokaryotic DNA replication is the process by which a prokaryote duplicates its DNA into another copy that is passed on to daughter cells. Although it
Prokaryotic_DNA_replication
Sequence in a genome
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. Propagation of the
Origin_of_replication
Plant organelle that conducts photosynthesis
points of origin. Multiple replication forks open up, allowing replication machinery to transcribe the DNA. As replication continues, the forks grow and
Chloroplast
Enzymes that catalyze DNA formation
of DNA. These enzymes are essential for DNA replication and usually work in groups to create two identical DNA duplexes from a single original DNA duplex
DNA_polymerase
Undesirable occurrence in eukaryotic cells
DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more
DNA_re-replication
DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur
DNA_replication_stress
Molecule that carries genetic information
into DNA strands during processes such as transcription and DNA replication. DNA exists in many possible conformations that include A-DNA, B-DNA, and
DNA
Mechanism of DNA replication
Semiconservative replication is the process by which DNA is replicated in all living cells. DNA replication involves separation (unwinding) of the two
Semiconservative_replication
Type of behavior of a dynamical system
"assisted replication" than "self-replication". In 2021 researchers succeeded in constructing a system with sixteen specially designed DNA sequences.
Self-replication
Damage in DNA which occurs naturally
cause aging. (Also see DNA damage theory of aging.) In replicating cells, such as cells lining the colon, errors occur upon replication of past damages in
DNA damage (naturally occurring)
DNA_damage_(naturally_occurring)
Parts of lagging strand in DNA replication
eukaryotes, DNA replication takes place in the nucleus. A plethora replication form in just one replicating DNA molecule, the start of DNA replication is moved
Okazaki_fragments
Events leading to cell division
These events include the growth of the cell, duplication of its DNA (DNA replication) and some of its organelles, and subsequently the partitioning of
Cell_cycle
Type of chromosome
bacteria chromosome replication is best understood in the well-studied bacteria Escherichia coli and Bacillus subtilis. Chromosome replication proceeds in three
Circular_chromosome
Formation of biological viruses during the infection process
proteins and nucleic acids. Virus replication occurs in seven stages: Attachment Entry (penetration) Uncoating Replication Assembly Maturation Release (liberation
Viral_replication
Virus that has DNA as its genetic material
polyadenylation site. dsDNA viruses make use of several mechanisms to replicate their genome. Bidirectional replication, in which two replication forks are established
DNA_virus
Replication of DNA
prokaryotes, DNA replication occurs when specific topoisomerases, helicases and gyrases (replication initiator proteins) uncoil the double-stranded DNA, exposing
DNA_synthesis
Sequence of DNA that determines traits in an organism
cell division: replication origins, telomeres, and the centromere. Replication origins are the sequence regions where DNA replication is initiated to
Gene
DNA synthesis technique
circle replication (RCR) is a process of unidirectional nucleic acid replication that can rapidly synthesize multiple copies of circular molecules of DNA or
Rolling_circle_replication
Alteration in the nucleotide sequence of a genome
organism, virus, or extrachromosomal DNA. Mutations result from errors during replication, mitosis, meiosis, or damage to DNA, which then may trigger error-prone
Mutation
DNA inside the nucleus of eukaryotic cells
of DNA duplication is usually called replication. The replication is termed semiconservative since each new cell contains one strand of original DNA and
Nuclear_DNA
Class of enzymes
DNA polymerase I (or Pol I) is an enzyme that participates in the process of prokaryotic DNA replication. Discovered by Arthur Kornberg in 1956, it was
DNA_polymerase_I
Protein found in humans
licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. It is a licensing factor that functions to limit DNA from replicating
DNA_replication_factor_CDT1
Set of methods in molecular biology
molecular biology that are used to assemble recombinant DNA molecules and to direct their replication within host organisms. The use of the word cloning refers
Molecular_cloning
Primary enzyme complex involved in prokaryotic DNA replication
DNA polymerase III holoenzyme is the primary enzyme complex involved in prokaryotic DNA replication. It was discovered by Thomas Kornberg (son of Arthur
DNA_polymerase_III_holoenzyme
Process of copying a segment of DNA into RNA
viral proteins needed for viral replication. This process is catalyzed by a viral RNA dependent RNA polymerase. A DNA transcription unit encoding for
Transcription_(biology)
Enzyme complex
DNA polymerase delta (DNA Pol δ) is an enzyme complex found in eukaryotes that is involved in DNA replication and repair. The DNA polymerase delta complex
DNA_polymerase_delta
System for fixing base errors of DNA replication
arise during DNA replication and recombination, as well as repairing some forms of DNA damage. Mismatch repair is strand-specific. During DNA synthesis the
DNA_mismatch_repair
DNA that does not code for proteins
non-coding DNA fraction include regulatory sequences that control gene expression; scaffold attachment regions; origins of DNA replication; centromeres;
Non-coding_DNA
Chemical compound
of DNA replication of plasmids with different replication origins and found that certain plasmids exhibited a delay in the inhibition of replication when
Hypochlorous_acid
Term in biochemistry
of DNA is important in DNA replication because it replicates the leading strand one way and the lagging strand the other way. During DNA replication, the
Antiparallel_(biochemistry)
Genetic mutation not inherited from a parent
Like many they can arise from DNA replication, recombination or through repairing double stranded breaks in the DNA. The most prone locations of copy
De_novo_mutation
DNA located in cellular organelles called chloroplasts
dehydrogenase ribosomal proteins tRNA replication origin regions tRNA small RNA ribosomal protein replication origin regions ribosomal RNA tRNAs ribosomal
Plastid_DNA
DNA located in mitochondria
(15 July 1974). "Mechanism of mitochondrial DNA replication in mouse L-cells: Asynchronous replication of strands, segregation of circular daughter molecules
Mitochondrial_DNA
Species of virus
has inserted the viral genome, the process of DNA replication of the host genome is halted and replication of viral genome begins. Under optimal conditions
T7_phage
Protein that binds to single-stranded DNA in eukaryotic cells
Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. In vitro, RPA shows a much higher affinity
Replication_protein_A
Genus of archaea
that the genes in the genome of Methanococcus jannaschii involved in DNA replication, transcription, and translation were more related to their counterparts
Sulfolobus
Replacement, insertion, or deletion of a single DNA or RNA nucleotide
take place during DNA replication. DNA replication occurs when one double-stranded DNA molecule creates two single strands of DNA, each of which is a
Point_mutation
In DNA replication, replication timing refers to the order in which segments of DNA along the length of a chromosome are duplicated. In eukaryotic cells
Replication_timing
Second subphase of interphase
initiates synthesis of new DNA. Complete replication fork assembly and activation only occurs on a small subset of replication origins. All eukaryotes possess
S_phase
Protein-coding gene in the species Homo sapiens
protein contains a replication factory-targeting sequence that is used to recruit it to sites of DNA replication known as replication factories. Activation
DNA_ligase_1
Species of virus
cycle, so that both cell division and host cell DNA replication are disturbed in favor of virus replication. The herpes simplex 1 genomes can be classified
Herpes_simplex_virus
Infectious agent that replicates in cells
which the material is replicated, varies considerably between different types of viruses. DNA viruses The genome replication of most DNA viruses takes place
Virus
Biological process
nucleus) is preceded by the S stage of interphase (during which the DNA replication occurs) and is followed by telophase and cytokinesis; which divides
Cell_division
Type of DNA molecule
rolling circle replication, many DNA viruses employ recombination-dependent replication to produce concatemers. In this mechanism, replication is initiated
Concatemer
Protein
called the replicator to start DNA replication. It is a replication initiation factor which promotes the unwinding of DNA at oriC. The DnaA proteins found
DnaA
Two nucleobases bound by hydrogen bonds
DNA and incoming nucleotides provides the mechanism through which DNA polymerase replicates DNA and RNA polymerase transcribes DNA into RNA. Many DNA-binding
Base_pair
High frequency of mutations within the genome of a cellular lineage
hairpins, leading to difficulty of replication. Under replication stress, such as defective machinery or further DNA damage, DNA breaks and gaps can form at
Genome_instability
Cellular mechanism
dividing cells, unrepaired DNA damage that does not kill the cell by blocking replication will tend to cause replication errors and thus mutation. The
DNA_repair
Fibrillar network
support, the nuclear lamina regulates important cellular events such as DNA replication and cell division. Additionally, it participates in chromatin organization
Nuclear_lamina
Protein complex formed during initiation of DNA replication
A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation
Pre-replication_complex
Two identical copies of a chromosome joined at the centromere
chromatid refers to the identical copies (chromatids) formed by the DNA replication of a chromosome, with both copies joined together by a common centromere
Sister_chromatids
Loss of structure in proteins and nucleic acids due to external stress
strands in DNA can be broken in order to "open" the double helix when biologically important mechanisms such as DNA replication, transcription, DNA repair
Denaturation_(biochemistry)
Class of enzymes
DNA Pol III stalls or becomes non-functional, then DNA Pol II is able to be specifically recruited to the replication point and continue replication.
DNA_polymerase_II
Family of protein complexes
plays a more limited role in replication. Pol α is responsible for the initiation of DNA replication at origins of replication (on both the leading and lagging
DNA_polymerase_alpha
Class of enzymes
antigen), RFC (replication factor C) and RPA (replication protein A). Either DNA polymerase epsilon or DNA polymerase delta along with DNA ligase can be
DNA_polymerase_epsilon
either transgenic DNA or replication and capsid encoding DNA, plus helper DNA. Every cell that is successfully transfected with all three DNA fragments will
Helper_dependent_virus
Protein complex in bacteria responsible for cell division
synthesis of the division septum. DNA replication in bacteria is tightly linked to cell division. For instance, blocking replication in B. subtilis results in
Divisome
Biological process
replication, sequestering it and thus preventing methylation. Because hemimethylated origins of replication are inactive, this mechanism limits DNA replication
DNA_methylation
Region of repetitive nucleotide sequences on chromosomes
primer to initiate replication. On the leading strand (oriented 5'-3' within the replication fork), DNA-polymerase continuously replicates from the point
Telomere
Small DNA molecule within a cell
used as vectors in molecular cloning, serving to drive the replication of recombinant DNA sequences within host organisms. In the laboratory, plasmids
Plasmid
Basic unit of life forms
In meiosis, the DNA is replicated only once, while the cell divides twice. DNA replication only occurs before meiosis I. DNA replication does not occur
Cell_(biology)
1958 experiment in DNA replicatication
hypothesis that DNA replication was semiconservative. In semiconservative replication, when the double-stranded DNA helix is replicated, each of the two
Meselson–Stahl_experiment
Biological process
of problems caused by DNA lesions during replication, resulting in errors in replication. In bacteria, extensive damage to DNA due to mutagens results
Mutagenesis
Protein family
effectively halts DNA polymerase movement. Tus helps end DNA replication in prokaryotes. They function by binding to DNA replication terminator sequences
Replication terminator Tus family
Replication_terminator_Tus_family
DNA structure
the absence of DNA replication, which suggests they process H-DNA in a replication-independent manner. Alternatively, the DNA-replication repair nuclease
Triple-stranded_DNA
Class of enzymes
DNA helix. A second topological challenge results from the linking or tangling of DNA during replication. Left unresolved, links between replicated DNA
Topoisomerase
British X-ray crystallographer (1920–1958)
Rosenberg, BH (1961). "The replication of DNA III. Changes in the number of strands in E. coli DNA during its replication cycle". Biophysical Journal
Rosalind_Franklin
Network of circular DNA
daughter kinetoplast. This unique mode of DNA replication may inspire potential drug targets. The best studied kDNA structure is that of Crithidia fasciculata
Kinetoplast
region of a nucleotide sequence where an RNA or DNA single-stranded primer binds to start replication. The primer binding site is on one of the two complementary
Primer_binding_site
Enzyme
while double-stranded DNA is being unwound by elongating RNA-polymerase or by helicase in front of the progressing replication fork. It is the only known
DNA_gyrase
Nuclear protein inhibiting DNA replication
negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNA interference results in re-replication of portions of the
Geminin
Control mechanism in the eukaryotic cell cycle
metabolically active and continuously grows; S phase, during which DNA replication takes place; G2, during which cell growth continues and the cell synthesizes
Cell_cycle_checkpoint
Bacteriophage that infects Escherichia coli
is capable of encoding for a DnaB helices. For the first few replication cycles, the lambda genome undergoes θ replication (circle-to-circle). This is
Lambda_phage
–O– linkage between phosphoric acid and two other compounds
During the replication of DNA, for example, the DNA polymerase I leaves behind a hole between the phosphates in the newly formed backbone. DNA ligase is
Phosphodiester_bond
Short strand of RNA or DNA that serves as a starting point for DNA synthesis
initiation of DNA synthesis. A synthetic primer is a type of oligo, short for oligonucleotide. DNA polymerases (responsible for DNA replication) are only
Primer_(molecular_biology)
Genetic point mutation that results in an amino acid change in a protein
can be repaired by the cell when there are errors in DNA replication by using mechanisms such as DNA proofreading and mismatch repair. They can also be
Missense_mutation
Structure formed by double-stranded molecules
This un-knotting is required for the replication of circular DNA and various types of recombination in linear DNA which have similar topological constraints
Nucleic_acid_double_helix
Topics referred to by the same term
itself DNA replication or DNA synthesis, the process of copying a double-stranded DNA molecule Semiconservative replication, mechanism of DNA replication Viral
Replication
Family of viruses
unique, as most DNA viruses enter the nucleus of host cells to being viral replication, whereas Poxviruses complete their full replication cycle within the
Poxviridae
Biological process
eukaryotes by which two sister chromatids formed as a consequence of DNA replication, or paired homologous chromosomes, separate from each other and migrate
Chromosome_segregation
Branch of biology that studies biological systems at the molecular level
hypothesis that DNA replication was semiconservative. In semiconservative replication, when the double-stranded DNA helix is replicated, each of the two
Molecular_biology
Phylum of viruses
is a large genome and the presence of many genes involved in DNA repair, DNA replication, transcription, and translation. Typically, viruses with smaller
Nucleocytoviricota
Mammalian protein found in Homo sapiens
antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Enzyme which generates DNA
complementary DNA molecule, through a process termed reverse transcription. Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their
Reverse_transcriptase
Protein-coding gene in the species Homo sapiens
proofreading to ensure replication accuracy during DNA synthesis, and in a number of types of replication-linked DNA repair following DNA damage. Germline mutations
POLD1
Protein family around which DNA winds to form nucleosomes
prevent DNA from becoming tangled and protect it from DNA damage. In addition, histones play important roles in gene regulation and DNA replication. Without
Histone
Cell division producing haploid gametes
frequent genetic cause of developmental disabilities. In meiosis, DNA replication is followed by two rounds of cell division to produce four daughter
Meiosis
Class of proteins
ICP8, is a nuclear protein that, along other replication proteins is required for viral DNA replication during lytic infection. Six herpes virus-group-common
Single-stranded binding protein
Single-stranded_binding_protein
Family of viruses
replication can occur. The only protein encoded in the viral genome that is essential for geminiviral DNA replication is the geminiviral replication protein
Geminiviridae
Science of genes, heredity and variation
of DNA polymerases. Processes that increase the rate of changes in DNA are called mutagenic: mutagenic chemicals promote errors in DNA replication, often
Genetics
DNA region replicating from a single origin
replicon model for replication initiation. According to the replicon model, two components control replication initiation: the replicator and the initiator
Replicon_(genetics)
Class of enzymes
DNA strands are linked together like chain links. This occurs after DNA replication, where two single strands are catenated and can still replicate but
Type_II_topoisomerase
Bacterial DNA primase
transfer to DNA polymerase III. DnaG performs this catalysis near the replication fork that is formed by DnaB helicase during DNA replication. DnaG must be
DnaG
American biologist
biochemistry of DNA replication in human cells, enabling the identification and functional characterization of components of the human replication machinery
Thomas_J._Kelly_(scientist)
Cell division into two identical cells
maintained. Mitosis is preceded by the S phase of interphase (during which DNA replication occurs) and is followed by telophase and cytokinesis, which divide
Mitosis
Eradicated viral disease
necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and
Smallpox
DNA polymerases that originate from thermophiles
used for nick translation and TaqMan, among other things, without DNA replication (amplification). Alice Chien and colleagues were the first to characterise
Thermostable_DNA_polymerase
membrane or in peroxisomes. bidirectional replication A common mechanism of DNA replication in which two replication forks move in opposite directions away
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
DNA REPLICATION
DNA REPLICATION
Female
Hebrew
(×“Ö¼Ö¸× Ö¸×”) Feminine form of Hebrew Dan, DANA means "judge." Compare with other forms of Dana.
Female
Native American
Native American Hopi name UNA means "remember." Compare with another form of Una.
Female
Hebrew
(×¢Ö¶×“Ö°× Ö¸×”) Hebrew name EDNA means "delight, pleasure, rejuvenation." In the apocryphal Book of Tobit, this is the name of the mother of Sarah. Compare with another form of Edna.
Female
Irish
Short form of Irish Gaelic CatrÃona, RÃONA means "pure."
Female
Portuguese
Portuguese form of Greek Lydia, LÃDIA means "of Lydia."
Female
Irish
Irish Gaelic name FÃONA means "vine."
Female
Italian
 Short form of Italian Adona, DONA means "my lord."
Female
English
Anglicized form of Irish Gaelic Úna, probably UNA means "famine, hunger." Compare with another form of Una.
Female
Serbian
(Bulgarian and Serbian Ðна): Bulgarian and Serbian form of Greek Hanna, ANA means "favor; grace."
Male
English
English surname transferred to unisex forename use, possibly DANA means "from Denmark."
Girl/Female
English American
A names ending in 'ina' or 'ena' (ie. Christina) used as a nickname. Famous bearer: In 1906...
Female
English
 Variant spelling of English Dinah, DINA means "judgment." Compare with another form of Dina.
Female
English
 Variant spelling of English Oona, possibly ONA means "famine, hunger." Compare with another form of Ona.
Female
Spanish
Portuguese and Spanish form of Latin Anna, ANA means "favor; grace."Â Compare with another form of Ana.
Female
Irish
Irish Gaelic form of French Catherine, CAITRÃONA means "pure."
Female
English
Anglicized form of Irish Gaelic Eithne, ENA means "kernel."
Female
Slavic
 Short form of Slavic Bogdana, DANA means "gift from God." Compare with other forms of Dana.
Female
Polish
Polish name of Lithuanian origin, GRAŻYNA means "beautiful."
Female
English
 English surname transferred to unisex forename use, possibly DANA means "from Denmark." Compare with other forms of Dana.
Female
Scottish
 Short form of Scottish Murdina, DINA means "sea warrior." Compare with another form of Dina.
DNA REPLICATION
DNA REPLICATION
Girl/Female
Hindu
Truth, Morality, Justice, Good behavior
Surname or Lastname
English
English : topographic name for someone who lived by a hillock (see Knapp), or habitational name for someone from a place named with this word.English : possibly a variant spelling of Napper, a variant of Napier.German (also Knäpper) : habitational name from either of two places in Westphalia named Knapp.German (Knäpper) : unflattering nickname from an agent derivative of knappen ‘to be stingy’ or, in some places, ‘to grab or snatch’.
Boy/Male
Tamil
Honey bee, Lover
Girl/Female
Assamese, Hindu, Indian, Kannada, Sindhi, Telugu
Fairy; Apsara; Princess; Angel
Boy/Male
Arabic, Australian
Beautiful; Variant of Jameelah
Boy/Male
British, English
From the Bend Shaped Like a Nose
Boy/Male
Tamil
Jayam
Female
Italian
Pet form of Italian Michela, MICHELINA means "who is like God?"
Boy/Male
Arabic, Australian
Splendid; Handsome; Happy
Girl/Female
Tamil
A little song, A small song
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DNA REPLICATION
n.
A viola da gamba.
n.
A descendant of Dan; an Israelite of the tribe of Dan.
n.
Lady; mistress; madam; -- a title of respect used in Spain, prefixed to the Christian name of a lady.
pl.
of Auto-da-fe
n.
A variant of Dan, a title of honor.
n.
A disease; black jaundice. See Mel/na.
n.
A title of honor equivalent to master, or sir.
n.
See Doa.
n.
A piece of DNA, usually circular, functioning as part of the genetic material of a cell, not integrated with the chromosome and replicating independently of the chromosome, but transferred, like the chromosome, to subsequent generations. In bacteria, plasmids often carry the genes for antibiotic resistance; they are exploited in genetic engineering as the vehicles for introduction of extraneous DNA into cells, to alter the genetic makeup of the cell. The cells thus altered may produce desirable proteins which are extracted and used; in the case of genetically altered plant cells, the altered cells may grow into complete plants with changed properties, as for example, increased resistance to disease.
n.
A title anciently given to the pope, and later to other church dignitaries and some monastic orders. See Don, and Dan.
n.
A small truck or sledge used in coal mines.
n.
An ancient musical instrument in use among the Jews. Dan. iii. 5. It is supposed to be the same with the psaltery.
adv.
Of each; an equal quantity; as, wine and honey, ana (or, contracted, aa), / ij., that is, of wine and honey, each, two ounces.
n.
Same as Auto-da-fe.
a. & adv.
No, not. See No.