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Type of transcription factor
The core binding factor (CBF) is a group of heterodimeric transcription factors. Core binding factors are composed of: a non-DNA-binding CBFβ chain (InterPro: IPR003417)
Core_binding_factor
Protein-coding gene in humans
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it
RUNX1
Chemical compound
under development as an anti-leukemic drug. Core-binding factor (CBF) is a heterodimeric transcription factor composed by the CBFβ and RUNX subunits (the
AI-10-49
Protein-coding gene in humans
Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is the beta subunit of a heterodimeric
CBFB
Distinct pattern of nucleotides in molecular biology
initial transcription site. The CAAT box signals the binding site for the RNA transcription factor, and is typically accompanied by a conserved consensus
CAAT_box
Protein that regulates the rate of DNA transcription
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic
Transcription_factor
– core binding factor alpha 1 subunit MeSH D12.776.930.155.200.200 – core binding factor alpha 2 subunit MeSH D12.776.930.155.200.300 – core binding factor
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Topics referred to by the same term
beat frequency; see Cilium Core binding factor, a type of transcription factor C-Repeat Binding Factor, transcription factors in plants A counting Bloom
CBF
Largest structure in the nucleus of eukaryotic cells
(upstream activating factor), TBP (TATA-box binding protein), and core binding factor (CBF), which bind promoter elements and form the preinitiation complex
Nucleolus
Evolutionary conserved protein domain
acute myeloid leukemia 1 protein, AML-1, or the core-binding factor alpha-B subunit) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and
Runt_domain
Protein found in humans
Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded by the CBFA2T3 gene. The
CBFA2T3
Protein-coding gene in humans
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the
RUNX2
Protein-coding gene in the species Homo sapiens
enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. It is a member of T cell factor/lymphoid enhancer factor (TCF/LEF)
Lymphoid enhancer-binding factor 1
Lymphoid_enhancer-binding_factor_1
Protein found in humans
in endometrial cancerous tumor samples and has been reported as a core binding factor in acute myeloid leukemia. Zinc Finger protein 730 is a Cys2His2-type
Zinc_finger_protein_730
Protein needed for initiation of transcription in prokaryotes
initiation factor that enables specific binding of RNA polymerase (RNAP) to gene promoters. It is homologous to archaeal transcription factor B and to eukaryotic
Sigma_factor
Region of DNA encouraging transcription
initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase. These transcription factors have specific
Promoter_(genetics)
Protein-coding gene in the species Homo sapiens
The TATA-binding protein (TBP) is a general transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30
TATA-binding_protein
Basic structural unit of DNA packaging in eukaryotes
non-sequence-specific DNA-binding factor. Although nucleosomes tend to prefer some DNA sequences over others, they are capable of binding practically to any
Nucleosome
Protein-coding gene in humans
Runx3 in this tissue. RUNX3 has been shown to interact with TLE1. Core binding factor RUNX1 RUNX2 GRCh38: Ensembl release 89: ENSG00000020633 – Ensembl
RUNX3
DNA sequence
TATA-containing genes. The TATA box is the binding site of the TATA-binding protein (TBP) and other transcription factors in some eukaryotic genes. Gene transcription
TATA_box
Bacteria use a variety of DNA-binding proteins, generally basic in pH. Since bacterial binding proteins have a diversity of functions, it has been difficult
Bacterial_DNA_binding_protein
better understanding of the complexities of the regulatory factors involved. The process of binding is central in determining the "strength" of promoters,
Promoter_activity
Transcription factor
transcription factors and histone modification enzymes as well as controlling DNA methylation. They were first discovered in 2002 as factors capable of binding to
Pioneer_factor
Proteins that bind with DNA
DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. Sequence-specific
DNA-binding_protein
Protein-coding gene in humans
vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones
PCAF
Protein-coding gene in the species Homo sapiens
loss/gain of function mutations. There are many predicted transcription factor binding sites in the TMEM8A promoter. Below is a table of the best possibilities
TMEM8A
O'Sullivan TE, Geary CD, Sun JC (December 2017). "Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses".
Trained_immunity
Protein that initiates male sex determination in therian mammals
(SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that
Sex-determining region Y protein
Sex-determining_region_Y_protein
Distribution of anaphoric elements
name implies, is a core component of government and binding theory. The following sentences illustrate some basic facts of binding. The words that bear
Binding_(linguistics)
General transcription factors
composed of TBP and several subunits called TATA-binding protein Associated Factors (TBP-associated factors, or TAFs). In a test tube, only TBP is necessary
Transcription_factor_II_D
Region of non-coding DNA that regulates the transcription of neighboring genes
CREs typically regulate gene transcription by binding to transcription factors. A single transcription factor may bind to many CREs, and hence control the
Cis-regulatory_element
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
associated with 40S ribosomal subunits, translation initiation factors, poly(A)+ mRNA and RNA-binding proteins (RBPs). While they are membraneless organelles
Stress_granule
Protein-coding gene in the species Homo sapiens
coiled coil domain – association with regulatory factors; 3. central DNA-binding domain – binding to the enhancer region of IFN-γ activated sequence
STAT4
2011 video game
The Binding of Isaac is a 2011 roguelike action-adventure game designed by independent developers Edmund McMillen and Florian Himsl. It was initially
The Binding of Isaac (video game)
The_Binding_of_Isaac_(video_game)
Class of molecules found in the outer membrane of Gram-negative bacteria
molecules consisting of three parts: an outer core polysaccharide termed the O-antigen, an inner core oligosaccharide and lipid A (from which toxicity
Lipopolysaccharide
Prokaryotic elongation factor
EF-Tu (elongation factor thermo unstable) is a prokaryotic elongation factor responsible for catalyzing the binding of an aminoacyl-tRNA (aa-tRNA) to
EF-Tu
Mammalian protein found in Homo sapiens
formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors. It is encoded
Transcription_factor_II_B
Protein-coding gene in humans
Boissel N, et al. (May 2016). "Comprehensive mutational profiling of core binding factor acute myeloid leukemia". Blood. 127 (20): 2451–9. doi:10.1182/blood-2015-12-688705
RAD21
Medical condition
"Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia". Clinical Cancer Research. 14 (21): 7095–101
Acute myeloblastic leukemia with maturation
Acute_myeloblastic_leukemia_with_maturation
Protein found in humans
activities of factor H, whereas self/non-self discrimination occurs predominantly through GAG binding to CCP modules 7 and/or GAG or sialic acid binding to 19–20
Factor_H
Process in genetics
the sigma factor (σ-factor), the polymerase can recognize specific binding sequences in the DNA, called promoters. The binding of the σ-factor to the promoter
Bacterial_transcription
box, the Inr element facilitates the binding of transcription Factor II D (TFIID). The Inr works by enhancing binding affinity and strengthening the promoter
Initiator_element
Protein involved in coagulation
modules whose hydrophobic cores merge in the domain-domain interface. This serves as a (probably rigid) template for factor VIIa binding. a transmembrane domain
Tissue_factor
Protein-coding gene in the species Homo sapiens
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that
Sterol regulatory element-binding protein 1
Sterol_regulatory_element-binding_protein_1
Protein-coding gene in the species Homo sapiens
Upstream binding transcription factor (UBTF), or upstream binding factor (UBF), is a protein that in humans is encoded by the UBTF gene. In humans, the
UBTF
Drug discovery
cysteines involved in 10 disulfide bonds. It acts as a slow, tight-binding inhibitor of factor Xa with a Ki value of 0.3–0.6 nM but it also inhibits trypsin
Discovery and development of direct Xa inhibitors
Discovery_and_development_of_direct_Xa_inhibitors
Protein complex assembled on mRNA
a stable heterotetramer core, which serves as a binding platform for other factors necessary for the mRNA pathway. The core of the EJC contains the protein
Exon_junction_complex
Protein family
zinc-containing domains found in a number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins). Some members
GATA_zinc_finger
Protein-coding gene in the species Homo sapiens
helix-turn-helix DNA binding domain, which is highly conserved among all IRF proteins. Beyond its function as a transcription factor, IRF-1 has also been
IRF1
Class of protein transcription factors
TFIID/TATA binding protein (TBP) TFIIB – recognizes the B recognition element (BRE) in promoters TFIID – binds to TBP and recognizes TBP associated factors (TAFs)
General_transcription_factor
Multiprotein complex that functions during the initiation phase of eukaryotic translation
All five core subunits of budding yeast's eIF3 are present in heat-induced stress granules, along with several other translation factors. A functional
Eukaryotic initiation factor 3
Eukaryotic_initiation_factor_3
Substance that forms a complex with a biomolecule
protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. The binding typically results
Ligand_(biochemistry)
Protein-coding gene in the species Homo sapiens
bHLH-LZ transcription factors, and USF1 has a high binding affinity for the core sequence CACGTG in the motif. USF1-DNA binding activity can be modulated
USF1
Protein-coding gene in the species Homo sapiens
2003). "Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein beta and delta in lipopolysaccharide-induced gene
Transcription_factor_Sp1
Protein-coding gene in the species Homo sapiens
protein consisting of the first 165 residues from the N-terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle
Myosin-11
Software methodology
The Twelve-Factor App methodology is a methodology for building software-as-a-service applications. These best practices are designed to enable applications
Twelve-Factor_App_methodology
Proteins that bind DNA
metabolism. Like many transcription factors, WRKY transcription factors are defined by the presence of a DNA-binding domain; in this case, it is the WRKY
WRKY_transcription_factor
Control of DNA to RNA conversion in cells
particular transcription factor that is important for regulation of methylation of CpG islands. An EGR1 transcription factor binding site is frequently located
Transcriptional_regulation
Protein structural motif
DNA binding. bHLH transcription factors are often important in development or cell activity. For one, BMAL1-Clock (also called ARNTL) is a core transcription
Basic_helix–loop–helix
Protein family
translation in bacterial cells. DNA-binding domain DNA-binding protein DNA-binding protein from starved cells Transcription factor Drlica K, Rouviere-Yaniv J (September
Histone-like DNA-binding protein
Histone-like_DNA-binding_protein
Protein-coding gene in the species Homo sapiens
gradients of these factors, their protection from proteolytic cleavage, and their presentation to specific cell-surface receptors. The binding of versican with
Versican
Antagonists of a youth's slang
activity in regulating prokaryote gene expression. Anti-sigma factors have both a sigma-binding domain and a sensory/signaling domain; this allows them to
Anti-sigma_factors
Oncogenic protein
consecutive GGAA microsatellites, EWS/FLI1 binding, and target gene expression. The core motif of ETS transcription factors includes a GGAA sequence. EWS/FLI1
EWS/FLI
Mammalian protein found in humans
as a transcription factor by binding DNA as a tetramer, a structure that is essential for its stability and effective DNA binding activity. Once bound
P53
Protein found in humans
doi:10.1006/geno.1998.5429. PMID 9790752. "Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan
CBFA2T2
Self-stabilizing region of a protein that binds to specific DNA sequences
expression contain DNA-binding domains. For example, proteins that regulate transcription by binding DNA are called transcription factors. The final output
DNA-binding_domain
Type of cis-regulatory element
transcription factors. Functionality and conservation of the W-box element across plant species has been shown by gel shift experiments, random binding site selection
W-box
(1998). "New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB". Genes &
B_recognition_element
Transcription factor
repeats of the core sequence CCCTC and thus was named CCCTC binding factor. Although CTCF was initially discovered as a transcription factor, more recent
CTCF
Protein-coding gene in the species Homo sapiens
L, Ehrenberg M (July 2006). "Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3". Biochimie. 88 (7): 747–757. doi:10.1016/j
Eukaryotic translation termination factor 1
Eukaryotic_translation_termination_factor_1
Protein-coding gene in the species Homo sapiens
peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors". The Journal of Biological Chemistry
GATA3
Protein found in humans
dense-core vesicles. It binds carboxypeptidase E (CPE), and disruption of this binding has been proposed to cause the loss of sorting BDNF into dense-core vesicles
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
DNA-binding protein
called the core domain, which binds allolactose, an allosteric effector molecule) A linker that connects the DNA-binding domain with the core domain (sometimes
Lac_repressor
Protein family around which DNA winds to form nucleosomes
transcribed genes, where it modulates nucleosome stability and transcription factor binding. In contrast, H3.3, a replacement variant of Histone H3, is associated
Histone
Protein-coding gene in the species Homo sapiens
mutation of the gene. Hepatocyte nuclear factor 4 alpha has been shown to interact with: Beta-catenin, CREB binding protein, MED1, MED14, Small heterodimer
Hepatocyte nuclear factor 4 alpha
Hepatocyte_nuclear_factor_4_alpha
Protein-coding gene in the species Homo sapiens
protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves
TAF2
Protein in humans
also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin
Pleiotrophin
Mammalian protein found in humans
epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB)
HER2
Enzymes that catalyze acyl group transfer from acetyl-CoA to histones
transcription factors. Research has emerged, since, to show that lysine acetylation and other posttranslational modifications of histones generate binding sites
Histone_acetyltransferase
Spectroscopic technique
(E_{f})} In a real photoemission experiment the ground state core electron binding energy cannot be directly probed, because the measured one incorporates
X-ray photoelectron spectroscopy
X-ray_photoelectron_spectroscopy
Protein-coding gene in the species Homo sapiens
Wimmer E (2000). "Identification of a nuclear respiratory factor-1 binding site within the core promoter of the human polio virus receptor/CD155 gene".
NRF1
Vertebrate receptor protein and transcription factor
AhR is a cytosolic transcription factor that is normally inactive, bound to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7
Aryl_hydrocarbon_receptor
Protein-coding gene in the species Homo sapiens
CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476
HIST1H3E
Regulatory DNA sequences
act by binding activator or repressor proteins (transcription factors) and the intervening DNA bends such that the bound proteins contact the core promoter
Distal_promoter
InterPro Family
Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function
Lymphotoxin
DNA response element in some eukaryotes
E-boxes with different functions have a different number and type of binding factor. The consensus sequence of the E-box is usually CANNTG; however, there
E-box
Protein-coding gene in the species Homo sapiens
PMID 15922600. Bernués J, Espel E, Querol E (1986). "Identification of the core-histone-binding domains of HMG1 and HMG2". Biochim. Biophys. Acta. 866 (4): 242–51
HIST3H3
Reaction that combines atomic nuclei
massive cores, silicon-burning is the final fusion cycle, leading to a build-up of iron and nickel nuclei.[citation needed] Nuclear binding energy makes
Nuclear_fusion
Protein-coding gene in the species Homo sapiens
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted
TGF_beta_1
Protein family
structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold". EMBO J. 19 (19): 5167–77. doi:10.1093/emboj/19
GntR-like bacterial transcription factors
GntR-like_bacterial_transcription_factors
Technical standard for authentication and authorization
by the choice of binding). So SAML Core defines "bare" SAML assertions along with SAML request and response elements. A SAML binding determines how SAML
SAML
Protein-coding gene in the species Homo sapiens
intron from the X-box binding protein 1 (XBP1) mRNA, and allowing it to become translated into a functional transcription factor, XBP1s. XBP1s upregulates
ERN1
Region of DNA adjacent to the 5′ end of the gene
The binding of the TATA box with the TATA binding protein initiates the formation of a transcription factor complex. This is followed by the binding of
5′_flanking_region
Complex of proteins necessary for gene transcription in eukaryotes and archaea
the Pol I preinitiation complex requires the binding of selective factor 1 (SL1 or TIF-IB) to the core element of the rDNA promoter. SL1 is a complex
Transcription preinitiation complex
Transcription_preinitiation_complex
Protein-coding gene in the species Homo sapiens
TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene. This gene is similar to a mouse gene that
TAF7L
Membrane proteins that adhere temporarily to membranes with which they are associated
blood coagulation factors ENTH, VHS and ANTH domains Structural domains mediate attachment of other proteins to membranes. Their binding to membranes can
Peripheral_membrane_protein
Protein-coding gene in the species Homo sapiens
transcription factors such as TFIIA and TFIIB and promotes transcription initiation in vitro. The core domain, which mediates this binding to DNA, shows
Tata-box binding protein like 2
Tata-box_binding_protein_like_2
Process of copying a segment of DNA into RNA
particular transcription factor that is important for regulation of methylation of CpG islands. An EGR1 transcription factor binding site is frequently located
Transcription_(biology)
Protein-coding gene in the species Homo sapiens
is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate
TAF1
Device to couple energy between circuits
together. It is then cut in two, forming two C shapes, and the core is assembled by binding the two C halves together with a steel strap. They have the advantage
Transformer
CORE BINDING-FACTOR
CORE BINDING-FACTOR
Surname or Lastname
English
English : unexplained.Southern Italian : from a short form of the personal names Boncore, literally ‘good heart’, a medieval omen name, or Belcore.
Male
English
Variant spelling of English Corey, possibly CORY means "deep hollow, ravine."
Surname or Lastname
English
English : variant spelling of Corp.
Girl/Female
Biblical
Hiding, binding.
Male
Italian
 Italian short form of Latin Salvatore, TORE means "savior." Compare with another form of Tore.
Surname or Lastname
English
English : variant spelling of Corey.
Male
English
English name, possibly of Irish Gaelic origin, from a place name COREY means "deep hollow, ravine."
Surname or Lastname
English
English : variant spelling of Cork.
Male
Scandinavian
 Variant spelling of Scandinavian Tor, TORE means "Thor" or "thunder." Compare with another form of Tore.
Female
English
Latin form of Greek Kore, CORA means "maiden." In mythology, this is a name borne by Persephone, a goddess of the underworld.
Surname or Lastname
French
French : from Old French corne ‘horn’ (Late Latin corna), a derogatory nickname for a cuckold (see Horn 4), or a metonymic occupational name for a hornblower or worker in horn.English : variant spelling of Corn.
Male
English
Variant spelling of English Corey, possibly CORIE means "deep hollow, ravine."
Biblical
hiding, binding
Male
English
Short form of English Isidore, DORE means "gift of Isis."
Surname or Lastname
English
English : variant of Balding.
Surname or Lastname
English
English : topographic name from Middle English score ‘steep place’ (Old English scoru), or a habitational name from Score in Ilfracombe or Scur Farm in Braunton, Devon.
Female
Greek
(ΚόÏη) Greek name KORE means "maiden." In mythology, this is a title belonging to Persephone, a goddess of the underworld.
Female
German
 Variant spelling of German Lora, LORE means "laurel." Compare with another form of Lore.
Male
English
Variant spelling of English Corey, possibly CORI means "deep hollow, ravine."
Surname or Lastname
English
English : habitational name from a place in Gloucestershire named Corse, from Welsh cors ‘marsh’, ‘bog’.Scottish : topographic name from northern Middle English cors, corse ‘cross’, or a habitational name for someone from any of various places, for example in Grampian and Orkney, named with this word.Danish or Dutch : from the personal name Corsse, a variant of Carsten, which was borne by Scandinavian settlers in New Netherland in the 17th century.
CORE BINDING-FACTOR
CORE BINDING-FACTOR
Female
Swedish
Swedish form of French Charlotte, CHARLOTTA means "man."
Girl/Female
Indian, Sanskrit
Conferring Splendour and Fame
Girl/Female
Gujarati, Hindu, Indian
Fair Woman Like a Swan
Boy/Male
Tamil
Shivalinga | ஷீவாலீநà¯à®•à®¾Â
A Lord Shiva name
Boy/Male
Tamil
King of wars
Girl/Female
English
From the linden tree island.
Boy/Male
Latin American English
Conqueror.
Boy/Male
Arabic, Muslim
Bright
Boy/Male
Tamil
Lord of the earth
Girl/Female
Hindu, Indian, Marathi
Remembrance
CORE BINDING-FACTOR
CORE BINDING-FACTOR
CORE BINDING-FACTOR
CORE BINDING-FACTOR
CORE BINDING-FACTOR
n.
A winding, bending, or twisting.
v. t.
To furnish or fit with cork; to raise on cork.
v. t.
To preserve and season with salt in grains; to sprinkle with salt; to cure by salting; now, specifically, to salt slightly in brine or otherwise; as, to corn beef; to corn a tongue.
n.
The center or inner part, as of an open space; as, the core of a square.
v. t.
To take out the core or inward parts of; as, to core an apple.
v. t.
To form by means of a core, as a hole in a casting.
n.
Care, heed, or attention.
n.
Medical or hygienic care; remedial treatment of disease; a method of medical treatment; as, to use the water cure.
v. t.
A building.
superl.
Severe; afflictive; distressing; as, a sore disease; sore evil or calamity.
n.
See Corf.
n.
The result of a judicial examination or inquiry, especially into some matter of fact; a verdict; as, the finding of a jury.
p. p.
of Come
n.
Anything shaped more or less like a mathematical cone; as, a volcanic cone, a collection of scoriae around the crater of a volcano, usually heaped up in a conical form.
n.
The most important part of a thing; the essence; as, the core of a subject.
a.
Making blind or as if blind; depriving of sight or of understanding; obscuring; as, blinding tears; blinding snow.
v. t.
To convert into coke.
imp. & p. p.
of Core
n.
A Hebrew dry measure; a cor or homer.
n.
That which cores; an instrument for coring fruit; as, an apple corer.