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Protein that regulates the rate of DNA transcription
molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information
Transcription_factor
Proteins that bind DNA
WRKY transcription factors (pronounced ‘worky’) are proteins that bind DNA. They are transcription factors that regulate many processes in plants and
WRKY_transcription_factor
Process of copying a segment of DNA into RNA
by an inactive transcription factor. Phosphorylation of the transcription factor may activate it and that activated transcription factor may then activate
Transcription_(biology)
Mammalian protein found in Homo sapiens
Transcription factor Jun, also known as c-Jun, is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms
Transcription_factor_Jun
Class of protein transcription factors
General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific
General_transcription_factor
Protein-coding gene in the species Homo sapiens
Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene
Transcription_factor_Sp1
Mammalian protein found in humans
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded
Microphthalmia-associated transcription factor
Microphthalmia-associated_transcription_factor
Region of non-coding DNA that regulates the transcription of neighboring genes
regulate. CREs typically regulate gene transcription by binding to transcription factors. A single transcription factor may bind to many CREs, and hence control
Cis-regulatory_element
Family of proteins
A winged-helix transcription factor is a type of transcription factor that binds to DNA using a protein domain called a winged-helix domain. In some cases
Winged-helix transcription factors
Winged-helix_transcription_factors
Protein needed for initiation of transcription in prokaryotes
sigma factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a bacterial transcription initiation
Sigma_factor
Protein complex
identified in 1989 as general transcription factor-δ or basic transcription factor 2, an essential factor for transcription in vitro. It was subsequently
Transcription_factor_II_H
Transcription factor
The GATA transcription factor family consists of six DNA-binding proteins (GATA1-6) that regulate transcription of DNA due to their ability to bind to
GATA_transcription_factor
Control of DNA to RNA conversion in cells
biology. The regulation of transcription is a vital process in all living organisms. It is orchestrated by transcription factors and other proteins working
Transcriptional_regulation
Mammalian protein found in Homo sapiens
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)
Transcription_factor_II_B
This list of manually-curated human transcription factors is taken from Lambert, Jolma, Campitelli, et al. More detailed information can be found in the
List of human transcription factors
List_of_human_transcription_factors
General transcription factors
Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase
Transcription_factor_II_D
Protein-coding gene in the species Homo sapiens
T-box transcription factor T, also known as Brachyury protein, is encoded for in humans and other apes by the TBXT gene. Brachyury functions as a transcription
T-box_transcription_factor_T
The Gal4 transcription factor is a positive regulator of gene expression of galactose-induced genes. This protein represents a large fungal family of transcription
Gal4_transcription_factor
Gene of Neurospora crassa required for asexual sporulation
The fluffy (fl) gene of Neurospora crassa is required for asexual sporulation and encodes an 88 kDa polypeptide containing a typical fungal Zn2Cys6 DNA-binding
Fluffy_transcription_factor
Complex of proteins necessary for gene transcription in eukaryotes and archaea
polymerase II active site for transcription. The minimal PIC includes RNA polymerase II and six general transcription factors: TFIIA, TFIIB, TFIID, TFIIE
Transcription preinitiation complex
Transcription_preinitiation_complex
Transcription factor
finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains
Zinc finger transcription factor
Zinc_finger_transcription_factor
Protein-coding gene in humans
The steroidogenic factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling the activity of genes related to the
Steroidogenic_factor_1
Protein family
molecular biology, transcription factor DP (Dimerization Partner) is a family of proteins which function as transcription factors. DP forms a heterodimer
Transcription_factor_DP
Protein-coding gene in the species Homo sapiens
Mitochondrial transcription factor A, abbreviated as TFAM or mtTFA, is a protein that in humans is encoded by the TFAM gene. This gene encodes a mitochondrial
TFAM
Prokaryotic protein
A ρ factor (Rho factor) is a bacterial protein involved in the termination of transcription. Rho factor binds to the transcription terminator pause site
Rho_factor
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
(AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and
AP-1_transcription_factor
Chemical compound
by regio/stereoselective Michael addition to ring A. NF-κB is a transcription factor that regulates many genes involved in cell survival, growth, immune
Withaferin_A
Nuclear protein
Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal)
Transcription_factor_II_A
Transcription is heterocatalytic function of DNA
promoters. General transcription factors are a group of proteins involved in transcription initiation and regulation. These factors typically have DNA-binding
Eukaryotic_transcription
Protein domain
a transcription factor Jun-B transcription factor CREB cAMP response element transcription factor OPAQUE2 (O2) transcription factor of the 22-kD zein
BZIP_domain
Mammalian protein found in Homo sapiens
known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. Thyroid transcription factor-1 (TTF-1) is a
NK2_homeobox_1
Protein that initiates male sex determination in therian mammals
(SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that
Sex-determining region Y protein
Sex-determining_region_Y_protein
Form of eukaryotic RNA polymerase II
POLR2F form homodimers). General transcription factors (GTFs) or basal transcription factors are protein transcription factors that have been shown to be important
RNA_polymerase_II_holoenzyme
Mammalian protein found in Homo sapiens
Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene. This
ATF4
Transcriptional repressor protein
1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene. YY1 is a ubiquitously distributed transcription factor belonging
YY1
Protein-coding gene in the species Homo sapiens
Transcription factor MafA is a protein that in humans is encoded by the MAFA gene. It is a member of the Maf family of transcription factors. In addition
Transcription_factor_MafA
Database of biological data
curated, non-redundant transcription factor (TF) binding profiles stored as position frequency matrices (PFM) and transcription factor flexible models (TFFM)
JASPAR
Protein found in humans
RE1-Silencing Transcription factor (REST), also known as Neuron-Restrictive Silencer Factor (NRSF), is a protein which in humans is encoded by the REST
RE1-silencing transcription factor
RE1-silencing_transcription_factor
Region of DNA encouraging transcription
polymerase and for proteins called transcription factors that recruit RNA polymerase. These transcription factors have specific activator or repressor
Promoter_(genetics)
Family of zinc finger transcription factors
In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic Cys2His2 zinc finger DNA-binding proteins that
Kruppel-like_factors
Protein family
transformation-specific) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, 27 in the
ETS transcription factor family
ETS_transcription_factor_family
Protein that responds to low oxygen
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They
Hypoxia-inducible_factor
Protein-coding gene in the species Homo sapiens
Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene. This gene encodes a member of the Sp subfamily of Sp/XKLF transcription
Sp2_transcription_factor
Conversion of a gene's sequence into a mature gene product or products
Pribnow box with the help of the sigma factor protein (σ factor) to start transcription. In eukaryotes, transcription is performed in the nucleus by three
Gene_expression
Class of DNA-binding proteins that regulate gene transcription
Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors. First
Activating transcription factor
Activating_transcription_factor
Subtype of DNA
microDNA is currently thought to affect cellular homeostasis through transcription factor binding and have been used as a cancer biomarker. MicroDNA was discovered
MicroDNA
Process in genetics
transcription factors. Transcription factors work to recognize specific DNA sequences and based on the cells needs, promote or inhibit additional transcription. Similar
Bacterial_transcription
DNA sequence that binds activators to increase the likelihood of gene transcription
the likelihood that transcription of a particular gene will occur. These proteins are usually referred to as transcription factors. Enhancers are cis-acting
Enhancer_(genetics)
Transcription factor
Pioneer factors are transcription factors that can directly bind condensed chromatin. They can have positive and negative effects on transcription and are
Pioneer_factor
Protein found in humans
ETS-related transcription factor Elf-3 is a protein that in humans is encoded by the ELF3 gene. It is a member of the ETS transcription factor family and
E74 like ETS transcription factor 3
E74_like_ETS_transcription_factor_3
Protein-coding gene in the species Homo sapiens
Myelin transcription factor 1 like is a protein that in humans is encoded by the MYT1L gene. This gene encodes a member of the zinc finger superfamily
MYT1L
Protein-coding gene in humans
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it
RUNX1
Protein-coding gene in the species Homo sapiens
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene. Sp4 transcription factor has been shown to interact with E2F1. GRCh38:
Sp4_transcription_factor
Protein-coding gene in the species Homo sapiens
transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start
TATA-binding_protein
Transcription factor
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer
Transcription_factor_II_E
Transcription factor protein
helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene. Basic helix-loop-helix (bHLH) transcription factors have been implicated
Twist-related_protein_1
Protein-coding gene in the species Homo sapiens
Transcription factor Sp3 is a protein that in humans is encoded by the SP3 gene. This gene belongs to a family of Sp1 related genes that encode transcription
Transcription_factor_Sp3
Mammalian protein found in humans
(hNanog) is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. hNanog is encoded
Homeobox_protein_NANOG
Protein-coding gene in the species Homo sapiens
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene. This gene encodes a transcription factor that
Activating transcription factor 2
Activating_transcription_factor_2
Family of transcription factor protein complexes
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of
NF-κB
Protein-coding gene in the species Homo sapiens
Transcription initiation factor TFIID subunit 1, also known as transcription initiation factor TFIID 250 kDa subunit (TAFII-250) or TBP-associated factor
TAF1
Protein-coding gene in the species Homo sapiens
E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene. It was named for its similarity to E74, an
ELF1
Protein-coding gene in humans
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the
RUNX2
Mammalian protein found in Homo sapiens
ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex. The 3D-structure of the archaeal homolog of XPB has been
ERCC3
Protein-coding gene in the species Homo sapiens
Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of the Sp family of zinc-finger
Sp7_transcription_factor
German molecular biologist
Baeuerle is known for his work on tyrosine sulfation of proteins, transcription factor NF-kappaB, and the development of bispecific T-cell engaging antibodies
Patrick_A._Baeuerle
Enzyme that transcribes DNA to small RNAs
initiation of transcription by Pol III, unlike bacterial σ factors and most of the basal transcription factors for Pol II transcription. This leads to
RNA_polymerase_III
Artificial transcription factors (ATFs) are engineered individual or multi molecule transcription factors that either activate or repress gene transcription (biology)
Artificial transcription factor
Artificial_transcription_factor
Protein-coding gene in the species Homo sapiens
Factor in the germline alpha (FIGalpha), folliculogenesis-specific basic helix-loop-helix or transcription factor FIGa, is a protein that in humans is
Factor_in_the_germline_alpha
Database of transcription factors
(The Yeast Transcription Factor Specificity Compendium) is a database of transcription factors for Saccharomyces cerevisiae. Transcription factor de Boer
YeTFaSCo
Small structural protein motif found mostly in transcriptional proteins
hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA. However, it has been found to encompass a wide variety of differing
Zinc_finger
DNA-binding structural motif
motif of the bZIP (Basic-region leucine zipper) class of eukaryotic transcription factors. The bZIP domain is 60 to 80 amino acids in length with a highly
Leucine_zipper
Protein-coding gene in the species Homo sapiens
Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located
TCF4
Protein that controls rate of transcription of GH genes
positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for
Pituitary-specific positive transcription factor 1
Pituitary-specific_positive_transcription_factor_1
Regions of DNA capable of binding to biomolecules
known as transcription factors, and are thus linked to transcriptional regulation. The sum of DNA binding sites of a specific transcription factor is referred
DNA_binding_site
Topics referred to by the same term
COUP transcription factor may refer to: COUP-TFI, a protein that in humans is encoded by the NR2F1 gene COUP-TFII, a protein that in humans is encoded
COUP_transcription_factor
Protein found in humans
COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by
COUP-TFII
Database of eukaryotic transcription factors
TRANSFAC (TRANScription FACtor database) is a manually curated database of eukaryotic transcription factors, their genomic binding sites and DNA binding
TRANSFAC
Mammalian protein found in humans
PAX8 gene. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain
PAX8
Immune system messenger protein which induces inflammation
transcription is activated by a variety of signaling pathways and transcription factors, depending on the cell type and stimulus. TNF transcription does
Tumor_necrosis_factor
Protein structural motif
dimerizing transcription factors. The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general
Basic_helix–loop–helix
the NLM. MeSH D12.776.260.103.500.500 – microphthalmia-associated transcription factor MeSH D12.776.260.103.500.750 – sterol regulatory element binding
List of MeSH codes (D12.776.260)
List_of_MeSH_codes_(D12.776.260)
Protein-coding gene in the species Homo sapiens
respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates
NRF1
Protein-coding gene in the species Homo sapiens
Transcription factor 15 (TCF-15) also known as Paraxis, is a protein that in humans is encoded by the TCF15 gene. Transcription factor 15 is found in the
Transcription_factor_15
Protein family
biology, the GntR-like bacterial transcription factors are a family of transcription factors. Many bacterial transcription regulation proteins bind DNA through
GntR-like bacterial transcription factors
GntR-like_bacterial_transcription_factors
General transcription initiation factor
Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIF is encoded
Transcription_factor_II_F
Human protein and coding gene
(NRF2) or nuclear factor erythroid-derived 2-like 2 (NFE2L2), is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine
NFE2L2
Database of transcription factor binding sites
Mapper(2) is a database of transcription factor binding sites in multiple genomes. Transcription factor Riva, Alberto (Jan 2012). "The MAPPER2 Database:
Mapper(2)
Protein-coding gene in the species Homo sapiens
Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead) is a protein that in humans is encoded by
Sp8_transcription_factor
Protein-coding gene in the species Homo sapiens
Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene. This gene encodes a member of the GATA family of zinc finger transcription
GATA4
Japanese stem cell researcher (born 1962)
multiple transcription factors, instead of transfecting one transcription factor per experiment. They started with 24 transcription factors known to be
Shinya_Yamanaka
Protein-coding gene in the species Homo sapiens
Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene. RELA, also known
RELA
Mammalian protein found in Homo sapiens
Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded
Oct-4
Protein-coding gene in the species Homo sapiens
Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene. Initiation of transcription by RNA polymerase
TAF9B
United States National Library of Medicine (NLM). This list covers transcription factors. For other protein-related codes, see List of MeSH codes (D12.776)
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Bacterial global transcription factor
Bacterial transcription factor Catabolite repressor/activator (Cra), formerly known as fructose repressor FruR. It is a transcription factor found in enteric
Catabolite repressor/activator
Catabolite_repressor/activator
Protein-coding gene in the species Homo sapiens
Upstream binding transcription factor (UBTF), or upstream binding factor (UBF), is a protein that in humans is encoded by the UBTF gene. In humans, the
UBTF
cerebellum. The development and location of the MHB is mediated by the transcription factors Otx2 and Gbx2. Otx2 is expressed in the anterior neural tube and
Isthmic_organizer
that are known or expected to function as human transcription factors: List of human transcription factors List of enzymes List of proteins List of disabled
Lists_of_human_genes
Mammalian protein found in Homo sapiens
Serum response factor, also known as SRF, is a transcription factor protein. Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens,
Serum_response_factor
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