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Protein involved in coagulation
Tissue factor, also called platelet tissue factor or Coagulation factor III, is a protein present in subendothelial tissue and leukocytes which plays a
Tissue_factor
Process of formation of blood clots
in platelets, and the exposure of subendothelial platelet tissue factor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation
Coagulation
Single-chain polypeptide capable of inhibiting blood clotting Factor Xa
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI
Tissue factor pathway inhibitor
Tissue_factor_pathway_inhibitor
Mammalian protein found in humans
to tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII)
Factor_VII
Protein found in humans
CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding
Connective tissue growth factor
Connective_tissue_growth_factor
Blood test that evaluates clotting
tissue factor they manufacture. The ISI value indicates how a particular batch of tissue factor compares to an international reference tissue factor.
Prothrombin_time
Mammalian protein found in Homo sapiens
factor IX with its cofactor, factor VIII in a complex known as intrinsic pathway; and factor VII with its cofactor, tissue factor in a complex known as extrinsic
Factor_X
Composite blood component made of protein and phospholipids
both phospholipids and tissue factor, neither of which are enzymes. Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase
Thromboplastin
Medication
medication used for the treatment of hemophilia A and hemophilia B. It is a tissue factor pathway inhibitor antagonist. It was developed by Pfizer. Marstacimab
Marstacimab
Abnormality of blood coagulation increasing the risk of blood clotting (thrombosis)
factor from damaged tissue. Tissue factor binds to circulating factor VIIa. The combination activates factor X to factor Xa and factor IX to factor IXa
Thrombophilia
Formation of a blood clot in a deep vein
monocytes to release tissue factor. Monocytes are also recruited early in the process. Tissue factor, via the tissue factor–factor VIIa complex, activates
Deep_vein_thrombosis
Medical condition
coagulation cascade. After a trauma factor VII initiates the process of coagulation in conjunction with tissue factor (TF/factor III) in the extrinsic pathway
Factor_VII_deficiency
Protein involved in coagulation
peptide, glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a two-chain form, where
Factor_IX
Instinctive response in humans and many animals
wounds. Saliva contains tissue factor which promotes the blood clotting mechanism. The enzyme lysozyme is found in many tissues and is known to attack
Wound_licking
Derived SI unit of equivalent dose of ionizing radiation
the whole body or for individual organs. 2. The tissue weighting factor WT, which is specific for tissue type T being irradiated. This is used with WR to
Sievert
Loose connective tissue composed mostly by adipocytes
Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. It also contains the stromal vascular
Adipose_tissue
Component of blood aiding in coagulation
Human platelets do not express tissue factor. Rat platelets do express tissue factor protein and carry both tissue factor pre-mRNA and mature mRNA. Platelet
Platelet
Topics referred to by the same term
that are formed from catechins in tea leaves Tissue factor, or tissue factor gene Transcription factor, a protein that binds to specific DNA sequences
TF
Medication
used for the treatment of hemophilia A and hemophilia B. It is an anti-tissue factor pathway inhibitor. The most common adverse reactions include injection
Concizumab
Low-density lipoprotein containing apolipoprotein(a)
thrombogenesis. It also may enhance coagulation by inhibiting the function of tissue factor pathway inhibitor. Moreover, Lp(a) carries atherosclerosis-causing cholesterol
Lipoprotein(a)
Monoclonal antibodies for tumors
cancer. It is a combination of tisotumab, a monoclonal antibody against tissue factor, and monomethyl auristatin E (MMAE), a potent inhibitor of cell division
Tisotumab_vedotin
Complex formed by blood clotting factors X and V
activates its substrate (inactive factor X) by cleaving it. Extrinsic tenase complex is made up of tissue factor, factor VII, and Ca2+ as an activating ion
Tenase
Series of events that restore integrity to damaged tissue after an injury
to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis (surface, epithelial layer)
Wound_healing
Process that prevents blood clots from growing
not uncommon. Many trauma patients have an overwhelming activation of tissue factor and thus massive hyperfibrinolysis. Hyperfibrinolysis may occur in other
Fibrinolysis
Test for coagulation of blood
combination of tissue factor and phospholipids. In contrast, APTT employs partial thromboplastin, containing only phospholipids and no tissue factor—hence the
Partial_thromboplastin_time
Unprogrammed cell death caused by external cell injury
the founders of modern pathology. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated
Necrosis
Formation of blood clots inside the blood vessels
endothelial lining of the vessel's wall. The main mechanism is exposure of tissue factor to the blood coagulation system. Inflammatory and other stimuli (such
Thrombosis
recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis. Additionally, Ixolaris, a tissue factor inhibitor
Arachnids_in_medicine
Family of proteins involved in anatomical development
intracellular fibroblast growth factor subfamily (iFGF). Human FGF18 is involved in cell development and morphogenesis in various tissues including cartilage. Human
Fibroblast_growth_factor
Blood clot within the heart's blood vessels
actually lead to an increased coronary thrombus formation due to increased tissue factor expression and delayed healing within the vessels. Furthermore, the
Coronary_thrombosis
Protein-coding gene in the species Homo sapiens
Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene. GRCh38: Ensembl release 89: ENSG00000105825 – Ensembl, May
TFPI2
Networks of fibres which bind pathogens
DNA strands, fibrin, activated platelets, coagulation factors such as tissue factor (TF) and factor XII. Together with content from their azurophilic granules
Neutrophil extracellular traps
Neutrophil_extracellular_traps
Genetic X-linked recessive bleeding disorder
individuals with Hemophilia A and B, including those with inhibitors. Tissue Factor Pathway Inhibitor (TFPI) Inhibitors Concizumab: A monoclonal antibody
Haemophilia_B
Medical condition
understood, but may be related to factors secreted by the tumors, in particular a circulating pool of cell-derived tissue factor-containing microvesicles. Some
Trousseau_sign_of_malignancy
Fragmented portion of a red blood cell
coagulation cascade which is usually a result of an increased exposure to tissue factor. The activation of the cascade leads to thrombi formation which causes
Schistocyte
Genetic engineering to produce pharmaceuticals
antibodies against tissue factor in plants and in mammalian cell culture and to compare them. In 2005 Sunol sold all its tissue factor antagonists to Tanox
Pharming_(genetics)
American doctor
(1994-06-15). "Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor". Blood. 83 (12):
Katherine_A._High
British surgeon and life peer (born 1964)
awarded a PhD by Imperial College London in 1998, with his thesis titled "Tissue factor, thrombin generation and cancer". Kakkar was elected as a Fellow of
Ajay_Kakkar,_Baron_Kakkar
Probability of ill health effects from ionizing radiation
the tissues or organs being irradiated using factor WT, to produce the effective dose quantity E. The sum of effective doses to all organs and tissues of
Effective_dose_(radiation)
Inflammatory disease involving a buildup of lesions in the walls of arteries
ruptures, tissue fragments are exposed and released. These tissue fragments are very clot-promoting, containing collagen and tissue factor; they activate
Atherosclerosis
Bacterial protein
of bacteria throughout the blood. However, OmpT can inactivate the tissue factor pathway inhibitor (TFPI), counteracting the host's immune response,
OmpT
Medical condition
caused by leaking of pancreatic digestive enzymes into the surrounding tissues. Factors affecting the development of phlegmon are virulence of bacteria and
Phlegmon
Viscoelastic method for hemostasis testing in whole blood
haemostasis via the physiological activator tissue factor. The result is influenced by extrinsic coagulation factors, platelets and fibrinogen. EXTEM is a screening
Thromboelastometry
Rigid organs of the skeleton of vertebrates
structures. Bone tissue (also known as osseous tissue or bone in the uncountable) is a form of hard tissue, specialised connective tissue that is mineralized
Bone
Category of diseases
nature. Some connective tissue diseases have strong or weak genetic inheritance risks. Others may be due to environmental factors, or a combination of genetic
Connective_tissue_disease
InterPro Domain
inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI). Kunitz STI protease inhibitor, the trypsin
Kunitz_domain
Cancer originating in connective tissue
risk factors associated with an increased risk of developing soft-tissue sarcoma. Previous exposure to ionizing radiation is one such risk factor. Exposure
Sarcoma
Blood clot (thrombus) that forms within a vein
compared to arterial ones. The process is thought to be initiated by tissue factor-affected thrombin production, which leads to fibrin deposition. The
Venous_thrombosis
Biomedical engineering discipline
biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves
Tissue_engineering
Protein or other substance that stimulates cellular proliferation
used by all sorts of other cells and tissues, during development and in the mature organism. While growth factor implies a positive effect on cell proliferation
Growth_factor
Blood clot
vessels, exposing the enzyme called factor VII, a protein normally circulating within the vessels, to the tissue factor, which is a protein encoded by the F3 gene
Thrombus
First stage of pregnancy
histamine-releasing factor Tissue plasminogen activator as well as its inhibitors Estradiol β1-integrins Fibroblast growth factor Transforming growth factor alpha Inhibin
Implantation_(embryology)
Enzyme
reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and tissue factor pathway inhibitor (TFPI-2)). They might have other biological activities
Metalloprotease_inhibitor
Protein that stimulates cell division and differentiation
cell-based therapy to bone tissue engineering applications in periodontics and oral implantology. EGF was the second growth factor to be identified. Initially
Epidermal_growth_factor
Infection that results in the death of the body's soft tissue
disease or flesh-eating bacteria, is an infection that kills the body's soft tissue. It is a serious disease that begins and spreads quickly. It is sometimes
Necrotizing_fasciitis
Dangerously low blood pressure due to damage from an organ infection
of effects, including reduced synthesis of anticoagulation factors such as tissue factor pathway inhibitor and thrombomodulin. The effects of the cytokines
Septic_shock
Type of adipose tissue
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). Brown adipose tissue is found in almost
Brown_adipose_tissue
Biological process in primates
transforming growth factor β2 (TGF-β2), a known inhibitory factor in breast development. Moreover, suppression of PGE2 in breast tissue is relevant because
Breast_development
Medical condition where blood clots block small blood vessels
mediator of DIC is the release of a transmembrane glycoprotein called tissue factor (TF). TF is present on the surface of many cell types (including endothelial
Disseminated intravascular coagulation
Disseminated_intravascular_coagulation
Growth factor and signaling protein otherwise known as FGF2
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by
Fibroblast_growth_factor_2
Physical effects resulting from activation of the immune system
Latin: inflammatio) is part of the biological defence response of body tissues. Inflammatory immunovascular responses can be triggered by a broad range
Inflammation
Australian biochemical researcher
that transitions tissue factor from a cryptic to active form. Specifically, he found that an allosteric disulfide bond in tissue factor plays a crucial
Philip_Hogg
Chemical compound
melanoma targeting CD37: AGS67E, to treat lymphoid malignancy targeting tissue factor in recurrent or persistent cervical cancers that progress on or after
Monomethyl_auristatin_E
Rare human disease
breast tissues may be caused by increased histologic sensitivity to certain hormones such as female sex hormones, prolactin, and growth factors. Breast
Breast_hypertrophy
Human bacterial infection
known as clostridial myonecrosis) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium
Gas_gangrene
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
transcription factors are also associated with numerous physiological functions especially in determination of organisms’ life span and tissue regeneration
AP-1_transcription_factor
Disease that causes scarring of the lungs
fibrosis are Transforming Growth Factor-Beta (TGF-β), Connective Tissue Growth Factor (CTGF), Epidermal Growth Factor Receptor (EGFR), Interleukin-13 (IL-13)
Pulmonary_fibrosis
Type of tissue death by ischemia
develops in the dead tissues. Diabetes mellitus is a risk factor for peripheral vascular disease, thus for dry gangrene, but also a risk factor for wet gangrene
Gangrene
Excess connective tissue in healing
connective tissue, including collagen and glycosaminoglycans. The process is initiated when immune cells such as macrophages release soluble factors that stimulate
Fibrosis
Species of fungus
response, tissue factor expression and activation of the coagulation cascade. This results in intravascular thrombosis and localized tissue infarction
Aspergillus_fumigatus
Mammalian protein involved in blood clotting
Von Willebrand factor (VWF) (German: [fɔn ˈvɪləbʁant]) is a blood glycoprotein that promotes primary hemostasis, specifically, platelet adhesion. It is
Von_Willebrand_factor
Mammalian protein found in humans
cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Tissue in the body that is not hardened by ossification
Soft tissue is tissue in the body that connects and surrounds or supports internal organs and bones, and includes muscle, tendons, ligaments, fat, fibrous
Soft_tissue
Rupturing of red blood cells and release of their contents
induces platelet activation, thrombin generation, procoagulant factors and tissue factor activation, contributing to the formation of thrombosis. This
Hemolysis
Fifth stage of death
the release of gases that infiltrate the body's tissues, and leads to the deterioration of the tissues and organs. The approximate time it takes putrefaction
Putrefaction
Exocrine gland in humans and other mammals
and other growth inhibiting hormones and local factors. This major structural change leads loose fat tissue to fill the empty space afterward. But a functional
Mammary_gland
Medical condition
of factors V, VII, VIII and IX leading to a thrombin burst, decreased activity of proteins C and S, and decreased anti-thrombin and tissue factor pathway
Post-cardiac_arrest_syndrome
Medical condition
blood cells and platelets. For several days after AMI, the levels of tissue factor and D-dimer, which are involved in coagulation, are high, which increases
Left_ventricular_thrombus
Biomarker indicative of breast cancer patients' prognosis
in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Isoforms of transforming growth factor-beta
Transforming_growth_factor
Malignant tumor that develops in soft tissue
A soft-tissue sarcoma (STS) is a malignant tumor, a type of cancer, that develops in soft tissue. A soft-tissue sarcoma is often a painless mass that grows
Soft-tissue_sarcoma
Type of extracellular vesicle
the same effects and may actually have a role in reducing clotting. Tissue factor, an initiator of coagulation, is found in high levels within microvesicles
Microvesicle
Protein found in humans
on target tissues is also coordinated with other hormones such as growth hormone and insulin. IGF1 is part of the insulin-like growth factor (IGF) system
Insulin-like_growth_factor_1
are signaling molecules produced by specialized cells in various human tissues and organs. They regulate diverse physiological processes by binding to
List_of_human_hormones
Mammalian protein found in Homo sapiens
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Family of biomolecules
neurotrophic factors are also released by the target tissue in order to guide the growth of developing axons. Most neurotrophic factors belong to one
Neurotrophic_factors
Protein family
proteolytically induced polymerization of fibrinogens. There are two pathways (Tissue factor and Contact) that result in thrombin converting fibrinogen to fibrin
Coagulin
Mammalian protein found in Homo sapiens
result. Contact activation pathway (also known as the intrinsic pathway) Tissue factor pathway (also known as the extrinsic pathway) GRCh38: Ensembl release
Factor_XI
Mammalian protein found in Homo sapiens
growth factor, Cyclin D1, phosphofructokinase-muscle isoform, nuclear factor of activated T-cell, Cyclin B1, Tissue Factor and tissue factor pathway
PAK1
Potentially fatal complication of pregnancy
Furthermore, amniotic fluid contains further elements such as tissue factor and other clotting factors that lead to a hypercoagulable state or consistent development
Amniotic_fluid_embolism
Immune system messenger protein which induces inflammation
and interference in surrounding tissue. TNF induces cell survival by default, but cell death can be induced by factors such as disruption of inflammatory
Tumor_necrosis_factor
Wound that does not heal quickly
in the inflammatory phase due to factors like infection or bacterial burden, ischaemia, presence of necrotic tissue, improper moisture balance of wound
Chronic_wound
Type of white blood cell
tissue. These resident macrophages are sessile (non-migratory), provide essential growth factors to support the physiological function of the tissue (e
Macrophage
Absorbed dose of ionizing radiation weighted with the quality factor
absorbed by tissue T, DT,R is the absorbed dose in grays (Gy) in tissue T by radiation type R and WR is the radiation weighting factor defined by regulation
Equivalent_dose
Pharmaceutical compound
endogenous signalling factor thymosin beta-4. It is claimed to increase muscle growth and accelerate wound healing and tissue repair, reduce inflammation
TB-500
and tissue homeostasis. Abnormalities in the cell division orientation leads to the malformations during development and cancerous tissues. Factors that
Cell_division_orientation
Blood coagulation test
ordered test and includes the parameters noted above. A RapidTEG uses tissue factor in addition to kaolin thereby further speeding up the reaction. In this
Thromboelastography
Effect of low temperature on skin and other tissues
Frostbite is an injury to skin or other living tissue that is allowed to freeze, especially affecting the fingers, toes, nose, ears, cheeks and chin. Most
Frostbite
Cell surface receptors
cells use the vascular system to disseminate to distant tissues. As a potent angiogenic factor, PDGF plays a critical role in vascular maturation and the
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Chemical compound
upon mechanical injury to the blood vessel wall, a cell-associated tissue factor becomes exposed and initiates a series of enzymatic reactions localized
Carboxyglutamic_acid
Insufficient blood flow due to abnormal distribution in the capillaries
over-expression of nitric oxide. The coagulation cascade is also disrupted. Tissue factor that initiates the clotting cascade is produced by activated monocytes
Distributive_shock
TISSUE FACTOR
TISSUE FACTOR
Girl/Female
Arabic
Brocade; Gold Tissue
Biblical
fissure
Girl/Female
Latin
F: Ameaning bringer of joy. In the Divine Comedy, Beatrice was Dante's guide through Paradise,...
Male
Yiddish
Yiddish form of Hebrew Yisrael, ISSUR means "God prevails" or "contender; soldier of God."
Girl/Female
Russian
Abbreviation of Natasha - the Russian form of the English Natalie 'Born at Christmas.
Girl/Female
German, Swedish
Noble; Nobility; God's Promise; God is My Oath; Form of Alice
Girl/Female
Arabic
Brocade; Gold Tissue
Male
Swedish
Pet form of Swedish Nils, NISSE means "victor of the people."
Boy/Male
Hindu, Indian, Traditional
Issue
Girl/Female
English
Diminutive of any name begining with Christ-, for example Christahel, Christian, or Christopher.....
Female
English
Variant spelling of English Missy, MISSIE means "honey-sap."
Female
English
English pet form of Spanish Teresa, TESSIE means "harvester."Â
Boy/Male
English
Diminutives of any masculine or feminine name begining with Christ-, for example Christahel,...
Boy/Male
Tamil
Issue
Boy/Male
English
Diminutives of any masculine or feminine name begining with Christ-, for example Christahel,...
Girl/Female
English
Diminutive of any name begining with Christ-, for example Christahel, Christian, or Christopher.....
Girl/Female
English American Greek
Abbreviation of Teresa, meaning harvester.
Boy/Male
Hindu
Issue
Female
Yiddish
(זִיסֶע) Yiddish name ZISSE means "sweet."
Female
English
Variant spelling of English Sissy, SISSIE means "blind."
TISSUE FACTOR
TISSUE FACTOR
Boy/Male
Finnish, Hindu, Indian, Sanskrit, Swedish
Lord; Ruler; Defender
Boy/Male
Biblical Greek
Friend of God.
Boy/Male
Welsh
Name of a saint.
Boy/Male
Hindu
Lord vishnus weapon, Circular
Boy/Male
Latin Greek
Husband of Akmene.
Boy/Male
Spanish
Conqueror.
Boy/Male
Hindu
King of poor
Girl/Female
English Hebrew
Jehovah has been gracious; has shown favor.
Boy/Male
Indian
Servant of the mighty (Allah)
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Glorious
TISSUE FACTOR
TISSUE FACTOR
TISSUE FACTOR
TISSUE FACTOR
TISSUE FACTOR
v. i.
To proceed, as from a source; as, water issues from springs; light issues from the sun.
a.
Tissue-producing; connected with the formation and development of the organic tissues.
v. t.
To deliver for use; as, to issue provisions.
imp. & p. p.
of Issue
v. t.
To send out; to put into circulation; as, to issue notes from a bank.
n.
That which passes, flows, or is sent out; the whole quantity sent forth or emitted at one time; as, an issue of bank notes; the daily issue of a newspaper.
v. t. & i.
To issue a second time.
v. i.
In pleading, to come to a point in fact or law, on which the parties join issue.
imp. & p. p.
of Tissue
v. i.
To extend; to pass or open; as, the path issues into the highway.
n.
In pleading, a single material point of law or fact depending in the suit, which, being affirmed on the one side and denied on the other, is presented for determination. See General issue, under General, and Feigned issue, under Feigned.
v. t.
To form tissue of; to interweave.
a.
Clothed in, or adorned with, tissue; also, variegated; as, tissued flowers.
v. t.
To send out officially; to deliver by authority; as, to issue an order; to issue a writ.
n.
The act of sending out, or causing to go forth; delivery; issuance; as, the issue of an order from a commanding officer; the issue of money from a treasury.
n.
One of the elementary materials or fibres, having a uniform structure and a specialized function, of which ordinary animals and plants are composed; a texture; as, epithelial tissue; connective tissue.
v. i.
To close; to end; to terminate; to turn out; as, we know not how the cause will issue.
n.
One who issues, emits, or publishes.
n.
A second or repeated issue.
n.
Fig.: Web; texture; complicated fabrication; connected series; as, a tissue of forgeries, or of falsehood.