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Transcription factor and coding gene in humans
transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein
STAT1
Biological signaling pathway h
phosphorylate (add phosphate groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many
JAK-STAT_signaling_pathway
InterPro Family
proteins to interact with each other come together to form STAT1-STAT1 homodimers. The STAT1-STAT1 homodimers can then enter the cell nucleus. They then initiate
Interferon_gamma
Family of intracellular transcription factors
family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in type II interferon
STAT_protein
Genus of RNA viruses
different mechanisms. P, V, and W contain STAT1 binding domains, and act as interferon antagonists by sequestering STAT1 in the nucleus and cytoplasm. The C
Henipavirus
Hemorrhagic fever caused by ebolaviruses
bound to its receptors on the neighbouring cell, the signalling proteins STAT1 and STAT2 are activated and move to the cell's nucleus. This triggers the
Ebola
Protein-coding gene in Homo sapiens
transcription activators. In response to IFN, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9) and form ISGF-3 (IFN-stimulated
STAT2
LTR ERVs in primates
relatively large 5% of a total genome-wide STAT1 ChIP-seq signal from the cells was absorbed by MER41 sequences. STAT1 and IRF1 profiling in IFN-γ-stimulated
MER41
Transcription factor activated by vitamin D
BAG1, CAV3, MED12, MED24, NCOR1, NCOR2, NCOA2 RXRA, RUNX1, RUNX1T1, SNW1, STAT1, and ZBTB16. Click on genes, proteins and metabolites below to link to respective
Vitamin_D_receptor
Immune disorder
Defects in B cells activation in response to TLRs ligands Nuclear defects STAT1 Hypogammaglobulinemia, reduced number of memory and plasma cells NF-κB Impaired
Common variable immunodeficiency
Common_variable_immunodeficiency
Protein in immune system
cell subset. Th1 cells, which express IFNγ, are generated by IL-27 through STAT1 dimerization and nuclear localization which subsequently leads to the expression
Interleukin_27
Mammalian protein found in Homo sapiens
phosphorylatio of the Stat1. Tyrosine-phosphorylated Stat1 molecules dissociate from their receptor tether and form homodimeric complexes. Activated Stat1 translocates
Interferon-gamma_receptor
Protein-coding gene in the species Homo sapiens
transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators
STAT4
Mammalian protein and protein-coding gene
FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ, PIK3R1, PTPN11, PTPN6, STAT1, SOCS1, SOCS6, SRC, and TEC. Cytokine receptor List of genes mutated in
KIT_(gene)
Form of localized cell signaling
mutation in a Fgf gene, causing a premature and constitutive activation of the Stat1 transcription factor. Chondrocyte cell division is prematurely terminated
Paracrine_signaling
Mammalian protein found in humans
while greatly upregulating PD-L2. It has been shown by STAT1-deficient knock-out mice that STAT1 is mostly responsible for upregulation of PD-L1 on macrophages
PD-L1
Medical condition
fight infection, in total there are 9 possible types of this condition. Stat1(CANDF7 mutation on Chromosome 2q32) CHR 2 Chronic mucocutaneous candidiasis
Chronic mucocutaneous candidiasis
Chronic_mucocutaneous_candidiasis
Protein that regulates the rate of DNA transcription
U (July 2008). "Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations". Proceedings of the National Academy
Transcription_factor
Protein
Hong F, Nguyen VA, Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Letters. 480 (2–3):
SOCS3
Method used to analyze protein interactions with DNA
affinities of a protein to different DNA sites. STAT1 DNA association: ChIP-seq was used to study STAT1 targets in HeLa S3 cells which are clones of the
ChIP_sequencing
Protein-coding gene in the species Homo sapiens
STAT1 and STAT2 are activated by these tyrosine kinases, and STAT1 and STAT2 mediate the antiviral and inflammatory effects of IFN-α/IFN-β. STAT1 and
Interferon_alpha-1
Signaling proteins released by host cells in response to the presence of pathogens
IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription
Interferon
Family of proteins
different signaling pathways involved in carcinogenesis responses such as STAT1 activation, gp96-activated macrophages, and activation of NK cells. Therefore
Heat_shock_protein
Matrix protein
to proliferate in the body. eVP24 disrupts the signaling pathway of STAT1. The STAT1 protein is phosphorylated by interferons in response to viral infection
Ebola_viral_protein_24
Mammalian protein found in humans
EIF3F EIF4EBP1, FKBP1A, GPHN, KIAA1303, PRKCD, RHEB, RICTOR, RPS6KB1, STAT1, STAT3, Two-pore channels: TPCN1; TPCN2, and UBQLN1. GRCh38: Ensembl release
MTOR
Type of macrophage
by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)". Blood. 107 (5): 2112–2122. doi:10.1182/blood-2005-01-0428
Tumor-associated_macrophage
Human protein and coding gene
shown to interact with: ASK1, DNAJC3, ILF3, METAP2, P53, PPP1CA, PRKRA, STAT1, and TARBP2. GRCh38: Ensembl release 89: ENSG00000055332 – Ensembl, May
Protein_kinase_R
Protein domain
SHE SLA; SLA2 SOCS1; SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS;
SH2_domain
Most expressed structure in coronaviruses
interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2". Cell Discovery. 6 (1): 65. doi:10.1038/s41421-020-00208-3. PMC 7490572
Coronavirus nucleocapsid protein
Coronavirus_nucleocapsid_protein
Interleukin
the IL-12 signalling pathway. The trait was mapped to mutations in the STAT1 gene, which were associated with lower production of interferon-γ, IL-17
Interleukin_12
DNA sequence
polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells". Journal of Neuroinflammation. 14 (1): 155. doi:10
TATA_box
Protein-coding gene in the species Homo sapiens
complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the
Interleukin_26
Cameroonian American geneticist
chemokine receptor mediated HIV-1 binding to HBMECs and that cross talk between STAT1 and PI3K pathways were mediating the BBB dysfunction after HIV infection
Georgette_D._Kanmogne
1 Interferon γ receptor 1 deficiency Interferon γ receptor 2 deficiency STAT1 deficiency MKL1 deficiency AD hyper-IgE AR hyper-IgE Pulmonary alveolar
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Protein-coding gene in the species Homo sapiens
contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA
PIAS1
Protein-coding gene in the species Homo sapiens
activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for
Interleukin-21_receptor
Species of flowering plant in the heather family
Shoji, K.; Suzuki, H. (2008). "Aqueous extract of Arbutus unedo inhibits STAT1 activation in human breast cancer cell line MDA-MB-231 and human fibroblasts
Arbutus_unedo
Mammalian protein found in Homo sapiens
NELFB NFE2L1 NFE2L2 NCOR2 NCOA1 PIN1 RBM39 RELA RB1 RFWD2 RUNX1 RUNX2 SMAD3 STAT1 STAT3 TBP TGIF1 c-Jun N-terminal kinases GRCh38: Ensembl release 89: ENSG00000177606
Transcription_factor_Jun
Protein-coding gene in humans
is enzyme pyruvate kinase M2 (PKM2) and a transcriptional coactivator of STAT1 responsible for the induction of the protein PDL-1 expression and its regulation
PKM2
State of being insusceptible or resistant to a noxious agent or process
IL12RB2, IL23R, ISG15, MCTS1, RORC, TBX21, TYK2, CYBB, JAK1, IFNGR1, IFNGR2, STAT1, USP18, IRF1, IRF8, NEMO, SPPL2A). Antiserum Antivenin Cell-mediated immunity
Immunity_(medicine)
resistance from laboratory to clinic; such targets include AKT, MTOR, HDAC4, STAT1 and the Folate Receptors. Until September 2017 he was founding President
Hani_Gabra
Family of viruses in the order Mononegavirales
factor 3 (IRF3) and signal transducer and activator of transcription 1 (STAT1), thus eliminating the cellular type 1 interferon pathway. Also, P protein
Rhabdoviridae
Protein-coding gene in the species Homo sapiens
pathway. TRADD has been shown to interact with: FADD, Keratin 18 RIPK1, STAT1, TNFRSF1A, TNFRSF25, and TRAF2. TRAF RIP GRCh38: Ensembl release 89: ENSG00000102871
TRADD
American immunologist
immune responses and the STAT1 gene that is required for innate responses. Schreiber's lab was the first to generate STAT1 deficient mice and has worked
Robert_D._Schreiber
Chemical compound
hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation". Antiviral Research. 184 104967. doi:10.1016/j.antiviral
Gemcitabine
Severe form of genetic dwarfism that is usually lethal
(FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum". J. Biol. Chem. 278 (19): 17344–9. doi:10
Thanatophoric_dysplasia
Chemical compound
activation has antiinflammatory effects by inhibiting chemokine production and STAT1 phosphorylation anti-fungal anti-microbial Certain individuals have experienced
Helenin
preferentially to un-methylated STAT1. Although the exact mechanism isn't clear, PIAS1 and PIASy both inhibit STAT1 signaling. PIAS3 was found to specifically
Protein inhibitor of activated STAT
Protein_inhibitor_of_activated_STAT
Mammalian protein found in Homo sapiens
(YLPQ), Y915 (YMPQ). The lower propensity for STAT1 activation may be a reflection of the lower number of STAT1 activation sequences, YZPQ (where X is any
Oncostatin_M
Protein-coding gene in the species Homo sapiens
Schurter BT, Shuai K, Herschman HR, David M (2001). "Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription". Cell. 104 (5): 731–41. doi:10
PRMT1
same IFN receptors as IFN-α and induces intracellular signalling through STAT1, STAT2, and Tyk2. This leads to the production of antiviral and immunomodulatory
Interferon_tau
Type of immune cell
B cells, and IL-10 CD4 T cells. The key THαβ transcription factors are STAT1 and STAT3 as well as IRFs. IL-10 from CD4 T cells activate NK cells' ADCC
Helper_T_cell
Viral disease
transcription of ISGs, and it inhibits activation of transcription factors, such as STAT1, that are involved in the antiviral response. nsP2 causes downregulation
Eastern_equine_encephalitis
Gene in the species Homo sapiens
signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C". Biochem. J. 379 (Pt 1): 199–208
IFN1@
Medical condition
negatively regulates STAT3 and inhibits other STAT proteins like STAT5 and STAT1. STAT5 is important for regulatory T cell (Treg) differentiation and function
STAT3_GOF
Form of protein microarray
S2CID 2753950. Wang Y., Wu T. R., Cai S., Welte T., Chin Y. E. (2000). "Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling
Antibody_microarray
Protein-coding gene in the species Homo sapiens
by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes
Interleukin_24
Species of virus
Mechanisms to Escape the IFN System: The Viral Protein P Interferes with IRF-3, Stat1, and PML Nuclear Bodies". Journal of Interferon & Cytokine Research. 26
Rabies_virus
Protein-coding gene in the species Homo sapiens
activates different signal transducer and activator (STAT) proteins namely STAT1, STAT3 and STAT5 and thus connects this cytokine to various biological processes
Interleukin_9
Argentinian immunologist
Specifically, cytokine-dependent TAM signaling is upregulated by type I interferon-STAT1 signaling, leading to the expression of cytokine and TLR suppressors. This
Carla_V._Rothlin
Protein involved in immune suppression
Following IL-35 binding to the IL-12Rβ2 and gp130 heterodimeric receptor, a STAT1/STAT4 complex is activated in T cells expressing CD4. Homodimer signaling
Interleukin_35
Glycoprotein exposed on the surface of the HIV virus
oxidative stress in the neuronal cells, and it is also known to activate STAT1 and induce interleukins IL-6 and IL-8 secretion in neuronal cells. HIV envelope
Envelope_glycoprotein_GP120
Protein-coding gene in the species Homo sapiens
Z, Zhong Z, Darnell JE (1995). "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation". Cell. 82 (2):
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Protein-coding gene in the species Homo sapiens
Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1. ENSG00000288185 GRCh38: Ensembl release 89: ENSG00000104998, ENSG00000288185
Interleukin 27 receptor, alpha subunit
Interleukin_27_receptor,_alpha_subunit
Protein-coding gene in the species Homo sapiens
"Interferon-gamma signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors". Invest. Ophthalmol. Vis. Sci.
IRF2
factors such as IFNy, signal transducers and activator of transcription 1 (STAT1), IL12B, Interferon-regulatory factor 1 (IRF1), the transcription factor
Immunologic constant of rejection
Immunologic_constant_of_rejection
Type I cytokine receptor for interleukin-27
and glycoprotein 130. IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of
Interleukin-27_receptor
Cytokine, alarmin, and growth factor
and activator of transcription (STAT)5A and 5B and, to a lesser extent, STAT1 and 3. These transcription factors upregulate pro-inflammatory cytokines
Thymic_stromal_lymphopoietin
Protein-coding gene in humans
phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes
IKBKE
Progressive cystic lung disease
uncontrolled LAM cell growth and increases LAM cell viability. Upregulation of STAT1 and STAT3 and autophagy are known mediators of LAM cell viability and survival
Lymphangioleiomyomatosis
Transmembrane protein
PLSCR1, PTPN1, PTPN11, PTPN6, PTPRK, SH2D3A, SH3KBP1, SHC1, SOS1, Src, STAT1, STAT3, STAT5A, UBC, and WAS, PAR2. In fruitflies, the epidermal growth
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Protein-coding gene in humans
Z, Zhong Z, Darnell JE (1995). "Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation". Cell. 82 (2):
CAMK2G
Protein family
the STAT binding site promotes GFAP transcription through binding the STAT1/3 complex, which is activated through the LIF pathway. Along with supporting
Neurogenins
Signaling within the same cell
also contributes to maintenance of EMT, possibly through activation of STAT1 and other distinct pathways. In addition, expression of PDGFRα and -β correlated
Autocrine_signaling
Mammalian protein found in humans
Foxp3− type 1 regulatory (Tr1) cells or Th17 cells from naïve T cells via STAT1, STAT4, and STAT5 phosphorylation. Several studies have shown that tumor-associated
CXCL9
Protein in the species Homo sapiens
receptor complex, JAK kinases are activated which phosphorylate and activate STAT1, STAT3, and STAT5. The OSMR portion of the IL-31 binding complex contains
Interleukin_31
Protein-coding gene in humans
division cycle 7-related protein kinase, MCM2, MCM3, MCM7, ORC2L, ORC6L, and STAT1. GRCh38: Ensembl release 89: ENSG00000100297 – Ensembl, May 2017 GRCm38:
MCM5
Protein-coding gene in humans
DaFonseca CJ, Tjernberg A (Apr 2002). "Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma". Proceedings of the National
CAMK2D
American virologist
alpha interferon and gamma interferon requires transcriptionally active Stat1 protein. J Virol. 1996;70(1):647-50. PubMed PMID: 8523587; PMCID: 189860
Curt_M._Horvath
Medical condition
constructs have shown immune activation with increased NF-κB signaling, STAT1 phosphorylation and interferon gene expression signature. This condition
ROSAH_syndrome
Genetic abnormality in leukemia cancer cells
transcriptional activation of specific genes and other downstream targets. JAK2, STAT1, STAT3 and STAT5 have been shown to be constitutively active in CML models
Philadelphia_chromosome
Group of cytokines
cells (Th17) IL22R Production of defensins from epithelial cells. Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum
Interleukin
Protein-coding gene in the species Homo sapiens
protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different
IFNAR2
Gene known for its role in breast cancer
Rad50 RAD51 RBBP4 RBBP7 RBBP8 RELA RB1 RBL1 RBL2 RPL31 SMARCA4 SMARCB1 STAT1 TOPBP1 UBE2D1 USF2 VCP XIST ZNF350 GRCh38: Ensembl release 89: ENSG00000012048
BRCA1
Literature-curated Transcription Factors (via ORegAnno) SMARCA4 STAT1 RBL2 TRIM28 EGR1 TFAP2C
Small integral membrane protein 14
Small_integral_membrane_protein_14
Protein-coding gene in the species Homo sapiens
been shown to interact with: CHIP GAGE HSP70 / HSP90 IRF8 KPNA2 MYD88 PCAF STAT1 TAT VEGFR2 REDD2 IRF2 Interferon regulatory factors GRCm38: Ensembl release
IRF1
Inferred motif from similar protein – High-throughput in vitro [884] VAAGTTT STAT1 ENSG00000115415 STAT Known motif – In vivo/Misc source [885] HTTCCYRGAAR
List of human transcription factors
List_of_human_transcription_factors
Heterodimeric receptor
Phosphotyrosine residues on IFNAR1 and IFNAR2 recruit STAT proteins (classically STAT1, STAT2, or STAT3, although STAT4, STAT5, and STAT6 may play a role in certain
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Protein-coding gene in the species Homo sapiens
response suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity suppression by virus of host JAK-STAT cascade via inhibition of
SCRIB
Biological process
kappa light polypeptide gene enhancer (NF-κB), activator protein (AP-1) and STAT1. This leads to enhanced microbicidal capacity and secretion of high levels
Macrophage_polarization
Protein-coding gene in humans
JAK2, MAPK8IP3, NCK1, NCK2, NEDD9, NEO1, P53, PIK3R1, PTEN, PXN, RB1CC1, STAT1, Src, Syk, TGFB1I1, TLN1, TSC2, YAP1. Tyrosine kinase GRCm38: Ensembl release
PTK2
500.750 – hepatocyte nuclear factor 1-beta MeSH D12.776.930.354.249.500 – stat1 transcription factor MeSH D12.776.930.354.249.750 – stat2 transcription
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Protein-coding gene in the species Homo sapiens
Jesus Ibarra-Sanchez M, Fu Y, et al. (2002). "Identification of a nuclear Stat1 protein tyrosine phosphatase". Mol. Cell. Biol. 22 (16): 5662–8. doi:10
PTPN2
Protein-coding gene in humans
KHDRBS1 KPNA4 mTOR MYOD1 NCOA1 NDUFA13 NFKB1 NR3C1 PML RAC1 RELA RET RPA2 Src STAT1 Stathmin TRIP10 Inhibitors Napabucasin Niclosamide seems to inhibit the
STAT3
Enzyme and coding gene in humans
IFN-β deficiency leads resistance to LPS-induced endotoxin shock, whereas STAT1-deficient mice are susceptible. Development of a TYK2 inhibitor appears
Tyrosine_kinase_2
Medication
by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated
Tofacitinib
Inherited retrovirus encoded in an organism's genome
with ERVs bound by signal transducer and activator of transcription 1 (STAT1) and/or Interferon regulatory factor (IRF1) in CD14+ macrophages. HERVs
Endogenous_retrovirus
Protein-coding gene in humans
stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169
CSRP2
Protein-coding gene in the species Homo sapiens
(myelogenous leukemia cells) Promoter RFX5 GM12878 (human lymphoblastoid) Promoter STAT1 GM12878 (human lymphoblastoid) Promoter TAF1 GM12878 (human lymphoblastoid)
ZNF337
cellular immune response through MAPK signaling pathways. H1 dephosphorylates STAT1 to prevent nuclear transcription and block IFNy-induced immune signaling
Lateral_body
STAT1
STAT1
STAT1
STAT1
Girl/Female
Indian
Pretty, Beautiful
Girl/Female
Hindu
Flowered
Girl/Female
Indian
Princess
Surname or Lastname
English
English : habitational name from any of the extremely numerous places called Sutton, from Old English sūð ‘south’ + tūn ‘enclosure’, ‘settlement’.
Boy/Male
African, Australian, Danish, French, German, Japanese, Latin, Nigerian, Teutonic
Bright in Mind and Spirit; Mind; Intellect; Eagle; Symbol of Purity; Strength and Royalty; Spirit
Male
Hebrew
(תֶּרַח) Hebrew name TERACH means "delay" and "station." In the bible, this is the name of a place in the wilderness where the Israelites stopped on their Exodus. It is also the name of the father of Abraham.
Girl/Female
Bengali, Hindu, Indian
Beauty
Boy/Male
American, British, English
Beekeeper
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi
Lightening
Girl/Female
Arthurian Legend American
Mother of Lancelot.
STAT1
STAT1
STAT1
STAT1
STAT1