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Group of cytokines
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)
Interleukin
Cytokine protein
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the
Interleukin_6
Protein that in humans is encoded by the IL33 gene
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production
Interleukin_33
Mammalian protein found in humans
Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It regulates the activities of
Interleukin_2
Mammalian protein found in Homo sapiens
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and
Interleukin_1_beta
Interleukin
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid
Interleukin_12
Anti-inflammatory cytokine
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is
Interleukin_10
Type of cytokine
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5
Interleukin_5
Mammalian protein found in Mus musculus
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells
Interleukin_4
Protein and coding gene in humans
Interleukin 13 (IL-13) and its relative interleukin-4 are signalling proteins of the adaptive immune systems of vertebrates. They are immunoregulatory
Interleukin_13
Mammalian protein found in humans
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,
Interleukin_8
Heterodimeric cytokine acting as mediator of inflammation
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit
Interleukin_23
Cytokine with structural similarity to Interleukin-2
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2
Interleukin_15
Protein-coding gene in the species Homo sapiens
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor
Interleukin_3
Mammalian protein found in Homo sapiens
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2
IL2RA
Immunosuppressive drug
antibody of the immunoglobulin IgG1 subclass against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in
Tocilizumab
Protein-coding gene in the species Homo sapiens
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by
Interleukin_18
Cell surface proteins
Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-9 receptor Interleukin-11 receptor
Interleukin_receptor
Group of cytokine proteins
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to
Interleukin-1_family
Protein-coding gene in the species Homo sapiens
Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic
Interleukin-6_receptor
Biopharmaceutical drug
subcutaneous injection. The antibody targets a subunit of human interleukin 12 and interleukin 23, which are naturally occurring proteins that regulate the
Ustekinumab
Protein and coding gene in humans
The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. IL-1RA was initially called the IL-1 inhibitor
Interleukin-1 receptor antagonist
Interleukin-1_receptor_antagonist
Protein-coding gene in the species Homo sapiens
Interleukin-36 gamma previously known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene. IL36G is well-expressed
IL36G
Group of proteins
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper
Interleukin_17
Intracellular signaling domain
The Toll/Interleukin-1 receptor/Resistance protein (TIR) homology domain is an intracellular signaling domain found in MyD88, SARM1, interleukin-1 receptors
Toll-interleukin_receptor
Monoclonal antibody against IL-17
psoriatic arthritis, and hidradenitis suppurativa. It binds to the protein interleukin (IL)-17A and is marketed by Novartis. Secukinumab is used to treat psoriasis
Secukinumab
Chemical compound
blocks activities of the cytokine Interleukin-6, which are mediated by the soluble Interleukin-6 receptor. Interleukin-6 is a cytokine, which plays a dominant
Olamkicept
Cytokine receptor which binds interleukin 1
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I receptor is primarily responsible
Interleukin-1_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 37 (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for the downregulation of pro-inflammatory
Interleukin_37
Receptors on the surface of cells
Interleukin-3 receptor Interleukin-4 receptor Interleukin-5 receptor Interleukin-6 receptor Interleukin-7 receptor Interleukin-9 receptor Interleukin-11 receptor
Type_I_cytokine_receptor
Protein-coding gene in the species Homo sapiens
Interleukin-1 alpha (IL-1 alpha) also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In
Interleukin_1-alpha
Protein-coding gene in the species Homo sapiens
The interleukin 4 receptor is a type I cytokine receptor. It is a heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα
Interleukin-4_receptor
Growth factor secreted by stromal cells in the bone marrow and thymus
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone
Interleukin_7
Drugs to suppress IL-6 signalling
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. Hence, anti-IL6
Anti-interleukin-6
Mammalian protein found in Homo sapiens
Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name
Interleukin_8_receptor,_alpha
Medical condition
corticosteroids such as prednisone. Medications that block the action of interleukin-1, such as anakinra, can be effective treatments when standard steroid
Adult-onset_Still's_disease
Protein-coding gene in the species Homo sapiens
beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12 subunit
Interleukin-12_subunit_beta
Protein-coding gene in the species Homo sapiens
Interleukin-17A is a protein that in humans is encoded by the IL17A gene. In rodents, IL-17A used to be referred to as CTLA8, after the similarity with
Interleukin-17A
Autoimmune diseases of the skin
interferon-γ and interleukin-17. Interleukin-23 is known to induce the production of interleukin-17 and interleukin-22. Interleukin-22 works in combination
Psoriasis
Protein-coding gene in the species Homo sapiens
Interleukin 16 is a pro-inflammatory pleiotropic cytokine. Its precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene.
Interleukin_16
Protein-coding gene in the species Homo sapiens
Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene. The protein encoded by this gene is a member of the interleukin
IL1RL2
Protein-coding gene in humans
The common gamma chain (γc) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to
Common_gamma_chain
Protein-coding gene in the species Homo sapiens
Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is produced by variety
Interleukin_9
Protein found on the surface of cells
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer
Interleukin-7_receptor
Mammalian protein found in Homo sapiens
Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and
Interleukin_8_receptor,_beta
Cell surface receptor for interleukin-10
Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. The α subunit (encoded in
Interleukin-10_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene. The
Interleukin-9_receptor
Type of interleukin receptor
Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human
Interleukin 1 receptor, type I
Interleukin_1_receptor,_type_I
Protein-coding gene in the species Homo sapiens
Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. The protein encoded by this gene is a cytokine receptor for interleukin
Interleukin-21_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first isolated
Interleukin_11
Pharmaceutical drug
disease. It is a slightly modified recombinant version of the human interleukin 1 receptor antagonist protein. It is marketed by Swedish Orphan Biovitrum
Anakinra
Protein found in humans
Interleukin 32 (IL32) is proinflammatory cytokine that in humans is encoded by the IL32 gene. Interleukin 32 can be found in higher mammals but not in
Interleukin_32
Protein-coding gene in the species Homo sapiens
Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening
Interleukin_34
Cytokine that belongs to the IL-17 cytokine family
Interleukin-25 (IL-25) – also known as interleukin-17E (IL-17E) – is a protein that in humans is encoded by the IL25 gene on chromosome 14. IL-25 was discovered
Interleukin_25
Protein-coding gene in the species Homo sapiens
Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. Interleukin 17A (IL17A)is a proinflammatory
IL17RA
Protein-coding gene in the species Homo sapiens
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the IL7R
Interleukin-7_receptor-α
Cell surface receptors specific for interleukin-5
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. The IL-5 receptor
Interleukin-5_receptor
Cell surface receptors for interleukin-13
The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively
Interleukin-13_receptor
Protein in immune system
Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is encoded by two distinct genes, Epstein-Barr virus-induced
Interleukin_27
Protein-coding gene in the species Homo sapiens
Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human
Interleukin 1 receptor, type II
Interleukin_1_receptor,_type_II
Protein-coding gene in the species Homo sapiens
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes
Interleukin 5 receptor alpha subunit
Interleukin_5_receptor_alpha_subunit
Protein-coding gene in the species Homo sapiens
Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member
Interleukin 36 receptor antagonist
Interleukin_36_receptor_antagonist
Protein-coding gene in the species Homo sapiens
Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin 1 induces synthesis of acute phase and
IL1RAP
Protein-coding gene in the species Homo sapiens
The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene. IL18R1 is also known as
IL18R1
Protein-coding gene in the species Homo sapiens
The interleukin-23 receptor is a type I cytokine receptor. It is encoded in human by the IL23R gene. In complex with the interleukin-12 receptor β1 subunit
Interleukin-23_receptor
Type of protein receptor
Interleukin-17 receptor (IL-17R) is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a
Interleukin-17_receptor
Lymphocyte receptor specific for Interleukin-2
The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds
IL-2_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene. IL10RB has also been designated CDw210b (cluster
Interleukin 10 receptor, beta subunit
Interleukin_10_receptor,_beta_subunit
Mammalian protein found in Homo sapiens
The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune
Interleukin-3_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene. In mice, CD4+ helper T-cells differentiate into type
Interleukin 27 receptor, alpha subunit
Interleukin_27_receptor,_alpha_subunit
Interleukin receptor
The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily. Endometrial IL-18 receptor mRNA and the ratio of IL-18
Interleukin-18_receptor
Type II cytokine receptor
Interferon-lambda receptor (IFNLR), formerly known as the interleukin-28 receptor (IL28R), is a type II cytokine receptor found largely in epithelial
Interferon-lambda_receptor
Immunoglobulin superfamily
very wide interleukin-1 receptor (IL-1R) family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1 receptor/Resistance
Interleukin-1_receptor_family
Protein-coding gene in the species Homo sapiens
Interleukin 30 (IL-30) forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus it is also called IL27-p28. IL-27 is composed
Interleukin_30
Interleukin 17F (IL-17F) is a signaling protein in humans, which is encoded by the IL17F gene and is considered a pro-inflammatory cytokine. This protein
Interleukin_17F
Protein and coding gene in humans
Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name
Interleukin 12 receptor, beta 1 subunit
Interleukin_12_receptor,_beta_1_subunit
Type I cytokine receptor
Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1 and beta 2 subunits. Chua AO, Chizzonite R, Desai
Interleukin-12_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 15 receptor, alpha subunit is a subunit of the interleukin 15 receptor that in humans is encoded by the IL15RA gene. The IL-15 receptor is
Interleukin 15 receptor, alpha subunit
Interleukin_15_receptor,_alpha_subunit
Protein, encoded in humans by IL22 gene
Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface
Interleukin_22
Medication used to treat autoimmune diseases
form of a humanized monoclonal antibody. The substance acts by binding interleukin 17A and neutralizing it, reducing inflammation. The most common side
Ixekizumab
Protein-coding gene in humans
Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene. IL1RL1 is a member of the Toll-like
IL1RL1
Protein-coding gene in the species Homo sapiens
Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70-75. The interleukin 2 receptor
IL2RB
Protein-coding gene in the species Homo sapiens
Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified
Interleukin 12 receptor, beta 2 subunit
Interleukin_12_receptor,_beta_2_subunit
Mammalian protein found in Homo sapiens
two subunits of the cytokine Interleukin-23. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40
Interleukin_23_subunit_alpha
Pharmaceutical drug
antibody targeted at interleukin-1β. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha. Common side
Canakinumab
Transmembrane proteins
cytokines, which includes all types of interferons and members of the interleukin-10 family These receptors are characterized by the lack of a WSXWS motif
Type_II_cytokine_receptor
Protein-coding gene in the species Homo sapiens
Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene. IL10RA has also been designated CDw210a (cluster
Interleukin 10 receptor, alpha subunit
Interleukin_10_receptor,_alpha_subunit
Family of interleukins
The IL-10 family is a family of interleukins. They are helical cytokines categorized based on their specific similarities and can be classified as class
IL-10_family
Category of small signaling proteins
surface of target cells. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones
Cytokine
Type I cytokine receptor for interleukin-27
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit
Interleukin-27_receptor
Protein in humans
The interleukin-31 receptor (IL-31R) is a receptor bound and activated by interleukin-31 (IL-31). It is a heterodimer consisting of IL-31 receptor A (IL31RA)
Interleukin-31_receptor
Protein complex
Interleukin-15 receptor is a type I cytokine receptor, binding interleukin-15. The IL-15 receptor is composed of the IL-2Rβ and γc subunits, along with
Interleukin-15_receptor
Monoclonal antibody
used for the treatment of atopic dermatitis (atopic eczema). It is an interleukin 13 antagonist. It is given by subcutaneous injection. The most common
Lebrikizumab
Protein-coding gene in the species Homo sapiens
Interleukin-29 (IL-29) is a cytokine and it belongs to type III interferons group, also termed interferons λ (IFN-λ). IL-29 (alternative name IFNλ1) plays
Interleukin_29
Type of immune cell
PTK7, Complement Receptor 1 and 2 (CR1, CR2) and the production of interleukin 8 (IL-8). Like all T cells, they express the T cell receptor-CD3 complex
Helper_T_cell
Human protein and coding gene
Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene. The protein encoded by this gene is a member of the interleukin
IL1F10
Protein-coding gene in the species Homo sapiens
Interleukin-36 alpha also known as interleukin-1 family member 6 (IL1F6) is a protein that in humans is encoded by the IL36A gene. GRCh38: Ensembl release
IL36A
Protein-coding gene in the species Homo sapiens
Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be
Interleukin 20 receptor, beta subunit
Interleukin_20_receptor,_beta_subunit
InterPro Family
Interleukin-38 (IL-38) is a member of the interleukin-1 (IL-1) family and the interleukin-36 (IL-36) subfamily. It is important for the inflammation and
Interleukin-38
Enzyme found in humans
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors
Caspase_1
INTERLEUKIN
INTERLEUKIN
INTERLEUKIN
INTERLEUKIN
Female
Gypsy/Romani
Variant spelling of Romani Violca, probably VIOLLCA means "violet color" or "violet flower."
Boy/Male
Biblical
From the beginning; an inheritance.
Boy/Male
Biblical
Poor, humble.
Boy/Male
Indian
Easy
Boy/Male
Arabic
Ruler; King
Boy/Male
American, British, English
Seaman
Boy/Male
Hindu, Indian
One who Holds Money
Boy/Male
Australian, Greek
Regal; Royal; Kingly
Girl/Female
English French
Blend of Cherie and Cerise: dear one; darling.
Boy/Male
Anglo, Australian, Celtic, Christian, Irish, Scottish
Dweller by the Dark Stream; Black Stranger
INTERLEUKIN
INTERLEUKIN
INTERLEUKIN
INTERLEUKIN
INTERLEUKIN