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Mammalian protein found in humans
The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin is a serine-threonine protein kinase that regulates cell growth
MTOR
Class of pharmaceutical drugs
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function
MTOR_inhibitors
Protein complex
controls protein synthesis. mTOR Complex 1 (mTORC1) is composed of the mTOR protein complex, regulatory-associated protein of mTOR (commonly known as raptor)
MTORC1
Cell cycle regulation pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence
PI3K/AKT/mTOR_pathway
Protein complex
mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and
MTORC2
Pharmaceutical drug
rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to
Sirolimus
acquired by Blackstone Inc. August 4, 2022 AHCO AdaptHealth MTOR Meritor AHCO replaced MTOR after it was acquired by Cummins. July 26, 2022 SIX Six Flags
List_of_S&P_600_companies
Condition involving social and behavioral differences
cells in post-mortem brain tissue. Genes associated with variation in the mTOR signaling pathway, which is involved in cell growth and survival, are also
Autism
Protein-coding gene in the species Homo sapiens
of p70S6K at threonine 389 has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations.[citation
P70-S6_Kinase_1
Protein-coding gene in the species Homo sapiens
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 is a protein that in humans is encoded by the LAMTOR4 gene. GRCh38: Ensembl release 89: ENSG00000188186
LAMTOR4
Chemical compound
dual mTOR/PI3K inhibitor. mTOR is a downstream effector of PI3K and is also independently regulated by hormones, growth factors, and nutrients. mTOR protein
Gedatolisib
Pharmaceutical compound
which acts as an inhibitor of the enzyme mechanistic target of rapamycin (mTOR). It is a dimeric molecule consisting of rapamycin joined to a desalkyl derivative
Rapalink-1
Medical condition
rare genetic disorder that is caused by a gain-of-function mutation in a mTOR gene. The facial features of this syndrome are triangular face with a pointed
Smith–Kingsmore_syndrome
American scientist who co-discovered mTOR
of cell signaling and cancer metabolism, most notably the co-discovery of mTOR. In 2021 and 2022, Sabatini was fired from the Howard Hughes Medical Institute
David_M._Sabatini
Genetic abnormality in leukemia cancer cells
cellular processes. Additionally, mTOR can act both upstream and downstream of AKT. Two multiprotein complexes of mTOR are involved in the PAM pathway,
Philadelphia_chromosome
Amino acid with a branched carbon chain
is a downstream component of the mammalian target of rapamycin complex (mTOR) pathway, which regulates adaptive hypertrophy and recovery in skeletal muscle
Branched-chain_amino_acid
Dissociative anesthetic and anti-depressant
effects on regulators such as brain-derived neurotrophic factor (BDNF) and mTOR. It is not clear whether ketamine alone is sufficient for antidepressant
Ketamine
SSRI antidepressant
transporter is uncertain. Sertraline is a REDD1-dependent mTOR inhibitor. It blocks AKT/mTOR pathway and has autophagy-inducing activity. Following a single
Sertraline
Inherited neurodegenerative disorder
Berger Z, Davies JE, Luo S, Oroz LG, et al. (June 2004). "Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly
Huntington's_disease
Psychoactive substance found in plants in the family Apocynaceae
be blocked by the serotonin 5-HT2A receptor antagonist ketanserin, by the mTOR inhibitor rapamycin, and by a TrkB antagonist. Ibogaine is metabolized in
Ibogaine
Failure of certain neurons to migrate during brain development
mammalian target of rapamycin (mTOR) pathway. Causative gene mutations for types 1 and 3 have not been identified. The mTOR pathway regulates a number of
Focal_cortical_dysplasia
Protein-coding gene in the species Homo sapiens
KIAA1024). The MINAR1 protein regulates and inhibits mTOR signaling by stabilizing DEPTOR, an mTOR complex component. A notable homolog is MINAR2, which
MINAR1
Type of endocrine gland cancer
develop a PanNet. Other genes that are frequently mutated include DAXX, mTOR, and ATRX. Medical imaging techniques, such as computed tomography (CT scan)
Pancreatic_cancer
Group of neurological disorders causing seizures
implications. Mutations in genes affecting ion channels, synaptic transmission, and mTOR signaling pathways have been linked to epilepsy syndromes, and molecular
Epilepsy
Chemical compound
target of rapamycin (mTOR), a serine-threonine protein kinase that regulates protein biosynthesis and cell growth. The activation of mTOR by leucine is mediated
Leucine
Protein-coding gene in humans
subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene. It is a subunit of both mTORC1 and
MLST8
Protein-coding gene in the species Homo sapiens
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 is a protein that in humans is encoded by the LAMTOR1 gene. GRCh38: Ensembl release 89: ENSG00000149357
Late endosomal/lysosomal adaptor, mapk and mtor activator 1
Late_endosomal/lysosomal_adaptor,_mapk_and_mtor_activator_1
Mass of cells which cannot spread throughout the body
hamartin inhibit the mTOR protein in normal cellular physiology. Inactivation of the TSC tumor suppressors causes an increase in mTOR activity. This leads
Benign_tumor
Chemical compound
first non-rapalog derived inhibitors of the mechanistic target of rapamycin (mTOR) subtypes mTORC1 and mTORC2. In animal studies it has anti-inflammatory,
Torin-1
pathway MAPK/ERK signalling pathway mTOR signalling pathway Nodal signalling pathway Notch signalling pathway PI3K/AKT/mTOR signalling pathway TGF beta signalling
List_of_signalling_pathways
Process of synapse elimination
during development; these changes have been linked to hyperactivation of the mTOR pathway and defective autophagy in neurons. Neuroplasticity Faust, Travis
Synaptic_pruning
American truck parts manufacturer
Inc. Formerly ArvinMeritor (2000–2011) Type Subsidiary Traded as NYSE: MTOR (delisted 2022) Industry Commercial vehicles systems and components Predecessor
Meritor
Drug that inhibits activity of immune system
active against tumors that are PI3K/AKT/mTOR-dependent. Everolimus is an analog of sirolimus and also is an mTOR inhibitor. Zotarolimus is a semi-synthetic
Immunosuppressive_drug
Aggressive type of brain cancer
intracellular signaling system known as phosphatidylinositol-3-OH kinase (PI3K)/AKT/mTOR, which is crucial for controlling cell survival. The third pathway is defined
Glioblastoma
Contact-based cell-cell signalling
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Juxtacrine_signalling
Rejection of transplanted tissue by the recipient's immune system
anti-proliferative agent. Where calcineurin inhibitors or steroids are contraindicated, mTOR inhibitors are used. Immunosuppressive drugs: Corticosteroids Prednisolone
Transplant_rejection
Medical condition
frequent overactivation of mTOR (mammalian target of rapamycin) signaling has also been observed in epithelioid sarcoma. The mTOR pathway has been described
Epithelioid_sarcoma
Malignant tumor characterized by uncontrolled cell growth in lung tissue
(17% of trials), microtubules (12%), VEGF (12%), immune pathways (10%), mTOR (1%), and histone deacetylases (<1%). Horn & Iams 2022, "Epidemiology". Bade
Lung_cancer
Chinese-American developmental biologist
these tumor suppressor genes to Rheb and mTOR signaling. This discovery provided the molecular basis for using mTOR inhibitors in the treatment of tuberous
Duojia_Pan
Excess connective tissue in healing
10 (IL-10). These initiate signal transduction pathways such as the AKT/mTOR and SMAD pathways that ultimately lead to the proliferation and activation
Fibrosis
Chemical compound
similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR). It is marketed by Novartis under the trade names Zortress (US) and Certican
Everolimus
Class of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Acetate_kinase
Form of programmed cell death
Necrotaxis Nemosis Mitotic catastrophe p53 Paraptosis Pseudoapoptosis PI3K/AKT/mTOR pathway Ruptosis Note that the average human adult has more than 13 trillion
Apoptosis
Largest known protein in human muscles
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Titin
Amino acid
sarcosine has been shown to modulate AMPA receptor function and downstream mTOR signalling in rodent models of depression. Long-term sarcosine administration
Sarcosine
Biological ability to detect and respond to cell population density
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Quorum_sensing
Medical condition
the RAS–mitogen-activated protein kinase (MAPK) pathway and the PI3K/AKT/mTOR pathway that regulates cellular growth, differentiation, proliferation and
Phakomatosis
Protein-coding gene in the species Homo sapiens
depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway". Molecular and Cellular Biology. 27 (16): 5619–29. doi:10.1128/MCB
GSPT1
Experimental antidepressant
the AMPA receptor, downstream activation of mammalian target of rapamycin (mTOR), and upregulation of brain-derived neurotrophic factor (BDNF) are central
Osavampator
Chemical compound
treatment of the Ty82 cells decreased the activity of their mTOR protein as well as PI3K/AKT/mTOR pathway (This pathway promotes the development and/or progression
Itaconic_acid
Series of molecular signals
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Notch_signaling_pathway
Protein-coding gene in the species Homo sapiens
Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, et al. (January 2014). "mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy"
NDRG1
Period of symptoms due to excessive or synchronous neuronal brain activity
treat seizures, with the most promising recent discoveries involving the mTOR pathway and the cytokine (small signaling protein) IL-1ß. Several other structures
Seizure
Genetic condition causing non-cancerous tumours
An mTOR inhibitor drug can help, though a lung transplant may be required. A 12-lead ECG should be performed every three to five years. The mTOR inhibitor
Tuberous_sclerosis
Group of autoimmune diseases resulting in abnormal growth of connective tissue
hearing loss) and progressive multifocal leucoencephalopathy. Sirolimus mTOR inhibitor, thereby reducing cytokine-induced lymphocyte proliferation. PO
Scleroderma
Monoamine neurotransmitter
protein serotonylation substrates include several metabolic enzymes (GAPDH, mTOR), Rab GTPases (Rab3a, Rab27a), Rho GTPases (RhoA, Rac1, Cdc42), proteins
Serotonin
Enlargement or overgrowth of a muscle organ
mechanical tension. Mechanical tension is known to activate pathways such as mTOR, which is responsible for protein synthesis, a mechanism that directly contributes
Muscle_hypertrophy
Early onset muscle loss due to ageing or immobility
synthesis. It is reported to have multiple targets, including stimulating mTOR and decreasing proteasome expression. Its use to prevent the loss of lean
Sarcopenia
interplay of these molecules. mTOR is a serine/threonine protein kinase, which is found in 2 complexes in cells: mTOR complex 1 and 2 (mTORC1 and mTORC2)
Immunometabolism
Chemical compound
production in a dose-dependent manner in endothelial cells via the PI3K/AKT/mTOR pathway. Combreglutinin, a Hydrolyzable Tannin from Combretum glutinosum
1-α-O-Galloylpunicalagin
System of signaling molecules within a cell
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Second_messenger_system
Pharmaceutical compound
receptor antagonist, and temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor, which is under development for the treatment of major depressive
Ketamine/temsirolimus
Family of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Protein_kinase_A
Chemical compound
MLN0128, INK128 and TAK-228) is an experimental small molecule inhibitor of mTOR which is administered orally. It targets both mTORC1 and mTORC2. Developed
Sapanisertib
Type of proteins
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
G_protein
Longer than typical lifespan, especially of humans
influence longevity are Insulin/IGF-1, mechanistic target of rapamycin (mTOR), AMP-activating protein kinase (AMPK), and Sirtuin pathways. Emerging research
Longevity
Type of spreading cancer
infections. PI3K/AKT/mTOR inhibitors block a signaling pathway that cancer cells use to grow, divide, and survive. In cancer, the PI3K/AKT/mTOR signaling network
Metastatic_breast_cancer
Class of enzymes
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Receptor_tyrosine_kinase
Genetic disorder caused by a mutation of chromosome 15
in the cerebellum of AS mice decreases ataxia symptoms. Additionally, the mTOR pathway plays a role in AS pathology. Specifically in AS mice, Purkinje cells
Angelman_syndrome
Uterine cancer that is located in tissues lining the uterus
inhibit the mTOR pathway may reduce the risk of disease worsening compared to having more chemotherapy or hormonal therapy. However, mTOR inhibitors may
Endometrial_cancer
Class of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Pyruvate_dehydrogenase_kinase
Family of proteins
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
MAP kinase kinase kinase kinase
MAP_kinase_kinase_kinase_kinase
Rare autosomal dominant cancer syndrome
involvement with cellular metabolism, possibly through modulation of the mTOR (mammalian target of rapamycin) pathway and/or oxidative phosphorylation
Birt–Hogg–Dubé_syndrome
Post-translational modification
endothelial cells, leading to lysine malonylation of mTOR at lysine 1218. This impairs the kinase activity of mTOR complex 1, which reduces endothelial proliferation
Lysine_malonylation
Project to catalogue genetic mutations responsible for cancer
modifications resulting in global hypomethylation, and genes of the PI3K/AKT/mTOR pathway; metabolic shift similar to the 'Warburg effect' correlates with
The_Cancer_Genome_Atlas
Transmembrane protein
by the TMEM127 gene. It has been demonstrated to be a negative regulator MTOR signalling. TMEM127 is a tumor suppressor gene, inactivating germline mutations
TMEM127
Protein-coding gene in the species Homo sapiens
the receptor is known to activate the PI3K/AKT/mTOR pathway The effector molecules of this pathway are mTOR and NFkB, collectively the effect is exerted
C-C_chemokine_receptor_type_7
Protein-coding gene in humans
Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. Two mRNAs from
RPTOR
Chemical compound
demonstrated synergistic effects when combined with CDK4/6 inhibitors or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models. The US Food and
Vepdegestrant
Chemical compound
skeletal muscle via phosphorylation of the mechanistic target of rapamycin (mTOR) and subsequent activation of mTORC1Tooltip mechanistic target of rapamycin
Β-Hydroxy β-methylbutyric acid
Β-Hydroxy_β-methylbutyric_acid
Italian biologist and writer with progeria (1995–2024)
Lattanzi, Giovanna (November 2016). "Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders". British
Sammy_Basso
Swiss multinational pharmaceutical corporation
biotechnology company Cambrian Biopharma announced it had licensed rights to mTOR inhibitor programs from Novartis. As part of the deal, Cambrian was setting
Novartis
Cascade of intracellular and molecular events for transmission/amplification of signals
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Signal_transduction
Protein-coding gene in the species Homo sapiens
DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by
DEPTOR
Tumors of the nervous or endocrine system within the pancreas
mutations in mTOR pathway genes, such as TSC2, PTEN and PIK3CA. The sequencing discovery might allow selection of which NETs would benefit from mTOR inhibition
Pancreatic neuroendocrine tumor
Pancreatic_neuroendocrine_tumor
American immunologist, author (born 1985)
In 2014, he discovered increased mTOR signaling in idiopathic multicentric Castleman disease and began testing an mTOR inhibitor on himself to assess its
David_Fajgenbaum
Chemical compound
structurally related to miltefosine. Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric AKT inhibitor targeting the pleckstrin
Perifosine
Mammalian protein found in Homo sapiens
Cantley LC (July 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. PMID 15261145
TSC2
Class of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Elongation_factor_2_kinase
Cytokine
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Transforming growth factor beta
Transforming_growth_factor_beta
Genetic disorder that causes early aging
it now has a more normal state.[citation needed] Studies of sirolimus, an mTOR Inhibitor, demonstrate that it can minimize the phenotypic effects of progeria
Progeria
Protein-coding gene in humans
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
CAMK2D
Chemical compound
derivative and prodrug of sirolimus. Temsirolimus is a specific inhibitor of mTOR and interferes with the synthesis of proteins that regulate proliferation
Temsirolimus
Cancer that originates in mammary glands
transitioning to a second one. Some respond to a third sequential therapy. Adding an mTOR inhibitor, everolimus, can further slow the tumors' progression. Those with
Breast_cancer
Chemical substance that enables neurotransmission
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Neurotransmitter
Species of plant
Yadav, Neelam; Mishra, Yoganchal (2020-10-02), "Targeting the PI3K/AKT/mTOR Signaling Pathway in Hepatocellular Carcinoma: Current State and Future Trends"
Cerbera_manghas
Chemical compound
and thus works by inhibiting the enzyme PIK3CG, disrupting the PI3K/AKT/mTOR signaling pathway which plays important roles in the development of cancer
Eganelisib
Biological signalling molecule
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Hormone
Aspect of cell metabolism
Complex is composed of five LAMTOR subunits, which work to regulate MAPK and mTOR complex 1. The LAMTOR subunits form a complex with Rag GTPase and v-ATPase
Ragulator-Rag_complex
Medical condition
hemangiomatosis. mTOR inhibitors, an inhibitor that is normally used for post-organ transplantation, has previously been used for vascular anomalies. mTOR is controlled
Diffuse neonatal hemangiomatosis
Diffuse_neonatal_hemangiomatosis
MTOR
MTOR
MTOR
MTOR
Boy/Male
Hindu, Indian, Kannada, Marathi, Telugu
Made of Pearls
Male
Egyptian
, the son of Amen-em-heb.
Boy/Male
Indian, Punjabi, Sikh
No Fear; Warrior of Waheguru
Girl/Female
Indian, Punjabi, Sikh
Radiating the Beauteous Light
Boy/Male
Spanish
Counselor-ruler.
Boy/Male
Indian
Boy/Male
Arabic, French, Muslim
Form of Ibrahim
Girl/Female
Muslim
Honor, Pride, Glory
Girl/Female
English
Cassandra was a Trojan prophetess, daughter of King Priam. A diminutive of Casirnir, Cassandra,...
Girl/Female
Indian
Perfect, Beautiful
MTOR
MTOR
MTOR
MTOR
MTOR