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Mammalian protein found in humans
The mechanistic target of rapamycin (mTOR), also known as mammalian target of rapamycin is a serine-threonine protein kinase that regulates cell growth
MTOR
Class of pharmaceutical drugs
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function
MTOR_inhibitors
Protein complex
controls protein synthesis. mTOR Complex 1 (mTORC1) is composed of the mTOR protein complex, regulatory-associated protein of mTOR (commonly known as raptor)
MTORC1
Cell cycle regulation pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence
PI3K/AKT/mTOR_pathway
Protein complex
mTOR Complex 2 (mTORC2) is an acutely rapamycin-insensitive protein complex formed by serine/threonine kinase mTOR that regulates cell proliferation and
MTORC2
Pharmaceutical drug
rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to
Sirolimus
Protein-coding gene in the species Homo sapiens
of p70S6K at threonine 389 has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations.[citation
P70-S6_Kinase_1
Medical condition
rare genetic disorder that is caused by a gain-of-function mutation in a mTOR gene. The facial features of this syndrome are triangular face with a pointed
Smith–Kingsmore_syndrome
Genetic abnormality in leukemia cancer cells
cellular processes. Additionally, mTOR can act both upstream and downstream of AKT. Two multiprotein complexes of mTOR are involved in the PAM pathway,
Philadelphia_chromosome
Condition involving social and behavioral differences
cells in post-mortem brain tissue. Genes associated with variation in the mTOR signaling pathway, which is involved in cell growth and survival, are also
Autism
Chemical compound
nutrients. mTOR protein is found in two functionally distinct protein assemblies: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTOR signaling serves
Gedatolisib
American scientist who co-discovered mTOR
of cell signaling and cancer metabolism, most notably the co-discovery of mTOR. In 2021 and 2022, Sabatini was fired from the Howard Hughes Medical Institute
David_M._Sabatini
Amino acid with a branched carbon chain
is a downstream component of the mammalian target of rapamycin complex (mTOR) pathway, which regulates adaptive hypertrophy and recovery in skeletal muscle
Branched-chain_amino_acid
Failure of certain neurons to migrate during brain development
mammalian target of rapamycin (mTOR) pathway. Causative gene mutations for types 1 and 3 have not been identified. The mTOR pathway regulates a number of
Focal_cortical_dysplasia
acquired by Blackstone Inc. August 4, 2022 AHCO AdaptHealth MTOR Meritor AHCO replaced MTOR after it was acquired by Cummins. July 26, 2022 SIX Six Flags
List_of_S&P_600_companies
Aggressive type of brain cancer
intracellular signaling system known as phosphatidylinositol-3-OH kinase (PI3K)/AKT/mTOR, which is crucial for controlling cell survival. The third pathway is defined
Glioblastoma
Process of synapse elimination
during development; these changes have been linked to hyperactivation of the mTOR pathway and defective autophagy in neurons. Neuroplasticity Faust, Travis
Synaptic_pruning
Dissociative anesthetic and anti-depressant
the NMDA receptor and downstream effects on regulators such as BDNF and mTOR. It is not clear whether ketamine alone is sufficient for antidepressant
Ketamine
Chemical compound
target of rapamycin (mTOR), a serine-threonine protein kinase that regulates protein biosynthesis and cell growth. The activation of mTOR by leucine is mediated
Leucine
Protein-coding gene in the species Homo sapiens
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 is a protein that in humans is encoded by the LAMTOR1 gene. GRCh38: Ensembl release 89: ENSG00000149357
Late endosomal/lysosomal adaptor, mapk and mtor activator 1
Late_endosomal/lysosomal_adaptor,_mapk_and_mtor_activator_1
Inherited neurodegenerative disorder
Berger Z, Davies JE, Luo S, Oroz LG, et al. (June 2004). "Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly
Huntington's_disease
Medical condition
frequent overactivation of mTOR (mammalian target of rapamycin) signaling has also been observed in epithelioid sarcoma. The mTOR pathway has been described
Epithelioid_sarcoma
Excess connective tissue in healing
10 (IL-10). These initiate signal transduction pathways such as the AKT/mTOR and SMAD pathways that ultimately lead to the proliferation and activation
Fibrosis
Enlargement or overgrowth of a muscle organ
mechanical tension. Mechanical tension is known to activate pathways such as mTOR, which is responsible for protein synthesis, a mechanism that directly contributes
Muscle_hypertrophy
Physical activity that improves health
"The neurology of mTOR". Neuron. 84 (2): 275–291. doi:10.1016/j.neuron.2014.09.034. PMC 4223653. PMID 25374355. Figure 2: The mTOR Signaling Pathway Wang
Exercise
Progressive cystic lung disease
and controls the activity of mTOR complex 1 (mTORC1) that directly phosphorylates p70 S6 kinase (S6K1) and 4E-BP1. mTOR forms two physically and functionally
Lymphangioleiomyomatosis
SSRI antidepressant
transporter is uncertain. Sertraline is a REDD1-dependent mTOR inhibitor. It blocks AKT/mTOR pathway and has autophagy-inducing activity. Following a single
Sertraline
Mass of cells which cannot spread throughout the body
hamartin inhibit the mTOR protein in normal cellular physiology. Inactivation of the TSC tumor suppressors causes an increase in mTOR activity. This leads
Benign_tumor
Protein-coding gene in the species Homo sapiens
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 is a protein that in humans is encoded by the LAMTOR4 gene. GRCh38: Ensembl release 89: ENSG00000188186
LAMTOR4
Type of endocrine gland cancer
develop a PanNet. Other genes that are frequently mutated include DAXX, mTOR, and ATRX. Medical imaging techniques, such as computed tomography (CT scan)
Pancreatic_cancer
Pharmaceutical compound
which acts as an inhibitor of the enzyme mechanistic target of rapamycin (mTOR). It is a dimeric molecule consisting of rapamycin joined to a desalkyl derivative
Rapalink-1
Malignant tumor characterized by uncontrolled cell growth in lung tissue
(17% of trials), microtubules (12%), VEGF (12%), immune pathways (10%), mTOR (1%), and histone deacetylases (<1%). "Carcinoma, Non-Small-Cell Lung". meshb
Lung_cancer
Chemical compound
treatment of the Ty82 cells decreased the activity of their mTOR protein as well as PI3K/AKT/mTOR pathway (This pathway promotes the development and/or progression
Itaconic_acid
Series of molecular signals
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Notch_signaling_pathway
Largest known protein in human muscles
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Titin
Chemical compound
skeletal muscle via phosphorylation of the mechanistic target of rapamycin (mTOR) and subsequent activation of mTORC1Tooltip mechanistic target of rapamycin
Β-Hydroxy β-methylbutyric acid
Β-Hydroxy_β-methylbutyric_acid
pathway MAPK/ERK signalling pathway mTOR signalling pathway Nodal signalling pathway Notch signalling pathway PI3K/AKT/mTOR signalling pathway TGF beta signalling
List_of_signalling_pathways
Experimental antidepressant
the AMPA receptor, downstream activation of mammalian target of rapamycin (mTOR), and upregulation of brain-derived neurotrophic factor (BDNF) are central
Osavampator
Contact-based cell-cell signalling
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Juxtacrine_signalling
Amino acid
sarcosine has been shown to modulate AMPA receptor function and downstream mTOR signalling in rodent models of depression. Long-term sarcosine administration
Sarcosine
Psychoactive substance found in plants in the family Apocynaceae
be blocked by the serotonin 5-HT2A receptor antagonist ketanserin, by the mTOR inhibitor rapamycin, and by a TrkB antagonist. Ibogaine is metabolized in
Ibogaine
Biological signalling molecule
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Hormone
Family of proteins
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
MAP kinase kinase kinase kinase
MAP_kinase_kinase_kinase_kinase
Genetic condition causing non-cancerous tumours
An mTOR inhibitor drug can help, though a lung transplant may be required. A 12-lead ECG should be performed every three to five years. The mTOR inhibitor
Tuberous_sclerosis
Form of programmed cell death
Necrotaxis Nemosis Mitotic catastrophe p53 Paraptosis Pseudoapoptosis PI3K/AKT/mTOR pathway Ruptosis Note that the average human adult has more than 13 trillion
Apoptosis
Drug that inhibits activity of immune system
active against tumors that are PI3K/AKT/mTOR-dependent. Everolimus is an analog of sirolimus and also is an mTOR inhibitor. Zotarolimus is a semi-synthetic
Immunosuppressive_drug
Chemical compound
first non-rapalog derived inhibitors of the mechanistic target of rapamycin (mTOR) subtypes mTORC1 and mTORC2. In animal studies it has anti-inflammatory,
Torin-1
Group of autoimmune diseases resulting in abnormal growth of connective tissue
hearing loss) and progressive multifocal leucoencephalopathy. Sirolimus mTOR inhibitor, thereby reducing cytokine-induced lymphocyte proliferation. PO
Scleroderma
American immunologist, author (born 1985)
In 2014, he discovered increased mTOR signaling in idiopathic multicentric Castleman disease and began testing an mTOR inhibitor on himself to assess its
David_Fajgenbaum
Type of proteins
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
G_protein
Project to catalogue genetic mutations responsible for cancer
modifications resulting in global hypomethylation, and genes of the PI3K/AKT/mTOR pathway; metabolic shift similar to the 'Warburg effect' correlates with
The_Cancer_Genome_Atlas
Process of cells digesting parts of themselves
and reactive oxygen species regulate the activity of the protein kinases mTOR and AMPK. These two kinases regulate autophagy through inhibitory phosphorylation
Autophagy
interplay of these molecules. mTOR is a serine/threonine protein kinase, which is found in 2 complexes in cells: mTOR complex 1 and 2 (mTORC1 and mTORC2)
Immunometabolism
Class of enzymes
DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR). They are protein serine/threonine kinases. The various 3-phosphorylated
Phosphoinositide_3-kinase
Uterine cancer that is located in tissues lining the uterus
inhibit the mTOR pathway may reduce the risk of disease worsening compared to having more chemotherapy or hormonal therapy. However, mTOR inhibitors may
Endometrial_cancer
Rejection of transplanted tissue by the recipient's immune system
anti-proliferative agent. Where calcineurin inhibitors or steroids are contraindicated, mTOR inhibitors are used. Immunosuppressive drugs: Corticosteroids Prednisolone
Transplant_rejection
Species of protozoa
inhibits the pathogen via disrupting its cell survival signal pathway PI3K/Akt/mTOR, has been used in a few cases with mixed results. Other treatments include
Naegleria_fowleri
Chemical compound
similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR). It is marketed by Novartis under the trade names Zortress (US) and Certican
Everolimus
Chemical compound
demonstrated synergistic effects when combined with CDK4/6 inhibitors or PI3K/mTOR pathway inhibitors in preclinical ER+ breast cancer models. The US Food and
Vepdegestrant
Early onset muscle loss due to ageing or immobility
synthesis. It is reported to have multiple targets, including stimulating mTOR and decreasing proteasome expression. Its use to prevent the loss of lean
Sarcopenia
Cytokine
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Transforming growth factor beta
Transforming_growth_factor_beta
Group of neurological disorders causing seizures
implications. Mutations in genes affecting ion channels, synaptic transmission, and mTOR signaling pathways have been linked to epilepsy syndromes, and molecular
Epilepsy
Medical drug glass
phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K/AKT/mTOR pathway. This signal pathway regulates cellular functions such as growth
Phosphoinositide 3-kinase inhibitor
Phosphoinositide_3-kinase_inhibitor
Class of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Acetate_kinase
Post-translational modification
endothelial cells, leading to lysine malonylation of mTOR at lysine 1218. This impairs the kinase activity of mTOR complex 1, which reduces endothelial proliferation
Lysine_malonylation
Biological ability to detect and respond to cell population density
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Quorum_sensing
Phenotype of senescent cells which secrete certain substances
for IL1A is highly dependent upon mTOR activity. mTOR activity increases levels of IL1A, mediated by MAPKAPK2. mTOR inhibition of ZFP36L1 prevents this
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Chemical substance that enables neurotransmission
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Neurotransmitter
Medical condition
only cause of RVH. Hypertrophy can also be caused by mechanical forces, mTOR pathways, nitric oxide and immune cells. Immune cells can cause hypertrophy
Right_ventricular_hypertrophy
Pharmaceutical compound
receptor antagonist, and temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor, which is under development for the treatment of major depressive
Ketamine/temsirolimus
Protein-coding gene in the species Homo sapiens
DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a protein that in humans is encoded by
DEPTOR
Monoamine neurotransmitter
protein serotonylation substrates include several metabolic enzymes (GAPDH, mTOR), Rab GTPases (Rab3a, Rab27a), Rho GTPases (RhoA, Rac1, Cdc42), proteins
Serotonin
Genetic disorder that causes early aging
it now has a more normal state.[citation needed] Studies of sirolimus, an mTOR Inhibitor, demonstrate that it can minimize the phenotypic effects of progeria
Progeria
Family of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Protein_kinase_A
Tumors of the nervous or endocrine system within the pancreas
mutations in mTOR pathway genes, such as TSC2, PTEN and PIK3CA. The sequencing discovery might allow selection of which NETs would benefit from mTOR inhibition
Pancreatic neuroendocrine tumor
Pancreatic_neuroendocrine_tumor
Protein-coding gene
regulator of mechanistic target of rapamycin (mTOR) suggesting that FLCN and FNIP1 may play a role in modulating mTOR activity through energy- or nutrient-sensing
Folliculin
Phytocannabinoid
TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma". British Journal of Cancer. 127 (8):
Cannabidiorcol
Chemical compound
MLN0128, INK128 and TAK-228) is an experimental small molecule inhibitor of mTOR which is administered orally. It targets both mTORC1 and mTORC2. Developed
Sapanisertib
Class of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Extracellular signal-regulated kinases
Extracellular_signal-regulated_kinases
Class of enzymes
SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1 Pyruvate dehydrogenase kinase
Pyruvate_dehydrogenase_kinase
Types of irreversible biochemical changes
well-studied among them the mTOR pathway. When energy and nutrients are scarce, the AMPK receptor senses this and switches off mTOR to conserve resources.
Hallmarks_of_aging
Rare autosomal dominant cancer syndrome
involvement with cellular metabolism, possibly through modulation of the mTOR (mammalian target of rapamycin) pathway and/or oxidative phosphorylation
Birt–Hogg–Dubé_syndrome
Longer than typical lifespan, especially of humans
influence longevity are Insulin/IGF-1, mechanistic target of rapamycin (mTOR), AMP-activating protein kinase (AMPK), and Sirtuin pathways. Emerging research
Longevity
System of signaling molecules within a cell
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Second_messenger_system
Italian biologist and writer with progeria (1995–2024)
Lattanzi, Giovanna (November 2016). "Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders". British
Sammy_Basso
Type of spinal cancer
association with tuberous sclerosis complex (TSC1 or TSC2) has been suggested. mTOR signaling is hyperactive in sporadic sacral chordomas: in one study 10 out
Chordoma
American truck parts manufacturer
Formerly ArvinMeritor (2000–2011) Company type Subsidiary Traded as NYSE: MTOR (delisted 2022) Industry Commercial vehicles systems and components Predecessor
Meritor
Type of blood cancer
neoplastic cells in DLBCL, NOS exhibit pathologically overactive NF-κB, PI3K/AKT/mTOR, JAK-STAT0, MAPK/ERK, B-cell receptor, toll-like receptor, and NF-κB signaling
Diffuse_large_B-cell_lymphoma
Medical condition
the RAS–mitogen-activated protein kinase (MAPK) pathway and the PI3K/AKT/mTOR pathway that regulates cellular growth, differentiation, proliferation and
Phakomatosis
Class of enzymes
RTK TGF beta MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones
Receptor_tyrosine_kinase
Resilient and smooth elastic tissue present in animals
Tariq M. (2018-09-05). "Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes"
Cartilage
Family of DNA viruses
activates PI3K which in turn activates PKB (Akt). PKB may then activate mTOR, which may target Stat3 for phosphorylation on the S727 residue. Another
Herpesviridae
ALK inhibitor for treatment of non-small-cell lung cancer
subsequently blocks cell signalling pathways, including STAT3 and the PI3K/AKT/mTOR pathway, and induces death (apoptosis) of tumour cells. When taken with a
Alectinib
Model of aging as a trade-off between growth, reproduction, and DNA maintenance
chaperones, and heat-shock proteins. Additionally, uptake of IGF-1 stimulates the mTOR pathway, which activates protein synthesis (and therefore growth) through
Disposable soma theory of aging
Disposable_soma_theory_of_aging
American biologist
Kaeberlein, he published seminal reports identifying the importance of the mTOR pathway in regulating longevity. In 2010, joined the Buck Institute for Research
Brian_K._Kennedy
Cell membrane organelle
sensing nutrient availability. When nutrients are plentiful, they activate mTOR signaling to support anabolic (biosynthetic) processes. During starvation
Lysosome
Award
Brian Druker American 2020 Michael N. Hall American “for their discovery of mTOR and its role in the control of cell metabolism and growth.” David M. Sabatini
Sjöberg_Prize
Protein-coding gene in the species Homo sapiens
Phosphorylated 4E-BP1 is thought to be a marker of upstream signaling (mTOR) activation. 4E-BP1 has seven phospho-sites, the three most important of
EIF4EBP1
Aspect of cell metabolism
Complex is composed of five LAMTOR subunits, which work to regulate MAPK and mTOR complex 1. The LAMTOR subunits form a complex with Rag GTPase and v-ATPase
Ragulator-Rag_complex
Protein-coding gene in the species Homo sapiens
Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, et al. (January 2014). "mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy"
NDRG1
MTOR
MTOR
MTOR
MTOR
Girl/Female
Indian, Tamil
Sweet Words
Girl/Female
Tamil
Sulakshana | ஸà¯à®²à®•à¯à®·à®£à®¾
Well brought up, Fortunate
Boy/Male
Indian, Telugu
Strength
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Crab
Girl/Female
German American French
Sweet or noble.
Girl/Female
Hindu, Indian
Covered with Gold
Boy/Male
Indian, Tamil
Very Handsome
Boy/Male
Arabic, Muslim
He who Renders the State Mighty
Girl/Female
Indian, Telugu
One of Name of Goddess Lalitha Devi
Girl/Female
Muslim/Islamic
Name of a poetess
MTOR
MTOR
MTOR
MTOR
MTOR