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Mammalian protein found in Homo sapiens
Transcription factor Jun, also known as c-Jun, is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms
Transcription_factor_Jun
Protein that regulates the rate of DNA transcription
molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information
Transcription_factor
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
proteins belonging to the c-Fos, c-Jun, ATF and JDP families. AP-1 was first discovered as a TPA-activated transcription factor that bound to a cis-regulatory
AP-1_transcription_factor
Protein-coding gene in the species Homo sapiens
Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in
JUNB
Class of DNA-binding proteins that regulate gene transcription
Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors. First
Activating transcription factor
Activating_transcription_factor
Proteins that bind DNA
WRKY transcription factors (pronounced ‘worky’) are proteins that bind DNA. They are transcription factors that regulate many processes in plants and
WRKY_transcription_factor
Protein-coding gene in the species Homo sapiens
Transcription factor JunD is a protein that in humans is encoded by the JUND gene. The protein encoded by this intronless gene is a member of the JUN
JunD
Class of protein transcription factors
General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific
General_transcription_factor
Protein needed for initiation of transcription in prokaryotes
sigma factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a bacterial transcription initiation
Sigma_factor
This list of manually-curated human transcription factors is taken from Lambert, Jolma, Campitelli, et al. More detailed information can be found in the
List of human transcription factors
List_of_human_transcription_factors
Protein-coding gene in the species Homo sapiens
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene. This gene encodes a transcription factor that
Activating transcription factor 2
Activating_transcription_factor_2
Nuclear protein
Transcription factor TFIIA is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. TFIIA is one of several general (basal)
Transcription_factor_II_A
Topics referred to by the same term
biblical manuscript Phosphorus-39, an isotope of phosphorus Pier 39 Transcription factor Jun, the Fos-binding protein p39 P39, a Latvian state regional road
P39
Transcription factor
finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains
Zinc finger transcription factor
Zinc_finger_transcription_factor
Transcription factor
The GATA transcription factor family consists of six DNA-binding proteins (GATA1-6) that regulate transcription of DNA due to their ability to bind to
GATA_transcription_factor
General transcription factors
Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase
Transcription_factor_II_D
Mammalian protein found in Homo sapiens
and heterodimers. When c-fos heterodimerizes with the transcription factor c-jun (from the Jun family), they form an AP-1 (Activator Protein-1) complex
Protein_c-Fos
Protein-coding gene in the species Homo sapiens
Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene
Transcription_factor_Sp1
Protein-coding gene in the species Homo sapiens
Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene. This gene encodes a member of the Sp subfamily of Sp/XKLF transcription
Sp2_transcription_factor
Family of proteins
A winged-helix transcription factor is a type of transcription factor that binds to DNA using a protein domain called a winged-helix domain. In some cases
Winged-helix transcription factors
Winged-helix_transcription_factors
Mammalian protein found in Homo sapiens
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC)
Transcription_factor_II_B
Mammalian protein found in humans
activate c-Jun N-terminal kinase (JNK); which phosphorylates c-Jun. The activated transcription factor c-Jun regulates nuclear transcription via AP-1 to
Nerve_growth_factor
Protein-coding gene in the species Homo sapiens
Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead) is a protein that in humans is encoded by
Sp8_transcription_factor
Protein family
transformation-specific) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, 27 in the
ETS transcription factor family
ETS_transcription_factor_family
Protein-coding gene in humans
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the
RUNX2
Protein that controls rate of transcription of GH genes
positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for
Pituitary-specific positive transcription factor 1
Pituitary-specific_positive_transcription_factor_1
Mammalian protein found in humans
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded
Microphthalmia-associated transcription factor
Microphthalmia-associated_transcription_factor
General transcription initiation factor
Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIF is encoded
Transcription_factor_II_F
Protein-coding gene in the species Homo sapiens
T-box transcription factor T, also known as Brachyury protein, is encoded for in humans and other apes by the TBXT gene. Brachyury functions as a transcription
T-box_transcription_factor_T
Protein-coding gene in the species Homo sapiens
Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located
TCF4
Protein-coding gene in the species Homo sapiens
Mivechi NF (June 2000). "c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity". The Journal
Heat_shock_factor_protein_1
Prokaryotic protein
A ρ factor (Rho factor) is a bacterial protein involved in the termination of transcription. Rho factor binds to the transcription terminator pause site
Rho_factor
DNA-binding structural motif
bZIPs to regulate transcriptional activities. Leucine zipper regulatory proteins include c-fos and c-jun (the AP1 transcription factor), important regulators
Leucine_zipper
Protein complex
identified in 1989 as general transcription factor-δ or basic transcription factor 2, an essential factor for transcription in vitro. It was subsequently
Transcription_factor_II_H
Protein domain
a transcription factor Jun-B transcription factor CREB cAMP response element transcription factor OPAQUE2 (O2) transcription factor of the 22-kD zein
BZIP_domain
Group of proteins
Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence. Their DNA-binding domain is a POU domain
Octamer_transcription_factor
Protein-coding gene in the species Homo sapiens
Transcription factor Sp3 is a protein that in humans is encoded by the SP3 gene. This gene belongs to a family of Sp1 related genes that encode transcription
Transcription_factor_Sp3
Protein-coding gene in the species Homo sapiens
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene. Sp4 transcription factor has been shown to interact with E2F1. GRCh38:
Sp4_transcription_factor
Human protein and coding gene
leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN and FOS, although
NFE2L2
Mammalian protein found in Homo sapiens
Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene. This
ATF4
Protein-coding gene in humans
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the
STAT3
Transcription factor
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer
Transcription_factor_II_E
Mammalian protein found in humans
(hNanog) is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. hNanog is encoded
Homeobox_protein_NANOG
Protein that responds to low oxygen
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. They
Hypoxia-inducible_factor
Protein-coding gene in the species Homo sapiens
Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene. MafK is one of the small Maf proteins
MAFK
Transcription factor and coding gene in humans
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the
STAT1
Transcription factor scaffold domain
trans-activating domain (TAD) is a transcription factor scaffold domain which contains binding sites for other proteins such as transcription coregulators. These binding
Transactivation_domain
Family of transcription factor protein complexes
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of
NF-κB
Protein-coding gene in the species Homo sapiens
Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene. Together with hSPT4, it composes DSIF in humans. SUPT5H
SUPT5H
Mammalian protein found in Homo sapiens
Serum response factor, also known as SRF, is a transcription factor protein. Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens,
Serum_response_factor
Protein that increases transcription of a gene or set of genes
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. Activators are considered to have
Activator_(genetics)
Transcription factor
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the
CTCF
Protein-coding gene in the species Homo sapiens
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene. This gene encodes an ETS-domain transcription factor that activates
SPI1
Protein-coding gene in the species Homo sapiens
transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start
TATA-binding_protein
Protein-coding gene in the species Homo sapiens
Myocyte-specific enhancer factor 2C also known as MADS box transcription enhancer factor 2, polypeptide C is a protein that in humans is encoded by the
MEF2C
Protein-coding gene in humans
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it
RUNX1
Protein-coding gene in the species Homo sapiens
the AP-1 family of transcription factors. JDP 2 was found by a Sos-recruitment system,[clarification needed] to dimerize with c-Jun to repress AP-1-mediated
Jun_dimerization_protein_2
Protein-coding gene in the species Homo sapiens
stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene. The upstream stimulatory factor (USF) gene encodes a transcription factor USF that
USF1
Protein-coding gene in humans
D, Butticè G (October 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in
ETS2
Protein-coding gene in humans
member of the ETS (erythroblast transformation-specific) family of transcription factors. Genes in the ETS family regulate embryonic development, cell proliferation
ERG_(gene)
Gene of the species Homo sapiens
transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds
ZNF148
Protein-coding gene in humans
central nervous system neurons. Activating transcription factor ATF3 has been shown to interact with: C-jun, DDIT3 JunD, P53, and SMAD3. GRCh38: Ensembl release
ATF3
Protein-coding gene in the species Homo sapiens
Transcription factor Sp7, also called Osterix (Osx), is a protein that in humans is encoded by the SP7 gene. It is a member of the Sp family of zinc-finger
Sp7_transcription_factor
Protein found in humans
McPherson L, Clayberger C, Krensky AM (Jun 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology. 178 (11):
KLF13
Protein-coding gene in the species Homo sapiens
Freemont PS (Jun 2003). "Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9"
FOXG1
American mathematician and statistician
Discovery of transcription factor binding sites using computational statistics (PhD thesis). Stanford University. OCLC 84915802. ProQuest 305549892. Jun S. Liu
Jun_S._Liu
Protein that initiates male sex determination in therian mammals
(SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that
Sex-determining region Y protein
Sex-determining_region_Y_protein
Protein-coding gene in humans
GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein
GATA1
Protein-coding gene in the species Homo sapiens
Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene. GTF2A1 has been shown to interact with TATA binding
GTF2A1
Family of zinc finger transcription factors
In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic Cys2His2 zinc finger DNA-binding proteins that
Kruppel-like_factors
Protein family
Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT
NFAT
Transcription factor protein
helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene. Basic helix-loop-helix (bHLH) transcription factors have been implicated
Twist-related_protein_1
Form of eukaryotic RNA polymerase II
POLR2F form homodimers). General transcription factors (GTFs) or basal transcription factors are protein transcription factors that have been shown to be important
RNA_polymerase_II_holoenzyme
Protein-coding gene in the species Homo sapiens
bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the Myc family of transcription factors. The protein
MYC
Protein-coding gene in the species Homo sapiens
GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression
GATA3
Protein-coding gene in the species Homo sapiens
Transcription factor EB is a protein that in humans is encoded by the TFEB gene. TFEB is a master gene for lysosomal biogenesis. It encodes a transcription
TFEB
Mammalian protein found in Homo sapiens
known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. Thyroid transcription factor-1 (TTF-1) is a
NK2_homeobox_1
Human protein and coding gene
also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. It is a member of the CCAAT/enhancer-binding
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Transcriptional repressor protein
1) is a transcriptional repressor protein in humans that is encoded by the YY1 gene. YY1 is a ubiquitously distributed transcription factor belonging
YY1
DNA pattern affecting anatomy development
eukaryotes. Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to
Homeobox
Protein family
regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain
Interferon_regulatory_factors
Protein
by the FOXO4 gene. FOXO4 is a member of the forkhead family of transcription factors in O subclass, which is characterized by a winged helix domain used
FOXO4
Protein-coding gene in the species Homo sapiens
1016/s0369-8114(02)00289-4. PMID 11980335. Garg A, Aggarwal BB (Jun 2002). "Nuclear transcription factor-kappaB as a target for cancer drug development". Leukemia
NFKB2
Protein-coding gene in the species Homo sapiens
activities. It is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Alternative splicing results
TCF20
Protein found in humans
COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by
COUP-TFI
Human protein
Browser A number of transcription factors with a matrix similarity greater than or equal to 0.5 that are predicted to regulate transcription of KIAA1143 are
KIAA1143
Family of intracellular transcription factors
the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular
STAT_protein
Protein involved in the pancreas and duodenum differentiation
and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary
PDX1
Protein-coding gene in the species Homo sapiens
1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10
Transcription initiation protein SPT3 homolog
Transcription_initiation_protein_SPT3_homolog
Mammalian protein found in humans
PAX8 gene. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain
PAX8
Transcription factor gene of the SOX family
Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene. SOX-9 recognizes the sequence CCTTGAG along with other members of the
SOX9
Protein-coding gene in the species Homo sapiens
TBX20 (gene) is a member of the T-box family that encodes the transcription factor TBX20. Studies in mouse, human and fruitfly have shown that this gene
TBX20
Protein-coding gene in the species Homo sapiens
Transcription factor Maf, also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog, is a transcription factor that
MAF_(gene)
Protein-coding gene in the species Homo sapiens
Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1
FLI1
Protein-coding gene in the species Homo sapiens
of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of
IRF1
Protein-coding gene in the species Homo sapiens
Factor in the germline alpha (FIGalpha), folliculogenesis-specific basic helix-loop-helix or transcription factor FIGa, is a protein that in humans is
Factor_in_the_germline_alpha
Protein-coding gene in the species Homo sapiens
the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor. KLF5 has been shown to interact with Protein
KLF5
Protein-coding gene in humans
gene. This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily
ELK4
Protein
(January 1999). "Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription". Cell. 96 (1): 143–52. doi:10.1016/s0092-8674(00)80967-8
MEN1
Protein-coding gene in the species Homo sapiens
Interferon regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon
IRF7
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TRANSCRIPTION FACTOR-JUN
TRANSCRIPTION FACTOR-JUN
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TRANSCRIPTION FACTOR-JUN
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TRANSCRIPTION FACTOR-JUN
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