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Experimental anti-insomnia drug
Seltorexant, also known by its developmental code names MIN-202 and JNJ-42847922, is an orexin antagonist medication which is under development for the
Seltorexant
Class of drugs
previously for anxiety disorders, up to phase 2 – half-life 3–7 hours Seltorexant (MIN-202, JNJ-42847922, JNJ-922) – selective OX2 antagonist – under development
Orexin_antagonist
Sleep medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Zolpidem
Drug whose use induces sleep
and daridorexant and selective orexin OX2 receptor antagonists like seltorexant have been shown in clinical studies to improve sleep onset, sleep duration
Hypnotic
Orexin receptor antagonist
receptor antagonist List of investigational insomnia drugs Vornorexant and seltorexant (other short-acting orexin antagonists) "YZJ 1139". AdisInsight. 14 September
Fazamorexant
Sedating antidepressant
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Doxepin
Investigational insomnia drugs
and 5-HT1D receptor agonist, and serotonin 5-HT2B receptor antagonist Seltorexant (JNJ-42847922; JNJ-7922; MIN-202) – orexin OX2 receptor antagonist Sunobinop
List of investigational insomnia drugs
List_of_investigational_insomnia_drugs
Class of CNS depressant drugs
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Benzodiazepine
Class of depressant drugs derived from barbituric acid
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Barbiturate
Orexin receptor antagonists (e.g., suvorexant, lemborexant, daridorexant, seltorexant) Psychedelics (serotonin 5-HT2A receptor agonists) (e.g., LSD, psilocybin
List_of_psychoactive_drugs
Chemical compound
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Dimdazenil
Disorder causing trouble with sleeping
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Insomnia
Medication used to treat insomnia
cleared in the earlier phases of elimination. The investigational agents seltorexant and vornorexant, which are still in clinical trials, have comparatively
Suvorexant
G-protein-coupled receptor
OX1 receptor antagonist SB-408124 – selective OX1 receptor antagonist Seltorexant (MIN-202, JNJ-42847922, JNJ-922) – selective OX2 receptor antagonist
Orexin_receptor
Medication
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Oveporexton
Tricyclic antidepressant
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Amitriptyline
Antidepressant medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Mirtazapine
Class of psychoactive drugs
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Nonbenzodiazepine
Insomnia medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Lemborexant
Orexin antagonist compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Almorexant
Muscle relaxant medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Tizanidine
Hypnotic medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Ramelteon
Muscle relaxant medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Baclofen
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
SB-408124
Species of flowering plant
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Valerian_(herb)
CNS depressant medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Phenibut
Medication used to treat insomnia
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Daridorexant
Medication used to treat insomnia
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Zaleplon
Hypnotic medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Eszopiclone
Index of chemical compounds with the same molecular formula
molecular formula C21H22FN7O (molar mass: 407.453 g/mol) may refer to: Seltorexant Eratrectinib This set index page lists chemical structure articles associated
C21H22FN7O
First-generation antihistamine used as a short-term sedative and hypnotic (sleep aid)
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Doxylamine
Stimulating neuropeptide
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Orexin-A
Chemical compound
Japan. Orexin receptor antagonist List of investigational insomnia drugs Seltorexant and fazamorexant (other short-acting orexin antagonists) Uchiyama M,
Vornorexant
Hypnotic medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Zopiclone
Investigational sleep apnea drugs
sleep apnoea therapeutics - Apnimed – undefined mechanism of action [28] Seltorexant (JNJ-42847922; JNJ-7922; MIN-202) – orexin OX2 receptor antagonist [29]
List of investigational sleep apnea drugs
List_of_investigational_sleep_apnea_drugs
Atypical antidepressant classified primarily as a melatonin receptor agonist
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Agomelatine
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Danavorexton
Neuropeptide that regulates arousal, wakefulness, and appetite
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Orexin
Pharmaceutical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Cleminorexton
Pharmaceutical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Rocavorexant
Protein-coding gene in the species Homo sapiens
- Selective OX2 antagonist SB-649,868 - Dual OX1 and OX2 antagonist Seltorexant - Selective OX2 antagonist Suvorexant - Dual OX1 and OX2 antagonist TCS-OX2-29
Orexin_receptor_type_2
List of pharmaceutical drugs under clinical development for treatment of depression
non-selective serotonin receptor agonist and psychedelic hallucinogen Seltorexant (JNJ-42847922; JNJ-7922; MIN-202) – orexin OX2 receptor antagonist SEP-4199
List of investigational antidepressants
List_of_investigational_antidepressants
Chemical compound
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Gaboxadol
Supplement and medication used to treat sleep disorders
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Melatonin as a medication and supplement
Melatonin_as_a_medication_and_supplement
Pharmaceutical compound
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Pellotine
Pharmaceutical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Balumorexton
Novel chemistry compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Alixorexton
Thienotriazolodiazepine drug
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Brotizolam
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Nivasorexant
Pharmaceutical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Ledasorexton
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
SB-649868
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Tebideutorexant
Antidepressant
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Trimipramine
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Suntinorexton
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Filorexant
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Firazorexton
Deliberate efforts to bring on sleep
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Sleep_induction
Pharmaceutical compound
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Tetrahydrocannabinol/cannabinol/cannabidiol
Tetrahydrocannabinol/cannabinol/cannabidiol
Almorexant EMPA Filorexant JNJ-10397049 Lemborexant MK-1064 SB-649868 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 See here instead. Agonists: Growth hormone
List of signaling peptide/protein receptor modulators
List_of_signaling_peptide/protein_receptor_modulators
Benzodiazepine
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Quazepam
Wakefulness medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Tasimelteon
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
EMPA_(drug)
Orexin antagonist
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
TCS-OX2-29
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
ACT-335827
Orexin antagonist
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
RTIOX-276
Anticonvulsant medication
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Tiagabine
Protein found in humans
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
Hypocretin (orexin) receptor 1
Hypocretin_(orexin)_receptor_1
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
JNJ-10397049
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
SB-334867
Chemical compound
Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists Melatonin Ramelteon
Etodroxizine
Chemical compound
Filorexant GSK-649868 (SB-649868) JNJ-10397049 Lemborexant MK-1064 MK-3697 MK-8133 Seltorexant Suvorexant TCS-1102 TCS-OX2-29 Vornorexant (ORN-0829, TS-142)
ACT-462206
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SELTOREXANT
SELTOREXANT
SELTOREXANT
SELTOREXANT
SELTOREXANT
SELTOREXANT
SELTOREXANT
SELTOREXANT
SELTOREXANT
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