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FIRAZOREXTON

  • Firazorexton

    • Chemical compound

    Firazorexton (INNTooltip International Nonproprietary Name; development code TAK-994) is an experimental orexin 2 (OX2) receptor agonist first described

    Firazorexton

    Firazorexton

    Firazorexton

  • Methamphetamine

    • Central nervous system stimulant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Methamphetamine

    Methamphetamine

    Methamphetamine

  • Danavorexton

    • Chemical compound

    and sleep apnea. It is related to another orexin receptor agonist, firazorexton (TAK-994), the development of which was discontinued for safety reasons

    Danavorexton

    Danavorexton

    Danavorexton

  • Cleminorexton

    • Pharmaceutical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Cleminorexton

    Cleminorexton

    Cleminorexton

  • Methylphenidate

    • Central nervous system stimulant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Methylphenidate

    Methylphenidate

    Methylphenidate

  • Lisdexamfetamine

    • Central nervous system stimulant prodrug

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Lisdexamfetamine

    Lisdexamfetamine

    Lisdexamfetamine

  • Caffeine

    • Central nervous system stimulant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Caffeine

    Caffeine

    Caffeine

  • Adderall

    • Drug mixture used mainly to treat ADHD and narcolepsy

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Adderall

    Adderall

    Adderall

  • Oveporexton

    • Medication

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Oveporexton

    Oveporexton

    Oveporexton

  • Ledasorexton

    • Pharmaceutical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Ledasorexton

    Ledasorexton

    Ledasorexton

  • Dextroamphetamine

    • CNS stimulant and isomer of amphetamine

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Dextroamphetamine

    Dextroamphetamine

    Dextroamphetamine

  • Orexin receptor

    • G-protein-coupled receptor

    receptor agonist Danavorexton (TAK-925) – selective OX2 receptor agonist Firazorexton (TAK-994) – selective OX2 receptor agonist Ledasorexton (E-2086) – selective

    Orexin receptor

    Orexin_receptor

  • Viloxazine

    • Medication used to treat ADHD and depression

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Viloxazine

    Viloxazine

    Viloxazine

  • Stimulant

    • Drug that increases alertness

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Stimulant

    Stimulant

    Stimulant

  • Bupropion

    • Medication mainly used for depression and smoking cessation

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Bupropion

    Bupropion

    Bupropion

  • Lemborexant

    • Insomnia medication

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Lemborexant

    Lemborexant

    Lemborexant

  • Xywav

    • Combination drug

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Xywav

    Xywav

  • List of investigational narcolepsy and hypersomnia drugs

    • Investigational narcolepsy and hypersomnia drugs

    orexin OX2 receptor agonist – narcolepsy, idiopathic hypersomnia [8] Firazorexton (TAK-994) – orexin OX2 receptor agonist – narcolepsy [9] Flecainide/modafinil

    List of investigational narcolepsy and hypersomnia drugs

    List_of_investigational_narcolepsy_and_hypersomnia_drugs

  • Armodafinil

    • Wakefulness-promoting medication

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Armodafinil

    Armodafinil

    Armodafinil

  • Paraxanthine

    • Chemical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Paraxanthine

    Paraxanthine

    Paraxanthine

  • Modafinil

    • Wakefulness-promoting medication

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Modafinil

    Modafinil

    Modafinil

  • Norepinephrine reuptake inhibitor

    • Medications that increase norepinephrine

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Norepinephrine reuptake inhibitor

    Norepinephrine reuptake inhibitor

    Norepinephrine_reuptake_inhibitor

  • Orexin antagonist

    • Class of drugs

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Orexin antagonist

    Orexin_antagonist

  • Wakefulness-promoting agent

    • Drug that increases wakefulness

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Wakefulness-promoting agent

    Wakefulness-promoting agent

    Wakefulness-promoting_agent

  • Atomoxetine

    • Medication used to treat ADHD

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Atomoxetine

    Atomoxetine

    Atomoxetine

  • Balumorexton

    • Pharmaceutical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Balumorexton

    Balumorexton

    Balumorexton

  • Amphetamine

    • Central nervous system stimulant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Amphetamine

    Amphetamine

    Amphetamine

  • Solriamfetol

    • Medication used for the treatment of excessive sleepiness

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Solriamfetol

    Solriamfetol

    Solriamfetol

  • Norepinephrine–dopamine reuptake inhibitor

    • Drug that inhibits the reuptake of norepinephrine and dopamine

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Norepinephrine–dopamine reuptake inhibitor

    Norepinephrine–dopamine reuptake inhibitor

    Norepinephrine–dopamine_reuptake_inhibitor

  • Sodium oxybate

    • Medication to treat symptoms of narcolepsy

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Sodium oxybate

    Sodium oxybate

    Sodium_oxybate

  • RTIOX-276

    • Orexin antagonist

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    RTIOX-276

    RTIOX-276

    RTIOX-276

  • Pitolisant

    • Medication to treat narcolepsy

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Pitolisant

    Pitolisant

    Pitolisant

  • List of modafinil analogues and derivatives

    • receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    List of modafinil analogues and derivatives

    List of modafinil analogues and derivatives

    List_of_modafinil_analogues_and_derivatives

  • Daridorexant

    • Medication used to treat insomnia

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Daridorexant

    Daridorexant

    Daridorexant

  • Seltorexant

    • Experimental anti-insomnia drug

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Seltorexant

    Seltorexant

    Seltorexant

  • Γ-Hydroxybutyric acid

    • Chemical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Γ-Hydroxybutyric acid

    Γ-Hydroxybutyric acid

    Γ-Hydroxybutyric_acid

  • Alixorexton

    • Novel chemistry compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Alixorexton

    Alixorexton

    Alixorexton

  • Ephedrine

    • Medication, stimulant and decongestant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Ephedrine

    Ephedrine

    Ephedrine

  • Pentylenetetrazol

    • Chemical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Pentylenetetrazol

    Pentylenetetrazol

    Pentylenetetrazol

  • Almorexant

    • Orexin antagonist compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Almorexant

    Almorexant

    Almorexant

  • Suvorexant

    • Medication used to treat insomnia

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Suvorexant

    Suvorexant

    Suvorexant

  • Orexin

    • Neuropeptide that regulates arousal, wakefulness, and appetite

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Orexin

    Orexin

    Orexin

  • Levoamphetamine

    • CNS stimulant and isomer of amphetamine

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Levoamphetamine

    Levoamphetamine

    Levoamphetamine

  • Eugeroic

    • Drug for wakefulness and alertness

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Eugeroic

    Eugeroic

    Eugeroic

  • Reboxetine

    • NRI antidepressant drug

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Reboxetine

    Reboxetine

    Reboxetine

  • Dopamine reuptake inhibitor

    • Class of drug

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Dopamine reuptake inhibitor

    Dopamine_reuptake_inhibitor

  • Fazamorexant

    • Orexin receptor antagonist

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Fazamorexant

    Fazamorexant

    Fazamorexant

  • Orexin-A

    • Stimulating neuropeptide

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Orexin-A

    Orexin-A

  • Pseudoephedrine

    • Synthetic decongestant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Pseudoephedrine

    Pseudoephedrine

    Pseudoephedrine

  • Orexin receptor type 2

    • Protein-coding gene in the species Homo sapiens

    the cavefish. Danavorexton/TAK-925 – selective OX2 receptor agonist Firazorexton/TAK-994 – selective OX2 receptor agonist Orexins – dual OX1 and OX2 receptor

    Orexin receptor type 2

    Orexin receptor type 2

    Orexin_receptor_type_2

  • Tebideutorexant

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Tebideutorexant

    Tebideutorexant

    Tebideutorexant

  • Suntinorexton

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Suntinorexton

    Suntinorexton

    Suntinorexton

  • Nivasorexant

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Nivasorexant

    Nivasorexant

    Nivasorexant

  • Vornorexant

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Vornorexant

    Vornorexant

    Vornorexant

  • Esmodafinil

    • Unmarketed enantiomer of modafinil

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Esmodafinil

    Esmodafinil

    Esmodafinil

  • Nomifensine

    • Withdrawn antidepressant medication

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Nomifensine

    Nomifensine

    Nomifensine

  • Filorexant

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Filorexant

    Filorexant

    Filorexant

  • Samelisant

    • Experimental drug to treat narcolepsy

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Samelisant

    Samelisant

  • SB-649868

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    SB-649868

    SB-649868

    SB-649868

  • H3 receptor antagonist

    • Antihistaminic drug

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    H3 receptor antagonist

    H3_receptor_antagonist

  • SB-408124

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    SB-408124

    SB-408124

    SB-408124

  • Mazindol

    • Appetite suppressant

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Mazindol

    Mazindol

    Mazindol

  • EMPA (drug)

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    EMPA (drug)

    EMPA (drug)

    EMPA_(drug)

  • Istradefylline

    • Chemical compound

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Istradefylline

    Istradefylline

    Istradefylline

  • TCS-OX2-29

    • Orexin antagonist

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    TCS-OX2-29

    TCS-OX2-29

    TCS-OX2-29

  • Rocavorexant

    • Pharmaceutical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Rocavorexant

    Rocavorexant

    Rocavorexant

  • Serdexmethylphenidate

    • CNS stimulant prodrug

    receptor agonists Alixorexton§ Balumorexton§ Cleminorexton§ Danavorexton§ Firazorexton§ Ledasorexton§ Oveporexton Histamine H3 receptor antagonists Pitolisant

    Serdexmethylphenidate

    Serdexmethylphenidate

    Serdexmethylphenidate

  • SB-334867

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    SB-334867

    SB-334867

    SB-334867

  • ACT-335827

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    ACT-335827

    ACT-335827

    ACT-335827

  • Hypocretin (orexin) receptor 1

    • Protein found in humans

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    Hypocretin (orexin) receptor 1

    Hypocretin (orexin) receptor 1

    Hypocretin_(orexin)_receptor_1

  • JNJ-10397049

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    JNJ-10397049

    JNJ-10397049

    JNJ-10397049

  • ACT-462206

    • Chemical compound

    Balumorexton (TAK-360) Cleminorexton (ORX750) Danavorexton (TAK-925) Firazorexton (TAK-994) Ledasorexton (E-2086) Orexin (A, B) Oveporexton (TAK-861) SB-668875

    ACT-462206

    ACT-462206

    ACT-462206

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