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TEBIDEUTOREXANT

  • Tebideutorexant

    • Chemical compound

    Tebideutorexant (developmental code names JNJ-61393215, JNJ-3215) is an orexin antagonist medication which is under development for the treatment of depression

    Tebideutorexant

    Tebideutorexant

    Tebideutorexant

  • Orexin antagonist

    • Class of drugs

    disorder, insomnia, and sleep apnea, up to phase 3 – half-life 2–3 hours Tebideutorexant (JNJ-61393215, JNJ-3215) – selective OX1 antagonist – under development

    Orexin antagonist

    Orexin_antagonist

  • Oveporexton

    • Medication

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Oveporexton

    Oveporexton

    Oveporexton

  • Rocavorexant

    • Pharmaceutical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Rocavorexant

    Rocavorexant

    Rocavorexant

  • Orexin receptor

    • G-protein-coupled receptor

    receptor antagonist TCS-OX2-29 – selective OX2 receptor antagonist Tebideutorexant (JNJ-61393215; JNJ-3215) – selective OX1 receptor antagonist List of

    Orexin receptor

    Orexin_receptor

  • List of investigational panic disorder drugs

    • Investigational panic disorder drugs

    metabotropic glutamate mGlu2 receptor positive allosteric modulator [5] Tebideutorexant (JNJ-61393215; JNJ-3215) – orexin OX1 receptor antagonist [6] Alprazolam

    List of investigational panic disorder drugs

    List_of_investigational_panic_disorder_drugs

  • Lemborexant

    • Insomnia medication

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Lemborexant

    Lemborexant

    Lemborexant

  • Ledasorexton

    • Pharmaceutical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Ledasorexton

    Ledasorexton

    Ledasorexton

  • Daridorexant

    • Medication used to treat insomnia

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Daridorexant

    Daridorexant

    Daridorexant

  • SB-649868

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    SB-649868

    SB-649868

    SB-649868

  • Suvorexant

    • Medication used to treat insomnia

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Suvorexant

    Suvorexant

    Suvorexant

  • Orexin

    • Neuropeptide that regulates arousal, wakefulness, and appetite

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Orexin

    Orexin

    Orexin

  • Almorexant

    • Orexin antagonist compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Almorexant

    Almorexant

    Almorexant

  • Seltorexant

    • Experimental anti-insomnia drug

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Seltorexant

    Seltorexant

    Seltorexant

  • Firazorexton

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Firazorexton

    Firazorexton

    Firazorexton

  • Danavorexton

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Danavorexton

    Danavorexton

    Danavorexton

  • Nivasorexant

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Nivasorexant

    Nivasorexant

    Nivasorexant

  • Cleminorexton

    • Pharmaceutical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Cleminorexton

    Cleminorexton

    Cleminorexton

  • Alixorexton

    • Novel chemistry compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Alixorexton

    Alixorexton

    Alixorexton

  • Balumorexton

    • Pharmaceutical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Balumorexton

    Balumorexton

    Balumorexton

  • Orexin-A

    • Stimulating neuropeptide

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Orexin-A

    Orexin-A

  • List of investigational anxiety disorder drugs

    • Investigational anxiety disorder drugs

    receptor antagonist [55] SYT-510 – anandamide reuptake inhibitor [56] Tebideutorexant (JNJ-3215; JNJ-61393215; Orexin-1) – orexin OX1 receptor antagonist

    List of investigational anxiety disorder drugs

    List_of_investigational_anxiety_disorder_drugs

  • Fazamorexant

    • Orexin receptor antagonist

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Fazamorexant

    Fazamorexant

    Fazamorexant

  • JNJ-10397049

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    JNJ-10397049

    JNJ-10397049

    JNJ-10397049

  • Filorexant

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Filorexant

    Filorexant

    Filorexant

  • ACT-462206

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    ACT-462206

    ACT-462206

    ACT-462206

  • Suntinorexton

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Suntinorexton

    Suntinorexton

    Suntinorexton

  • List of investigational antidepressants

    • List of pharmaceutical drugs under clinical development for treatment of depression

    Ropanicant (SUVN-911) – α4β2 nicotinic acetylcholine receptor antagonist Tebideutorexant (JNJ-61393215; JNJ-3215) – orexin OX1 receptor antagonist Tildacerfont

    List of investigational antidepressants

    List_of_investigational_antidepressants

  • Vornorexant

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Vornorexant

    Vornorexant

    Vornorexant

  • EMPA (drug)

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    EMPA (drug)

    EMPA (drug)

    EMPA_(drug)

  • SB-408124

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    SB-408124

    SB-408124

    SB-408124

  • Orexin receptor type 2

    • Protein-coding gene in the species Homo sapiens

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Orexin receptor type 2

    Orexin receptor type 2

    Orexin_receptor_type_2

  • TCS-OX2-29

    • Orexin antagonist

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    TCS-OX2-29

    TCS-OX2-29

    TCS-OX2-29

  • Hypocretin (orexin) receptor 1

    • Protein found in humans

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    Hypocretin (orexin) receptor 1

    Hypocretin (orexin) receptor 1

    Hypocretin_(orexin)_receptor_1

  • SB-334867

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    SB-334867

    SB-334867

    SB-334867

  • RTIOX-276

    • Orexin antagonist

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    RTIOX-276

    RTIOX-276

    RTIOX-276

  • ACT-335827

    • Chemical compound

    (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102 Tebideutorexant (JNJ-61393215) Vornorexant (ORN-0829, TS-142) OX2 Agonists: AEX-19

    ACT-335827

    ACT-335827

    ACT-335827

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