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FAZAMOREXANT

  • Fazamorexant

    • Orexin receptor antagonist

    Fazamorexant (INNTooltip International Nonproprietary Name), sold under the brand name Mengping, is an orexin receptor antagonist which is used in the

    Fazamorexant

    Fazamorexant

    Fazamorexant

  • Orexin antagonist

    • Class of drugs

    2022, formerly under development for sleep apnea – half-life 8 hours Fazamorexant (Mengping) – dual OX1 and OX2 antagonist – approved for insomnia in China

    Orexin antagonist

    Orexin_antagonist

  • Seltorexant

    • Experimental anti-insomnia drug

    antidepressants List of investigational insomnia drugs Vornorexant and fazamorexant (other short-acting orexin antagonists) Sun Y, Tisdale RK, Kilduff TS

    Seltorexant

    Seltorexant

    Seltorexant

  • Zolpidem

    • Sleep medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Zolpidem

    Zolpidem

    Zolpidem

  • Doxepin

    • Sedating antidepressant

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Doxepin

    Doxepin

    Doxepin

  • Balumorexton

    • Pharmaceutical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Balumorexton

    Balumorexton

    Balumorexton

  • Mirtazapine

    • Antidepressant medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Mirtazapine

    Mirtazapine

    Mirtazapine

  • Amitriptyline

    • Tricyclic antidepressant

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Amitriptyline

    Amitriptyline

    Amitriptyline

  • Benzodiazepine

    • Class of CNS depressant drugs

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Benzodiazepine

    Benzodiazepine

    Benzodiazepine

  • Oveporexton

    • Medication

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Oveporexton

    Oveporexton

    Oveporexton

  • Insomnia

    • Disorder causing trouble with sleeping

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Insomnia

    Insomnia

    Insomnia

  • Barbiturate

    • Class of depressant drugs derived from barbituric acid

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Barbiturate

    Barbiturate

    Barbiturate

  • Orexin-A

    • Stimulating neuropeptide

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Orexin-A

    Orexin-A

  • Lemborexant

    • Insomnia medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Lemborexant

    Lemborexant

    Lemborexant

  • Valerian (herb)

    • Species of flowering plant

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Valerian (herb)

    Valerian (herb)

    Valerian_(herb)

  • Tizanidine

    • Muscle relaxant medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Tizanidine

    Tizanidine

    Tizanidine

  • Daridorexant

    • Medication used to treat insomnia

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Daridorexant

    Daridorexant

    Daridorexant

  • Hypnotic

    • Drug whose use induces sleep

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Hypnotic

    Hypnotic

    Hypnotic

  • Nonbenzodiazepine

    • Class of psychoactive drugs

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Nonbenzodiazepine

    Nonbenzodiazepine

    Nonbenzodiazepine

  • List of investigational insomnia drugs

    • Investigational insomnia drugs

    (Quviviq; ACT-541468; nemorexant) – orexin OX1 and OX2 receptor antagonist Fazamorexant (Mengping; HY-901139; YZJ-1139) – orexin OX1 and OX2 receptor antagonist

    List of investigational insomnia drugs

    List_of_investigational_insomnia_drugs

  • Baclofen

    • Muscle relaxant medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Baclofen

    Baclofen

    Baclofen

  • Doxylamine

    • First-generation antihistamine used as a short-term sedative and hypnotic (sleep aid)

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Doxylamine

    Doxylamine

    Doxylamine

  • Phenibut

    • CNS depressant medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Phenibut

    Phenibut

    Phenibut

  • Orexin

    • Neuropeptide that regulates arousal, wakefulness, and appetite

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Orexin

    Orexin

    Orexin

  • Ramelteon

    • Hypnotic medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Ramelteon

    Ramelteon

    Ramelteon

  • EMPA (drug)

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    EMPA (drug)

    EMPA (drug)

    EMPA_(drug)

  • Vornorexant

    • Chemical compound

    receptor antagonist List of investigational insomnia drugs Seltorexant and fazamorexant (other short-acting orexin antagonists) Uchiyama M, Kambe D, Imadera

    Vornorexant

    Vornorexant

    Vornorexant

  • Zaleplon

    • Medication used to treat insomnia

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Zaleplon

    Zaleplon

    Zaleplon

  • Firazorexton

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Firazorexton

    Firazorexton

    Firazorexton

  • Danavorexton

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Danavorexton

    Danavorexton

    Danavorexton

  • Orexin receptor

    • G-protein-coupled receptor

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Orexin receptor

    Orexin_receptor

  • Zopiclone

    • Hypnotic medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Zopiclone

    Zopiclone

    Zopiclone

  • Eszopiclone

    • Hypnotic medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Eszopiclone

    Eszopiclone

    Eszopiclone

  • Agomelatine

    • Atypical antidepressant classified primarily as a melatonin receptor agonist

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Agomelatine

    Agomelatine

    Agomelatine

  • Tebideutorexant

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Tebideutorexant

    Tebideutorexant

    Tebideutorexant

  • Cleminorexton

    • Pharmaceutical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Cleminorexton

    Cleminorexton

    Cleminorexton

  • Suvorexant

    • Medication used to treat insomnia

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Suvorexant

    Suvorexant

    Suvorexant

  • Ledasorexton

    • Pharmaceutical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Ledasorexton

    Ledasorexton

    Ledasorexton

  • Alixorexton

    • Novel chemistry compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Alixorexton

    Alixorexton

    Alixorexton

  • Tiagabine

    • Anticonvulsant medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Tiagabine

    Tiagabine

    Tiagabine

  • Suntinorexton

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Suntinorexton

    Suntinorexton

    Suntinorexton

  • Gaboxadol

    • Chemical compound

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Gaboxadol

    Gaboxadol

    Gaboxadol

  • Melatonin as a medication and supplement

    • Supplement and medication used to treat sleep disorders

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Melatonin as a medication and supplement

    Melatonin as a medication and supplement

    Melatonin_as_a_medication_and_supplement

  • SB-408124

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    SB-408124

    SB-408124

    SB-408124

  • Almorexant

    • Orexin antagonist compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Almorexant

    Almorexant

    Almorexant

  • Dimdazenil

    • Chemical compound

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Dimdazenil

    Dimdazenil

    Dimdazenil

  • Filorexant

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Filorexant

    Filorexant

    Filorexant

  • Nivasorexant

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Nivasorexant

    Nivasorexant

    Nivasorexant

  • Pellotine

    • Pharmaceutical compound

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Pellotine

    Pellotine

    Pellotine

  • Quazepam

    • Benzodiazepine

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Quazepam

    Quazepam

    Quazepam

  • SB-649868

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    SB-649868

    SB-649868

    SB-649868

  • Brotizolam

    • Thienotriazolodiazepine drug

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Brotizolam

    Brotizolam

    Brotizolam

  • SB-334867

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    SB-334867

    SB-334867

    SB-334867

  • Sleep induction

    • Deliberate efforts to bring on sleep

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Sleep induction

    Sleep_induction

  • Trimipramine

    • Antidepressant

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Trimipramine

    Trimipramine

    Trimipramine

  • TCS-OX2-29

    • Orexin antagonist

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    TCS-OX2-29

    TCS-OX2-29

    TCS-OX2-29

  • Tetrahydrocannabinol/cannabinol/cannabidiol

    • Pharmaceutical compound

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Tetrahydrocannabinol/cannabinol/cannabidiol

    Tetrahydrocannabinol/cannabinol/cannabidiol

    Tetrahydrocannabinol/cannabinol/cannabidiol

  • Tasimelteon

    • Wakefulness medication

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Tasimelteon

    Tasimelteon

    Tasimelteon

  • Orexin receptor type 2

    • Protein-coding gene in the species Homo sapiens

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Orexin receptor type 2

    Orexin receptor type 2

    Orexin_receptor_type_2

  • Hypocretin (orexin) receptor 1

    • Protein found in humans

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Hypocretin (orexin) receptor 1

    Hypocretin (orexin) receptor 1

    Hypocretin_(orexin)_receptor_1

  • Rocavorexant

    • Pharmaceutical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    Rocavorexant

    Rocavorexant

    Rocavorexant

  • RTIOX-276

    • Orexin antagonist

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    RTIOX-276

    RTIOX-276

    RTIOX-276

  • ACT-335827

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    ACT-335827

    ACT-335827

    ACT-335827

  • Etodroxizine

    • Chemical compound

    mirtazapine) Triprolidine Orexin receptor antagonists Daridorexant Fazamorexant Lemborexant Seltorexant† Suvorexant Vornorexant Melatonin receptor agonists

    Etodroxizine

    Etodroxizine

    Etodroxizine

  • JNJ-10397049

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    JNJ-10397049

    JNJ-10397049

    JNJ-10397049

  • ACT-462206

    • Chemical compound

    ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant

    ACT-462206

    ACT-462206

    ACT-462206

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