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Family of cell adhesion molecules
The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs). All selectins are single-chain transmembrane glycoproteins
Selectin
Type-1 transmembrane protein
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the
P-selectin
Mammalian protein found in Homo sapiens
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell
E-selectin
Protein-coding gene in the species Homo sapiens
Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. SELPLG codes for PSGL-1, the high affinity counter-receptor
P-selectin glycoprotein ligand-1
P-selectin_glycoprotein_ligand-1
Mammalian protein found in Homo sapiens
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in humans by
L-selectin
This is a list of astronauts by year of selection: people selected to train for a human spaceflight program to command, pilot, or serve as a crew member
List of astronauts by year of selection
List_of_astronauts_by_year_of_selection
Movement of white blood cells out of blood vessels and towards the inflamed site
presenting pre-formed P-selectins on the endothelial cell surface. P-selectins bind PSGL-1 as a ligand. E-selectins: E-selectin is expressed on activated
Leukocyte_extravasation
Multiprotein complex that forms a point of contact or adhesion in animal cells
selectin is limited to leukocyte collaborations with vascular endothelium. There are three types of selectins found in humans; L-selectin, P-selectin
Cell_junction
adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs
Soluble cell adhesion molecules
Soluble_cell_adhesion_molecules
Cell-surface glycoprotein
sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below) Transcripts
CD44
Chemical compound
that are present on the cell surface. The sialyl-LewisX determinant, E-selectin ligand carbohydrate structure, is constitutively expressed on granulocytes
Sialyl-Lewis_X
Subset of cell adhesion proteins
are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein
Cell_adhesion_molecule
Biochemistry concept
sialo fucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination
Carcinoembryonic_antigen
for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. GLYCAM1 binds to L-selectin by presenting one
GLYCAM1
Physical effects resulting from activation of the immune system
Inflammatory cytokines induce the immediate expression of P-selectin on endothelial cell surfaces and P-selectin binds weakly to carbohydrate ligands on the surface
Inflammation
Monoclonal antibody
Adakveo among others, is a monoclonal antibody medication that binds to P-selectin. It is a medication used to reduce the frequency of vaso-occlusive crisis
Crizanlizumab
Type of chemical bond
has indeed been observed for interactions of P-selectin with PSGL-1 or anti-P-selectin antibody, L-selectin with PSGL-1, myosin with actin, integrin alpha
Catch_bond
Storage granules of endothelial cells
store and release two principal molecules, von Willebrand factor and P-selectin, and thus play a dual role in hemostasis and inflammation. Weibel–Palade
Weibel–Palade_body
Venules in some lymphatic organs
addressins, which are specific adhesion molecules that attach to the L-selectins on lymphocytes and anchor them to the HEV wall in preparation for crossing
High_endothelial_venules
process by interacting with L-selectin, which is present on the surface of lymphocytes. The adhesion molecule L-selectin binds to sulfated carbohydrate
Peripheral_node_addressin
Class of compounds
function. Sulfatide also acts as an L-selectin and P-selectin ligand, but it does not act as an E- selectin ligand. Selectins are adhesion molecules that facilitate
Sulfatide
First stage of pregnancy
carbohydrate moieties on its extracellular domain that are ligands of L-selectin, a cell adhesion molecule on the surface of trophoblast cells. An in vitro
Implantation_(embryology)
Medical condition
four classes of selectin blocking agents: (i) carbohydrate-based inhibitors targeting all P-, E-, and L-selectins, (ii) antihuman selectin antibodies, (iii)
Allergic_conjunctivitis
the selectin family, mucin-like family, and the Ig superfamily. Naive lymphocyte extravasation into Peyer’s patches is often mediated by L-selectin and
Lymphocyte_homing_receptor
Medical condition
microvesicles. Some adenocarcinomas secrete mucin that can interact with selectin found on platelets, thereby causing small clots to form. Moreover, most
Trousseau_sign_of_malignancy
Medical condition
attributable to the absence of neutrophil sialyl-LewisX, a ligand of P- and E-selectin on vascular endothelium. It is associated with SLC35C1. This disorder was
Congenital disorder of glycosylation type IIc
Congenital_disorder_of_glycosylation_type_IIc
Danish healthcare company
Amivantamab " " Advanced or metastatic colorectal cancer I/II " Inclacumab selectin P Pfizer VOC in Sickle cell disease III Est. prim. completion 2023-12 5-6%
Genmab
Process of cell attachment
and selectins. Cadherins and IgSF are homophilic CAMs, as they directly bind to the same type of CAMs on another cell, while integrins and selectins are
Cell_adhesion
Protein domain named after the epidermal growth factor protein
between different selectin types. For example, EGF-like domains appear essential to ligand binding by P-selectin but not L-selectin, and are thus essential
EGF-like_domain
Mammalian hormone released from the pituitary gland
Davenpeck KL, et al. (October 1995). "Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules". Blood. 86 (7):
Vasopressin
Monoclonal antibody
of P-selectin to the P-selectin glycoprotein ligand (PSGL)-1 located on the surface of leukocytes. A crystal structure of inclacumab and P-selectin reveals
Inclacumab
Cascade of intracellular and molecular events for transmission/amplification of signals
YAP1. Calcium-dependent cell adhesion molecules such as cadherins and selectins can also mediate mechanotransduction. Specialised forms of mechanotransduction
Signal_transduction
Class of drugs to lower cholesterol
Pravastatin Aplactin, Lipostat, Prasterol, Pravachol, Pravaselect, Sanaprav, Selectin, Selektine, Vasticor Fermentation-derived (a fermentation product of bacterium
Statin
Biomarkers of blood signals
hemostasis) include platelet factor 4 (PF4), β-thromboglobulin (β-TG), and P-selectin. Lippi G, Cervellin G, Franchini M, Favaloro EJ (November 2010). "Biochemical
Coagulation_activation_marker
Formation of a blood clot in a deep vein
patients who are acutely or critically ill. Inhibition of factor XI, P-selectin, E-selectin, and a reduction in formation of neutrophil extracellular traps are
Deep_vein_thrombosis
Component of blood aiding in coagulation
injury. Granule characteristics: α granules (alpha granules) — containing P-selectin, platelet factor 4, transforming growth factor-β1, platelet-derived growth
Platelet
Protein domain
"ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding". Blood. 108 (7): 2275–9. doi:10.1182/blood-2006-02-005827. PMC 1895557
ADAM_(protein)
Medical condition
activation-regulated chemokine)/CCL17 (CC chemokine ligand 17) and/or E-selectin may interact with the cutaneous leucocyte-associated antigen (CLA) receptor
Leukemia_cutis
human activin receptor-like kinase 1 cancer Aselizumab mab humanized L-selectin (CD62L) severely injured patients Atezolizumab Tecentriq mab humanized
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Human glycoprotein
pro-inflammatory cytokines, inducible nitric oxide synthase, tissue factor, P-selectin, intercellular adhesion molecule-1, phosphorylation of the extracellular
Ulinastatin
Type of immune cell
effector memory T cells lack the C-C chemokine receptor type 7 (CCR7) and L-selectin (CD62L) receptors, which prevents them from trafficking to the lymph nodes
Helper_T_cell
Protein-coding gene in the species Homo sapiens
protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]. Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes
PODXL2
Human sialoglycoprotein
glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and the affinity of the binding may be pivotal
Podocalyxin
Fat-laden M2 macrophages seen in atherosclerosis
blood vessel walls. Recruitment is facilitated by the molecules P-selectin and E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion
Foam_cell
Saccharide polymer
cells can express certain selectins transiently in response to damage or injury to the cells. In response, a reciprocal selectin–oligosaccharide interaction
Oligosaccharide
Biological process in animal connective tissue
Activated platelets have the ability to bind glycoproteins and glycolipids (P-selectin ligands such as PSGL-1) on the surface of cancer cells to form a physical
Epithelial–mesenchymal transition
Epithelial–mesenchymal_transition
Medical condition
pain control. In 2019, crizanlizumab, a monoclonal antibody targeting P-selectin, was approved in the United States to reduce the frequency of vaso-occlusive
Sickle_cell_disease
Cuban-American vascular surgeon
States. Her work with University of Miamicolleague Zhao-Jun Liu showed E-selectin to be an important factor in promoting angiogenesis and healing, as well
Omaida_C._Velazquez
Transmembrane receptors involved in cellular adhesion and signalling
as cadherins, the immunoglobulin superfamily cell adhesion molecules, selectins and syndecans, to mediate cell–cell and cell–matrix interaction. Ligands
Integrin
Chemical warfare agent
et al. (2019). "Alteration in serum levels of ICAM-1 and P-, E- and L-selectins in seriously eye-injured long-term following sulfur-mustard exposure"
Mustard_gas
Group of signal transduction pathways involved in embryonic development
Dact1. Meanwhile Wnt is activated during the early outgrowth phase by E-selectin. The link between PGE2 and Wnt suggests that a chronic inflammation-related
Wnt_signaling_pathway
Protein found in humans
enter lymph nodes. It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances
CD34
Protein found in humans
preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into
Addressin
Unspecialized biological cell that can become specialized
Wojciechowski JC, Charles N, Liesveld JL, King MR (January 2008). "P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor
Stem_cell
T cell which has not yet encountered its cognate antigen
Naive T cells are commonly characterized by the surface expression of L-selectin (CD62L) and C-C Chemokine receptor type 7 (CCR7); the absence of the activation
Naive_T_cell
Mammalian protein involved in blood clotting
specific functions: The D'/D3 domain: Binds to factor VIII, heparin, and P-selectin. The A1 domain: Binds to the platelet GPIb-receptor, collagen types IV
Von_Willebrand_factor
Membrane receptor
bind to a number of other ligands in the circulation such as thrombin, P-selectin, factor XI, factor XII, high molecular weight kininogen as well as bacteria
Glycoprotein_Ib-IX-V_complex
Protein-coding gene in the species Homo sapiens
"Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome
GLG1
Protein receptor active in neurons
(August 2016). "Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages". Glia. 64
Neuropilin
Cellular component of platelets
Willebrand factor). The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis. The other
Alpha_granule
White blood cells of the immune system
(TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression
T_cell
Sendai virus, virus of rodents
Noguchi M, Sato N, Sugimori H, Mori K, Oshimi K (October 2001). "A minor E-selectin ligand, CD65, is critical for extravascular infiltration of acute myeloid
Murine_respirovirus
Type of adipose tissue
metabolic indicators, and with lower levels of C-reactive protein and E-selectin. Cold exposure increases circulating irisin. Irisin improves insulin sensitivity
Brown_adipose_tissue
Maternal lymphocytes that make up 70% of the total found during pregnancy
immunoglobulin-like receptors. Notably, mouse models suggest that they lack CD16 and L-selectin, proteins that are prominent on pNKs (peripheral NK cells).[clarification
Uterine_natural_killer_cells
Protein-coding gene in the species Homo sapiens
Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis". Cancer Research. 65 (14): 6220–7. doi:10
B4GALNT2
Polymer-based, crosslinked hydrogel particle
nanogels have been functionalized with fucoidan to target overexpressed P-selectin receptors on platelets and endothelial cells. After loading with miRNA
Nanogel
Biochemical classification for carbohydrates
antigen determination. SLex is also important to proper immune response. P-selectin release from Weibel-Palade bodies, on blood vessel endothelial cells, can
Glycoconjugate
American biochemist
SUSTAIN study, a Phase II trial evaluating the use of SelG1, an anti-P-selectin antibody, in the reduction of vaso-occlusive pain crises in patients with
Richard_D._Cummings
Enzyme
and acidic residues within +5 or -5 residues of the target tyrosine. P-selectin glycoprotein ligand-1 (PSGL-1) has been extensively studied as a substrate
Tyrosylprotein sulfotransferase
Tyrosylprotein_sulfotransferase
Protein-coding gene in the species Homo sapiens
interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. SNX17 has been shown to interact with
SNX17
Israeli immunologist and cancer researcher (1934–2026)
dangerous liaisons. Adv Cancer Res. 100:203-29, 2008. Witz IP. The selectin-selectin ligand axis in tumor progression. Cancer Metastasis Rev, 27:19–30
Isaac_Witz
Mammalian protein found in Homo sapiens
syndromes: adhesion and tethering defects involving beta 2 integrins and selectin ligands". Current Opinion in Hematology. 9 (1): 30–5. doi:10
Integrin_beta_2
Tendency of material in contact with blood to produce a clot
adhere, spread pseudopods, and release soluble agonists such as ADP and P-selectin that recruit more platelets; exposed phosphatidylserine on their membranes
Thrombogenicity
Israeli cancer researcher
P., Friedmann-Morvinski, D., Madi, A., & Satchi-Fainaro, R. (2021). P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
Ronit_Satchi-Fainaro
Protein-coding gene in humans
resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. CD107a has also been shown to be a marker of
LAMP1
Protein with oligosaccharide modifications
proteins of coldwater fish Interact with specific carbohydrates Lectins, selectins (cell adhesion lectins), antibodies Receptor Various proteins involved
Glycoprotein
Blood clot (thrombus) that forms within a vein
pathways lead to monocyte association with endothelial proteins, such as P-selectin, prompting monocytes to release tissue factor-filled microvesicles, which
Venous_thrombosis
Indian automotive manufacturer company
Fiat 1100 Selectin 1958 followed by Super Select
Premier_Automobiles_Limited
Subset of T lymphocytes
(TCM cells) express CD45RO, C-C chemokine receptor type 7 (CCR7), and L-selectin (CD62L). Central memory T cells also have intermediate to high expression
Memory_T_cell
Mammalian protein found in Homo sapiens
3-hydroxy-3-methylglutaryl-CoA reductase on the expression of VCAM-1 and E-selectin in endothelial cells". The Biochemical Journal. 360 (Pt 2): 363–370. doi:10
HMG-CoA_reductase
Branch of medicine studying the immune system
opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion
Immunology
Mammalian protein found in humans
BG, Hieshima K, Fukuda M, Kannagi R, et al. (December 2004). "Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine
C-C_motif_chemokine_ligand_27
Protein domain
system and is associated with Kn(a/b), McC(a), Sl(a) and Yk(a) antigens. Selectins InterPro: IPR002396 CD62E CD62L CD62P Human genes encoding proteins containing
Sushi_domain
for sialylated Lewis carbohydrates associated with adenocarcinomas and e-selectin-mediated metastatic risk. It is commonly tested along with CEA, CA19-9
CA_242_(tumor_marker)
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also plays
Proteasome
Protein-coding gene in the species Homo sapiens
displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity". Int. Arch. Allergy Immunol. 126 (1): 78–90. doi:10.1159/000049497
OSGEP
'rolling interaction' occurs in three stages: Initial binding of a lymphocyte selectin and its ligand. This creates an unstable interaction where the lymphocyte
Gut-specific_homing
Medical condition
changes. Endothelial cells also are responsible for the production of E-selectin, which recruits lymphocytes into the tissue beneath the endothelium that
Heart failure with preserved ejection fraction
Heart_failure_with_preserved_ejection_fraction
Biological ability of cells to distinguish between types of neighboring cells
the site of an injury. A common example of this is selectin-expressing cells in animals. Selectin is a receptor protein found on the membranes of leukocytes
Cell–cell_recognition
Molecular process that occurs within living cells
express ligands on their cell surface to allow this interaction to occur. P-selectin glycoprotein ligand-1 (PSGL-1) is such a ligand, and contains a lot of
O-linked_glycosylation
Topics referred to by the same term
(disambiguation) Ilam (disambiguation) Eelam, Tamil name for Sri Lanka E-selectin, also known as endothelial-leukocyte adhesion molecule 1 (ELAM-1) This
Elam_(disambiguation)
thrombasthenia. CD62E E-selectin is a cell adhesion molecule expressed only on endothelial cells activated by cytokines. CD62L L-selectin is a cell adhesion
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein-coding gene in humans
neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology. 178 (12): 8053–63. doi:10.4049/jimmunol
ADAM8
Protein-coding gene in humans
fail to maintain antibody based immunity. STAT3 caused upregulation in E-selectin, a factor in metastasis of cancers. Hyperactivation of STAT3 occurs in
STAT3
Overview of and topical guide to immunology
(CD352) SLAMF7 (CD319) SLAMF8 (CD353) SLAMF9 Cadherins Selectins E-selectin L-selectin P-selectin Others Lymphocyte homing receptors CD34 GLYCAM-1 Addressin
Outline_of_immunology
Method of delivering medication
therapy. Biodegradable particles bearing ligands to P-selectin, endothelial selectin (E-selectin) and ICAM-1 have been found to adhere to inflamed endothelium
Targeted_drug_delivery
transportation, defense, and medical industries. Energid's Actin and Selectin products provide advanced robotics technology in the form of extendable
Energid_Technologies
Medical imaging technique
efficiencies, partly due to a dual-ligand selectin-integrin cell arrest system. One ligand:receptor pair (PSGL-1:selectin) has a fast bond on-rate to slow the
Contrast-enhanced_ultrasound
Layer of cells that line the inner surface of blood vessels
activated, which is characterized by the expression of molecules such as E-selectin, VCAM-1 and ICAM-1, which stimulate the adhesion of immune cells. Additionally
Endothelium
British academic
"Levels of Soluble Platelet Endothelial Cell Adhesion Molecule-1 and P-Selectin Are Decreased in Children with Autism Spectrum Disorder". Biological Psychiatry
Paul_Ashwood
SELECTIN
SELECTIN
SELECTIN
Girl/Female
German, Swedish
God is Gracious; God has Shown Favor
Boy/Male
Tamil
Female
Egyptian
, a princess of the royal line of Seti I.
Girl/Female
Hindu
Shubh ghari
Boy/Male
Indian, Punjabi, Sikh
Guru's Victory
Boy/Male
Hindu, Indian, Marathi
Shining Beautifully
Male
Croatian
, golden.
Girl/Female
Muslim/Islamic
Forehead
Girl/Female
Tamil
Dipanjali | தீபாஂஜலி
Boy/Male
Indian, Punjabi, Sikh
Shinning Lamp
SELECTIN
SELECTIN
SELECTIN
SELECTIN
SELECTIN
a.
Exerting the power of choice; selecting; as, an elective act.
a.
Selecting; tending to select.
n.
The act of selecting or detaching soldiers; a draft (see Draft, n., 2)
a.
Selecting; choosing (what is true or excellent in doctrines, opinions, etc.) from various sources or systems; as, an eclectic philosopher.
n.
Act of choosing; the voluntary act of selecting or separating from two or more things that which is preferred; the determination of the mind in preferring one thing to another; election.
v.
The art of selecting and combining the stops or registers of an organ.
n.
The act of excerpting or selecting.
n.
A kind of divination, performed by selecting passages of Scripture at hazard, and drawing from them indications concerning future events.
v.
The power of choosing; the faculty or endowment of the soul by which it is capable of choosing; the faculty or power of the mind by which we decide to do or not to do; the power or faculty of preferring or selecting one of two or more objects.
p. pr. & vb. n.
of Select
n.
The exercise of the imagination in selecting and treating a theme, or more commonly in contriving the arrangement of a piece, or the method of presenting its parts.
v. t.
To represent by selecting the important features and those which are expressible in the medium employed, and omitting the others.
n.
A selecting or detaching of soldiers from an army, or from any part of it, or from a military post; also from any district, or any company or collection of persons, or from the people at large; also, the body of men thus drafted.
n.
Care in selecting; judgment or skill in distinguishing what is to be preferred, and in giving a preference; discrimination.
n.
The act of selecting, or the state of being selected; choice, by preference.