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Class of drugs to lower cholesterol
Statins (or HMG-CoA reductase inhibitors) are a class of medications that lower cholesterol. They are typically prescribed to people who are at high risk
Statin
Cholesterol-lowering medication
Atorvastatin, sold under the brand name Lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and to
Atorvastatin
Statin medication
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and
Rosuvastatin
HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related
Discovery and development of statins
Discovery_and_development_of_statins
Medication used to treat high cholesterol
Generally it is used together with dietary changes and a statin. Alone, it is less preferred than a statin. It is taken by mouth. It is also available in the
Ezetimibe
Drug of the fibrate class, mainly used to reduce cholesterol levels
commonly used compared to statins because it treats a different type of cholesterol abnormality than statins. While statins have strong evidence for reducing
Fenofibrate
Medical condition
Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people
Statin-associated autoimmune myopathy
Statin-associated_autoimmune_myopathy
Lipid-lowering medication
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. It is used along with exercise, diet, and
Simvastatin
Combination drug
consisting of an extended release form of the lipid-lowering drug niacin and the statin drug simvastatin. It is used for the treatment of dyslipidemia. It was approved
Niacin/simvastatin
Biochemical cofactor and antioxidant
an adjunctive therapy to reduce inflammation in periodontitis. Although statins may reduce CoQ10 in the blood it is unclear whether they reduce CoQ10 in
Coenzyme_Q10
Pathological, often painful, involuntary muscle contraction
Hydroxymethylglutaryl-coenzyme A reductase inhibitors (HMG-CoA inhibitors or statins) Statins may sometimes cause myalgia and cramps among other possible side effects
Skeletal_muscle_cramp
Japanese biochemist (1933–2024)
relationship between fungi and cholesterol biosynthesis led to the development of statin drugs, which are some of the best-selling pharmaceuticals in history. Endo
Akira_Endo_(biochemist)
Chemical compound
salt) is a member of the blood cholesterol lowering medication class of statins. Pitavastatin is an inhibitor of HMG-CoA reductase, the enzyme that catalyses
Pitavastatin
Cholesterol-lowering medication
with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin; or alone
Bempedoic_acid
Type of bright reddish purple fermented rice
the United States and other countries. Lovastatin and other prescription statin drugs inhibit cholesterol synthesis by blocking action of the enzyme HMG-CoA
Red_yeast_rice
Abnormal amount of lipids in the blood
low risk, the use of statin therapy depends on individual patient factors such as age, cholesterol levels, and risk factors. Statins are considered the
Dyslipidemia
Abnormally elevated levels of lipids or lipoproteins in the blood
specifically PPARα, to decrease free fatty acid production. Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels
Hyperlipidemia
Inflammatory disease involving a buildup of lesions in the walls of arteries
atherosclerotic disease may include medications to lower cholesterol such as statins, blood pressure medication, and anticoagulant therapies to reduce the risk
Atherosclerosis
Genetic disorder characterized by high cholesterol levels
without FH (such as dietary modification and statin tablets). Nevertheless, treatment (including higher statin doses and PCSK9 inhibitors) is usually effective
Familial_hypercholesterolemia
High levels of cholesterol in the blood
cholesterol levels in the blood. Statins are the typically used medications, in addition to healthy lifestyle interventions. Statins can reduce total cholesterol
High_cholesterol
Sterol biosynthesized by all animal cells
begins with the mevalonate or HMG-CoA reductase pathway, the target of statin drugs, which encompasses the first 18 steps. This is followed by 19 additional
Cholesterol
Australian investigative journalist
challenged the scientific consensus on cholesterol, saturated fat and statins. She argued that high-blood cholesterol and high saturated fat consumption
Maryanne_Demasi
British cardiologist and writer
Malhotra is a British cardiologist and author, whose COVID-19 vaccine and anti-statin views have been criticised as misinformation by experts. He contends that
Aseem_Malhotra
Chemical compound
known as mevalonate and is of major pharmaceutical importance. Drugs like statins (which lower levels of cholesterol) stop the production of mevalonate by
Mevalonic_acid
Pharmaceutical drug
with a statin or statin with other lipid-lowering therapies in people unable to reach LDL-C goals with the maximum tolerated dose of a statin, or alone
Inclisiran
Combination drug
acid/ezetimibe is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia
Bempedoic_acid/ezetimibe
Substance that reduces or suppresses inflammation
Statins like atorvastatin and simvastatin are used to treat inflammatory conditions like rheumatoid arthritis and chronic kidney disease. Statins may
Anti-inflammatory
Mammalian protein found in Homo sapiens
the widely available cholesterol-lowering drugs known collectively as statins, which help to treat dyslipidemia. HMG-CoA reductase is anchored in the
HMG-CoA_reductase
Mammalian protein found in humans
Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated. While
PCSK9
Cholesterol lowering medication in the statin class
Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk
Pravastatin
American physician and author
cardiovascular disease take a statin?" The authors claimed that a study had shown that a substantial percentage of statin drug users had experienced side
John_Abramson
Organic compound and a form of vitamin B3
decreasing the risk of cardiovascular disease in those already prescribed a statin drug. A 2010 review had concluded that nicotinic acid was effective as a
Nicotinic_acid
Pharmaceutical drug
cholesterol for adults whose cholesterol is not controlled by diet and statin treatment. It is a human monoclonal antibody that belongs to a novel class
Alirocumab
Medication
treat abnormal blood lipid levels. It is generally less preferred than statins. Use is recommended together with dietary changes and exercise. It is unclear
Gemfibrozil
Chemical compound
Fluvastatin is a member of the statin drug class, used to treat hypercholesterolemia and to prevent cardiovascular disease. It was patented in 1982 and
Fluvastatin
Class of chemical compounds
particles, with or without high LDL-C levels. Fibrates may be compared to statin drugs, which reduce LDL-cholesterol (LDL-C) and have only limited effects
Fibrate
19th-century English proverb
a day was generally comparable for people over age 50 years to using a statin drug to reduce low-density lipoprotein cholesterol, concluding that eating
An apple a day keeps the doctor away
An_apple_a_day_keeps_the_doctor_away
Drugs for heart or blood vessels diseases
and beta-blockers. Antihyperlipidemic agents most often prescribed are statins, ezetimibe and fibrates. They either lower low-density lipoprotein cholesterol
Cardiovascular_agents
Chemical compound
(INN, brand names: Baycol, Lipobay) is a synthetic member of the class of statins used to lower cholesterol and prevent cardiovascular disease. It was marketed
Cerivastatin
American medical society
current president of NLA. In 2014, the NLA proposed a working definition of statin intolerance and made general recommendations for health professionals. The
National_Lipid_Association
Antibiotic medication
sudden cardiac deaths in stable coronary heart disease patients not using statins. Clarithromycin has been known to cause jaundice, cirrhosis, and kidney
Clarithromycin
Autoimmune disease resulting in skeletal muscle weakness
failure in 45% and death in 25–40% of people with myasthenia gravis. Statins: Statins are drugs that lower blood cholesterol levels in order to reduce the
Myasthenia_gravis
Inflammation of skeletal muscle
that can cause myositis are statins, which are used to lower cholesterol levels. One of the most common side effects of statin therapy is muscle pain which
Myositis
Cholesterol-lowering medication
plasma levels of PCSK9 by more than 93%. In a separate phase I study with statin-treated participants, daily doses of 10 and 20 mg reduced LDL levels at
Enlicitide_chloride
Series of interconnected biochemical reactions
IPP and DMAPP. It is best known as the target of statins, a class of cholesterol lowering drugs. Statins inhibit HMG-CoA reductase within the mevalonate
Mevalonate_pathway
Chemical compound
is intended to treat dyslipidemia. In a clinical trial, as an add-on to statins, compared with placebo, it decreased concentrations of LDL-C (by up to
Obicetrapib
Chemical compound
Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular
Lovastatin
Any ester of glycerol having all three hydroxyl groups esterified with fatty acids
]] [[ ]] ]] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". Chemistry portal Diglyceride acyltransferase, an enzyme
Triglyceride
Condition in which damaged skeletal muscle breaks down rapidly
well as intense or prolonged exercise, particularly in hot conditions. Statins (a class of prescription drugs to lower cholesterol) are considered a small
Rhabdomyolysis
Protein-coding gene in humans
coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a community cohort study (the Malmo Diet
APOA5
Subgroup of the idiopathic inflammatory myopathies
myopathies. There are three major subtypes based on autoantibodies, of which statin-associated autoimmune myopathy has been increasing in recent years. It is
Immune-mediated necrotizing myopathy
Immune-mediated_necrotizing_myopathy
Chemical compound
glycoside. Melitidin was discovered in bergamot orange juice and exhibits statin-like properties in preclinical research. Brutieridin Di Donna, Leonardo;
Melitidin
Cholesterol and blood pressure medication
the treatment of high cholesterol and high blood pressure. It contains a statin and a calcium channel blocker. Amlodipine/atorvastatin is marketed under
Amlodipine/atorvastatin
Restriction in blood supply to tissues
(October 2015). "Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered
Ischemia
Drug combination
the lipid-modifying drug/vitamin niacin in extended release form and the statin drug lovastatin (trade name Mevacor). The combination preparation was developed
Niacin/lovastatin
Progressive neurodegenerative disease
associated with a higher risk of onset and worsened course of AD. The use of statins to lower cholesterol may be of benefit in AD. Antihypertensive and antidiabetic
Alzheimer's_disease
Fat reducing drug
2018 by the American College of Cardiology & American Heart Association. Statins (HMG-CoA reductase inhibitors) are particularly well suited for lowering
Lipid-lowering_agent
Pharmaceutical clinical trial
Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin) was a clinical trial aimed at evaluating whether statins reduce heart
JUPITER_trial
Traditional Chinese medicine formulation
extract of red yeast rice and contains a mixture of naturally occurring statins, including monacolin K, which is chemically identical to lovastatin. In
Xuezhikang
Pharmaceutical drug
sequestrants, which along with niacin and the statins, are the three main types of cholesterol-lowering agents. The statins are considered the first-line agents
Colesevelam
Medical condition
higher cholesterol levels conferred a relative protection), and neither did statin drugs worsen the risk. The Heart Protection Study found no increase in either
Hypocholesterolemia
Protein-coding gene in the species Homo sapiens
]] [[ ]] ]] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". Apolipoprotein C GRCh38: Ensembl release 89: ENSG00000234906
Apolipoprotein_C-II
Class of steroids derived from plants
that complements statins. Phytosterols further reduce cholesterol levels by about 9% to 17% in statin users. The type or dose of statin does not appear
Phytosterol
Pharmaceutical clinical trial
trial designed to assess the efficacy of niacin (extended-release) added to statin therapy in reducing cardiovascular events in patients with established atherosclerotic
AIM-HIGH_(trial)
Drug combination used for the treatment of dyslipidemia
combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US). Ezetimibe reduces blood cholesterol
Ezetimibe/simvastatin
Rejecting scientific or historical consensus
GM foods, and are "evidence insensitive". Statin denialism is a rejection of the medical worth of statins, a class of cholesterol-lowering drugs. Cardiologist
Denialism
Class of pharmacological agent
inhibition of the ROCK pathway contributes to the cardiovascular benefits of statin therapy. Furthermore, ROCK inhibitors may have clinical applications for
Rho_kinase_inhibitor
Class of enzymes
]] [[ ]] ]] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430". Squalene synthase (SQS) is an enzyme participating in the
Farnesyl-diphosphate farnesyltransferase
Farnesyl-diphosphate_farnesyltransferase
Muscular degenerative disorder primarily of the hip and shoulders
may be triggered or worsened in genetically susceptible individuals by statins, because of their effects on HMG-CoA reductase. By definition, all limb-girdle
Limb–girdle muscular dystrophy
Limb–girdle_muscular_dystrophy
American pharmaceutical company
cholesterol" and targeted for patients that could not - or would not - take statins (statins are the standard-of-care medicine for lowering levels of bad cholesterol)
Esperion_Therapeutics
One of the five major groups of lipoprotein
for LDL reduction than the statins, including statins alone at high dose (though not necessarily the combination of statins plus ezetimibe). They have
Low-density_lipoprotein
Medical condition
specifically PPARα, to decrease free fatty acid production. Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin), can decrease LDL levels
Combined_hyperlipidemia
Prediction algorithm for cardiovascular disease
indicates that primary prevention with lipid lowering therapy (such as statins) should be considered. In the UK, current National Institute for Health
QRISK
Class of natural products
statins, which are cholesterol-lowering drugs that are mainly metabolized by CYP3A4. Co-administration of clarithromycin or erythromycin with statins
Macrolide
One of the five major groups of lipoprotein
their statin treatment showed no increase in heart health, but did experience an increase in the risk of stroke. In contrast, while the use of statins is
High-density_lipoprotein
contributions to research on statins, cholesterol-lowering medications. His initial investigations focused on the role of statins in suppressing inflammatory
Kalipada_Pahan
Chemical compound
Mevastatin (compactin, ML-236B) is a hypolipidemic agent that belongs to the statins class. It was isolated from the mold Penicillium citrinum by Akira Endo
Mevastatin
Dutch pharmaceutical company
headquartered in Nijmegen. Medications made by Synthon include: Simvastatin (A statin) Tamsulosin (An alpha blocker for the symptomatic treatment of benign prostatic
Synthon_(company)
Wooly, dust-like fungal structure or substance
may help reduce "bad" cholesterol as effectively as certain commercial statin drugs. Nonetheless, other work has shown it may not be reliable (perhaps
Mold
Medication taken to relieve cold symptoms
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics
Cold_medicine
Group of similar medications
Renin inhibitor Selective glucocorticoid receptor modulator Serotonergic Statin – HMG-CoA reductase inhibitor This type of categorisation of drugs is from
Drug_class
American biopharmaceutical company
indicated in the United States as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with clinical atherosclerotic cardiovascular
Alnylam_Pharmaceuticals
Protein-coding gene in the species Homo sapiens
endogenous ligand for the receptor. Moreover, the effects of cholesterol, statins, and bisphosphonates on osteoclastogenesis in bone tissue require ERRα;
Estrogen-related receptor alpha
Estrogen-related_receptor_alpha
Citrus fruit from Southeast Asia
anticoagulants, some anticancer agents, some anti-infective agents, some statins, and some immunosuppressants. The seeds of the pomelo are monoembryonic
Pomelo
Medication
hypertriglyceridemia ≥ 150 mg/dL. Further, it is often required to be used with a statin (maximally-tolerated dose). The most common side effects are musculoskeletal
Ethyl_eicosapentaenoic_acid
Perceived cardiac abnormality in which one's heartbeat can be felt
kidney disease; blood loss and pain; anemia; drugs such as antidepressants, statins, alcohol, nicotine, caffeine, cocaine and amphetamines; electrolyte imbalances
Palpitations
Substance used in medical imaging
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics
Contrast_agent
Drug to relieve nasal congestion
Angiotensin II receptor antagonists Renin inhibitors Antihyperlipidemics Statins Fibrates Bile acid sequestrants skin (D) Emollients Cicatrizants Antipruritics
Decongestant
Pharmaceutical drugs for preventing bone loss
differentiation of osteoblasts. Statins are another class of drugs that inhibit the HMG-CoA reductase pathway. Unlike bisphosphonates, statins do not bind to bone
Bisphosphonate
Medication
paraxanthine) cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil) Statins (e.g., simvastatin) See also: Receptor/signaling modulators
Nitroglycerin_(medication)
Death of a region of brain cells due to poor blood flow
anticoagulant medication in people with atrial fibrillation. Aspirin or statins may be recommended by physicians for prevention. A stroke is a medical
Stroke
Species of archaeon
action where statins inhibit methanogenesis directly. It appears that this other mechanism may predominate when the lactone form of statins, particularly
Methanobrevibacter_smithii
Substance used to diagnose, cure, treat, or prevent disease
disorder, soared. Mevacor (lovastatin) is the first and most influential statin in the American market. The 1991 launch of Pravachol (pravastatin), the
Medication
Men's and women's track and field team
Women's 60 Meter Dash Rank Name Time Year 1 Imani Sharp 7.61 2026 2 Shireese Statin 7.65 1998 3 Kyri Jackson 7.67 2020 T4 Allison Garner 7.68 2015 T4 Meghan
Detroit Mercy Titans track and field
Detroit_Mercy_Titans_track_and_field
Medical condition
patient is removed from statin therapy. Common types of myopathy due to statins include myalgia, myositis, and rhabdomyolysis. Statins induce myopathy by inhibiting
Acquired non-inflammatory myopathy
Acquired_non-inflammatory_myopathy
Chemical compound
stroke, and cardiovascular death by 25% relative to a placebo in those with statin-resistant hypertriglyceridemia. EPA is obtained in the human diet by eating
Eicosapentaenoic_acid
American singer (born 1934)
claim that all four of his daughters had found a preparation called Acne-Statin a "real help" in keeping their skin clear. The FTC filed a complaint against
Pat_Boone
Medical condition
embolism is treated by removing the cause and giving supportive therapy; statin drugs have been found to improve the prognosis. The symptoms experienced
Cholesterol_embolism
Protein-coding gene in the species Homo sapiens
coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a community cohort study (the Malmo Diet
SMG6
Muscular disease in which the muscle fibers do not function correctly
including patients already taking lower doses of the drug," the agency states. Statin-associated autoimmune myopathy (I40) Acute myocarditis (I41) Myocarditis
Myopathy
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