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Type of white blood cell
Neutrophils are a type of phagocytic white blood cell and part of innate immunity. More specifically, they form the most abundant type of granulocytes
Neutrophil
Unusual presence of neutrophils
Neutrophil hypersegmentation can be defined as the presence of neutrophils whose nuclei have six or more lobes or the presence of more than 3% of neutrophils
Hypersegmented_neutrophil
Protein-coding gene in the species Homo sapiens
Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase, subtype human leukocyte elastase
Neutrophil_elastase
Abnormally low concentration of neutrophils (a type of white blood cell) in the blood
Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. Neutrophils make up the majority of circulating white
Neutropenia
Measure of the number of neutrophils present in blood
Absolute neutrophil count (ANC) is a measure of the number of neutrophil granulocytes (also known as polymorphonuclear cells, PMN's, polys, granulocytes
Absolute_neutrophil_count
Networks of fibres which bind pathogens
Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens. In humans
Neutrophil extracellular traps
Neutrophil_extracellular_traps
Category of white blood cells
of two subpopulations: neutrophil-killers and neutrophil-cagers. One litre of human blood contains about five billion neutrophils, which are about 12–15
Granulocyte
Type of cells of the immunological system
infection and other diseases. Types of white blood cells are granulocytes (neutrophils, eosinophils, and basophils), and agranulocytes (monocytes, and lymphocytes
White_blood_cell
Group of autoantibodies
Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophils (the
Anti-neutrophil cytoplasmic antibody
Anti-neutrophil_cytoplasmic_antibody
Prognostic marker
The neutrophil to lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic strokes. In
Neutrophil to lymphocyte ratio
Neutrophil_to_lymphocyte_ratio
Neutrophil collagenase (EC 3.4.24.34, matrix metalloproteinase 8, PMNL collagenase, MMP-8) is an enzyme. This enzyme catalyses the following chemical reaction
Neutrophil_collagenase
Medical condition
(also called neutrophil leukocytosis or occasionally neutrocytosis) is leukocytosis of neutrophils, that is, a high number of neutrophils in the blood
Neutrophilia
Type of autoantibody
or perinuclear anti-neutrophil cytoplasmic antibodies, are antibodies that stain the material around the nucleus of a neutrophil. They are a special class
P-ANCA
Neutrophil swarming is a type of coordinated neutrophil movement that acts in response to acute tissue inflammation or infection. The term comes from
Neutrophil_swarming
Mammalian protein found in humans
monocyte-derived neutrophil chemotactic factor (MDNCF), has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other
Interleukin_8
Health disease test
Neutrophil oxidative burst test (or chronic granulomatous disease (CGD) test) is a measure of neutrophil oxidation and is a useful assay in the diagnosis
Neutrophil_oxidative_index
Immune cells that responds to any antigen
A non-specific immune cell is an immune cell (such as a macrophage, neutrophil, or dendritic cell) that responds to many antigens, not just one antigen
Nonspecific_immune_cell
Type of cell
, neutrophils). Band neutrophils are an intermediary step prior to the complete maturation of segmented neutrophils. Polymorphonuclear neutrophils are
Band_cell
Autoimmune disease with chronic blood vessel inflammation
proteinase 3, an enzyme prevalent in neutrophil granulocytes. In vitro studies have found that ANCAs can activate neutrophils, increase their adherence to endothelium
Granulomatosis with polyangiitis
Granulomatosis_with_polyangiitis
Inflammatory change in neutrophils
toxic vacuolization, is the formation of vacuoles in the cytoplasm of neutrophils in response to severe infections or inflammatory conditions. Toxic vacuolation
Toxic_vacuolation
Enzyme in neutrophils and other immune cells
by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophils (a subtype of white blood cells), and produces hypohalous acids to carry
Myeloperoxidase
Protein-coding gene in the species Homo sapiens
Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), is a protein that in humans is encoded by the LCN2
Lipocalin-2
Cells that ingest harmful matter within the body
bacteria, and dead or dying cells. They include monocytes, macrophages, neutrophils, tissue dendritic cells, and mast cells. Their name comes from the Greek
Phagocyte
Human blood group classification
reference neutrophil count. The term "Duffy-null associated neutrophil count" (DANC) has been proposed as a replacement. The distinctive neutrophils that are
Duffy_antigen_system
and cell biology, reverse migration is the phenomenon in which some neutrophils migrate away from the inflammation site, against the chemokine gradient
Reverse migration (immunology)
Reverse_migration_(immunology)
Immune system chemical weapon
myeloid cells and lymphoid cells. Myeloid cells, including macrophages and neutrophils, are especially implicated in the respiratory burst. They are phagocytic
Respiratory_burst
Protein-coding gene in the species Homo sapiens
Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene. The protein encoded by this gene is a 47 kDa
Neutrophil_cytosolic_factor_1
Biological system protecting an organism against disease
innate immune system, such as dendritic cells, macrophages, monocytes, neutrophils, and epithelial cells, to identify two classes of molecules: pathogen-associated
Immune_system
Mamilian biological material
from the neutrophils and are thus called human neutrophil peptides. Human neutrophil peptides are also known as α-defensins. Human neutrophil-derived alpha-defensins
Alpha_defensin
Protein-coding gene in the species Homo sapiens
Neutrophil cytosol factor 4 is a protein that in humans is encoded by the NCF4 gene. The protein encoded by this gene is a cytosolic regulatory component
Neutrophil_cytosolic_factor_4
Medication
name Neupogen among others, is a medication used to treat low neutrophil count. Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation
Filgrastim
Surroundings of tumors including nearby cells and blood vessels
tumor growth. Tumor associated neutrophils can be divided into N1- and N2-polarized neutrophils. N1-polarized neutrophils accumulate in the tumor in its
Tumor_microenvironment
Species of bacterium
hyaluronic acid surrounds the bacterium, protecting it from phagocytosis by neutrophils. In addition, the capsule and several factors embedded in the cell wall
Streptococcus_pyogenes
Biologist (born 1962)
the Max Planck Institute for Infection Biology. His research focuses on Neutrophil Extracellular Traps (NETs) which he discovered together with Volker Brinkmann
Arturo_Zychlinsky
Blood test
cell called a neutrophil in an attempt to detect disease. Neutrophils typically have two or three lobes. In general, older neutrophils have more lobes
Arneth_count
Transfusion of white blood cells
blood. Granulocytes are a category of white blood cell that includes neutrophils, eosinophils, and basophils. Granulocyte transfusions were historically
Granulocyte_transfusion
Medical condition
dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. It is a severe
Agranulocytosis
Increase in immature blood cell types
mentions of left shift refer to the white blood cell lineage, particularly neutrophil-precursor band cells, thus signifying bandemia. Less commonly, left shift
Left_shift_(medicine)
Antifungal medication
organ transplantation, low birth weight babies, and those with low blood neutrophil counts. It is given either by mouth or by injection into a vein. Common
Fluconazole
Medical condition
Neutrophil-specific granule deficiency (previously known as lactoferrin deficiency) is a rare congenital immunodeficiency characterized by an increased
Neutrophil-specific granule deficiency
Neutrophil-specific_granule_deficiency
Medical condition
with the lamin B receptor, wherein several types of white blood cells (neutrophils and eosinophils) have nuclei with unusual shape (being bilobed, peanut
Pelger–Huët_anomaly
Mammalian protein found in Homo sapiens
Unlike granulocyte colony-stimulating factor, which specifically promotes neutrophil proliferation and maturation, GM-CSF affects more cell types, especially
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Protein found in humans
Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton
Neutrophil_cytosolic_factor_2
Enzyme
endopeptidase E". The five chymotrypsin-like elastases, chymotrypsin-C, and neutrophil elastase are all serine proteases. The "macrophage elastase" is a matrix
Elastase
Blood test
(CBC), measures the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal
White_blood_cell_differential
Cell membrane engulfing a large particle
nutrients. The two main cells that do this are the Macrophages and the Neutrophils of the immune system. Where phagocytosis is used as a means of feeding
Phagocytosis
Immunity strategy in living beings
vasodilation of the blood vessels, and attract phagocytes, especially neutrophils. Neutrophils then trigger other parts of the immune system by releasing factors
Innate_immune_system
Japanese voice actor (born 1982)
was the second main character in Cells at Work! as White Blood Cell (Neutrophil) U-1146. He attended the Amusement Media Academy and the Japan Narration
Tomoaki_Maeno
Partially differentiated usually unipotent cell
Angioblast (endothelial precursor cells) Myeloid precursor cells Plasmablast Neutrophil progenitor Retinal precursor cells The prospect of regenerative medicine
Precursor_cell
Movement of white blood cells out of blood vessels and towards the inflamed site
neutrophils begin destroying host tissues at unprecedented rates, claiming the lives of about 200,000 people in the United States alone. Neutrophil dysfunction
Leukocyte_extravasation
Type of autoantibody
pattern results from binding of ANCAs to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). For
C-ANCA
Process by which cells lose secretory granules
different cells involved in the immune system, including granulocytes (neutrophils, basophils, eosinophils, and mast cells). It is also used by certain
Degranulation
Protein-coding gene in the species Homo sapiens
Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in
MMP8
Protein-coding gene in the species Homo sapiens
regulatory factor in neutrophil migration across the basement membrane. MMP9 plays several important functions within neutrophil action, such as degrading
MMP9
Medical condition
rates of neutrophil production by the bone marrow. It causes a temporary condition with a low absolute neutrophil count and because the neutrophils make up
Cyclic_neutropenia
Medical condition
infection. It is particularly associated with neutropenia, a low level of neutrophil granulocytes (the most common form of white blood cells) in the blood
Neutropenic_enterocolitis
Subtype of white blood cell
count in an otherwise normal person). A high lymphocyte count with a low neutrophil count might be caused by lymphoma. Pertussis toxin (PTx) of Bordetella
Lymphocyte
Medical condition
Neutrophil immunodeficiency syndrome is a condition caused by mutations in the Rac2 gene. It is a primary immunodeficiency by neutrophilia with severe
Neutrophil immunodeficiency syndrome
Neutrophil_immunodeficiency_syndrome
Protein family
mammalian immune system, inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citrea inhibits neutrophil elastase 1000-fold less potently
Ecotin
Mammalian protein found in humans
especially neutrophil elastase. When the blood contains inadequate or defective A1AT (as in alpha-1 antitrypsin deficiency), neutrophil elastase can
Alpha-1_antitrypsin
Medical condition
hypersegmented neutrophils (defined as the presence of neutrophils with six or more lobes or the presence of more than 3% of neutrophils with at least
Megaloblastic_anemia
Mammalian protein found in humans
survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF is produced by endothelium, macrophages, and a
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Fluorescent dye used to stain DNA
release of DNA by a neutrophil as foggy area in the center of the view field indicating the spontaneous activation of neutrophil extracellular traps formation
Hoechst_stain
Chemical compound
rabbit neutrophil functions such as: the transient auto-aggregation of these cells in suspension and equally transient fall in circulating neutrophils when
N-Formylmethionine-leucyl-phenylalanine
N-Formylmethionine-leucyl-phenylalanine
Disorder common in infants and young children
blood cells known as granulocytic neutrophils, granulocytes, segmented neutrophils, segs, polysegmented neutrophils, or polys. These antibodies, IgG antibodies
Autoimmune_neutropenia
Medical condition
refers to retention (kathexis) of neutrophils in the bone marrow (myelo). The disorder shows prominent neutrophil morphologic abnormalities. [citation
Myelokathexis
Mammalian protein found in humans
on circulating neutrophils and is shed following neutrophil priming. Expression of L-selectin in neutrophils decreases with neutrophil aging. Classical
L-selectin
Japanese manga series
Camacho (English) One of the Neutrophils working in the same poorly maintained body, working alongside U-1196 and U-8787. Neutrophil (好中球, Kōchūkyū) / White
Cells_at_Work!_Code_Black
Inclusions in the cytoplasm of neutrophils
basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1–3 μm in diameter. Not much is known about their formation
Döhle_bodies
Medical condition
granulocyte colony-stimulating factor (filgrastim), which increases the neutrophil count and decreases the severity and frequency of infections. Although
Severe_congenital_neutropenia
Protein-coding gene in the species Homo sapiens
alpha 1 also known as human alpha defensin 1, human neutrophil peptide 1 (HNP-1) or neutrophil defensin 1 is a human protein that is encoded by the DEFA1
DEFA1
Protein-coding gene in the species Homo sapiens
microglia), dendritic cells (especially in the colon), NK cells, ILC1 cells, neutrophils and renal proximal tubule cells. The AOAH gene has been found in many
AOAH
Medical condition
leukocyte (primarily neutrophils) is usually accompanied by a "left upper shift" in the ratio of immature to mature neutrophils and macrophages. The proportion
Leukocytosis
Mammalian protein found in humans
found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutrophils from the body. PECAM-1 is a highly glycosylated protein with a mass of
CD31
Category of substances produced by neutrophils when they encounter a foreign antigen
commonly known as leukopoietin, is a category of substances produced by neutrophils when they encounter a foreign antigen. Leukopoietin stimulates the bone
Leukocyte-promoting_factor
Mammalian protein found in humans
to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimulation of
CXCL5
Branch of medicine studying the immune system
up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes
Immunology
Chemical compound
absolute neutrophil counts and absolute lymphocyte counts, assessed over a 24-hour period four times throughout the study. Absolute neutrophil counts below
Mavorixafor
Type of granules
granulation refers to dark coarse granules found in granulocytes, particularly neutrophils, in patients with inflammatory conditions. Along with Döhle bodies and
Toxic_granulation
Vertebrate cell
meaning tissue, and cyte, meaning cell). Part of their job is to clear out neutrophils once they have reached the end of their lifespan. Histiocytes are derived
Histiocyte
Group of antimicrobial peptides in vertebrates
in the human. Cathelicidins are stored in the secretory granules of neutrophils and macrophages and can be released following activation by leukocytes
Cathelicidin antimicrobial peptide
Cathelicidin_antimicrobial_peptide
Skin disease
red, well-demarcated papules and plaques that show dense infiltrates by neutrophil granulocytes on histologic examination. The syndrome was first described
Febrile neutrophilic dermatosis
Febrile_neutrophilic_dermatosis
Permanent enlargement of the lung airways
which leads to neutrophil activation. This neutrophil activation leads to further tissue destruction and airway distortion by neutrophils in addition to
Bronchiectasis
Chronic disease caused by bacterial infection
involvement; their pathobiology features surges of TNF-α, IL-6, and IL-8, and neutrophil-rich infiltrates. Beyond T cells and macrophages, humoral immunity and
Leprosy
Atypical antipsychotic medication
marginal neutrophil counts before and after initiation and they are at risk of premature clozapine discontinuation. A knowledge of neutrophil biology allows
Clozapine
Species of bacterium
phagocytophilum) is a Gram-negative bacterium that is unusual in its tropism to neutrophils. It causes anaplasmosis in sheep and cattle, also known as tick-borne
Anaplasma_phagocytophilum
American voice actress (born 1992)
With the Weakest Crest Alma Cells at Work! Code Black White Blood Cell (Neutrophil) 8787 Blue Reflection Ray Yuzu Lupin the 3rd Part 6 Finn Clark Love Live
Lizzie_Freeman
Mucus that is coughed up from the lower airways
antibiotics can reduce symptoms. The green color is caused by degenerating neutrophil verdoperoxidase. Whitish gray sputum color against a white color background
Sputum
Enzyme complex
the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms. Human isoforms of the catalytic
NADPH_oxidase
Test for white blood cells in urine
esterase enzyme released by white blood cells (leukocytes), particularly neutrophils, when they are activated or recruited to a site of infection or inflammation
Leukocyte_esterase
Medical condition
glycogenolysis in GSD Ib, impairment of the neutrophil's ability to take up glucose, resulting in neutrophil dysfunction and neutropenia These fundamental
Glycogen storage disease type I
Glycogen_storage_disease_type_I
Abnormal white blood cell inclusion
crystals of death, are amorphous blue-green cytoplasmic inclusions found in neutrophils and occasionally in monocytes. They appear brightly coloured and refractile
Critical_green_inclusion
Protein domain
C-terminal tripeptide PTS1 are in the concave face of TPRs 1, 2 and 3. Neutrophil cytosolic factor 2 is an essential to NADPH oxidase complex which in turn
Tetratricopeptide_repeat
Nuclear medicine procedure
scan is a nuclear medicine procedure in which white blood cells (mostly neutrophils) are removed from the patient, tagged with the radioisotope Indium-111
Indium-111_WBC_scan
Chronic autoimmune disorder leading to blistering skin
them to secrete IL-8 (CXCL8) in the lamina propria, recruiting neutrophils. Neutrophil recruitment results in a very rapid onset of inflammation. Therefore
Dermatitis_herpetiformis
Protein-coding gene in humans
PMID 1837963. Brandt E, Van Damme J, Flad HD (1991). "Neutrophils can generate their activator neutrophil-activating peptide 2 by proteolytic cleavage of platelet-derived
CXCL7
Measurement of calprotectin protein in stool
in the stool. Elevated faecal calprotectin indicates the migration of neutrophils to the intestinal mucosa, which occurs during intestinal inflammation
Faecal_calprotectin
Inflammation of membranes around the brain
present (see table) indicates whether meningitis is bacterial (usually neutrophil-predominant) or viral (usually lymphocyte-predominant), although at the
Meningitis
Protein complex found in mammals
comprises as much as 60% of the soluble protein content of the cytosol of a neutrophil, and it is secreted by an unknown mechanism during inflammation. Faecal
Calprotectin
Medical condition
of myeloperoxidase–an iron-containing protein expressed primarily in neutrophil granules. There are two types of myeloperoxidase deficiency: primary/inherited
Myeloperoxidase_deficiency
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