AI & ChatGPT searches , social queries for ADAM17
Search references for ADAM17. Phrases containing ADAM17
See searches and references containing ADAM17!
Search references for ADAM17. Phrases containing ADAM17
See searches and references containing ADAM17!ADAM17
Protein found in humans
A disintegrin and metalloprotease 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM
ADAM17
Chemical compound
further research. More specifically, aderbasib is an inhibitor of ADAM10 and ADAM17. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL" (PDF)
Aderbasib
Exopeptidase enzyme that acts on angiotensin I and II
pressure in check. mACE2 is cleaved by the enzyme ADAM17 in a process regulated by substrate presentation. ADAM17 cleavage releases the extracellular domain
Angiotensin-converting enzyme 2
Angiotensin-converting_enzyme_2
Protein domain
(metargidin)". Li Y, Brazzell J, Herrera A, Walcheck B (October 2006). "ADAM17 deficiency by mature neutrophils has differential effects on L-selectin
ADAM_(protein)
Enzyme family
needed] the yield of agonists. Sheddase inhibitors active on ADAM10 and ADAM17 can potentiate anti-cancer therapy. It has been postulated that the activity
Sheddase
regulation of growth factor availability and mediating cell-matrix interactions. ADAM17 and ADAM15 have recently been identified in endothelial cells (EC). ADAMTS
Proteases_in_angiogenesis
Mammalian protein found in Homo sapiens
a short transmembrane domain, and a cytoplasmic tail. It is cleaved by ADAM17. The nature of the interactions between L-selectin and ligand depends on
L-selectin
Biological process in primates
PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". J Mammary Gland
Breast_development
Activation of a protein by exposure to its substrate
reaction in a lipid raft but lacks a substrate for activity.[citation needed] (ADAM17), also called TACE, is sequestered into lipid rafts away from its substrate
Substrate_presentation
Protein found in humans
CD163 function. sCD163 shedding occurs as a result of enzymatic cleavage by ADAM17. sCD163 is upregulated in a large range of inflammatory diseases including
CD163
Family of proteolytic enzymes
only the prodomain is required for APP processing. Other ADAM proteins, ADAM17 (also called TACE, tumor necrosis factor-α converting enzyme), ADAM9, and
Alpha_secretase
Protein-coding gene in the species Homo sapiens
pathways, such as the Notch signaling pathway, through the upregulation of ADAM17. GRCh38: Ensembl release 89: ENSG00000105447 – Ensembl, May 2017 GRCm38:
GRWD1
Protein-coding gene in the species Homo sapiens
expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis, the differentiation of pre-adipocytes
DLK1
Transmembrane protein
PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (June 2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". Journal of Mammary
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Mammalian protein found in Homo sapiens
implicated in the proteolytic cleavage of LRP1 such as ADAM10, ADAM12, ADAM17 and MT1-MMP. LRP1 is also continuously endocytosed from the membrane and
LRP1
Human protein-encoding gene
shown to interact with: CD117, CD29 CD46, CD49c, CD81, PTGFRN, TSPAN4. CD63 ADAM17 CD81 Tetraspanin Myogenesis Fertilisation GRCh38: Ensembl release 89: ENSG00000010278
CD9
Protein found in humans
proteolytic processing of the amyloid precursor protein. ADAM10, along with ADAM17, cleaves the ectodomain of the triggering receptor expressed on myeloid
ADAM10
Species of coronavirus causing SARS and COVID-19
H, Gierer S, Liepold T, Jahn O, Pöhlmann S (January 2014). "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry
SARS-related_coronavirus
Protein-coding gene in humans
Hattori C, Szabó B, et al. (2003). "Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase". Biochem. Biophys. Res. Commun. 301 (1): 231–5.
ADAM9
Protein-coding gene in the species Homo sapiens
time. Part of the ectodomain of TREM2 can be processed by enzymes (ADAM10, ADAM17) and released as a soluble version, called soluble TREM2 (sTREM2). This
TREM2
Enzyme found in humans
carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17". British Journal of Cancer. 93 (11): 1267–1276. doi:10.1038/sj.bjc.6602861
Carbonic_anhydrase_9
Protein-coding gene in humans
SARS-CoV-2 infection. The enzyme Adam17 has similar ACE2 cleavage activity as TMPRSS2, but by forming soluble ACE2, Adam17 may actually have the protective
TMPRSS2
Disintegrin and metalloproteinase domain-containing protein 17; encoded by ADAM17 gene CD156c Disintegrin and metalloproteinase domain-containing protein
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein-coding gene in humans
PJ, et al. (Oct 2001). "Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)". Journal of
CX3CL1
Organisms capable of living at high altitudes
gene known to be involved in regulating response to low oxygen levels, ADAM17, has different allele frequencies in both high-elevation yaks and human
Organisms_at_high_altitude
Protein-coding gene in the species Homo sapiens
Rabie T, Strehl A, Ludwig A, Nieswandt B (2005). "Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V." J. Biol. Chem. 280
GP5_(gene)
PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, acne) ADAM17 deficiency Blau syndrome Majeed syndrome (Chronic recurrent multifocal osteomyelitis
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Protein-coding gene in the species Homo sapiens
phosphorylated and ubiquitinated. MAPK1 has been shown to interact with: ADAM17, CIITA, DUSP1, DUSP3, ELK1, FHL2, HDAC4, MAP2K1, MAP3K1 MAPK14, MKNK1, MKNK2
MAPK1
Chemical compound
Interleukin-6 receptor can be cleaved from the cell membrane by the protease ADAM17 generating a soluble receptor. The soluble interleukin-6 receptor can still
Olamkicept
Protein-coding gene in the species Homo sapiens
cleavage of the AXL extracellular domain by the metalloproteinases ADAM10 and ADAM17 can downregulate this signalling activity. Signalling pathways activated
AXL_receptor_tyrosine_kinase
Protein family
mice, iRhoms are key trafficking chaperones required for the ER export of ADAM17/TACE and its maturation. iRhoms are thus required for the TNF-alpha and
Rhomboid_protease
HGNC:189; O75078 256 ADAM12 HGNC:190; O43184 257 ADAM15 HGNC:193; Q13444 258 ADAM17 HGNC:195; P78536 259 ADAM18 HGNC:196; Q9Y3Q7 260 ADAM19 HGNC:197; Q9H013
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
Protein-coding gene in the species Homo sapiens
PMID 18398673. S2CID 13229645. Sternlicht MD, Sunnarborg SW (June 2008). "The ADAM17-amphiregulin-EGFR axis in mammary development and cancer". Journal of Mammary
Amphiregulin
was rather limited in comparison to other ADAM enzymes such as ADAM10 and ADAM17. With renewed interest in reproductive genomics and sperm proteomics, there
ADAM20
Designer cytokine
Philip; Putoczki, Tracy; Ernst, Matthias; Rose-John, Stefan (2 April 2018). "ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling"
Hyper-IL-6
Protein-coding gene in humans
MF, Apte SS (Nov 1998). "Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of
ADAM19
Protein-coding gene in the species Homo sapiens
has been mapped to chromosome 14. MAD2L1 has been shown to interact with: ADAM17, BUB1B, CDC20, CDC27 and Estrogen receptor beta, MAD2L2, Mad1, and UBD.
MAD2L1
American chemist
(NDH4409) and retro olvanil 8 (NDH4417). Hydroxamates reduced the activity of ADAM17 and matrix metalloproteinases (MMPs), and attenuated expression of EMMPRIN
Ned_D._Heindel
RNA family
have been implicated in tumorigenesis, including ADAM10, IGF1R, CCNG1 and ADAM17. Recent studies demonstrated that miR-122 may directly regulate different
MiR-122
Sub-discipline of biology
desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis. Mol. Cell Biol. 26(13):5086-95
Degradomics
ADAM17
ADAM17
ADAM17
ADAM17
Boy/Male
Australian, Egyptian, French
Lord Shiva; The Sun
Surname or Lastname
English (Lancashire)
English (Lancashire) : variant of Irish Madden.
Girl/Female
Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Telugu
The Cuckoo; Bird
Girl/Female
Gujarati, Indian, Sanskrit
Simple
Girl/Female
Greek Latin
Messenger.
Boy/Male
Hindu
Boy/Male
Australian, Hebrew
The Lord has Remembered
Female
Vietnamese
Vietnamese name KIM-LY means "golden lion."
Boy/Male
Hindu
Boy/Male
Hindu
Symbol
ADAM17
ADAM17
ADAM17
ADAM17
ADAM17