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Search references for P SELECTIN. Phrases containing P SELECTIN
See searches and references containing P SELECTIN!P SELECTIN
Type-1 transmembrane protein
P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the
P-selectin
Family of cell adhesion molecules
subsets of selectins: E-selectin (in endothelial cells) L-selectin (in leukocytes) P-selectin (in platelets and endothelial cells) L-selectin is the smallest
Selectin
Protein-coding gene in the species Homo sapiens
Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. SELPLG codes for PSGL-1, the high affinity counter-receptor
P-selectin glycoprotein ligand-1
P-selectin_glycoprotein_ligand-1
Movement of white blood cells out of blood vessels and towards the inflamed site
presenting pre-formed P-selectins on the endothelial cell surface. P-selectins bind PSGL-1 as a ligand. E-selectins: E-selectin is expressed on activated
Leukocyte_extravasation
adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs
Soluble cell adhesion molecules
Soluble_cell_adhesion_molecules
Mammalian protein found in Homo sapiens
E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell
E-selectin
Subset of cell adhesion proteins
are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). The best-characterized ligand for the three selectins is P-selectin glycoprotein
Cell_adhesion_molecule
Type of chemical bond
P-selectin:PSGL-1 bonds exhibited increasing bond lifetime as step loads were applied between 0 and ~10 pN for monomeric interaction but 1 and ~20 pN
Catch_bond
Monoclonal antibody
of P-selectin to the P-selectin glycoprotein ligand (PSGL)-1 located on the surface of leukocytes. A crystal structure of inclacumab and P-selectin reveals
Inclacumab
Physical effects resulting from activation of the immune system
Inflammatory cytokines induce the immediate expression of P-selectin on endothelial cell surfaces and P-selectin binds weakly to carbohydrate ligands on the surface
Inflammation
Israeli cancer researcher
Z., Brem, H., Hyde, T. M., Magod, P., Friedmann-Morvinski, D., Madi, A., & Satchi-Fainaro, R. (2021). P-selectin axis plays a key role in microglia immunophenotype
Ronit_Satchi-Fainaro
Storage granules of endothelial cells
store and release two principal molecules, von Willebrand factor and P-selectin, and thus play a dual role in hemostasis and inflammation. Weibel–Palade
Weibel–Palade_body
Chemical compound
bind to L-selectin. For the binding to L-selectin to occur, sialyl-LewisX must undergo sulfation. For sialyl-LewisX to bind to P-selectin, an O-linked
Sialyl-Lewis_X
Formation of a blood clot in a deep vein
patients who are acutely or critically ill. Inhibition of factor XI, P-selectin, E-selectin, and a reduction in formation of neutrophil extracellular traps
Deep_vein_thrombosis
Monoclonal antibody
Adakveo among others, is a monoclonal antibody medication that binds to P-selectin. It is a medication used to reduce the frequency of vaso-occlusive crisis
Crizanlizumab
Class of compounds
function. Sulfatide also acts as an L-selectin and P-selectin ligand, but it does not act as an E- selectin ligand. Selectins are adhesion molecules that facilitate
Sulfatide
Mammalian hormone released from the pituitary gland
Davenpeck KL, et al. (October 1995). "Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules". Blood. 86
Vasopressin
Mammalian protein found in Homo sapiens
L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in humans by
L-selectin
Multiprotein complex that forms a point of contact or adhesion in animal cells
P-selectin and E-selectin. L-selectin deals with lymphocytes, monocytes and neutrophils, P-selectin deals with platelets and endothelium and E-selectin deals only
Cell_junction
Biochemical classification for carbohydrates
antigen determination. SLex is also important to proper immune response. P-selectin release from Weibel-Palade bodies, on blood vessel endothelial cells,
Glycoconjugate
Medical imaging technique
been made to outfit microbubbles with monoclonal antibodies that bind P-selectin, ICAM-1, and VCAM-1, but the adhesion to the molecular target was poor
Contrast-enhanced_ultrasound
Small particle, often in plants
proteins, both membrane-associated receptors (for example, αIIbβ3 and P-selectin) and soluble cargo (for example, platelet factor 4 [PF4] and fibrinogen)
Granule_(cell_biology)
Tendency of material in contact with blood to produce a clot
adhere, spread pseudopods, and release soluble agonists such as ADP and P-selectin that recruit more platelets; exposed phosphatidylserine on their membranes
Thrombogenicity
American immunologist
walls were coated with P-selectin, ICAM-1, or both. Infused neutrophils were found to readily attach and then roll on P-selectin, but could not attach
Timothy_A._Springer
Cell-surface glycoprotein
sialofucosylations rendering the selectin-binding glycoform of CD44 called HCELL (for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below) Transcripts
CD44
Unspecialized biological cell that can become specialized
SD, Wojciechowski JC, Charles N, Liesveld JL, King MR (January 2008). "P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor
Stem_cell
Mammalian protein found in Homo sapiens
(HUVEC) with hOSM results in delayed but prolonged upregulation of P-selectin, and E-selectin which facilitates leukocyte adhesion and rolling, necessary for
Oncostatin_M
Biological process in animal connective tissue
Activated platelets have the ability to bind glycoproteins and glycolipids (P-selectin ligands such as PSGL-1) on the surface of cancer cells to form a physical
Epithelial–mesenchymal transition
Epithelial–mesenchymal_transition
Medical condition
pain control. In 2019, crizanlizumab, a monoclonal antibody targeting P-selectin, was approved in the United States to reduce the frequency of vaso-occlusive
Sickle_cell_disease
Surface glycoproteins involved in hemostasis
von Willebrand factor (vWF), α-thrombin, leukocyte integrin αMβ2 and P-selectin. The binding between GPIbα and vWF mediates the capture of platelets to
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Mammalian protein involved in blood clotting
specific functions: The D'/D3 domain: Binds to factor VIII, heparin, and P-selectin. The A1 domain: Binds to the platelet GPIb-receptor, collagen types IV
Von_Willebrand_factor
Membrane receptor
bind to a number of other ligands in the circulation such as thrombin, P-selectin, factor XI, factor XII, high molecular weight kininogen as well as bacteria
Glycoprotein_Ib-IX-V_complex
Biomarkers of blood signals
hemostasis) include platelet factor 4 (PF4), β-thromboglobulin (β-TG), and P-selectin. Lippi G, Cervellin G, Franchini M, Favaloro EJ (November 2010). "Biochemical
Coagulation_activation_marker
Component of blood aiding in coagulation
injury. Granule characteristics: α granules (alpha granules) — containing P-selectin, platelet factor 4, transforming growth factor-β1, platelet-derived growth
Platelet
Protein complex found in mammals
spread on S100A8/A9, leading to the formation of distinct populations of P-selectin+ and phosphatidylserine+ platelets. The prothrombotic pathway initiated
Calprotectin
Protein domain named after the epidermal growth factor protein
between different selectin types. For example, EGF-like domains appear essential to ligand binding by P-selectin but not L-selectin, and are thus essential
EGF-like_domain
Family of proteins
disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion
Poly_(ADP-ribose)_polymerase
Protein-coding gene in the species Homo sapiens
interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. SNX17 has been shown to interact with
SNX17
Addition of a sulfate group to a tyrosine group in a protein
tyrosines found in human PSGL-1 not only enhance its binding to P-selectin but also enables its pH-selective binding to the immune checkpoint protein VISTA
Tyrosine_sulfation
Cellular component of platelets
Willebrand factor). The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis. The other
Alpha_granule
Protein-coding gene in the species Homo sapiens
beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin". J. Biol. Chem. 279 (21): 21984–91. doi:10.1074/jbc
GCNT1
Species of virus
genome damage. The receptors for EV71 and CVA16 have been identified as P-selectin glycoprotein ligand-1 and scavenger receptor class B, member 2 (SCARB2);
Enterovirus_71
Fat-laden M2 macrophages seen in atherosclerosis
blood vessel walls. Recruitment is facilitated by the molecules P-selectin and E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular cell
Foam_cell
Polymer-based, crosslinked hydrogel particle
nanogels have been functionalized with fucoidan to target overexpressed P-selectin receptors on platelets and endothelial cells. After loading with miRNA
Nanogel
Transition of leucocytes in immune system
antagonists IL-1Ra Adhesion molecules β2-integrins Fc receptors CD14 P-selectin CD45 Bacterial products LPS fMetLeuPhe Viral products dsRNA BCRF1 (IL-10-homologue)
Immunologic_activation
Protein involved in the breakdown of blood clots
tPA activity was reported to be associated with an increase in plasma P-selectin concentration. Tissue plasminogen activator also plays a role in cell
Tissue-type plasminogen activator
Tissue-type_plasminogen_activator
Medical condition
progression and spread of various types of cancers; 4) overexpression of the P-selectin glycoprotein ligand-1 gene whose protein product promotes cell attachment
Primary_effusion_lymphoma
Blood clot (thrombus) that forms within a vein
pathways lead to monocyte association with endothelial proteins, such as P-selectin, prompting monocytes to release tissue factor-filled microvesicles, which
Venous_thrombosis
Immune cells found in lymph nodes
replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1". Journal of Immunology. 183 (1): 524–32. doi:10
Follicular_dendritic_cells
American biochemist
receipt of results of a Phase II trial evaluating the use of SelG1, an anti-P-selectin antibody, in the reduction of vaso-occlusive pain crises in patients with
Richard_D._Cummings
Topics referred to by the same term
refer to: Psel (river), a tributary of the Dnieper in Russia and Ukraine P-selectin Printed segmented electroluminescence Pseudaminic acid synthase, an enzyme
Psel
Protein-coding gene in the species Homo sapiens
essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide
FUT7
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB8
Protein family
thrombospondin (TSP), complement receptor 1 (CR1), chondroitin sulfate A (CSA), P-selectin, endothelial protein C receptor (EPCR), and heparan sulfate. The DBL domain
Plasmodium falciparum erythrocyte membrane protein 1
Plasmodium_falciparum_erythrocyte_membrane_protein_1
Human glycoprotein
pro-inflammatory cytokines, inducible nitric oxide synthase, tissue factor, P-selectin, intercellular adhesion molecule-1, phosphorylation of the extracellular
Ulinastatin
Post vaccination adverse effects
"Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance". Blood. 109 (7): 2832–2839
Embolic and thrombotic events after COVID-19 vaccination
Embolic_and_thrombotic_events_after_COVID-19_vaccination
Method of delivering medication
therapy. Biodegradable particles bearing ligands to P-selectin, endothelial selectin (E-selectin) and ICAM-1 have been found to adhere to inflamed endothelium
Targeted_drug_delivery
Enzyme found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMD12
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
Proteasome
express the cutaneous lymphocyte antigen (CLA) molecule, a modified form of P-selectin glycoprotein ligand-1. Lymphocytes move to the epidermis where they reside
Skin_immunity
Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-12. "ART1 - GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor - Homo sapiens (Human)".
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Molecular process that occurs within living cells
express ligands on their cell surface to allow this interaction to occur. P-selectin glycoprotein ligand-1 (PSGL-1) is such a ligand, and contains a lot of
O-linked_glycosylation
Elimination of autoreactive lymphocytes by the immune system
cells, express on their surface glycoprotein PSGL1, which is a ligand for P-selectin, expressed on the thymic endothelium. But out of all the aforementioned
Central_tolerance
German-American biologist and researcher (1954–2023)
induction of alpha IIb/beta 3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity. J Exp Med. 1993;178:579–87. Peerschke EI, Reid
Ellinor_Peerschke
Premature form of T cells present in the thymus
cortico-medullary junction. Molecules known to be important for thymus entry include P-selectin (CD62P) and the chemokine receptors CCR7 and CCR9. Following thymus entry
Thymocyte
Mammalian protein found in Homo sapiens
Johnson KJ, Glovsky MM, et al. (September 1994). "C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation. 94 (3):
C5a_receptor
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMA7
Protein-coding gene in the species Homo sapiens
receptors. The binding of versican with leukocyte adhesion molecules L-selectin, P-selectin, and CD44 is also mediated by the interaction of CS chains of versican
Versican
Protein-coding gene in humans
Mochizuki S, et al. (2007). "Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells"
ADAM28
Enzyme found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMD8
Protein-coding gene in the species Homo sapiens
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMD14
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB5
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB4
Mammalian protein found in Homo sapiens
Hosaka S, Shah MR, Pope RM, Koch AE (March 1996). "Soluble forms of P-selectin and intercellular adhesion molecule-3 in synovial fluids". Clinical Immunology
ICAM3
Pharmaceutical drug
Cerletti C (2007). "Parnaparin, a low-molecular-weight heparin, prevents P-selectin-dependent formation of platelet-leukocyte aggregates in human whole blood"
Parnaparin_sodium
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB3
Enzyme found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMD13
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO) Additionally, the UPS also plays
PSMD1
Protein-coding gene in humans
(1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein
CHST2
Protein-coding gene in the species Homo sapiens
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
Proteasome (prosome, macropain) subunit, alpha 1
Proteasome_(prosome,_macropain)_subunit,_alpha_1
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB10
American biologist
2131-2137 Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice TN Mayadas, RC Johnson, H Rayburn, RO Hynes, DD Wagner
Denisa_Wagner
Protein-coding gene in the species Homo sapiens
displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity". Int. Arch. Allergy Immunol. 126 (1): 78–90. doi:10.1159/000049497
Opticin
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB6
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMA5
British academic
A.; Rogers, S. J.; Ashwood, P. (2012). "Levels of Soluble Platelet Endothelial Cell Adhesion Molecule-1 and P-Selectin Are Decreased in Children with
Paul_Ashwood
Protein-coding gene in the species Homo sapiens
(February 1994). "A role for the epidermal growth factor-like domain of P-selectin in ligand recognition and cell adhesion". J. Cell Biol. 124 (4): 609–18
TMEM8A
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMA6
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB7
Enzyme found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMC1
Belgian molecular biologist (born 1965)
18252–18259. 2011, P.S. Raman, C.S. Alves, D. Wirtz, K. Konstantopoulos, Single molecule binding of CD44 to fibrin versus P-selectin predicts their distinct
Denis_Wirtz
332 – cytochrome p-450 cyp1a1 MeSH D12.776.422.220.453.040.555 – cytochrome p-450 cyp1a2 MeSH D12.776.422.220.453.040.777 – cytochrome p-450 cyp2b1 MeSH D12
List_of_MeSH_codes_(D12.776)
Enzyme found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMD2
625.903 – l-selectin MeSH D23.050.301.350.700 – selectins MeSH D23.050.301.350.700.300 – e-selectin MeSH D23.050.301.350.700.510 – l-selectin MeSH D23.050
List_of_MeSH_codes_(D23)
Protein-coding gene in humans
(1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein
CHST1
Protein found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMB9
Overview of and topical guide to immunology
(CD352) SLAMF7 (CD319) SLAMF8 (CD353) SLAMF9 Cadherins Selectins E-selectin L-selectin P-selectin Others Lymphocyte homing receptors CD34 GLYCAM-1 Addressin
Outline_of_immunology
Ligand-targeted liposomes for use in medical applications
D J, Goetz (June 2001). "Ligand coated nanosphere adhesion to E- and P-selectin under static and flow conditions". Annals of Biomedical Engineering. 29
Ligand-targeted_liposome
Enzyme
and acidic residues within +5 or -5 residues of the target tyrosine. P-selectin glycoprotein ligand-1 (PSGL-1) has been extensively studied as a substrate
Tyrosylprotein sulfotransferase
Tyrosylprotein_sulfotransferase
Enzyme found in humans
cytokines such as TNF-α, IL-β, IL-8, adhesion molecules (ICAM-1, VCAM-1, P-selectin) and prostaglandins and nitric oxide (NO). Additionally, the UPS also
PSMD7
P SELECTIN
P SELECTIN
P SELECTIN
P SELECTIN
P SELECTIN
P SELECTIN
P SELECTIN
P SELECTIN
P SELECTIN