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Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin
Lymphotoxin_beta_receptor
InterPro Family
immune responses. Lymphotoxin alpha (LT-α, previously known as TNF-beta) and lymphotoxin beta (LT-β), the two forms of lymphotoxin, each have distinctive
Lymphotoxin
Protein found in humans
Lymphotoxin-alpha (LT-α) formerly known as tumor necrosis factor-beta (TNF-β) is an immune signalling protein (a cytokine) that in humans is encoded by
Lymphotoxin_alpha
Protein-coding gene in the species Homo sapiens
molecules of beta), which serves as the primary ligand for the lymphotoxin-beta receptor. A less common form is the lymphotoxin-alpha 2/beta 1 complex.
Lymphotoxin_beta
Protein superfamily of cytokine receptors
structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell. 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A
TNF_receptor_superfamily
Protein that binds to a cytokine
coupled receptors. TGF-beta receptor family, which are Serine/threonine kinase receptors. Includes the TGF beta receptors Cytokine receptors may be both
Cytokine_receptor
Topics referred to by the same term
LTBR may refer to: Lymphotoxin beta receptor, a cell surface receptor for lymphotoxin involved in apoptosis and cytokine release LTBR, the ICAO airport
LTBR
Mammalian protein found in Homo sapiens
version of the human interleukin 1 receptor antagonist protein. Anakinra blocks the biologic activity of IL-1 alpha and beta by competitively inhibiting IL-1
Interleukin_1_beta
Secreted protein of the TNF superfamily
herpesvirus entry mediator (HVEM), as well as decoy receptor 3. LIGHT stands for "homologous to lymphotoxin, exhibits inducible expression and competes with
LIGHT_(protein)
Protein-coding gene in the species Homo sapiens
response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation
TRAF3
Protein-coding gene in humans
by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602–6. doi:10.1074/jbc
TRAF2
Protein and coding gene in humans
1992). "The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci". Genomics. 13 (3):
Interleukin-1 receptor antagonist
Interleukin-1_receptor_antagonist
Protein-coding gene in the species Homo sapiens
by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". The Journal of Biological Chemistry. 276 (18): 14602–6
IKBKB
Overview of and topical guide to immunology
Tumor necrosis factor (TNF) receptor family - Trimeric cytokine receptors TNFRSF1A (CD120a) TNFRSF1B (CD120b) TNFRSF3 (Lymphotoxin βR) TNFRSF4 (CD134, OX40)
Outline_of_immunology
Small cytokines or signaling proteins secreted by cells
to the homeostatic chemokine receptors, there is significant promiscuity (redundancy) associated with binding receptor and inflammatory chemokines. This
Chemokine
factor receptor LPHN1 Lymphocyte function-associated antigen 1 Lymphokine Lymphoproliferative response Lymphotoxin Lymphotoxin alpha Lymphotoxin beta Lymphotoxin
Index_of_immunology_articles
Protein-coding gene in the species Homo sapiens
"Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological
Diablo_homolog
Immune system messenger protein which induces inflammation
to lymphotoxin was discovered, termed lymphotoxin-β. In 1998, at the Seventh International TNF Congress, TNF-β was officially renamed to lymphotoxin-α
Tumor_necrosis_factor
Brazilian-American immunologist
B; Hubner, W; Chen, BK; Genden, E; Skobe, M; et al. (2007). "Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the
Sergio_A._Lira
Protein-coding gene in the species Homo sapiens
"Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". The Journal of Biological
Baculoviral IAP repeat-containing protein 2
Baculoviral_IAP_repeat-containing_protein_2
Protein-coding gene in the species Homo sapiens
by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". The Journal of Biological Chemistry. 276 (18): 14602–6
MAP3K8
predominantly triggered by CD40, lymphotoxin β receptor (LT), and the B-cell activating receptor belonging to the TNF family (BAFF receptor). The alternative NF-κB
Interleukin-1 receptor associated kinase
Interleukin-1_receptor_associated_kinase
Animal model used in laboratory research
study the effect of lymphotoxins on metabolism. Mice without lymphotoxin alpha, lymphotoxin beta, or a lymphotoxin beta receptor had poorly composed microbiota
Diet-induced_obesity_model
Signaling proteins released by host cells in response to the presence of pathogens
Smith GL (December 2000). "The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral
Interferon
Pathologic overview
cells. The collaboration between LTB on Th17 cells and LTBR (Lymphotoxin beta receptor) on meningeal radio-resistant cells is very crucial for the induction
Pathology of multiple sclerosis
Pathology_of_multiple_sclerosis
Interleukin
(November 1996). "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits". Proceedings of the National Academy
Interleukin_12
Protein-coding gene in the species Homo sapiens
(IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding"
Interleukin_3
Protein-coding gene in the species Homo sapiens
activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". The Journal of Biological Chemistry. 271 (25): 14661–4. doi:10
TRAF5
Membrane receptor protein found in humans
factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that
Tumor necrosis factor receptor 1
Tumor_necrosis_factor_receptor_1
Protein superfamily
embryogenesis. The superfamily contains 19 members that bind to 29 members of TNF receptor superfamily. An occurrence of orthologs in invertebrates hints at ancient
Tumor necrosis factor superfamily
Tumor_necrosis_factor_superfamily
Protein-coding gene in humans
by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602–6. doi:10.1074/jbc
CHUK
Protein-coding gene in the species Homo sapiens
bridging channels is also associated with dendritic cell reception of lymphotoxin beta signaling, which augments their blood pathogen uptake, resulting in
GPR183
Group of cytokines
same chromosomal location. The receptors can both bind all three forms of IL-1 (IL-1 alpha, IL-1 beta and IL-1 receptor antagonist). The crystal structures
Interleukin
Cytokine protein
the innate immune system, called pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). These are present on the cell surface and intracellular
Interleukin_6
Mammalian protein found in Mus musculus
fibrosis. The receptor for interleukin-4 is known as the IL-4Rα. This receptor exists in 3 different complexes throughout the body. Type 1 receptors are composed
Interleukin_4
Type of cytokine
high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF". Cell. 66 (6):
Interleukin_5
Protein-coding gene in the species Homo sapiens
by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602–6. doi:10.1074/jbc
MAP3K14
Category of small signaling proteins
cells. They typically function by interacting with specific cytokine receptors on the surface of target cells. Cytokines include chemokines, interferons
Cytokine
Protein found in humans
PNAd expression, as well as the expression of MAdCAM-1, is dependent on lymphotoxin signaling in the HEVs of lymph nodes. In inflammatory bowel diseases
Addressin
Mammalian protein
apoptosis primarily in tumor cells, by binding to certain death receptors. TRAIL and its receptors have been used as the targets of several anti-cancer therapeutics
TRAIL
Protein-coding gene in the species Homo sapiens
"Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling"
TANK_(gene)
Medication
Peginterferon beta-1a, sold under the brand name Plegridy, is medication used to treat multiple sclerosis. The most common side effects include headache
Peginterferon_beta-1a
Membrane receptor protein found in humans
factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that
Tumor necrosis factor receptor 2
Tumor_necrosis_factor_receptor_2
Growth factor secreted by stromal cells in the bone marrow and thymus
cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRß) during early T cell development. This cytokine can be produced
Interleukin_7
Group of cytokine proteins
natural antagonist IL-1Ra (IL-1 receptor antagonist). All three of them include a beta trefoil fold and bind IL-1 receptor (IL-1R) and activate signaling
Interleukin-1_family
Cytokine in the interferon family
Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS)
Interferon_beta-1b
Cytokine
SOCS1 and aryl hydrocarbon receptor interacting protein (AIP). The mammalian types are designated IFN-α (alpha), IFN-β (beta), IFN-κ (kappa), IFN-δ (delta)
Interferon_type_I
Protein
β-Thromboglobulin (β-TG), or beta-thromboglobulin, is a chemokine protein secreted by platelets. It is a type of chemokine (C-X-C motif) ligand 7. Along
Β-Thromboglobulin
Protein family
bioactivity. The biological effect is carried out through ligation of chemokine receptors CCR1 (ligand CCL3) and CCR5 (ligands CCL3 and CCL4) and the signal is
Macrophage inflammatory protein
Macrophage_inflammatory_protein
Mammalian protein found in Homo sapiens
Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced
RANKL
Venules in some lymphatic organs
The normal phenotype of HEV is possibly maintained by DC-secreted lymphotoxin (TNF-beta). HEV cuboidal endothelial cells express the adhesion molecules
High_endothelial_venules
Protein found in humans
protein in the tumor necrosis factor (TNF) superfamily. It binds to the Fas receptor (CD95) to induce apoptosis, and also activates non-apoptotic pathways such
Fas_ligand
Type of cytokine produced primarily by monocytes and macrophages
Some monokines are: interleukin 1 tumor necrosis factor-alpha alpha and beta interferon colony stimulating factors Monokines released from macrophages
Monokine
Protein-coding gene in humans
encoded by the TNFSF9 gene. 4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also
TNFSF9
Mammalian protein found in humans
(December 1995). "Molecular characterization of two murine eosinophil beta chemokine receptors". Journal of Immunology. 155 (11): 5299–5305. doi:10.4049/jimmunol
CCL4
Protein-coding gene in humans
tissues such as skin in humans. It is recognized by the ectodysplasin A receptor. The protein encoded by this gene is a type II membrane protein that can
Ectodysplasin_A
Anti-inflammatory cytokine
signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four
Interleukin_10
Mammalian protein found in humans
exists as both monomer and dimer and both forms are able to bind chemokine receptor CXCR2. However, CXCL1 chemokine is able to dimerize only at higher (micromolar)
CXCL1
Mammalian protein found in humans
gene symbol is CXCL8. Its receptors were similarly renamed: Interleukin 8 receptor, alpha — CXCR1 Interleukin 8 receptor, beta — CXCR2 GRCh38: Ensembl release
Interleukin_8
Class of proteins produced by muscle
concentrations. Receptors for myokines are found on muscle, fat, liver, pancreas, bone, heart, immune, and brain cells. The location of these receptors reflects
Myokine
Mammalian protein found in Homo sapiens
12 subunit beta, is used by both IL-23 (where it partners with IL-23p19) and IL-12 (where it partners with IL-12A). A functional receptor for IL-23 (the
Interleukin_23_subunit_alpha
Family of proteins
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors in the bone marrow, thereby
Colony-stimulating_factor
Protein found in humans
known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily encoded by the
Herpesvirus_entry_mediator
Mammalian protein found in humans
and IL-21. IL-2 signals through a IL-2 receptor, a complex consisting of three chains, termed alpha (CD25), beta (CD122) and gamma (CD132). The gamma chain
Interleukin_2
Group of proteins
surface receptor IL-17R. There are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC. After binding to the receptor, IL-17 activates
Interleukin_17
Protein-coding gene in the species Homo sapiens
encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–384. doi:10.1006/geno
Interleukin 36 receptor antagonist
Interleukin_36_receptor_antagonist
Protein
is encoded by the TNFSF8 gene. CD153 is a cytokine ligand for the TNF receptor CD30. It plays a role in the T cell-dependent anti-mycobacterial immune
TNFSF8
InterPro Family
heterodimeric receptor consisting of Interferon gamma receptor 1 (IFNGR1) and Interferon gamma receptor 2 (IFNGR2). IFN-γ binding to the receptor activates
Interferon_gamma
Mammalian protein found in humans
novel beta-chemokine". Blood. 89 (9): 3315–22. PMID 9129037. Baba M, Imai T, Nishimura M, et al. (1997). "Identification of CCR6, the specific receptor for
CCL20
Mammalian protein found in humans
its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including
CCL19
Mammalian protein found in Homo sapiens
"Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood. 93 (3): 804–15. doi:10.1182/blood
Leukemia_inhibitory_factor
Family of transcription factor protein complexes
select set of cell-differentiating or developmental stimuli, such as lymphotoxin β-receptor (LTβR), BAFF or RANKL, activate the non-canonical NF-κB pathway
NF-κB
Formation of blood cellular components
haematopoietic cells is stem cell factor (SCF), which binds to the c-kit receptor on the HSC. Absence of SCF is lethal. There are other important glycoprotein
Haematopoiesis
Mammalian protein found in Homo sapiens
damage normally caused by the presence of the beta-amyloid plaque. Chemokines and chemokine receptors, of which CXCR stands out, regulate multiple processes
Stromal_cell-derived_factor_1
Two important groups of soluble factors
(colony-stimulating factors), MAF (macrophage activation factors), and lymphotoxin. Most factors act in many points throughout the B cell lifecycle, activation
B cell growth and differentiation factors
B_cell_growth_and_differentiation_factors
Protein-coding gene in humans
interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic
CXCL11
Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human)". www.uniprot.org. Retrieved 2015-10-13. "IL10RB - Interleukin-10 receptor subunit beta precursor
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Mammalian protein found in humans
1997). "Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6". The Journal of Biological Chemistry. 272 (51): 32078–83. doi:10
CCL7
Cytokine with structural similarity to Interleukin-2
IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is
Interleukin_15
Mammalian protein found in humans
inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence
CXCL2
Pharmaceutical drug
CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2 TNF TNFA Lymphotoxin TNFB/LTA TNFC/LTB TNFSF4 TNFSF5/CD40LG TNFSF6 TNFSF7 TNFSF8 TNFSF9 TNFSF10
Interferon_alfa-2b
Pharmaceutical drug
CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2 TNF TNFA Lymphotoxin TNFB/LTA TNFC/LTB TNFSF4 TNFSF5/CD40LG TNFSF6 TNFSF7 TNFSF8 TNFSF9 TNFSF10
Peginterferon_alfa-2a
Protein-coding gene in the species Homo sapiens
I and type II, based on their interactions to a specific cell surface receptor. In recent years, a novel class of cytokines with IFN-like activities has
Interferon_alpha-1
Mammalian protein found in Homo sapiens
KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein
Stem_cell_factor
Protein-coding gene in the species Homo sapiens
entirely of beta-pleated sheets. Crystal structure analysis of the mature form of IL-1α shows that it has two binding sites for the IL-1 receptor. There is
Interleukin_1-alpha
Mammalian protein found in Homo sapiens
Coprecipitation of Jak1, Jak2 and Tyk2 with receptors containing cytoplasmic parts of the LIFR or OSMR. All beta receptor subunits of the gp130 system also possess
Oncostatin_M
Mammalian protein found in humans
thrombocytes. Although it can bind to receptors CCR1, CCR3, CCR4 and CCR5, belonging to seven transmembrane G-protein coupled receptor (GPCRs) family, it has the
CCL5
Type of multinucleate cell
lymphotoxins, such as perforin or granzyme, that will kill the infected T helper cell. However, if T helper cells are nearby, the gp41 HIV receptors displayed
Syncytium
Protein-coding gene in the species Homo sapiens
(2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32
MST1
Type of white blood cell
activating M1 macrophages, TH1 cells express Fas ligand (FasL) and lymphotoxin beta (LT-β) to help kill chronically infected macrophages that can no longer
Macrophage
Protein-coding gene in the species Homo sapiens
function) is more similar to type I interferons. It binds to a heterodimeric receptor composed of one subunit IFNL1R specific for IFN-λ and a second subunit
Interleukin_29
Protein-coding gene in the species Homo sapiens
interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol
Cardiotrophin_1
Mammalian protein found in Homo sapiens
observations, it has also been proposed that the anti-tumour effects of lymphotoxin α and β could be mediated in IL-22BP dependent manner. In lung infection
IL22RA2
Veterinary medication
CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2 TNF TNFA Lymphotoxin TNFB/LTA TNFC/LTB TNFSF4 TNFSF5/CD40LG TNFSF6 TNFSF7 TNFSF8 TNFSF9 TNFSF10
Recombinant feline interferon omega
Recombinant_feline_interferon_omega
Protein-coding gene in the species Homo sapiens
encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–384. doi:10.1006/geno
Interleukin_37
Mammalian protein found in humans
Leonard WJ (October 2000). "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain". Proceedings of the National Academy of Sciences
Interleukin_21
Protein found in humans
cell surface. As a result, the macrophage expresses more CD40 and TNF receptors on its surface, which helps increase the level of activation. The activated
CD40_ligand
Mammalian protein found in Homo sapiens
tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. This cytokine is
B-cell_activating_factor
Pharmaceutical drug
CXCL13 CXCL14 CXCL15 CXCL16 CXCL17 CX3CL CX3CL1 XCL XCL1 XCL2 TNF TNFA Lymphotoxin TNFB/LTA TNFC/LTB TNFSF4 TNFSF5/CD40LG TNFSF6 TNFSF7 TNFSF8 TNFSF9 TNFSF10
Peginterferon_alfa-2b
Protein and coding gene in humans
multi-subunit receptor with IL-4. This receptor is a heterodimer receptor complex consisting of alpha IL-4 receptor (IL-4Rα) and alpha Interleukin-13 receptor (IL-13R1)
Interleukin_13
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LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
LYMPHOTOXIN BETA-RECEPTOR
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