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Mammalian protein found in Homo sapiens
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and
Interleukin_1_beta
Group of cytokines
cytokines that mediate immune responses. Interleukin 1 alpha and interleukin 1 beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation
Interleukin
Type of interleukin receptor
to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor
Interleukin 1 receptor, type I
Interleukin_1_receptor,_type_I
Enzyme found in humans
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors
Caspase_1
Protein and coding gene in humans
inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory
Interleukin-1 receptor antagonist
Interleukin-1_receptor_antagonist
Protein-coding gene in the species Homo sapiens
until 1985 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 alpha and interleukin-1 beta. IL-1α is also
Interleukin_1-alpha
Protein-coding gene in the species Homo sapiens
the signaling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by
Interleukin 1 receptor, type II
Interleukin_1_receptor,_type_II
Protein-coding gene in the species Homo sapiens
1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type
IL1RL2
Protein-coding gene in the species Homo sapiens
this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein
MPGES-1
Protein fold
the interleukin 1 cytokine family (interleukin-1 alpha, interleukin-1 beta and interleukin-1 receptor antagonist); and in fibroblast growth factors 1 and
Beta_trefoil_fold
Protein domain
with similar properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1). At the time, ICE was the only known caspase
Caspase
Infection caused by Bacillus anthracis bacteria
lethal factor was presumed to cause macrophages to make TNF and interleukin 1 beta (IL1β). TNF is a cytokine whose primary role is to regulate immune
Anthrax
Chemical compound
treat joint diseases such as osteoarthritis. It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial
Diacerein
Protein-coding gene in the species Homo sapiens
largest and most studied one; it shares the beta barrel structure that is spread within the interleukin-1 family. IL-37a,b,c are being expressed in a
Interleukin_37
Mammalian protein found in Homo sapiens
The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune
Interleukin-3_receptor
Protein-coding gene in the species Homo sapiens
Subunit beta of interleukin 12 (also known as IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, or interleukin-12
Interleukin-12_subunit_beta
Family of proteins involved in anatomical development
related to interleukin 1-beta. Both families have the same beta trefoil fold consisting of 12-stranded beta-sheet structure, with the beta-sheets are
Fibroblast_growth_factor
SNRI medication
pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interleukin 6 (IL-6) and may increase the production
Duloxetine
Mammalian protein found in humans
pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion"
Interleukin_8
Protein-coding gene in the species Homo sapiens
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor
Interleukin_3
Group of cytokine proteins
The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections
Interleukin-1_family
Monoclonal antibody
to interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine, and downmodulates the cellular signaling events that produce inflammation. IL-1 beta has
Gevokizumab
Mammalian protein found in humans
of resistance to gemtuzumab ozogamicin have been elucidated. On September 1, 2017, the FDA approved Pfizer's Mylotarg. Gemtuzumab ozogamicin was initially
CD33
Human protein and coding gene
platform triggering activation of inflammatory caspases and processing of proIL-beta". Molecular Cell. 10 (2): 417–426. doi:10.1016/S1097-2765(02)00599-3. PMID 12191486
PYCARD
Ballooning or rupturing of a blood vessel in the brain
macrophages, and mast cells. The inflammatory mediators are: interleukin 1 beta, interleukin 6, tumor necrosis factor alpha (TNF alpha), MMP1, MMP2, MMP9
Intracranial_aneurysm
Protein-coding gene in the species Homo sapiens
associated with Familial Mediterranean Fever". BMC Medical Genetics. 15 (1): 74. doi:10.1186/1471-2350-15-74. PMC 4094690. PMID 24980720. Bakkaloglu
MEFV
Interleukin
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid
Interleukin_12
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Chemotherapy and immunosuppressant medication
experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells". European Journal of Clinical
Methotrexate
Medical condition
rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis
Anemia_of_chronic_disease
Mammalian protein found in Homo sapiens
involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As
IL2RA
Protein and coding gene in humans
Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor and the interleukin 23 receptor. IL12RB1, is the name
Interleukin 12 receptor, beta 1 subunit
Interleukin_12_receptor,_beta_1_subunit
Genetic autoinflammatory disease
daily colchicine regimen has been successful. Canakinumab, an anti-interleukin-1-beta monoclonal antibody, has likewise been shown to be effective in controlling
Familial_Mediterranean_fever
Protein-coding gene in the species Homo sapiens
TREM2 promotes phagocytosis of apoptotic neurons or the uptake of amyloid beta by microglia. Variants of TREM2 that encode proteins with reduced affinity
TREM2
Medical condition featuring permanent bending of fingers
such as transforming growth factor-beta, platelet-derived growth factor, epidermal growth factor, interleukin-1 beta, and connective tissue growth factor
Dupuytren's_contracture
Cytokine receptor which binds interleukin 1
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. Two forms of the receptor exist. The type I receptor is primarily responsible
Interleukin-1_receptor
Protein found in humans
signalling roles in their own right. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed
Arrestin_beta_2
Shaham and Junying Yuan working in Horvitz's laboratory identified interleukin-1-beta-converting enzyme as the mammalian homolog of the CED-3 enzyme. In
History_of_apoptosis_research
Type of cytokine
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5
Interleukin_5
Peptide hormone involved in appetite regulation
nesfatin-1. Ghrelin cells are not terminally differentiated in the pancreas: they are progenitor cells that can give rise to A-cells, PP cells and Beta-cells
Ghrelin
Topics referred to by the same term
for NAT traversal ICE (chemotherapy), a cancer treatment Caspase 1, or Interleukin-1 beta Converting Enzyme Ice-ice, a disease condition of seaweed Integrative
Ice_(disambiguation)
Inflammation of nervous tissue
response to brain injury include: interleukin-6 (IL-6), which is produced during astrogliosis, and interleukin-1 beta (IL-1β) and tumor necrosis factor
Neuroinflammation
Score of dietary inflammation
with several inflammatory markers, including interleukin 1 beta, interleukin 4, interleukin 6, interleukin 10, tumor necrosis factor TNFα-R2, C-reactive
Dietary_inflammatory_index
Disease caused by accumulation of crystals
inflammatory response including the release of pro-inflammatory interleukin 1 alpha, interleukin 1 beta, cytokines, kinins, lipid inflammatory mediators, complement
Crystallopathy
Transmembrane proteins
interferon-alpha/beta receptor interferon-gamma receptor Interferon type III receptor Interleukin-10 receptor Interleukin-20 receptor Interleukin-22 receptor
Type_II_cytokine_receptor
Species of bacterium
The immune systems' Paneth cells of the gut attack HIV by producing interleukin 1 beta (IL-1β), which results in extensive collateral damage—sloughing of
Lactiplantibacillus_plantarum
Protein-coding gene in the species Homo sapiens
Interleukin-2 receptor subunit beta is a protein that in humans is encoded by the IL2RB gene. Also known as CD122; IL15RB; P70-75. The interleukin 2 receptor
IL2RB
Protein-coding gene in the species Homo sapiens
Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted
TGF_beta_1
Class of organic compounds used in medicine and agriculture
Sulfonylureas are also used experimentally to inhibit release of interleukin 1 beta from the NALP3 (or NLRP3) inflammasome. Sulfonylureas – as opposed
Sulfonylurea
Type I cytokine receptor
Interleukin 12 receptor is a type I cytokine receptor, binding interleukin 12 and consisting of beta 1 and beta 2 subunits. Chua AO, Chizzonite R, Desai
Interleukin-12_receptor
Receptors on the surface of cells
a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for
Type_I_cytokine_receptor
Protein-coding gene in humans
Gordon S, et al. (June 2007). "Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function". Protein Science. 16 (6):
CLEC7A
Protein-coding gene in the species Homo sapiens
Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene. The protein encoded
IL36B
Protein-coding gene in the species Homo sapiens
CD4 T cells". European Journal of Immunology. 28 (1): 1–11. doi:10.1002/(SICI)1521-4141(199801)28:01<1::AID-IMMU1>3.0.CO;2-V. PMID 9485180. Timms JF, Carlberg
Signal-regulatory protein alpha
Signal-regulatory_protein_alpha
Chemical compound
pro-inflammatory cytokines, Interleukin 1 beta, i.e., IL-1β (which is enzymatically cleaved to its active form by caspase 1) and tumor necrosis factor;
Itaconic_acid
Medical condition
interleukin 1 beta and/or IL-18 responses), purely auto-immune disorders (in which the adaptive immunity is dysregulated, with a dysregulated type 1 interferon
Fever_of_unknown_origin
High calcium (Ca2+) level in the blood serum
metastasis releases local cytokines including IL-6, IL-8, IL-11, interleukin-1 beta, TNF alpha, and macrophage inflammatory protein. These cytokines activate
Hypercalcaemia
Widening of blood vessels
vasodilation is caused by cytokines. Interferon gamma, TNF-a, interleukin 1 beta, and interleukin 12 are a few examples of some inflammatory cytokines produced
Vasodilation
Enzyme involved in prostaglandin synthesis
regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha". The Journal of Biological Chemistry
Cyclooxygenase-1
Protein-coding gene in the species Homo sapiens
Interleukin 9, also known as IL-9, is a pleiotropic cytokine (cell signalling molecule) belonging to the group of interleukins. IL-9 is produced by variety
Interleukin_9
Human protein and coding gene
"Gasdermin D pore structure reveals preferential release of mature interleukin-1". Nature. 593 (7860): 607–611. Bibcode:2021Natur.593..607X. doi:10
NLRP3
Protein-coding gene in the species Homo sapiens
antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor
Interleukin-4_receptor
Protein-coding gene in the species Homo sapiens
Interleukin 36 receptor antagonist (IL-36RA) is a member of the interleukin-36 family of cytokines. It was previously named Interleukin-1 family member
Interleukin 36 receptor antagonist
Interleukin_36_receptor_antagonist
Mammalian protein found in humans
(1–2): 57–66. PMID 3887178. Weinberg JB, Mason SN, Wortham TS (June 1992). "Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta
CCL4
Ulceration of the gastrointestinal tract
emergence of peptic ulcer disease. The human IL1B gene encodes for Interleukin 1 beta, and other genes that encode for tumour necrosis factor (TNF) and
Peptic_ulcer_disease
Non-receptor tyrosine kinase and coding gene in humans
between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor
Janus_kinase_2
Cytokine with structural similarity to Interleukin-2
structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and
Interleukin_15
Medical condition
activities of interleukin 1(alpha) and interleukin 1(beta). Therefore, the pathophysiologic immune and inflammatory responses are nullified. Interleukin 1 receptor
Deficiency of the interleukin-1–receptor antagonist
Deficiency_of_the_interleukin-1–receptor_antagonist
Protein-coding gene in the species Homo sapiens
1016/S0014-4827(03)00261-1. PMID 14499622. Wang T, Arifoglu P, Ronai Z, Tew KD (15 June 2001). "Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal
GSTP1
Form of programmed cell death
Korsmeyer SJ (December 1996). "BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases". Proceedings of the National Academy
Apoptosis
Enzyme found in humans
to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme". The Journal of Biological Chemistry. 269 (49):
Caspase_6
Protein receptor that recognizes bacterial molecules and stimulates an immune reaction
2002). "Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1". Biochemical and Biophysical Research
NOD1
Species of flowering plant
tissue, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), which are key indicators of inflammation. The
Taraxacum_mongolicum
Autosomal recessive metabolic disorder
state, biomarker changes are seen in IL-6 (interleukin-6), IL-10 (interleukin-10), IL-1beta (interleukin-1 beta), TNF-gamma (tumor necrosis factor-gamma)
Maple_syrup_urine_disease
Protein found in humans
inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/s1074-7613(00)80450-1. PMID 9208847. Goltsev YV, Kovalenko AV, Arnold E, Varfolomeev EE, Brodianskii
Caspase_8
Enzyme involved in prostanoid synthesis
vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever"
Cyclooxygenase-3
American biologist (born 1958)
the mammalian homologue of ced-3 known as interleukin-1 beta-converting enzyme(ICE), later called caspase-1. Junying Yuan established an independent lab
Junying_Yuan
Class of pharmaceutical drugs
inflammatory cytokine Interleukin 1 beta (IL-1β) in mice by mTOR inhibition (with rapamycin in doses of 20 mg/kg/day, human equivalent about 1.6 mg/kg/day) has
MTOR_inhibitors
Protein-coding gene in humans
domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on
NOD2
Mammalian protein found in Mus musculus
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells
Interleukin_4
Mammalian protein found in Homo sapiens
subunit and an IL-12p40 subunit. The IL-12p40, also known as Interleukin 12 subunit beta, is used by both IL-23 (where it partners with IL-23p19) and
Interleukin_23_subunit_alpha
Growth factor secreted by stromal cells in the bone marrow and thymus
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone
Interleukin_7
Lymphocyte receptor specific for Interleukin-2
(November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science. 310 (5751): 1159–63. Bibcode:2005Sci
IL-2_receptor
MC, Lin WW (August 2002). "Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation". Exp. Cell Res. 278 (2): 166–74
Lymphotoxin_beta_receptor
Solid, crystalline form of cholesterol
1161/CIRCRESAHA.115.306656. PMC 4793711. PMID 26837745. Libby P (2017). "Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS
Cholesterol_crystal
Interaction motifs found in a wide array of proteins
recruitment domain-containing protein 16 [3] caspase-1: apoptosis-related cysteine peptidase (interleukin 1, beta, convertase; ICE) [4][permanent dead link] caspase-2:
CARD_(domain)
Mammalian protein found in Homo sapiens
Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and
Interleukin_8_receptor,_beta
Protein found in humans
to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme". The Journal of Biological Chemistry. 269 (49):
Caspase_3
Rare genetic disease
There is an increased secretion of the fever promoting cytokine interleukin 1 beta (IL-1β) in MKD, most likely mediated by defective protein prenylation
Mevalonate_kinase_deficiency
Protein-coding gene in the species Homo sapiens
Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene. IL10RB has also been designated CDw210b (cluster
Interleukin 10 receptor, beta subunit
Interleukin_10_receptor,_beta_subunit
Protein found in humans
KR (July 1994). "Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5' leader sequences distinct from the iron responsive
Ferritin_light_chain
Family of transcription factor protein complexes
necrosis factor alpha (TNFα), interleukin 1-beta (IL-1β), bacterial lipopolysaccharides (LPS), isoproterenol, cocaine, endothelin-1 and ionizing radiation.
NF-κB
Protein and coding gene in humans
Interleukin 13 (IL-13) and its relative interleukin-4 are signalling proteins of the adaptive immune systems of vertebrates. They are immunoregulatory
Interleukin_13
an increase in pro-inflammatory cytokines such as TNF-a, Interleukin 6 and Interleukin 1 beta. Halothane and Desflurane were proposed to have similar effects
Complications of anesthetic gases
Complications_of_anesthetic_gases
Protein-coding gene in the species Homo sapiens
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor, is a protein which in humans is encoded by the IL18 gene. The protein encoded
Interleukin_18
Type of programmed cell death
1995). "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme". Science. 267 (5206): 2000–3. Bibcode:1995Sci.
Pyroptosis
Narrowing of the exit of the heart's left ventricle
the release of inflammatory mediators such as interleukin-1-beta and transforming growth factor beta-1 occurs. Subsequently, fibroblasts differentiate
Aortic_stenosis
Mammalian protein found in humans
Leonard WJ (April 1998). "Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent
Janus_kinase_1
American biologist (born 1947)
elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme". Cell. 75 (4): 641–52. doi:10.1016/0092-8674(93)90485-9
H._Robert_Horvitz
Protein found in humans
heterotrimeric G complex, which consists of three subunits: α (alpha), β (beta) and γ (gamma). Several important signalling pathways are triggered by separated
CX3C motif chemokine receptor 1
CX3C_motif_chemokine_receptor_1
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INTERLEUKIN 1-BETA
INTERLEUKIN 1-BETA
INTERLEUKIN 1-BETA
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INTERLEUKIN 1-BETA
INTERLEUKIN 1-BETA
INTERLEUKIN 1-BETA
INTERLEUKIN 1-BETA
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