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Protein domain
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts
Ectodomain
Subfamily of viruses in the family Coronaviridae
forms a layer 7.8 nm thick. It has three domains, a short N-terminal ectodomain, a triple-spanning transmembrane domain, and a C-terminal endodomain.
Coronavirus
participate in a wide variety of cell surface remodeling processes, including ectodomain shedding, regulation of growth factor availability and mediating cell-matrix
Proteases_in_angiogenesis
Mammalian protein found in humans
form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form
Collagen,_type_XVII,_alpha_1
Subunit of the envelope protein complex of retroviruses
Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells. As a result of its importance
Gp41
Protein fragment in Homo sapiens
is roughly 60 kDA in size. This cleaving process is called “receptor ectodomain shedding. In humans and rabbits, tumor-necrosis factor alpha converting
Growth hormone-binding protein
Growth_hormone-binding_protein
Protein found in humans
at the cellular surface. Once cleaved, the sheddases release soluble ectodomains with an altered location and function. Although a single sheddase may
ADAM10
Marker on immune cells
membrane proteins, each with three main regions: an N-terminal extracellular ectodomain (residues 23–182 in CD8A and 23–170 in CD8B), a single transmembrane helix
CD8
Medical condition
PMID 25824603. Joutel A, Andreux F, Gaulis S, et al. (March 2000). "The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL
CADASIL
Cell receptor found in humans
dimer by two disulphide links extending from each α-chain. The overall 3D ectodomain structure, possessing four ligand binding sites, resembles an inverted
Insulin_receptor
Mammalian protein found in Homo sapiens
comprising a short cytoplasmic domain, a transmembrane segment, and an ectodomain consisting of a ~100 kDa fibronectin type III (FNIII) domain. FNDC5 was
FNDC5
Protein-coding gene in the species Homo sapiens
CNS. SORL1 is a multi domain single-pass membrane protein whose large ectodomain resides primarily in endosomal tubules, being connected by its transmembrane
SORL1
Topics referred to by the same term
Desquamation, pathologic or non-pathologic skin shedding Sheddase and Ectodomain shedding Shedding game, a family of card games where the objective is
Shedding
Species of virus
C, V and W. There are two envelope glycoproteins. The G glycoprotein ectodomain assembles as a homotetramer to form the viral anti-receptor or attachment
Nipah_virus
Protein found in humans
releases a soluble 17kDa extracellular domain (ectodomain) from the pro-TNF-α molecule. This soluble ectodomain is the cytokine commonly known as TNF-α, which
ADAM17
Mammalian protein and protein-coding gene
12129. PMID 8647802. Lev S, Yarden Y, Givol D (May 1992). "A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced
KIT_(gene)
Protein family
member were cloned. All syndecans have an N-terminal signal peptide, an ectodomain, a single hydrophobic transmembrane domain, and a short C-terminal cytoplasmic
Syndecan
Protein-coding gene in the species Homo sapiens
consists of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a
TGF_beta_receptor_2
Mammalian protein found in Homo sapiens
endocytic clearance of proteases and inhibitors, proteolytic cleavage of its ectodomain allows the free LRP1 to compete with the membrane-bound form and prevent
LRP1
Enzyme family
extracellular portions of transmembrane proteins, releasing the soluble ectodomains from the cell surface. Many sheddases are members of the ADAM or aspartic
Sheddase
Membrane receptor
transmembrane (TM) protein which consists of a leucine-rich repeat (LRR) ectodomain (extracellular domain), a single transmembrane helix, and a relatively
Glycoprotein_Ib-IX-V_complex
Group of cell surface receptors expressed by leukocytes
glycoproteins with typically small ectodomains of 6 to 10 nm. NTRs have either an N-terminal or C terminal ectodomains. Ectodomains have a high sequence diversity
Non-catalytic tyrosine-phosphorylated receptor
Non-catalytic_tyrosine-phosphorylated_receptor
Subfamily of proteins
Protein Data. "RCSB PDB - 5IRY: Crystal structure of human Desmocollin-1 ectodomain". www.rcsb.org. Retrieved 2020-04-25. Desmocollins at the U.S. National
Desmocollin
Protein-coding gene in the species Homo sapiens
cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by FJX1. The ectodomain of FAT1 can also be shed from the cell
FAT1
Class of immune system proteins
directly by pathogen-associated molecular patterns (PAMPs). Its receptor ectodomain recognizes the cleaved form of the cytokine spätzle, which is secreted
Toll-like_receptor
Mammalian protein found in Homo sapiens
released through the process of ectodomain shedding and are replaced by newly synthesized L-selectin proteins. Ectodomain shedding is largely accomplished
L-selectin
Cholesterol-transporting protein most notably implicated in Alzheimer's disease
regulation of amyloid-beta formation positive regulation of membrane protein ectodomain proteolysis vasodilation intracellular transport synaptic transmission
Apolipoprotein_E
Gonadotropin that regulates the development of reproductive processes
"Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor". Proceedings of the National Academy of Sciences of the
Follicle-stimulating_hormone
Antiretroviral drug used to treat HIV
Gao JL, Shen WP, Grimm MC, Deng X, et al. (June 1999). "T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of
Enfuvirtide
Deadly zoonotic disease
American bat led the modern rabies virus to gain the head of a G-protein ectodomain thousands of years ago. This change occurred in an organism that had both
Rabies_in_animals
Protein-coding gene in the species Homo sapiens
cell migration to bone marrow positive regulation of membrane protein ectodomain proteolysis positive regulation of glucose metabolic process hematopoietic
GPLD1
Protein-coding gene in the species Homo sapiens
87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences
Heparin-binding EGF-like growth factor
Heparin-binding_EGF-like_growth_factor
Subtype of glial cell in the central nervous system
can be cleaved by γ-secretase and translocated to the nucleus. The NG2 ectodomain can also modulate AMPA and NMDA receptor-dependent LTP. Constitutive and
Oligodendrocyte progenitor cell
Oligodendrocyte_progenitor_cell
Mammalian protein found in Homo sapiens
nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis positive regulation of interferon-gamma production MAPK cascade
Interleukin_1_beta
Protein-coding gene in the species Homo sapiens
glycoproteins and lipids. This ectodomain component includes an Ig-like V-type domain, where ligands bind the receptor. The TREM2 ectodomain is modified after protein
TREM2
Protein-coding gene in the species Homo sapiens
2004). "Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory
P2RX3
Protein found in humans
and cerebrospinal fluid., commonly denoted sCD163. It is generated by ectodomain shedding of the membrane bound receptor, which may represent a form of
CD163
Protein-coding gene in the species Homo sapiens
processing positive regulation of catalytic activity membrane protein ectodomain proteolysis Notch receptor processing amyloid precursor protein catabolic
PEN-2
Protein-coding gene in the species Homo sapiens
cytosol membrane protein intracellular domain proteolysis membrane protein ectodomain proteolysis protein homotetramerization signal peptide processing Sources:Amigo
HM13
Protein-coding gene in humans
arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
ADAM9
Immune system messenger protein which induces inflammation
regulation of interleukin-6 production positive regulation of membrane protein ectodomain proteolysis positive regulation of humoral immune response mediated by
Tumor_necrosis_factor
Family of proteolytic enzymes
known as APPsα - into the extracellular environment in a process known as ectodomain shedding. ADAM10 consists of two protein domains, a disintegrin domain
Alpha_secretase
Family of proteins
are homologous to EGFR, but lack sequences within the ligand binding ectodomain. All four ErbB receptor family members are nearly same in the structure
ErbB
Mammalian protein found in Homo sapiens
839068. PMID 19738140. Lev S, Yarden Y, Givol D (May 1992). "A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced
Stem_cell_factor
Genetically engineered T cell
antigen recognition domain is exposed to the outside of the cell, in the ectodomain portion of the receptor. It interacts with potential target molecules
CAR_T_cell
Protein-coding gene in the species Homo sapiens
growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to
CELSR2
Protein receptor active in neurons
also be found in soluble forms created by alternative splicing or by ectodomain shedding from the cell surface. The pleiotropic nature of the NRP receptors
Neuropilin
Protein-coding gene in the species Homo sapiens
regulation of ERK1 and ERK2 cascade negative regulation of membrane protein ectodomain proteolysis visual perception platelet degranulation response to organic
TIMP3
Belgian molecular biologist (1931–2019)
based on the M2 protein on the surface of the influenza A virus. The ectodomain of the M2 protein remains unchanged in all human influenza viruses known
Walter_Fiers
Protein-coding gene in humans
epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to
CELSR1
Protein-coding gene in the species Homo sapiens
proliferation response to hormone negative regulation of membrane protein ectodomain proteolysis negative regulation of endopeptidase activity negative regulation
TIMP1
Protein-coding gene in the species Homo sapiens
and other enzymes present in the ECM. Proteolytic cleavage releases an ectodomain containing two binding sites for TGF-beta. Due to high affinity to its
TGFBR3
Family of four EGF proteins
NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds
Neuregulin
Protein domain
(ICAM) cell adhesion molecules. CD2 mediates T-cell adhesion via its ectodomain, and signal transduction utilising its 117-amino acid cytoplasmic tail
Immunoglobulin_C2-set_domain
Protein-coding gene in humans
of gonadotropin and TSH receptors. The cysteine residues flanking the ectodomain form stabilising disulfide bonds that support the secondary structure
LGR5
Species of virus
this particle to the host cell. Each E protein monomer comprises three ectodomains, ED1 to ED3, and a transmembrane segment. ED2 includes the dimerization
Dengue_virus
Medical condition
receptor (GHR). These can result in defective hormone binding to the ectodomain or reduced efficiency of dimerization of the receptor after hormone occupancy
Laron_syndrome
British-American virologist (1950–2023)
their replication. Fields Virology (2001) Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein. Proceedings of the National
Robert_A._Lamb
Enzyme found in humans
the primary protease responsible for the release of the amyloidogenic ectodomain of Pmel17 in melanocytes, a process essential for the formation of the
Beta-secretase_2
InterPro Family
cholinergic response to virus positive regulation of membrane protein ectodomain proteolysis positive regulation of epithelial cell migration positive
Interferon_gamma
Substance that causes red blood cells to agglutinate
subdomain forms elastic protein chains linking the hemagglutinin to the ectodomain. On the viral capsids of influenza types A and B, hemagglutinin is initially
Hemagglutinin
Protein-coding gene in the species Homo sapiens
protein reveal that, when complexed with the ligand neurotensin, the Vps10 ectodomain of sortilin forms a ten-bladed beta-propeller structure with an inner
Sortilin_1
Protein-coding gene in the species Homo sapiens
'tail' is embedded in the phospholipid bilayer and the upper and lower ectodomains form the 'head' and 'body' respectively. Adjacent interfaces of the subunits
P2RX4
Protein domain
disintegrin and metalloproteinase with thrombospondin motifs) family Ectodomain shedding Brocker, C; Vasiliou, V; Nebert, DW (October 2009). "Evolutionary
ADAM_(protein)
Chinese-born American biochemist
N-Terminal Fusion Peptide Solubilizes the Influenza Virus HA2Subunit Ectodomain†". Biochemistry. 37 (39): 13643–13649. doi:10.1021/bi981098l. ISSN 0006-2960
Jue_Chen_(scientist)
Protein-coding gene in the species Homo sapiens
Jindrichova M, Kuzyk P, Li S, Stojilkovic SS, Zemkova H (June 2012). "Conserved ectodomain cysteines are essential for rat P2X7 receptor trafficking". Purinergic
P2RX7
Classification of blood types
A. (April 2023). "Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation". Journal of Thrombosis and Haemostasis. 21 (4): 995–1009
ABO_blood_group_system
Mammalian protein found in Homo sapiens
Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported
Neprilysin
Protein-coding gene in the species Homo sapiens
human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347
MAN1A1
Protein-coding gene in the species Homo sapiens
each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.[supplied by OMIM] BOC (gene)
BOC_(gene)
Family of transport proteins
repel beta2. A disintegrin and metalloproteinase (ADAM) 10 sheds beta 2's ectodomain possibly inducing neurite outgrowth. Beta 3 and beta 1 bind to neurofascin
Voltage-gated_sodium_channel
Model for the mechanism of T-cell receptor triggering
TCR/peptide-MHC complex. Phosphatases CD45 and CD148 with much larger ectodomains than TCR are sterically excluded from the close contact zones, while
Kinetic-segregation model of T cell activation
Kinetic-segregation_model_of_T_cell_activation
Protein-coding gene in humans
Gaulis S, Domenga V, Cecillon M, Battail N, et al. (March 2000). "The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL
NOTCH3
Protein-coding gene in humans
human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347
Β-Mannosidase
Protein-coding gene in the species Homo sapiens
interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not
TIMP2
Protein-coding gene in the species Homo sapiens
predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively
RNF43
Mammalian protein found in Homo sapiens
N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding". The Journal of Biological Chemistry. 290 (3): 1654–1663. doi:10
CORIN
Protein found in humans
(July 2005). "Crystal structure of human toll-like receptor 3 (TLR3) ectodomain". Science. 309 (5734): 581–585. Bibcode:2005Sci...309..581C. doi:10.1126/science
Toll-like_receptor_3
Protein-coding gene in the species Homo sapiens
formation mitotic cytokinesis positive regulation of membrane protein ectodomain proteolysis receptor-mediated endocytosis plasma membrane tubulation cell
SNX9
Protein-coding gene in the species Homo sapiens
M, Aulabaugh A, et al. (November 2006). "The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition". The
LINGO1
Type of protein
precursor protein (APP) and Notch. Substrate recognition occurs via nicastrin ectodomain binding to the N-terminus of the target, which is then passed via a poorly
Gamma_secretase
Protein-coding gene in the species Homo sapiens
The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural
PCDHA9
Gene found in coronaviruses of the Betacoronavirus genus
a type I transmembrane protein with an N-terminal signal peptide, an ectodomain that has an immunoglobulin fold, and a C-terminal endoplasmic reticulum
ORF7a
Protein superfamily
Sebald W, Dreyer MK (June 2000). "Crystal structure of the BMP-2-BRIA ectodomain complex". Nature Structural Biology. 7 (6): 492–6. doi:10.1038/75903.
Three-finger_protein
Enzyme found in humans
post-translationally by metalloproteinases which cause shedding of the enzyme's ectodomain. Unlike other CA isozymes, CA IX is not inhibited by high lactate concentrations
Carbonic_anhydrase_9
Protein hormone
contain a heptahelical transmembrane domain and a large glycosylated ectodomain, distantly related to the receptors for the glycoproteohormones, such
Relaxin
Protein-coding gene in the species Homo sapiens
human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347
MGAT2
Glycoprotein present in some enveloped viruses
esterase fusion trimer using X-ray crystallography of the bromelain-cleaved ectodomain. Both hemagglutinin and hemagglutinin esterase fusion protein are similar
Hemagglutinin_esterase
Protein-coding gene in humans
involved in inflammatory response positive regulation of membrane protein ectodomain proteolysis positive regulation of protein kinase B signaling positive
ADAM8
Protein-coding gene in the species Homo sapiens
GnT-V in these cells increased the cleavage and shedding of PTPkappa ectodomain and increased migration of WiDr cells in transwell assays. As a result
PTPRK
Protein-coding gene in the species Homo sapiens
Samulowitz U, Fachinger G, et al. (September 2002). "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts"
PTPRB
Protein-coding gene in the species Homo sapiens
diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor
Herpesvirus_entry_mediator
Mammalian protein found in Homo sapiens
et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. Bibcode:2003BBRC..309
NCR1
Medication
also known as CDKN1B. Trastuzumab has been shown to inhibit HER2/neu ectodomain cleavage in breast cancer cells. Experiments in laboratory animals indicate
Trastuzumab
Protein-coding gene in the species Homo sapiens
Lichtenthaler SF, Lemberg MK, Fluhrer R (August 2018). "Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent
Rhomboid-related_protein_2
Protein-coding gene in the species Homo sapiens
human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/JVI.67.1.150-160.1993. PMC 237347
MANEA
Mammalian protein found in Homo sapiens
trimeric transmembrane protein, (2) primary secreted form, and (3) truncated ectodomain. RANKL is identified as a part of the TNF family; RANKL is specifically
RANKL
Class of enzymes
transmembrane part reaching through the cellular membrane, and a large cellular ectodomain sticking out of the cell containing the active site. Metalloaminopeptidases
Aminopeptidase
Protein-coding gene in the species Homo sapiens
regulation of norepinephrine secretion positive regulation of membrane protein ectodomain proteolysis negative regulation of insulin secretion involved in cellular
Alpha-2A_adrenergic_receptor
Protein family
Ludwig A, Frank M, Saftig P (August 2006). "Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion". The
Protocadherin
ECTODOMAIN
ECTODOMAIN
ECTODOMAIN
ECTODOMAIN
Boy/Male
Hindu, Indian, Sanskrit
Connection
Boy/Male
Muslim
Blossoms, Flowers
Female
English
Anglicized unisex form of Scottish Gaelic Aonghas, INNES means "excellent valor."Â
Boy/Male
Hindu
Lamp
Boy/Male
Tamil
Scanda | ஸà¯à®•à®¾à®‚டாÂ
Lord Murugan
Surname or Lastname
English (Lancashire)
English (Lancashire) : habitational name from a place in Lancashire named Brindle, from Old English burna ‘stream’ + hyll ‘hill’.Altered spelling of South German Brindl, Bründl, a topographic name for someone who lived by a spring or stream, from a diminutive of Middle High German brun(ne) ‘spring’, ‘stream’, or of Brendle or Brendel.
Male
Icelandic
Icelandic form of Old Norse Hallþórr, HALLDÓR means "Thor's rock."
Boy/Male
Hindu
Lord of law or one who is well versed in law, Name of Lord Shiva
Girl/Female
English
which is the Greek form of Elijah.
Surname or Lastname
North German
North German : metonymic occupational name for a cooper, from Middle Low German budde ‘tub’, ‘vat’. Compare Buettner.German and Danish : from a derivative of the Germanic personal name Bodo, cognate with English Budd.English : variant spelling of Budd.
ECTODOMAIN
ECTODOMAIN
ECTODOMAIN
ECTODOMAIN
ECTODOMAIN