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APOLIPOPROTEIN E

  • Apolipoprotein E
  • Cholesterol-transporting protein most notably implicated in Alzheimer's disease

    Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular

    Apolipoprotein E

    Apolipoprotein E

    Apolipoprotein_E

  • Apolipoprotein
  • Proteins that bind lipids to transport them in body fluids

    Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fats, cholesterol and fat soluble vitamins) to form lipoproteins. They transport

    Apolipoprotein

    Apolipoprotein

    Apolipoprotein

  • Apolipoprotein B
  • Protein found in humans

    Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. Its measurement is commonly used to detect the risk of atherosclerotic

    Apolipoprotein B

    Apolipoprotein B

    Apolipoprotein_B

  • Lipoprotein
  • Biochemical assembly for transporting hydrophobic lipid molecules

    of apolipoprotein C-II and apolipoprotein E to the nascent chylomicron. The chylomicron at this stage is then considered mature. Via apolipoprotein C-II

    Lipoprotein

    Lipoprotein

    Lipoprotein

  • Apolipoprotein AI
  • Protein used in lipid metabolism

    Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene. As the major component of high-density lipoprotein (HDL) particles

    Apolipoprotein AI

    Apolipoprotein AI

    Apolipoprotein_AI

  • Low-density lipoprotein receptor-related protein 8
  • Cell surface receptor, part of the low-density lipoprotein receptor family

    Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the

    Low-density lipoprotein receptor-related protein 8

    Low-density lipoprotein receptor-related protein 8

    Low-density_lipoprotein_receptor-related_protein_8

  • Biological specificity
  • Tendency of a characteristic to occur in a particular species

    humans is the gene apolipoprotein E (APOE4) on chromosome 19. While chimpanzees may have the APOE gene, the study "The apolipoprotein E (APOE) gene appears

    Biological specificity

    Biological_specificity

  • Donanemab
  • Monoclonal antibody against amyloid beta

    Alzheimer's disease (early symptomatic Alzheimer's disease) who are apolipoprotein E ε4 (ApoE ε4) heterozygotes or non-carriers with confirmed amyloid pathology

    Donanemab

    Donanemab

  • David M. Holtzman
  • Medical researcher

    underlying neurodegeneration. Holtzman's work has studied mechanisms by which apoE, amyloid beta, and tau metabolism are implicated in neurodegeneration in the

    David M. Holtzman

    David M. Holtzman

    David_M._Holtzman

  • Apolipoprotein C-III
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is secreted by

    Apolipoprotein C-III

    Apolipoprotein C-III

    Apolipoprotein_C-III

  • Alzheimer's disease
  • Progressive neurodegenerative disease

    development. The strongest genetic risk factor is from an allele of apolipoprotein E, a protein involved in the metabolism of fats in mammals. Other risk

    Alzheimer's disease

    Alzheimer's disease

    Alzheimer's_disease

  • Cholesterol
  • Sterol biosynthesized by all animal cells

    dense cholesterol transport particles, contain apolipoprotein B-48, apolipoprotein C, and apolipoprotein E (the principal cholesterol carrier in the brain)

    Cholesterol

    Cholesterol

    Cholesterol

  • Very low-density lipoprotein
  • One of the five major groups of lipoprotein

    Nascent VLDL released from the liver contains apolipoprotein B100, apolipoprotein C1 (apoC1), apolipoprotein E (apoE), cholesterol, cholesteryl esters, and triglycerides

    Very low-density lipoprotein

    Very_low-density_lipoprotein

  • Dendritic cell
  • Accessory cell of the mammalian immune system

    from apolipoprotein E." (PDF). J Immunol. 181 (10): 6859–71. doi:10.4049/jimmunol.181.10.6859. PMID 18981105. S2CID 23966566. Bellemore SM, Nikoopour E, Au

    Dendritic cell

    Dendritic cell

    Dendritic_cell

  • Antagonistic pleiotropy hypothesis
  • Proposed evolutionary explanation for senescence

    Jasienski M, Kalemba-Drozdz M, Kapiszewska M, et al. (2015-03-22). "Apolipoprotein E ( ApoE ) polymorphism is related to differences in potential fertility

    Antagonistic pleiotropy hypothesis

    Antagonistic pleiotropy hypothesis

    Antagonistic_pleiotropy_hypothesis

  • Kidney ischemia
  • Kidney disease

    increase or decrease risk of renal ischemic injury. Genes such as Apolipoprotein E (APO E), which controls cholesterol metabolism, NADPH Oxidase which regulates

    Kidney ischemia

    Kidney_ischemia

  • Apolipoprotein D
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein D (ApoD) is a protein that in humans is encoded by the APOD gene. Unlike other lipoproteins, which are mainly produced in the liver, apolipoprotein

    Apolipoprotein D

    Apolipoprotein D

    Apolipoprotein_D

  • Dementia with Lewy bodies
  • Type of progressive dementia

    Berge G, Sando SB, Rongve A, Aarsland D, White LR (November 2014). "Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian

    Dementia with Lewy bodies

    Dementia with Lewy bodies

    Dementia_with_Lewy_bodies

  • Cerebral amyloid angiopathy
  • Disease of blood vessels of the brain

    cleavage of the APP into Aβ. An immune mechanism has also been proposed. Apolipoprotein E (APOE) subtypes ε2 and ε4 are associated with an increased risk of

    Cerebral amyloid angiopathy

    Cerebral amyloid angiopathy

    Cerebral_amyloid_angiopathy

  • Astrocyte
  • Type of brain cell

    are the major source of cholesterol in the central nervous system. Apolipoprotein E transports cholesterol from astrocytes to neurons and other glial cells

    Astrocyte

    Astrocyte

    Astrocyte

  • Amyloid-beta precursor protein
  • Mammalian protein found in humans

    as a likely explanation for observations that high cholesterol and apolipoprotein E genotype are major risk factors for Alzheimer's disease. Although the

    Amyloid-beta precursor protein

    Amyloid-beta precursor protein

    Amyloid-beta_precursor_protein

  • Mendelian randomization
  • Statistical method in genetic epidemiology

    Research, Netherlands) in which he advocated a study design using Apolipoprotein E allele as an anchor to study the observed relationship between low

    Mendelian randomization

    Mendelian randomization

    Mendelian_randomization

  • Apolipoprotein C-IV
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene. APOC4 is a member of the apolipoprotein

    Apolipoprotein C-IV

    Apolipoprotein C-IV

    Apolipoprotein_C-IV

  • Fish scale
  • Hard skeletal covering of fish

    The apolipoprotein E (ApoE), which allows the transport and metabolism of triglycerides and cholesterol, has an interaction with shh, because ApoE provides

    Fish scale

    Fish scale

    Fish_scale

  • Lipoprotein(a)
  • Low-density lipoprotein containing apolipoprotein(a)

    Lipoprotein(a) is a low-density lipoprotein variant containing a protein called apolipoprotein(a). Genetic and epidemiological studies have identified lipoprotein(a)

    Lipoprotein(a)

    Lipoprotein(a)

    Lipoprotein(a)

  • Chylomicron
  • One of the five major groups of lipoprotein

    lipoproteins (HDLs) donate essential components including apolipoprotein C-II (APOC2) and apolipoprotein E (APOE) to the mature chylomicron. APOC2 is a crucial

    Chylomicron

    Chylomicron

    Chylomicron

  • Granzyme
  • Class of proteins

    separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice". PLOS ONE. 8 (10) e78939. Bibcode:2013PLoSO...878939H

    Granzyme

    Granzyme

  • Wax ester
  • Ester of a fatty acid and a fatty alcohol

    E. (2012). "A wax ester and astaxanthin-rich extract from the marine copepod Calanus finmarchicus attenuates atherogenesis in female apolipoprotein E-deficient

    Wax ester

    Wax_ester

  • Sulfatide
  • Class of compounds

    has been studied by looking at apolipoprotein E (apoE), specifically the ε4 allele. The ε4 allele of apolipoprotein E is the only known genetic risk factor

    Sulfatide

    Sulfatide

  • Bennet Omalu
  • Nigerian-American forensic pathologist and neuropathologist

    Caroline G; Mohammed, Nebil; Lam, Troy; Yue, John K (September 1, 2018). "Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development

    Bennet Omalu

    Bennet Omalu

    Bennet_Omalu

  • Atherosclerosis
  • Inflammatory disease involving a buildup of lesions in the walls of arteries

    Allahverdian S, Asonye E, Sahin B, Jaw JE, et al. (May 2019). "Smooth Muscle Cells Contribute the Majority of Foam Cells in ApoE (Apolipoprotein E)-Deficient Mouse

    Atherosclerosis

    Atherosclerosis

    Atherosclerosis

  • Dementia
  • Cognitive decline

    American subjects exhibit lower risks associated with gene changes in the apolipoprotein E gene than do non-Hispanic white subjects. In the United States in 2017

    Dementia

    Dementia

    Dementia

  • Common disease-common variant
  • Hypothesis for alleles

    The hypothesis has held in the case of putative causal variants in apolipoprotein E, including APOE ε4, associated with Alzheimer's disease. IL23R has

    Common disease-common variant

    Common_disease-common_variant

  • Apolipoprotein C-I
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein C-I is a protein component of lipoproteins that in humans is encoded by the APOC1 gene. The protein encoded by this gene is a member of

    Apolipoprotein C-I

    Apolipoprotein C-I

    Apolipoprotein_C-I

  • Amyloid plaques
  • Extracellular deposits of the amyloid beta protein

    distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)". Proceedings of the National

    Amyloid plaques

    Amyloid plaques

    Amyloid_plaques

  • LRP1
  • Mammalian protein found in Homo sapiens

    protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein

    LRP1

    LRP1

    LRP1

  • Inclusion body myositis
  • Inflammatory muscle disease in older adults

    of proteins, including amyloid-β (Aβ), tau, ubiquitinated proteins, apolipoprotein E, and β-synuclein in skeletal muscle. ... active immunization markedly

    Inclusion body myositis

    Inclusion_body_myositis

  • Lothian birth-cohort studies
  • included the investigation of the influence of the E4 allele on the Apolipoprotein E (APOE) gene on cognitive ageing as well as testing the effects of other

    Lothian birth-cohort studies

    Lothian_birth-cohort_studies

  • Reelin
  • Large secreted extracellular matrix glycoprotein involved in neuronal migration

    role was unknown until then.[citation needed] The Reelin receptors, apolipoprotein E receptor 2 (ApoER2) and very-low-density lipoprotein receptor (VLDLR)

    Reelin

    Reelin

    Reelin

  • Aging brain
  • Degradation of functioning of the brain

    Gallo, Linda C.; Zeng, Donglin; Fornage, Myriam (December 2018). "Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation

    Aging brain

    Aging_brain

  • Lipoprotein receptor-related protein
  • Protein family

    They include: LRP1 LRP1B LRP2 (megalin) LRP3 LRP4 LRP5 LRP6 LRP8, apolipoprotein e receptor LRP10 LRP11 LRP12 LRPAP1 (low density lipoprotein receptor-related

    Lipoprotein receptor-related protein

    Lipoprotein_receptor-related_protein

  • LDL receptor
  • Mammalian protein found in Homo sapiens

    recognizes apolipoprotein B100 (ApoB100), which is embedded in the outer phospholipid layer of very low-density lipoprotein (VLDL), their remnants—i.e. intermediate-density

    LDL receptor

    LDL receptor

    LDL_receptor

  • Vitellogenin
  • Protein family

    I-like lipid antigen presenting molecule. Apolipoprotein B can exist in two forms: B-100 and B-48. Apolipoprotein B-100 is present on several lipoproteins

    Vitellogenin

    Vitellogenin

  • Nun Study
  • Alzheimer's article on nuns

    abilities, even if not having exercised before. In 1992, a gene called apolipoprotein E was established as a possible factor in Alzheimer's disease, but its

    Nun Study

    Nun_Study

  • Jan Breslow
  • American physician and medical researcher

    different variants of human apolipoprotein E (ApoE), a component of very low-density lipoprotein. People with different ApoE variants are now known to have

    Jan Breslow

    Jan_Breslow

  • Macular degeneration
  • Vision loss due to damage to the macula of the eye

    genetic variations associated with AMD includes complement factors, apolipoprotein E, fibroblast growth factor 2, DNA excision repair protein, and age-related

    Macular degeneration

    Macular degeneration

    Macular_degeneration

  • Gladys Maestre
  • Venezuela-born Neuroscientist

    memory-based diseases, demonstrating that the presence of the Ԑ4 allele of the apolipoprotein gene is related to the risk of Alzheimer's disease. Maestre has led

    Gladys Maestre

    Gladys Maestre

    Gladys_Maestre

  • Lecanemab
  • Monoclonal antibody against amyloid beta

    one or no copy of ApoE4, a certain form of the gene for the protein apolipoprotein E. Lecanemab was authorized for medical use in the European Union in

    Lecanemab

    Lecanemab

  • Behavioural genetics
  • Study of genetic-environment interactions influencing behaviour

    Schmechel DE, Gaskell PC, et al. (June 1994). "Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease". Nature Genetics. 7

    Behavioural genetics

    Behavioural genetics

    Behavioural_genetics

  • Smith–Lemli–Opitz syndrome
  • Recessive genetic condition

    excretion of toxic metabolites may vary from person to person. Maternal apolipoprotein E has also been implicated in individual variability in SLOS, although

    Smith–Lemli–Opitz syndrome

    Smith–Lemli–Opitz syndrome

    Smith–Lemli–Opitz_syndrome

  • Aldehyde dehydrogenase
  • Group of enzymes

    allele was a risk of late-onset Alzheimer's disease independent of the apolipoprotein E gene (the odds for LOAD in carriers of ALDH2*2 allele almost twice

    Aldehyde dehydrogenase

    Aldehyde dehydrogenase

    Aldehyde_dehydrogenase

  • Biochemistry of Alzheimer's disease
  • disease, such as patients homozygous for the epsilon 4 variant of the apolipoprotein E gene (APOE4, a genetic risk factor for Alzheimer's disease), as well

    Biochemistry of Alzheimer's disease

    Biochemistry_of_Alzheimer's_disease

  • Nerve injury
  • Damage to nervous tissue

    produce apolipoprotein E which is involved in rescuing cholesterol in damaged nerves. In the same investigation, temporal levels of apolipoprotein E mRNA

    Nerve injury

    Nerve injury

    Nerve_injury

  • E-box
  • DNA response element in some eukaryotes

    "Identification of a non-canonical E-box motif as a regulatory element in the proximal promoter region of the apolipoprotein E gene". The Biochemical Journal

    E-box

    E-box

  • Hypothalamic–pituitary–gonadal axis
  • Relationship between biological organs

    associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele". BMC Med. Genet. 9 37. doi:10.1186/1471-2350-9-37

    Hypothalamic–pituitary–gonadal axis

    Hypothalamic–pituitary–gonadal axis

    Hypothalamic–pituitary–gonadal_axis

  • Atheroma
  • Accumulation of degenerative material in the inner layer of artery walls

    Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice". Biomolecules. 12 (9). MDPI AG: 1205. doi:10.3390/biom12091205

    Atheroma

    Atheroma

    Atheroma

  • C-reactive protein
  • Mammalian protein found in humans

    associated to point mutation Cys130Arg in the APOE gene, coding for apolipoprotein E, establishing a link between lipid values and inflammatory markers

    C-reactive protein

    C-reactive protein

    C-reactive_protein

  • Margaret Pericak-Vance
  • American human geneticist

    findings of genes that increase the risk of certain diseases, such as apolipoprotein E and Alzheimer's disease, interleukin-7 receptor and multiple sclerosis

    Margaret Pericak-Vance

    Margaret_Pericak-Vance

  • VLDL receptor
  • Protein found in humans

    receptor has an important role in cholesterol uptake, metabolism of apolipoprotein E-containing triacylglycerol-rich lipoproteins, and neuronal migration

    VLDL receptor

    VLDL receptor

    VLDL_receptor

  • Apolipoprotein L1
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different isoforms have been found for

    Apolipoprotein L1

    Apolipoprotein L1

    Apolipoprotein_L1

  • Subarachnoid hemorrhage
  • Bleeding into the brain's subarachnoid space

    example, having two copies of ApoE4 (a variant of the gene encoding apolipoprotein E that also plays a role in Alzheimer's disease) seems to increase risk

    Subarachnoid hemorrhage

    Subarachnoid hemorrhage

    Subarachnoid_hemorrhage

  • APOA5
  • Protein-coding gene in humans

    Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. It is significantly expressed in liver. The protein encoded

    APOA5

    APOA5

    APOA5

  • Familial dysbetalipoproteinemia
  • Medical condition

    patients. This condition is more likely when a mutation in apolipoprotein E (ApoE) is present. ApoE serves as a ligand for the liver receptor for chylomicrons

    Familial dysbetalipoproteinemia

    Familial dysbetalipoproteinemia

    Familial_dysbetalipoproteinemia

  • DNA methylation
  • Biological process

    polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E". The Journal of Biological Chemistry. 279 (28): 29147–29154. doi:10

    DNA methylation

    DNA methylation

    DNA_methylation

  • Extracellular vesicle
  • Vesicles found outside cells

    PMID 27176225. Nikitidou E, Khoonsari PE, Shevchenko G, Ingelsson M, Kultima K, Erlandsson A (2017). "Increased Release of Apolipoprotein E in Extracellular Vesicles

    Extracellular vesicle

    Extracellular_vesicle

  • Nobuyo Maeda
  • Japanese geneticist

    Maeda and her coworkers found that deleting the mouse gene for apolipoprotein E (ApoE) – a component of very low-density lipoprotein – caused the animals

    Nobuyo Maeda

    Nobuyo_Maeda

  • Alzheon
  • S2CID 207844779. Hauser, Paul S.; Ryan, Robert O. (October 2013). "Impact of Apolipoprotein E on Alzheimer's Disease". Current Alzheimer Research. 10 (8): 809–817

    Alzheon

    Alzheon

  • Alzheimer's disease and COVID-19
  • primary genetic risk factor for late onset AD is the presence of the Apolipoprotein E (APOE) 4 allele. APOE is a protein that is responsible for transporting

    Alzheimer's disease and COVID-19

    Alzheimer's disease and COVID-19

    Alzheimer's_disease_and_COVID-19

  • DAB1
  • Protein-coding gene in humans

    receptors, very low density lipoprotein receptor (VLDLR; 192977) and apolipoprotein E receptor-2 (ApoER2; 602600), are also required. Both receptors bound

    DAB1

    DAB1

    DAB1

  • Methylenetetrahydrofolate reductase
  • Rate-limiting enzyme in the methyl cycle

    Nishiyama M, Kato Y, Hashimoto M, Yukawa S, Omori K (May 2000). "Apolipoprotein E, methylenetetrahydrofolate reductase (MTHFR) mutation and the risk

    Methylenetetrahydrofolate reductase

    Methylenetetrahydrofolate reductase

    Methylenetetrahydrofolate_reductase

  • Apolipoprotein A-II
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. It is the second most abundant protein of the high density lipoprotein particles

    Apolipoprotein A-II

    Apolipoprotein A-II

    Apolipoprotein_A-II

  • Cajal–Retzius cell
  • Cell that guides radial neuronal migration

    including the very low density lipoprotein receptor (VLDLR), the apolipoprotein E receptor type 2 (ApoER2), and the cytoplasmic adapter protein disabled

    Cajal–Retzius cell

    Cajal–Retzius_cell

  • Apolipoprotein C
  • Chemical compound

    In the field of molecular biology, apolipoprotein C is a family of four low molecular weight apolipoproteins, designated as C-I, C-II, C-III, and C-IV

    Apolipoprotein C

    Apolipoprotein_C

  • Biology of depression
  • Branch of biology concerning depressive disorders in humans

    analysis of 182 case controlled genetic studies published in 2008 found Apolipoprotein E epsilon 2 to be protective, and GNB3 825T, MTHFR 677T, SLC6A4 44bp

    Biology of depression

    Biology_of_depression

  • SCARB1
  • Mammalian protein

    Tailleux A, Fruchart JC, Siest G, Clavey V (September 2002). "Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances

    SCARB1

    SCARB1

    SCARB1

  • Apolipoprotein C-II
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene

    Apolipoprotein C-II

    Apolipoprotein C-II

    Apolipoprotein_C-II

  • Thiosalicylic acid
  • Chemical compound

    S-trans,trans-Farnesyl Thiosalicylic Acid Attenuates Atherosclerosis in Apolipoprotein E Knockout Mice". Circulation. 105 (20): 2416–2422. doi:10.1161/01.CIR

    Thiosalicylic acid

    Thiosalicylic_acid

  • Apolipoprotein H
  • Protein-coding gene in humans

    β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded

    Apolipoprotein H

    Apolipoprotein H

    Apolipoprotein_H

  • Harald Hampel
  • Holtzman, David M.; Apostolova, Liana G.; Hampel, Harald; et al.: Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical

    Harald Hampel

    Harald Hampel

    Harald_Hampel

  • Blood lipids
  • Lipids in the blood, either free or bound to other molecules

    are ultimately taken up by liver hepatocytes via interaction between apolipoprotein E and the LDL receptor or lipoprotein receptor-related proteins. Cholesterol

    Blood lipids

    Blood_lipids

  • Olfactory tubercle
  • Area at the bottom of the forebrain

    in olfactory functioning due to Alzheimer's disease and the role of apolipoprotein E in olfaction". Annals of the New York Academy of Sciences. 855 (1):

    Olfactory tubercle

    Olfactory tubercle

    Olfactory_tubercle

  • Boston criteria
  • Diagnostic criteria for cerebral amyloid angiopathy

    in 1995 through the Methods segment of an analysis of CAA and the apolipoprotein E ε4 allele. This was further elaborated in 1996, where the criteria

    Boston criteria

    Boston_criteria

  • Japanese Americans
  • Americans of Japanese ancestry

    second generation pro-bands. Also, research has been put on concerning apolipoprotein E genotypes; this polymorphism has three alleles (*e2, *e3, and *e4)

    Japanese Americans

    Japanese Americans

    Japanese_Americans

  • Alpha-7 nicotinic receptor
  • Type of cell receptor found in humans

    Xianbao (January 2017). "Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on

    Alpha-7 nicotinic receptor

    Alpha-7 nicotinic receptor

    Alpha-7_nicotinic_receptor

  • Causal model
  • Conceptual model in philosophy of science

    1080/00325481.1979.11715231. PMID 450828. Katan MB (March 1986). "Apolipoprotein E isoforms, serum cholesterol, and cancer". Lancet. 1 (8479): 507–8.

    Causal model

    Causal model

    Causal_model

  • Alzheimer's disease in the Hispanic/Latino population
  • component of AD, with mutations in the amyloid precursor protein (APP), apolipoprotein E APOE), presenilin 1 (PSEN1), bridging Integrator 1 (BIN1), SORL1, and

    Alzheimer's disease in the Hispanic/Latino population

    Alzheimer's_disease_in_the_Hispanic/Latino_population

  • Porphyromonas gingivalis
  • Species of bacterium

    H, Chen J, Lien E, et al. (June 2004). "Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice"

    Porphyromonas gingivalis

    Porphyromonas_gingivalis

  • SORL1
  • Protein-coding gene in the species Homo sapiens

    Gearing M, Rees HD, Fang G, Heilman CJ, et al. (August 2004). "Loss of apolipoprotein E receptor LR11 in Alzheimer disease". Archives of Neurology. 61 (8):

    SORL1

    SORL1

    SORL1

  • KLF4
  • Protein-coding gene in the species Homo sapiens

    polarization and plaque formation in atherosclerosis. It up-regulates Apolipoprotein E, which is an anti-atherosclerotic factor. It is also involved in the

    KLF4

    KLF4

    KLF4

  • Alzheimer's disease among East Asians
  • susceptibility loci. The genotype of apolipoprotein E (ApoE) is the strongest genetic risk factor for sporadic AD. ApoE is a multifunctional protein that

    Alzheimer's disease among East Asians

    Alzheimer's_disease_among_East_Asians

  • Central nervous system effects from radiation exposure during spaceflight
  • Space radiation effects on the brain

    injury, such as concussion. Apolipoprotein E (ApoE) has been shown to be an important and common factor in CNS responses. ApoE controls the redistribution

    Central nervous system effects from radiation exposure during spaceflight

    Central_nervous_system_effects_from_radiation_exposure_during_spaceflight

  • Memory disorder
  • Damage to the brain's memory capacity

    Along with these biological factors, when the patient also had the apolipoprotein E (ApoE4) allele (a known genetic risk factor for Alzheimer's disease)

    Memory disorder

    Memory_disorder

  • Lipoprotein-associated phospholipase A2
  • Protein-coding gene in the species Homo sapiens

    injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice". Circulation. 103 (20): 2495–500. doi:10.1161/01.cir

    Lipoprotein-associated phospholipase A2

    Lipoprotein-associated phospholipase A2

    Lipoprotein-associated_phospholipase_A2

  • APOF
  • Protein-coding gene in the species Homo sapiens

    Apolipoprotein F is a protein that in humans is encoded for by the APOF gene. The product of this gene is one of the minor apolipoproteins found in plasma

    APOF

    APOF

    APOF

  • Peter St George-Hyslop
  • British-Canadian neurologist and neuroscientist

    discovery of the presenilins (PSEN1 and PSEN2), Nicastrin, TREM2, Apolipoprotein E and SORL1 genes. Presenilin mutations are the most common cause of

    Peter St George-Hyslop

    Peter_St_George-Hyslop

  • Yo-El Ju
  • South Korean neurologist (born 1979)

    in bed to match the time asleep, can attenuate the effects of the apolipoprotein E ε4 genotype on the development of incident Alzheimer's Disease. Many

    Yo-El Ju

    Yo-El Ju

    Yo-El_Ju

  • Homeostatic plasticity
  • Capacity of neurons to regulate their own excitability relative to network activity

    Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G (September 2019). "Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies". Nature

    Homeostatic plasticity

    Homeostatic plasticity

    Homeostatic_plasticity

  • Prevention of dementia
  • Possible prevention methods of dementia

    M (2004). "Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population". Neuroepidemiology. 23 (3):

    Prevention of dementia

    Prevention_of_dementia

  • Nitrotyrosine
  • Chemical compound

    antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice". Kidney International. 67 (6): 2288–2294. doi:10.1111/j

    Nitrotyrosine

    Nitrotyrosine

    Nitrotyrosine

  • Alzheimer's Disease Neuroimaging Initiative
  • Multisite study

    the major AD genetic risk factor, APOE ε4, the gene for a form of apolipoprotein E, and other studies lumbar puncture to collect cerebrospinal fluid (CSF)

    Alzheimer's Disease Neuroimaging Initiative

    Alzheimer's_Disease_Neuroimaging_Initiative

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APOLIPOPROTEIN E

  • Eves
  • Surname or Lastname

    English

    Eves

    English : metronymic from Eve.

    Eves

  • Ewer
  • Surname or Lastname

    English

    Ewer

    English : occupational name for a transporter or server of water, Middle English ewer (Old Northern French evier, Old French aiguier, from Latin aquarius, a derivative of aqua ‘water’). There has been considerable confusion with Ure.

    Ewer

  • Evrard
  • Surname or Lastname

    English and French

    Evrard

    English and French : from the Germanic personal name Eberhard (see Everett).

    Evrard

  • Evitt
  • Surname or Lastname

    English

    Evitt

    English : variant spelling of Evett.

    Evitt

  • Eyer
  • Surname or Lastname

    English

    Eyer

    English : variant of Ayer.German : variant of Egger 2.

    Eyer

  • Evett
  • Surname or Lastname

    English

    Evett

    English : from a pet form of the female personal name Eve.

    Evett

  • Ewers
  • Surname or Lastname

    English

    Ewers

    English : variant of Ewer.

    Ewers

  • Ewbank
  • Surname or Lastname

    English

    Ewbank

    English : variant spelling of Eubank.

    Ewbank

  • Evetts
  • Surname or Lastname

    English

    Evetts

    English : metronymic from Evett.

    Evetts

  • Eye
  • Surname or Lastname

    English

    Eye

    English : habitational name from places in Cambridge, Hereford, and Suffolk named from Old English ēg, a term denoting low-lying land, an island or promontory, or an area of dry land in a marsh.

    Eye

  • Exum
  • Surname or Lastname

    English

    Exum

    English : probably a variant of Axsom. This name is concentrated in NC.

    Exum

  • Ezell
  • Surname or Lastname

    English

    Ezell

    English : of unknown origin. The name was well established in the Carolinas by the mid 18th century. In one branch of the family the name was changed to Israel; this is a derivative, not the origin.Americanized form (under French influence) of German Esel, a nickname from Middle High German esel ‘donkey’.

    Ezell

  • Excell
  • Surname or Lastname

    English (Kent)

    Excell

    English (Kent) : habitational name from either of two places in Warwickshire named Exhall.

    Excell

  • Ewell
  • Surname or Lastname

    English

    Ewell

    English : habitational name from Ewell in Surrey or from Ewell Minnis or Temple Ewell in Kent, all named with Old English ǣwell ‘river source’.

    Ewell

  • Eyre
  • Surname or Lastname

    English

    Eyre

    English : variant spelling of Ayer.

    Eyre

  • Evitts
  • Surname or Lastname

    English

    Evitts

    English : metronymic from Evett.

    Evitts

  • Exton
  • Surname or Lastname

    English

    Exton

    English : habitational name from places so called in Devon, Hampshire, Leicestershire, and Somerset. The first and last derive their name from the Celtic river name Exe, while the place in Hampshire, recorded in 940 as East Seaxnatune, is named from Old English Ēastseaxe ‘East Saxon’, and the Leicestershire place name is from Old English oxa ‘of the oxen’. In each case the final element is from Old English tūn ‘settlement’.

    Exton

  • Exley
  • Surname or Lastname

    English

    Exley

    English : habitational name from a place in West Yorkshire, near Halifax, so named from a British ecclēsia name meaning ‘church’ (see Eccles) + Old English lēah ‘woodland clearing’. The surname is common in West Yorkshire.Americanized spelling of the German family name Öchsle, a diminutive of Ochs.

    Exley

  • Eyles
  • Surname or Lastname

    English

    Eyles

    English : variant spelling of Iles.

    Eyles

  • Eyres
  • Surname or Lastname

    English

    Eyres

    English : variant spelling of Ayers.

    Eyres

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APOLIPOPROTEIN E

Online names & meanings

  • Nityasundar
  • Boy/Male

    Hindu

    Nityasundar

    Ever good looking

  • Apryll
  • Girl/Female

    English Latin

    Apryll

    The month April; symbolizes spring.

  • Akendra
  • Boy/Male

    Indian

    Akendra

    Name of a God

  • Apekshita
  • Girl/Female

    Hindu, Indian

    Apekshita

    Wish

  • Girika | கிரிகா
  • Girl/Female

    Tamil

    Girika | கிரிகா

    Summit of a mountain

  • Rukm
  • Boy/Male

    Hindu

    Rukm

    Gold

  • Ujvalita
  • Girl/Female

    Hindu, Indian, Marathi

    Ujvalita

    Lighted; Shining

  • Sridha
  • Girl/Female

    Indian, Telugu

    Sridha

    Part of Goddess Laxmi

  • Brodrig
  • Boy/Male

    American, British, English

    Brodrig

    From the Broad Ridge

  • Shivea
  • Boy/Male

    Hindu

    Shivea

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Other words and meanings similar to

APOLIPOPROTEIN E

AI search in online dictionary sources & meanings containing APOLIPOPROTEIN E

APOLIPOPROTEIN E

  • Thrum-eyed
  • a.

    Having the anthers raised above the stigma, and visible at the throat of the corolla, as in long-stamened primroses; -- the reverse of pin-eyed.

  • Wall-eye
  • n.

    An American fresh-water food fish (Stizostedion vitreum) having large and prominent eyes; -- called also glasseye, pike perch, yellow pike, and wall-eyed perch.

  • Yellow-eyed
  • a.

    Having yellow eyes.

  • Yester-evening
  • n.

    The evening of yesterday; the evening last past.

  • Vitre-o-electic
  • a.

    Containing or exhibiting positive, or vitreous, electricity.

  • Two-edged
  • a.

    Having two edges, or edges on both sides; as, a two-edged sword.

  • White-eye
  • n.

    Any one of several species of small Old World singing of the genus Zosterops, as Zosterops palpebrosus of India, and Z. c/rulescens of Australia. The eyes are encircled by a ring of white feathers, whence the name. Called also bush creeper, and white-eyed tit.

  • Wych-elm
  • n.

    A species of elm (Ulmus montana) found in Northern and Western Europe; Scotch elm.

  • Volta-electric
  • a.

    Of or pertaining to voltaic electricity, or voltaism.

  • Worm-eaten
  • a.

    Eaten, or eaten into, by a worm or by worms; as, worm-eaten timber.

  • Wall-eye
  • n.

    An eye in which the iris is of a very light gray or whitish color; -- said usually of horses.

  • Tulip-eared
  • a.

    Having erect, pointed ears; prick-eared; -- said of certain dogs.

  • Witch-elm
  • n.

    See Wych-elm.

  • Tout-ensemble
  • n.

    All together; hence, in costume, the fine arts, etc., the general effect of a work as a whole, without regard to the execution of the separate perts.

  • Wall-eye
  • n.

    The alewife; -- called also wall-eyed herring.

  • Wall-eyed
  • a.

    Having an eye of a very light gray or whitish color.

  • Rope's-end
  • v. t.

    To punish with a rope's end.

  • Volta-electrometer
  • n.

    An instrument for the exact measurement of electric currents.