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Search references for TREM2. Phrases containing TREM2
See searches and references containing TREM2!TREM2
Protein-coding gene in the species Homo sapiens
receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived
TREM2
Medical condition
caused by autosomal recessive loss of function mutations in either the TREM2 or TYROBP gene that are found most frequently in the Finnish and Japanese
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
Polycystic_lipomembranous_osteodysplasia_with_sclerosing_leukoencephalopathy
Mammalian protein found in humans
presence of amyloid and tau proteins, its expression is known to be tied to TREM2. CD33 is the target of gemtuzumab ozogamicin (trade name: Mylotarg®; Pfizer/Wyeth-Ayerst
CD33
Neuroscientist
identification of MS4A4A as the major regulator of TREM2 and the identification of multiple TREM2 Alzheimer Disease risk variants. His lab also analyzed
Carlos_Cruchaga
Cognitive decline
neurofibrillary tangles formed by hyperphosphorylated tau proteins. A protein (TREM2) malfunction can affect the microglial role of clearing cellular debris
Dementia
Progressive neurodegenerative disease
autosomal dominant Alzheimer's disease are ABCA7 and SORL1. Alleles in the TREM2 gene have been associated with a three to five times higher risk of developing
Alzheimer's_disease
Topics referred to by the same term
TREM1, a triggering receptor expressed on myeloid cells 1, a human gene TREM2, a triggering receptor expressed on myeloid cells 2, a human gene Trem Desportivo
Trem
Medical researcher
Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM. TREM2 function impedes tau seeding in neuritic plaques. Nat Neurosci. 2019 Aug;22(8):1217-1222
David_M._Holtzman
Ghanaian-British stem cell Scientist
Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant., 2018; (contrib.) Modeling
James_Adjaye
Protein found in humans
with axonal damage, demyelination, and neuronal loss. Signaling by a DAP12-TREM2 complex in microglia is downstream of CSF1R signaling and is needed for
Colony stimulating factor 1 receptor
Colony_stimulating_factor_1_receptor
British neuroscientist
Rita Guerreiro; Aleksandra Wojtas; Jose Bras; et al. (10 January 2013). "TREM2 variants in Alzheimer's disease". The New England Journal of Medicine. 368
Tammaryn_Lashley
American geneticist (born 1958)
innate immune gene, TREM2. Knockout of CD33 in AD mice attenuated amyloid-beta pathology and improved cognition while knockout of TREM2 led to opposite effects
Rudolph_E._Tanzi
Algerian professor (born 1969)
macrophages then dominate. In 2023, Park, et al., and others reported that TREM2 tumor macrophages suppress immunity. They limit natural killer cell recruitment
Miriam_Merad
Burning tobacco and inhaling the smoke
parenchyma; the expression levels of a panel of seven genes (KMO, CD1A, SPINK5, TREM2, CYBB, DNASE2B, FGG) are increased in the lung tissue of smokers. Passive
Tobacco_smoking
British-Canadian neurologist and neuroscientist
include the discovery of the presenilins (PSEN1 and PSEN2), Nicastrin, TREM2, Apolipoprotein E and SORL1 genes. Presenilin mutations are the most common
Peter_St_George-Hyslop
Chinese-American neuroscientist
2018 study in mice, the Gan lab demonstrated that haploinsufficiency of TREM2, the strongest immune cell-specific risk factor for AD, impairs microglia
Li_Gan
Samuel; Noggle, Scott. "Use of iPSC systems to define roles of microglial TREM2/DAP12 and CR3/DAP12 complexes and their genetic variants in specifying risk
Sam_Gandy
Dementia research charity
studied data from more than 25,000 people to link a rare variant of the TREM2 gene – which is known to play a role in the immune system – to a higher
Alzheimer's_Research_UK
Fat-laden M2 macrophages seen in atherosclerosis
genetic expression, determining that they could be pro- or anti-inflammatory, TREM2+ lipid-associated macrophages, or Mox (oxidative stress) macrophages, further
Foam_cell
Protein-coding gene in the species Homo sapiens
single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties.
TREML1
Lanier, Lewis L.; Seaman, William E.; Nakamura, Mary C. (February 2006). "TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function"
Immunoreceptor tyrosine-based activation motif
Immunoreceptor_tyrosine-based_activation_motif
Protein domain
TIMD4; TRA@; TRAV20; TRBC1; TRBV19; TRBV3-1; TRBV5-4; TRBV7-2; TRDV2; TREM1; TREM2; TREML1; TREML2; TREML4; TRGV3; TRGV5; TRGV7; TRGV9; VCAM1; VCAN; VPREB1;
V-set_domain
Study of role of genetics in the nervous system
an increased likelihood of developing the condition. Other genes such as TREM2 can raise the risk. The alleles alone do not directly cause the disease
Neurogenetics
Protein found in humans
the triggering receptor expressed on myeloid cells 2 (TREM2), to produce soluble TREM2 (sTREM2), which has been proposed as a CSF and sera biomarker of
ADAM10
American singer-songwriter (born 1952)
he often uses a Swart Atomic Space Tones amplifier and a Fulltone Supa-Trem2 pedal. He mostly records using Pro Tools, but in his recording studio Buddy
Buddy_Miller
encodes PU.1, a transcription factor necessary for microglial development. TREM2, a cell surface receptor on microglia, is associated with Alzheimer's as
Role_of_microglia_in_disease
British neuroscientist
1176/appi.ajp.2008.07111711. PMC 2574742. PMID 18519524. Guerreiro, R (2013). "TREM2 Variants in Alzheimer's Disease". NEJM. 368 (2): 117–127. doi:10.1056/NEJMoa1211851
Alison_Goate
genes linked to immune function that are risk factors for AD, such as TREM2. TREM2 are highly expressed in microglia, the immune cell of the brain, tying
Alzheimer's disease in the Hispanic/Latino population
Alzheimer's_disease_in_the_Hispanic/Latino_population
Q13061 17341 TREH HGNC:12266; O43280 17342 TREM1 HGNC:17760; Q9NP99 17343 TREM2 HGNC:17761; Q9NZC2 17344 TREML1 HGNC:20434; Q86YW5 17345 TREML2 HGNC:21092;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Medical condition
known as DAP12) or the triggering receptor expressed on myeloid cells 2 (TREM2) protein. While different gene mutations occur within the pathway for Nasu-Hakola
Hereditary diffuse leukoencephalopathy with spheroids
Hereditary_diffuse_leukoencephalopathy_with_spheroids
HCRT Nasopharyngeal carcinoma; 607107; TP53 Nasu–Hakola disease; 221770; TREM2 Nasu–Hakola disease; 221770; TYROBP Naxos disease; 601214; JUP Nemaline
List_of_OMIM_disorder_codes
Protein-coding gene in the species Homo sapiens
response in AD, since triggering receptor expressed on myeloid cells 2 (TREM2), a microglial factor associated with inflammation in AD, is a cargo protein
VPS35
Japanese company
and Launches INNOTEST® Assays for the Two Promising Biomarkers NPTX2 and sTREM2". Businesswire.com. 19 November 2021. Retrieved 16 December 2021. "About
Fujirebio
Professor of neuroimmunology
disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis". Nature Aging. 2 (1):
Michal_Schwartz
Protein-coding gene in the species Homo sapiens
Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct
TYROBP
2012-11-12. Retrieved 2023-07-02. Guerreiro, Rita; et al. (2013-01-10). "TREM2 Variants in Alzheimer's Disease". New England Journal of Medicine. 368 (2)
2012_in_science
Icelandic neurologist (born 1949)
treatments. Stefansson and the deCODE team have also discovered variants in the TREM2 and ABCA7 genes that increase risk of AD. Stefansson and his team have used
Kári_Stefánsson
Dutch epidemiologist
N Engl J Med. 2013 Oct 17;369(16):1529-36. Jonsson T, et al. Variant of TREM2 Associated with the Risk of Alzheimer's Disease. N Engl J Med. 2013;368:107-116
Albert Hofman (epidemiologist)
Albert_Hofman_(epidemiologist)
Mammalian protein found in Homo sapiens
deficiency is responsible for Jak3 deficiency in the brain, reduced microglial TREM2 expression, microglial activation and compromised clearance of Aβ and pTau
Janus_kinase_3
Protein-coding gene in the species Homo sapiens
S2CID 52869488. Jiao B, Liu X, Tang B, et al. (October 2014). "Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland
PLD3
TREM2
TREM2
TREM2
TREM2
Girl/Female
Hindu
Ghosh
Girl/Female
Hindu, Indian, Sanskrit, Tamil
Destiny
Boy/Male
Irish
Sadness.
Surname or Lastname
English
English : variant of Box, with the addition of the agent suffix -er.Jewish (from Poland and Ukraine) : from an Americanized spelling of Yiddish bokser ‘St. John’s bread’, presumably an ornamental name.
Girl/Female
American, Australian, Christian
A Combination of Tammy and Pamela
Boy/Male
Indian, Tamil
King of Writer
Boy/Male
Arabic, Muslim
Servant of the Self Subsisting / Eternal (Allah)
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Lord Shiva
Girl/Female
Hindu
Beautiful
Boy/Male
Spanish
Fire.
TREM2
TREM2
TREM2
TREM2
TREM2