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Genetically engineered T cell
Chimeric antigen receptor T cells (CAR T cells)—also known as chimeric immunoreceptors, chimeric T cell receptors or artificial T cell receptors—are receptor
CAR_T_cell
Delivery methods of CAR-T cells
receptor (CAR)-T cell delivery is the methodology by which clinicians introduce the cancer-targeting therapeutic system of the CAR-T cell to the human
Engineered CAR T cell delivery
Engineered_CAR_T_cell_delivery
Cancer of plasma cells
stem cell transplant. Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions. New approaches utilizing CAR-T cell therapy
Multiple_myeloma
Immunotherapy using T cells
immunotherapies are T cell therapies. Other therapies include CAR-T therapy, CAR-NK therapy, macrophage-based immunotherapy and dendritic cell therapy. Although
Cellular adoptive immunotherapy
Cellular_adoptive_immunotherapy
American biopharmaceutical company
next-generation cell therapies, including CAR T cell (chimeric antigen receptor therapies), using technologies intended to improve T-cell persistence, function
Lyell_Immunopharma
Interdisciplinary medical specialty
immune response, spearheaded by the CAR-T cells. There are various known inhibitory receptors on the CAR-T cell; through manipulation of these receptors
Molecular_oncology
Hematologic cancer that affects lymphocytes
stem-cell transplantation. Chimeric antigen receptor-modified (CAR) T-cell therapy has become part of the standard of care in refractory B-cell lymphomas
Lymphoma
(CAR T-cell) immune therapies. As principal investigator, O'Rourke led the first-in-human trial using a single infusion of engineered autologous CAR T-Cells
Donald_O'Rourke
American immunologist
contributions to T cell engineering and chimeric antigen receptor (CAR) therapy, an immunotherapy based on the genetic engineering of a patient's own T cells to treat
Michel_Sadelain
Type of cytotoxic lymphocyte
Compared to CAR T cells, CAR NK cells retain unchanged expression of NK cell activating receptors. Thus, NK cells recognize and kill tumor cells even if,
Natural_killer_cell
Experimental lentiviral approach to generating CAR-T cells inside the body
Targeted lentiviral delivery for in vivo CAR-T cell generation is an experimental approach to CAR-T cell therapy in which retargeted lentiviral vectors
Targeted lentiviral delivery for in vivo CAR T-cell generation
Targeted_lentiviral_delivery_for_in_vivo_CAR_T-cell_generation
Type of cancer
(February 2019). "Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia". Journal of Hematology
Leukemia
American pediatric oncologist
CAR T-cell therapy to the first pediatric patient in the world. Grupp also helps lead trials on a CRISPR-based gene editing therapy for Sickle cell disease
Stephan_Grupp
American biomedical engineer
chimeric antigen receptor (CAR) T cells directly inside the body, aiming to reduce the cost and manufacturing time of CAR-T cell therapy. Brudno earned dual
Yevgeny_Brudno
Drug company
current generation of CAR-T cells. Resultantly, CellPryme-M CAR-T cells performed significantly better than conventional CAR-T cells in highly aggressive
Prescient_Therapeutics
Artificial stimulation of the immune system to treat cancer
therapies, including chimeric antigen receptor (CAR) T cell therapy, involve modifying a patient's immune cells to recognize cancer-specific antigens. These
Cancer_immunotherapy
Autoimmune disease of skin and muscle
Novel approaches such as CD19 chimeric antigen receptor (CAR) T-cell therapy, plasma cell–directed therapies, and neonatal Fc receptor (FcRn) inhibitors
Dermatomyositis
Type of cancer immunotherapy
Unlike CAR-T, which uses cell surface antigens, TCR-T can recognize MHC's larger set of intracellular antigen fragments. However, TCR-T cell therapy
T cell receptor T cell therapy
T_cell_receptor_T_cell_therapy
target for CAR T cell therapy because they produce antibodies that cause tissue damage. Early clinical trials have shown that CAR T cell mediated B lymphocyte
Immunoengineering
Chain reaction of white blood cell activation
elevated in CRS are not produced by CAR-T cells, but by myeloid cells that are pathogenically licensed through T-cell-mediated activating mechanisms. For
Cytokine_release_syndrome
Natural killer T cells genetically engineered to combat cancer
cells, innate immune effectors, to express chimeric antigen receptors (CARs) that target specific tumor-associated antigens. Unlike CAR-T cells, CAR-NK
CAR-NK
an anti-TAG-72 antibody conjugated with toxins for cancer treatment. CAR T cells engineered to recognize TAG-72 have been tested in ovarian and colorectal
Tumor-associated glycoprotein 72
Tumor-associated_glycoprotein_72
Hospital in Maharashtra, India
overall) in 2023. It has spearheaded the CAR-T cell trial which has led to the approval indigenous CAR-T cell therapy in India. Importantly, with a mission
Tata_Memorial_Centre
Activation or suppression of the immune system to treat disease
(2) T cell receptor-engineered T cells (TCR-T cells), and (3) chimeric antigen receptor T cells (CAR-T cells), with newer adaptations including CAR-NK
Immunotherapy
Israeli immunologist (1941–2025)
involving genetic modifications of T lymphocytes extracted from a cancer patient to produce chimeric antigen receptor (CAR) T-Cells, which are then injected back
Zelig_Eshhar
French biopharmaceutical company
Cellectis has developed CAR T-cell treatments for blood cancer. Most CAR-T therapies under development as of 2017 involved taking T-cells from the person with
Cellectis
Surroundings of tumors including nearby cells and blood vessels
receptors (CAR) T cell therapy is an immunotherapy treatment that uses genetically modified T lymphocytes to effectively target tumor cells. CARs are programmed
Tumor_microenvironment
Hospital in New Jersey, United States
relapsed after at least two other kinds of treatment; it initiated the first CAR T-cell therapy clinical trials and is a member of the NCI-approved Georgetown
John_Theurer_Cancer_Center
Gene therapy medication
and fever. Lisocabtagene maraleucel, a chimeric antigen receptor (CAR) T cell (CAR-T) therapy, is the third gene therapy approved by the US Food and Drug
Lisocabtagene_maraleucel
Biotechnology group
received emergency use authorization from the US FDA. In 2022, Carvykti, a CAR-T cell therapy developed by Janssen Biotech and Legend Biotech, was approved
GenScript_Biotech
American physician and immunologist
for Cancer Cell Therapy, which modified the chimeric antigen receptor T cell (CAR-T) to identify B-cell lymphoblastic leukemia and B-cell lymphoma. In
Crystal_Mackall
CD19-targeted CAR T therapies, which eliminate many healthy B cells and suppress the immune system, CART4-34 spares most normal B cells because IGHV4-34
CART4-34_therapy
Group of autoimmune diseases resulting in abnormal growth of connective tissue
basiliximab, alemtuzumab, abatacept, haematopoietic stem cell transplantation, CD19 CAR-T, bispecific antibodies, anifrolumab (via IFN-I), belimumab
Scleroderma
Type of blood cancer
these patients appears to be improved by using CAR-T therapy. Chimeric antigen receptor T cell (i.e. CAR-T) adoptive cellular immunotherapy has emerged
Diffuse_large_B-cell_lymphoma
Blood that has been modified for therapeutic or other purposes
blood can be genetically modified to treat hematologic diseases. Source: CAR T-cell therapy is a type of personalized cancer immunotherapy designed to strengthen
Gene therapy for blood diseases
Gene_therapy_for_blood_diseases
American gene editing company
Sciences to explore using foralumab to aid chimeric antigen receptor (CAR) T cell therapy, and with Philadelphia-based iECURE to advance candidates into
Precision_BioSciences
American physician-scientist
chimeric antigen receptor (CAR) T-cell therapies for cancer. Dr. Kochenderfer's research has focused on developing new CAR T-cell therapies for hematologic
James_N._Kochenderfer
Emerging treatment for multiple sclerosis
transmembrane is to anchor the CAR in the T cell membrane. Intracellular domains: cytoplasmic protein domains located inside the T cell, responsible for transmitting
CAR Treg therapy in multiple sclerosis
CAR_Treg_therapy_in_multiple_sclerosis
Gene therapy medication
Idecabtagene vicleucel is a B-cell maturation antigen (BCMA)-directed genetically modified autologous chimeric antigen receptor (CAR) T-cell therapy. Each dose is
Idecabtagene_vicleucel
American neurologist and researcher (born 1978)
Mackall developed CAR-T cells that attack the GD2. Working together, Monje and Mackall discovered that GD2-CAR T cells kill cultured DIPG cells which carry
Michelle_Monje
Mammalian proteins found in humans
development of CAR T-cell therapies, which have been shown to have efficacy in in vitro mouse models. The company Invectys developed the CAR T-cell therapy IVS-3001
HLA-G
American biotechnology company
genetically engineered autologous CAR T cell therapy - a cell-based therapy which relies on chimeric antigen receptors and T cells. Founded in 2009, and based
Kite_Pharma
Treatment using biotechnology to convert viruses into therapeutic agents
receptor T cell (CAR T cell) are a type of immunotherapy that makes use of viral gene editing. CAR T cell use an ex vivo method in which T lymphocytes
Virotherapy
Type of blood cancer
Yang, Dong-Hua; Zhao, Hong-Bing (31 March 2023). "CAR T-Cell therapy for the management of mantle cell lymphoma". Molecular Cancer. 22 (1): 67. doi:10
Mantle_cell_lymphoma
Gene therapy medication
Kymriah, is a CAR T cells medication for the treatment of B-cell acute lymphoblastic leukemia (ALL) which uses the body's own T cells to fight cancer
Tisagenlecleucel
Family of receptors found on NK cells
glycoproteins expressed on the plasma membrane of natural killer (NK) cells and a minority of T cells. In humans, they are encoded in the leukocyte receptor complex
Killer-cell immunoglobulin-like receptor
Killer-cell_immunoglobulin-like_receptor
Medical therapy involving transplant of cells expanded ex vivo
leukemia (MLL) gene with CD19 CAR-T cells. In 2016, researchers developed a technique that used cancer cells' RNA to produce T cells and an immune response.
Adoptive_cell_transfer
Application of science to healthcare
PMID 36171658. "CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI". www.cancer.gov. 6 December 2013. Retrieved 28 July 2026. "CAR-T Cell Therapy".
Biomedical_sciences
Cell based gene therapy
brexucabtagene autoleucel, a CD19-directed chimeric antigen receptor (CAR) T-cell therapy. Participants received a single infusion of brexucabtagene autoleucel
Brexucabtagene_autoleucel
Gene therapy medication used to treat multiple myeloma
autoleucel is a BCMA (B-cell maturation antigen)-directed genetically modified autologous chimeric antigen receptor (CAR) T-cell therapy. Each dose is customized
Ciltacabtagene_autoleucel
Australian scientist and cancer researcher
blood cells which can protect against viruses and cancer. Specifically, Jenkins' research group uses using chimeric antigen receptor (CAR) T cell therapy
Misty_Jenkins
Medication to treat large B-cell lymphoma
genetically engineered to produce a specific T-cell receptor. The resulting chimeric antigen receptor T cells (CAR-Ts) that react to the cancer are then given
Axicabtagene_ciloleucel
American biopharmaceutical company
signed an agreement with Opus Bio, Inc for a chimeric antigen receptor (CAR-T) cell product candidate targeting CD22. In April 2015 the company entered into
Juno_Therapeutics
amaurosis FDA-approved CAR T cell therapies "FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma" (Press release)
List_of_gene_therapies
Method in molecular biology to make pores in cell membranes
role in the ex vivo manipulation of immune cells for the development of cell-based therapies, such as CAR T-cell therapy. Moreover, in vivo applications
Electroporation
Gene therapy medication
GlobeNewswire. "A Study of CD19 Targeted CAR T Cell Therapy in Adult Patients with Relapsed or Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)". ClinicalTrials
Obecabtagene_autoleucel
Italian-American physician-scientist
of Pennsylvania. His research focuses on chimeric antigen receptor T-cell (CAR-T) therapy, particularly mechanisms of resistance and strategies to improve
Marco_Ruella
American immunologist
receptor (CAR)-T cells for cancer patients. She demonstrated that it is possible to use engineered CAR-T cells to identify and kill tumour cells that express
Marcela_Maus
Procedure separating white blood cells from blood
its use is controversial and rare. Leukapheresis is used in evolving CAR-T cell therapy to obtain leukocytes from a cancer patient or donor which can
Leukapheresis
Protein-coding gene in the species Homo sapiens
preclinical and phase I clinical studies. A Phase 1b/2 study of JNJ-4528, a CAR-T cell therapy directed against BCMA in myeloma patients refractory to a proteasome
B-cell_maturation_antigen
Antibody fragment
have been used to create immunotoxins and chimeric antigen receptor (CAR) T cells for treating liver cancer. Blocking the Wnt binding domain of GPC3 by
Single-domain_antibody
"CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function". Cancer Immunology Research. 9 (9): 999–1007. doi:10.1158/2326-6066
List of unusual biological names
List_of_unusual_biological_names
Chemical compound
antigen receptor T cell (CAR-T) associated cytokine release syndrome (CRS). GM-CSF is produced by CAR-T cells upon recognition of target cells, which activates
Lenzilumab
Enzyme found in humans
receptor T cells (CAR T cells). CAR T cells are genetically modified T cells that exhibit cytotoxicity to tumor cells. Evidence shows that CAR T cells are
Caspase-9
Vehicle that uses hydrogen fuel for motive power
combustion cars are not commercially available.[citation needed] In the light road vehicle segment, by the end of 2022, 70,200 fuel cell electric vehicles
Hydrogen_vehicle
American journalist and author (1990–2025)
disease. A bone marrow transplant, chemotherapy, and a clinical trial of CAR-T cell therapy were unable to slow the progression of the leukemia, and her doctors
Tatiana_Schlossberg
Protein complex on the surface of T cells that recognizes antigens
The T-cell receptor (TCR) is a protein complex, located on the surface of T cells (also called T lymphocytes). They are responsible for recognizing fragments
T-cell_receptor
Hospital in Riyadh, Saudi Arabia
Oncology Centre engages in research and development of treatments, such as CAR T-cell therapy for blood cancers. KFSHRC’s genomic medicine services include
King Faisal Specialist Hospital and Research Centre
King_Faisal_Specialist_Hospital_and_Research_Centre
Independent biomedical research institute in Wellington, New Zealand
began New Zealand's first clinical trial of CAR T-cell therapy, trialling a third-generation CAR T-cell therapy. The concept of a Wellington-based, independent
Malaghan Institute of Medical Research
Malaghan_Institute_of_Medical_Research
Medical condition
against diffuse large B-cell lymphoma are chimeric antigen receptor (CAR) T cell therapy and therapeutic blocking of programmed cell death protein 1 pathway
Aggressive_lymphoma
Muscular inflammatory disease of unknown origin
2025). "BCMA CAR T cells in a patient with relapsing idiopathic inflammatory myositis after initial and repeat therapy with CD19 CAR T cells". Nature Medicine
Inflammatory_myopathy
German oncologist and immunologist (born 1965)
immunotherapy. Chimeric antigen receptor (CAR)-T cell therapies (CARVAC) are promising immunotherapies for treating B-cell-derived hematologic cancers. Achieving
Uğur_Şahin
A T memory stem cell (TSCM) is a type of long-lived memory T cell with the ability to reconstitute the full diversity of memory and effector T cell subpopulations
T_memory_stem_cell
Medical condition
with chimeric antigen receptor (CAR) T cells that recognize CD19+ B cells. This shows that CD19-targeting CAR T cells could be a new therapy for patients
Antisynthetase_syndrome
New Zealand actor (1947–2026)
Neill said that after his chemotherapy had stopped working, he underwent CAR T-cell therapy as part of an Australian clinical trial. He also said that a recent
Sam_Neill
Infection originating in a tooth
hematopoietic stem cell transplantation, or CAR T-cell therapy, in which bone marrow suppression and a decline in white blood cell count are expected
Odontogenic_infection
Design and construction of synthetic systems that perform complex immunological functions
tisagenlecleucel, the first chimeric antigen receptor T cell (CAR-T) therapy, for patients up to 25 years old with B cell precursor acute lymphoblastic leukemia that
Synthetic_immunology
Australian biotechnology company
tumour cell surface, as well as helped to reverse the tumour's harsh microenvironment, making it receptive to receiving CAR T-cell therapy. B-cell immunotherapies
Imugene
German biotechnology company
therapies, such as pairing CAR-T cell treatments with mRNA-based vaccines. These vaccines encode target structures that boost CAR-T cell activity and persistence
BioNTech
Legal document in the US
restrict the availability of CAR T-cell cancer therapy to only the largest (predominantly urban) hospitals by classifying CAR T-cell therapy a "new" provision
Certificate_of_need
Medical innovation prize
for his pioneering work in CAR T cell therapy, which reprograms patients’ immune cells to target and destroy cancer cells. June’s research led to the
Broermann Medical Innovation Award
Broermann_Medical_Innovation_Award
American pharmaceutical company
27, 2021. Ide-cel is a BCMA-directed genetically modified autologous CAR-T-cell immunotherapy. In August 2018, the company announced a collaboration with
Bluebird_bio
Topics referred to by the same term
up Car, car, CAR, or Appendix:Variations of "car" in Wiktionary, the free dictionary. A car is a motor vehicle with wheels. Car, Cars, CAR or CARS may
Car_(disambiguation)
Carbohydrate tumor antigen
immunotherapy, particularly in chimeric antigen receptor T cells (CAR T cell) therapy. Studies of CAR T cells cultivated to target Neu5Gc-GM3 have shown excellent
Neu5Gc-GM3
Medical techniques to separate one or more components of blood
lymphocytes. Lymphocytes are harvested to use in manufacture of CAR T cell products for T-cell-based immunotherapies. Single use kits – Apheresis is done using
Apheresis
American biochemist (born 1985)
CB-010, an allogeneic anti-CD19 CAR-T cell therapy, through the ANTLER Phase 1 clinical trial in relapsed or refractory B cell non-Hodgkin lymphoma. In 2024
Rachel_Haurwitz
Canadian-born immunologist and virologist (1970 – 2024)
towards a functional cure of HIV, including chimeric antigen receptor (CAR) T cell immunotherapy and gene editing approaches capable of protecting against
Todd_M._Allen
American pharmaceutical company
on specific antigens expressed by the cancer cells. Canvaxin is an example of this therapy. CAR-T cell therapy: In 2023, the company partnered with research
CancerVax Corp (defunct company)
CancerVax_Corp_(defunct_company)
Ability of the immune system to quickly and specifically recognize an antigen
use of CAR T to kill the B cells that cause autoimmunity; some targets all B cells, some only memory B cells, and a few aiming to only kill B cells that
Immunological_memory
Treatment of cancer using drugs that inhibit cell division or kill cells
therapy used in patients with B cell lymphoma. This anti-CD19 CAR-T cell therapy is commonly known to decrease CAR-T cells which bind to the glycoprotein
Chemotherapy
Medical procedure to replace blood or immune stem cells
evaluation and management prior to treatment for hematologic malignancies and CAR T-cell therapy". Supportive Care in Cancer. 33 (10) 853. doi:10.1007/s00520-025-09845-4
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
Notable events in the history of immunology
– First autologous CAR T-cell therapy tisagenlecleucel approved for the treatment of pediatric B-ALL; second autologous CAR T-cell therapy axicabtagene
Timeline_of_immunology
Contagious disease caused by SARS-CoV-2
for CAR T cell-induced CRS and neurotoxicity and is a viable therapeutic option due to the observed increase of pathogenic GM-CSF secreting T cells in
COVID-19
Treatment and research hospital in New York City
From Robertson Foundation". "FDA approves CAR-T cell therapy to treat adults with certain types of large B-cell lymphoma". FDA. September 10, 2019. Archived
Memorial Sloan Kettering Cancer Center
Memorial_Sloan_Kettering_Cancer_Center
Branch of medicine dealing with, or specializing in, cancer
Cancer vaccines and other immunotherapies, such as checkpoint inhibitors, CAR-T cell therapy, and cytokine therapies, remain active areas of research and clinical
Oncology
Hospital in Guangdong, China
intervention (CMI), combined immunotherapy for cancer (CIC including NK and CAR-T cell immunotherapy), and personalized treatment which both prolongs and improves
Fuda Cancer Hospital-Guangzhou
Fuda_Cancer_Hospital-Guangzhou
American physician scientist and rapper
and National Marrow Donor Program. She directs research on CAR T cell therapy and stem cell transplantation. Rouce leads a weekend science program at Baylor
Rayne_Rouce
Medicine pertaining to the mouth
preparation before cytotoxic chemotherapy, hematopoietic stem cell transplantation, or CAR T-cell therapy. It is not uncommon for an individual to experience
Oral_medicine
American immunologist and oncologist
Laureates 2024 – Breakthrough Prize in Life Sciences 2024 – Abarca Prize, for CAR-T cell therapy to fight blood cancer 2024 – VinFuture Prize, alongside Zelig
Carl_H._June
Polish mathematician
international teams on cancer therapy modeling, including studies on CAR-T cell therapy for glioblastoma and hormone-sensitive prostate cancer treatment
Urszula_Alicja_Foryś
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