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Searches containing ERBB

ERBB

  • ErbB
  • Family of proteins

    The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered

    ErbB

    ErbB

  • HER2
  • Mammalian protein found in humans

    tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic

    HER2

    HER2

    HER2

  • ERBB3
  • Protein found in humans

    Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded

    ERBB3

    ERBB3

    ERBB3

  • Epidermal growth factor receptor
  • Transmembrane protein

    of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her

    Epidermal growth factor receptor

    Epidermal growth factor receptor

    Epidermal_growth_factor_receptor

  • Receptor tyrosine kinase
  • Class of enzymes

    different RTK classes have been identified. RTK class I (EGF receptor family) (ErbB family) RTK class II (Insulin receptor family) RTK class III (PDGF receptor

    Receptor tyrosine kinase

    Receptor tyrosine kinase

    Receptor_tyrosine_kinase

  • Amitriptyline
  • Tricyclic antidepressant

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Amitriptyline

    Amitriptyline

    Amitriptyline

  • Testosterone
  • Primary male sex hormone

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Testosterone

    Testosterone

    Testosterone

  • ERBB4
  • Protein-coding gene in the species Homo sapiens

    Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different

    ERBB4

    ERBB4

    ERBB4

  • Dexamethasone
  • Corticosteroid medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Dexamethasone

    Dexamethasone

    Dexamethasone

  • Canertinib
  • Chemical compound

    inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug.

    Canertinib

    Canertinib

    Canertinib

  • Boehringer Ingelheim
  • German pharmaceutical company

    cell lung cancer (NSCLC) / ovarian cancer Phase III Afatinib Irreversible ErbB family blocker Breast cancer / head and neck cancer. Already approved for

    Boehringer Ingelheim

    Boehringer Ingelheim

    Boehringer_Ingelheim

  • Proliferation marker protein Ki-67
  • Mammalian protein found in humans

    PMID 20152769. Bánkfalvi A (November 2000). "Comparative methodological analysis of erbB-2/HER-2 gene dosage, chromosomal copy number and protein overexpression in

    Proliferation marker protein Ki-67

    Proliferation marker protein Ki-67

    Proliferation_marker_protein_Ki-67

  • Elranatamab
  • Medication

    agents (L01) CI monoclonal antibodies ("-mab") Receptor tyrosine kinase ErbB: HER1/EGFR (Cetuximab Panitumumab) HER2/neu (Pertuzumab Trastuzumab (+hyaluronidase)

    Elranatamab

    Elranatamab

  • Insulin
  • Peptide hormone

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Insulin

    Insulin

    Insulin

  • V-erbA-related gene
  • Protein-coding gene in the species Homo sapiens

    after its similarity to v-erbA (P03373), a helper of an oncoprotein called v-erbB in avian erythroblastosis virus. Comparatively little is known about ear-2

    V-erbA-related gene

    V-erbA-related gene

    V-erbA-related_gene

  • Brelgometon
  • Pharmaceutical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Brelgometon

    Brelgometon

    Brelgometon

  • Imatinib
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Imatinib

    Imatinib

    Imatinib

  • Insulin-like growth factor 1
  • Protein found in humans

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Insulin-like growth factor 1

    Insulin-like growth factor 1

    Insulin-like_growth_factor_1

  • E2511
  • Pharmaceutical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    E2511

    E2511

  • Nerve growth factor
  • Mammalian protein found in humans

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Nerve growth factor

    Nerve growth factor

    Nerve_growth_factor

  • Zilurgisertib
  • Medication

    agents (L01) CI monoclonal antibodies ("-mab") Receptor tyrosine kinase ErbB: HER1/EGFR (Cetuximab Panitumumab) HER2/neu (Pertuzumab Trastuzumab (+hyaluronidase)

    Zilurgisertib

    Zilurgisertib

    Zilurgisertib

  • Monoclonal antibody
  • Antibodies from clones of the same blood cell

    (May 1998). "Human tumor growth suppression by apoptosis induced with anti-ErbB-2 chimeric monoclonal antibody". Jpn J Cancer Res. 89 (5): 562–570. doi:10

    Monoclonal antibody

    Monoclonal antibody

    Monoclonal_antibody

  • ACD856
  • TrkA and TrkB positive modulator

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    ACD856

    ACD856

  • Cell signaling
  • System of communication

    Lene; Grandal, Michael; et al. (May 2008). "Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer". Histochemistry and Cell Biology

    Cell signaling

    Cell signaling

    Cell_signaling

  • Antineoplastic
  • Class of drugs used to treat malignant tumors

    (epidermal growth factor receptor) expression Selectively binds to HER-2 (ErbB-2), blocking HER-2-mediated PI3K and MAPK signaling pathways, inhibiting

    Antineoplastic

    Antineoplastic

    Antineoplastic

  • Afatinib
  • Chemical compound

    (June 2012). "A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing

    Afatinib

    Afatinib

    Afatinib

  • Panitumumab
  • Pharmaceutical drug

    the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans). Panitumumab is manufactured by Amgen and was originally

    Panitumumab

    Panitumumab

  • Neuregulin 3
  • Protein-coding gene in Homo sapiens

    co-receptor as it has not been observed to bind any ligand. NRGs bind to the ERBB receptors to promote phosphorylation of specific tyrosine residues on the

    Neuregulin 3

    Neuregulin 3

    Neuregulin_3

  • LGMN
  • Protein-coding gene in the species Homo sapiens

    process negative regulation of neuron apoptotic process negative regulation of ERBB signaling pathway renal system process antigen processing and presentation

    LGMN

    LGMN

    LGMN

  • YAP1
  • Protein-coding gene in the species Homo sapiens

    protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus"

    YAP1

    YAP1

    YAP1

  • Epidermal growth factor
  • Protein that stimulates cell division and differentiation

    EJ (July 2002). "Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display". Biochemistry. 41 (27): 8732–41.

    Epidermal growth factor

    Epidermal growth factor

    Epidermal_growth_factor

  • Androgen receptor
  • Mammalian protein found in humans

    (August 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc

    Androgen receptor

    Androgen receptor

    Androgen_receptor

  • Neuregulin 1
  • Protein-coding gene in the species Homo sapiens

    all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms

    Neuregulin 1

    Neuregulin 1

    Neuregulin_1

  • Trastuzumab deruxtecan
  • Medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Trastuzumab deruxtecan

    Trastuzumab deruxtecan

    Trastuzumab_deruxtecan

  • Mosunetuzumab
  • Monoclonal antibody

    agents (L01) CI monoclonal antibodies ("-mab") Receptor tyrosine kinase ErbB: HER1/EGFR (Cetuximab Panitumumab) HER2/neu (Pertuzumab Trastuzumab (+hyaluronidase)

    Mosunetuzumab

    Mosunetuzumab

  • Wnt signaling pathway
  • Group of signal transduction pathways involved in embryonic development

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Wnt signaling pathway

    Wnt_signaling_pathway

  • Eutropoflavin
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Eutropoflavin

    Eutropoflavin

    Eutropoflavin

  • Vascular endothelial growth factor
  • Protein involved in blood vessel growth

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Vascular endothelial growth factor

    Vascular_endothelial_growth_factor

  • Osimertinib
  • Chemical compound, used as a medication to treat lung cancer

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Osimertinib

    Osimertinib

    Osimertinib

  • Trametinib
  • Anticancer medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Trametinib

    Trametinib

    Trametinib

  • Dihexa
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Dihexa

    Dihexa

    Dihexa

  • Zinc finger transcription factor
  • Transcription factor

    including the ability to correct abnormal gene expression profiles (e.g., erbB-2 overexpression in human adenocarcinomas) and anti-retrovirals (e.g. HIV-1)

    Zinc finger transcription factor

    Zinc_finger_transcription_factor

  • Nintedanib
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Nintedanib

    Nintedanib

    Nintedanib

  • Poziotinib
  • Chemical compound

    Develop Core Technologies". BusinessKorea. Roskoski R (September 2014). "ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors".

    Poziotinib

    Poziotinib

    Poziotinib

  • Julian Downward
  • English research director

    cellular growth regulatory protein and the avian retroviral oncogene, v-erbB. This work led to the identification of the closely related cellular oncogene

    Julian Downward

    Julian Downward

    Julian_Downward

  • Breast development
  • Biological process in primates

    (1998). "Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis". Cell Growth Differ. 9 (9): 777–85

    Breast development

    Breast_development

  • Orlistat
  • Drug designed to treat obesity

    apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene". Annals of Oncology. 16 (8): 1253–1267. doi:10.1093/annonc/mdi239

    Orlistat

    Orlistat

    Orlistat

  • Axitinib
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Axitinib

    Axitinib

    Axitinib

  • Fibroblast growth factor receptor-like 1
  • Protein found in humans

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Fibroblast growth factor receptor-like 1

    Fibroblast growth factor receptor-like 1

    Fibroblast_growth_factor_receptor-like_1

  • Alectinib
  • ALK inhibitor for treatment of non-small-cell lung cancer

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Alectinib

    Alectinib

    Alectinib

  • Insulin-like growth factor
  • Proteins similar to insulin that stimulate cell proliferation

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Insulin-like growth factor

    Insulin-like growth factor

    Insulin-like_growth_factor

  • Bevacizumab
  • Medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Bevacizumab

    Bevacizumab

  • Germinoma
  • Medical condition

    carboxypeptidase II erbB-3 receptor Early prostate cancer antigen-2 SPINK1 GOLM1 PCA3 TMPRSS2 hPG80 Germ cell tumor NANOG Bladder cancer erbB-3 receptor NMP22

    Germinoma

    Germinoma

    Germinoma

  • IGF-1 LR3
  • Synthetic protein

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    IGF-1 LR3

    IGF-1_LR3

  • Growth factor
  • Protein or other substance that stimulates cellular proliferation

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Growth factor

    Growth_factor

  • Alacizumab pegol
  • Pharmaceutical drug

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Alacizumab pegol

    Alacizumab_pegol

  • Gilbertian mimicry
  • Form of mimicry in plants

    result is long-lasting hypersensitivity in bitten mammals, implying that ErbB is involved in signalling mammalian pain. The mechanism is, according to

    Gilbertian mimicry

    Gilbertian mimicry

    Gilbertian_mimicry

  • Faricimab
  • Medication for macular degeneration

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Faricimab

    Faricimab

    Faricimab

  • Targeted covalent inhibitors
  • Type of inhibitor

    wild-type EGFR that are expected to lead to a wider therapeutic index. The pan-ErbB inhibitor Neratinib was approved in the US in 2017 and in the EU in 2018

    Targeted covalent inhibitors

    Targeted covalent inhibitors

    Targeted_covalent_inhibitors

  • DLG4
  • Mammalian protein found in Homo sapiens

    Garcia RA, Vasudevan K, Buonanno A (March 2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses". Proc. Natl

    DLG4

    DLG4

    DLG4

  • Tau-protein kinase
  • Class of enzymes

    (protein-serine/threonine kinases). This enzyme participates in 14 metabolic pathways: erbb signaling pathway, cell cycle, wnt signaling pathway, hedgehog signaling

    Tau-protein kinase

    Tau-protein kinase

    Tau-protein_kinase

  • Sara García Alonso
  • Spanish cancer researcher and reserve astronaut

    dissertation focused on mechanisms of resistance to antibody-drug conjugates in ErbB receptors and it won her the university's Outstanding Doctorate Award the

    Sara García Alonso

    Sara García Alonso

    Sara_García_Alonso

  • Encorafenib
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Encorafenib

    Encorafenib

    Encorafenib

  • Tropomyosin receptor kinase B
  • Protein and coding gene in humans

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Tropomyosin receptor kinase B

    Tropomyosin receptor kinase B

    Tropomyosin_receptor_kinase_B

  • VEGF receptor
  • Protein family

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    VEGF receptor

    VEGF receptor

    VEGF_receptor

  • Fibroblast growth factor
  • Family of proteins involved in anatomical development

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Fibroblast growth factor

    Fibroblast_growth_factor

  • Avapritinib
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Avapritinib

    Avapritinib

    Avapritinib

  • STAT5A
  • Protein-coding gene in the species Homo sapiens

    Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1 (1) 2005.0008. doi:10

    STAT5A

    STAT5A

    STAT5A

  • Hemopoietic growth factor
  • Class of proteins

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Hemopoietic growth factor

    Hemopoietic_growth_factor

  • Amivantamab/hyaluronidase
  • Medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Amivantamab/hyaluronidase

    Amivantamab/hyaluronidase

  • Robert Roskoski
  • American academic

    and regulation. Pharmacol. Res. 66, 105–143. Roskoski R Jr. (2014) The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol. Res. 79, 34–74

    Robert Roskoski

    Robert Roskoski

    Robert_Roskoski

  • Dabrafenib
  • Anti-cancer medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Dabrafenib

    Dabrafenib

    Dabrafenib

  • Filgrastim
  • Medication

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Filgrastim

    Filgrastim

    Filgrastim

  • Anti-VEGF
  • Medication which blocks growth of blood vessels

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Anti-VEGF

    Anti-VEGF

    Anti-VEGF

  • Tyrosine kinase inhibitor
  • Drug typically used in cancer treatment

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Tyrosine kinase inhibitor

    Tyrosine kinase inhibitor

    Tyrosine_kinase_inhibitor

  • Fibroblast growth factor receptor 2
  • Protein-coding gene in the species Homo sapiens

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Fibroblast growth factor receptor 2

    Fibroblast growth factor receptor 2

    Fibroblast_growth_factor_receptor_2

  • Glucose-6-phosphate isomerase
  • Mammalian protein found in Homo sapiens

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Glucose-6-phosphate isomerase

    Glucose-6-phosphate isomerase

    Glucose-6-phosphate_isomerase

  • Fibroblast growth factor receptor 3
  • Gene involved in the most common form of dwarfism

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Fibroblast growth factor receptor 3

    Fibroblast growth factor receptor 3

    Fibroblast_growth_factor_receptor_3

  • Cyclotraxin B
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Cyclotraxin B

    Cyclotraxin B

    Cyclotraxin_B

  • Epiregulin
  • Protein found in humans

    growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary

    Epiregulin

    Epiregulin

    Epiregulin

  • Erythropoietin
  • Protein that stimulates red blood cell production

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Erythropoietin

    Erythropoietin

    Erythropoietin

  • Pegfilgrastim
  • Monoclonal antibody

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Pegfilgrastim

    Pegfilgrastim

  • Trastuzumab
  • Medication

    signaling is stronger and longer acting compared to heterodimers between other ERBB members. It has been reported that Trastuzumab induces the formation of

    Trastuzumab

    Trastuzumab

    Trastuzumab

  • Phosphorylation cascade
  • Signal pathway enzyme chain

    ; Deng, Lei; Mann, Matthias (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology. 1 2005.0008. doi:10.1038/msb4100012

    Phosphorylation cascade

    Phosphorylation cascade

    Phosphorylation_cascade

  • KIT gene
  • Mammalian protein and protein-coding gene

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    KIT gene

    KIT gene

    KIT_gene

  • Cerebrolysin
  • Experimental drug for neurodegenerative disorders

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Cerebrolysin

    Cerebrolysin

    Cerebrolysin

  • Toceranib
  • Chemical compound used in the treatment of tumors

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Toceranib

    Toceranib

    Toceranib

  • Neuregulin 4
  • Protein-coding gene in the species Homo sapiens

    (April 1999). "Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene. 18 (17): 2681–9. doi:10.1038/sj.onc

    Neuregulin 4

    Neuregulin 4

    Neuregulin_4

  • Ciliary neurotrophic factor receptor
  • Protein found in humans

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Ciliary neurotrophic factor receptor

    Ciliary neurotrophic factor receptor

    Ciliary_neurotrophic_factor_receptor

  • Cetuximab
  • Pharmaceutical drug

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Cetuximab

    Cetuximab

    Cetuximab

  • Robatumumab
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Robatumumab

    Robatumumab

  • Amivantamab
  • Monoclonal antibody

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Amivantamab

    Amivantamab

    Amivantamab

  • Integrin
  • Transmembrane receptors involved in cellular adhesion and signalling

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Integrin

    Integrin

    Integrin

  • Futuximab
  • Monoclonal antibody

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Futuximab

    Futuximab

  • Risk factors of schizophrenia
  • Risk factors related to schizophrenia

    spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system". Proc Natl Acad Sci U S A. 106 (11):

    Risk factors of schizophrenia

    Risk factors of schizophrenia

    Risk_factors_of_schizophrenia

  • Dehydroepiandrosterone sulfate
  • Chemical compound

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    Dehydroepiandrosterone sulfate

    Dehydroepiandrosterone sulfate

    Dehydroepiandrosterone_sulfate

  • SNTB2
  • Protein-coding gene in the species Homo sapiens

    S2CID 20910888. Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses". Proc. Natl

    SNTB2

    SNTB2

    SNTB2

  • Matuzumab
  • Monoclonal antibody

    Retrieved January 5, 2010. Leahy DJ (April 2008). "A molecular view of anti-ErbB monoclonal antibody therapy". Cancer Cell. 13 (4): 291–3. doi:10.1016/j.ccr

    Matuzumab

    Matuzumab

  • Catenin beta-1
  • Mammalian protein found in humans

    Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ (June 2002). "ErbB-beta-catenin complexes are associated with human infiltrating ductal breast

    Catenin beta-1

    Catenin beta-1

    Catenin_beta-1

  • RET proto-oncogene
  • Mammalian protein

    Nesvacumab (against angiopoietin 2) CNTF Agonists: Axokine CNTF Dapiclermin EGF (ErbB) EGF (ErbB1/HER1) Agonists: Amphiregulin Betacellulin EGF (urogastrone) Epigen

    RET proto-oncogene

    RET proto-oncogene

    RET_proto-oncogene

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