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Marker on immune cells
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the
CD8
T cell that kills infected, damaged or cancerous cells
TC, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8+ T-cell or cd8) is a T lymphocyte (a type of white blood cell) that kills cancer
Cytotoxic_T_cell
Receptor on the surface of a eukaryotic cell
CD8.4 is a murine chimeric coreceptor. The extracellular and transmembrane part of the coreceptor is from wild-type CD8 coreceptor, whereas the intracellular
CD8.4
White blood cells of the immune system
cells, each respectively named for the presence of proteins CD8 or CD4 on the cell surface. CD8+ T cells, also known as "killer T cells," are cytotoxic,
T_cell
Ratio of cells in immunology
cytotoxic T cells (with the surface marker CD8). Both CD4+ and CD8+ T cells contain several subsets. The CD4+/CD8+ ratio in the peripheral blood of healthy
CD4+/CD8+_ratio
Protein-coding gene in humans
T-cell surface glycoprotein CD8 alpha chain (Cluster of Differentiation 8a), is a protein encoded by CD8A gene. The CD8 protein is a cell surface glycoprotein
CD8A
Type of cells of the immunological system
individual's immune system integrity. CD8+ cytotoxic T cells: T cells displaying co-receptor CD8 are known as CD8+ T cells. These cells bind antigens presented
White_blood_cell
Medical condition
Primary cutaneous acral CD8 positive T cell lymphoproliferative disorder (CD8+ TLPD) is one type of the lymphoproliferative disorders, subclass cutaneous
Primary cutaneous acral CD8 positive T cell lymphoproliferative disorder
Primary_cutaneous_acral_CD8_positive_T_cell_lymphoproliferative_disorder
Cellular process
molecules to CD8 T cells (cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8+ T cells into
Cross-presentation
the ability to directly kill infected cells. CD103 is expressed by many CD8+ TRM cells and rarely by CD4+ TRM cells, usually in conjunction with CD49a
Tissue-resident_memory_T_cell
Medical condition
leukemia are transformed CD8+ T-cell with clonal rearrangements of β chain T-cell receptor genes for the majority of cases and a CD8- T-cell with clonal rearrangements
Large granular lymphocytic leukemia
Large_granular_lymphocytic_leukemia
Subset of T lymphocytes
information is currently based on observations in the cytotoxic T cells (CD8-positive) subset, similar populations appear to exist for both the helper
Memory_T_cell
Type of immune cell
express CD4) or MHC class I (in the case of cytotoxic T cells which express CD8). MHC Class II binding pockets are flexible with respect to the length of
Helper_T_cell
Immune cell
(positive for both CD4 and CD8). The final stage in maturation is the single positive stage (positive for either CD4 or CD8). In humans, circulating CD34+
Thymocyte
Viral pulmonary disease of humans
antigens to induce an immune response, especially those of macrophages and CD8+ T lymphocytes. After activation of the immune system, cytotoxic T lymphocytes
Hantavirus_pulmonary_syndrome
Medical condition
initial CD8+ T cell expansion that regularly occurs in an HIV infection. This persistent CD8+ T cell expansion occurs in the setting of a low CD4+/CD8+ T cell
Diffuse infiltrative lymphocytosis syndrome
Diffuse_infiltrative_lymphocytosis_syndrome
Protein-coding gene in the species Homo sapiens
2002 as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. Later, the expression was detected in Th17 cells, regulatory
HAVCR2
Protein-coding gene in the species Homo sapiens
γδ T cells, activated CD8+ αβ T cells and activated macrophages. In humans, it is expressed by NK cells, γδ T cells and CD8+ αβ T cells. NKG2D recognizes
NKG2D
Classification in immunology
of CD8). Human immunodeficiency virus binds CD4 and a chemokine receptor on the surface of a T helper cell to gain entry. The number of CD4 and CD8 T cells
Cluster_of_differentiation
Mammalian protein found in humans
lymphocytes. The major sources of IL-2 are activated CD4+ T cells and activated CD8+ T cells. Put shortly, the function of IL-2 is to stimulate the growth of
Interleukin_2
Cell surface proteins, part of the acquired immune system
T lymphocytes (CTLs). A CTL expresses CD8 receptors, in addition to T-cell receptors (TCRs). When a CTL's CD8 receptor docks to a MHC class I molecule
Major histocompatibility complex
Major_histocompatibility_complex
Accessory cell of the mammalian immune system
dendritic cells are able to activate antigen-specific naive CD8+ T cells, the formation of CD8+ memory T cells requires the interaction of dendritic cells
Dendritic_cell
Pharmaceutical compound
CD122-preferential IL-2 pathway agonist designed to activate and proliferate CD8+ T cells and NK cells. It is being developed by Nektar Therapeutics. In August
Bempegaldesleukin
Mammalian protein found in humans
endogenous danger signals. In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. The binding of PD-L1 to
PD-L1
Human disease caused by protist parasites
highest levels of IL-10 mRNA in spleen cells is in CD8+ and other non-FoxP3+ T cells. White blood cell CD8+ T cells from VL patients have elevated IL-10 levels
Visceral_leishmaniasis
Mammalian protein found in humans
transfected DCs and PD-1 expressing transgenic (Tg) CD4+ and CD8+ T cells suggest that CD8+ T cells are more susceptible to inhibition by PD-L1, although
Programmed cell death protein 1
Programmed_cell_death_protein_1
Lymphocytes that become large as a result of antigen stimulation
lymphocytes, atypical lymphocytes, Downey cells or Türk cells are cytotoxic (CD8+) lymphocytes that become large as a result of antigen stimulation. Typically
Reactive_lymphocyte
Endocrine gland
formed, the thymocyte will begin to express the cell surface proteins CD4 and CD8 simultaneously. The survival and nature of the T cell then depend on its
Thymus
Protein complex on the surface of T cells that recognizes antigens
CD4 or CD8, depending on the T-cell subtype. CD4 is expressed on helper T cells and regulatory T cells, and is specific for MHC class II. CD8, on the
T-cell_receptor
Marker on immune cells
main roles is to send signals to other types of immune cells, including CD8 killer cells, which then destroy the infectious particle. If CD4 cells become
CD4
1991 box set by John Coltrane
The Prestige Recordings is a box set by jazz musician John Coltrane. In review for AllMusic Lindsay Planer wrote: "The 16 CDs in this compendium represent
The_Prestige_Recordings
Skin condition where patches lose pigment
cytokine and chemokine production promoting the recruitment of cytotoxic CD8+ T cells. Mitochondrial antioxidants, NRF2 inhibitors, and TBK1 inhibitors
Vitiligo
Vital immune process that is essential for T cell immune response triggering
(also known as Tc, killer T cell, or cytotoxic T-lymphocyte (CTL)) express CD8 co-receptors and are a population of T cells that are specialized for inducing
Antigen_presentation
Protein found in humans
on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion
CD38
Protein complex and T cell co-receptor
cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of
CD3_(immunology)
Aspect of T-cell interactions
interactions between TCR and MHC and co-receptor interactions with CD4 or CD8 to signal T cell maturation occur during selection. The TCRs of T cells recognize
MHC_restriction
Immune hypersensitivity reaction causing rash
The pathogenic immune response in EM involves both CD4+ helper T cells and CD8+ cytotoxic T cells, which orchestrate a type IV hypersensitivity reaction
Erythema_multiforme
Protein family
and Cytomegalovirus that allows them to evade the human immune system's CD8 T-cell response by interfering with an infected cell's ability to show viral
Infected_cell_protein_47
InterPro Family
secreted by CD4+ T helper 1 (Th1) cells, natural killer (NK) cells, and CD8+ cytotoxic T cells. The expression of type II IFN is upregulated and downregulated
Interferon_gamma
Medical therapy involving transplant of cells expanded ex vivo
metastatic melanoma tumors. Tumor-derived TILs are generally mixtures of CD8+ and CD4+ T cells with few major contaminating cells. In 1989 Zelig Eshhar
Adoptive_cell_transfer
Chemical compound
telomerase activation activity. A preliminary in vitro study on human CD4 and CD8 T cells found that cycloastragenol may moderately increase telomerase activity
Cycloastragenol
Lab mouse strain lacking immunity and fur
and/or CD8+ T cells delayed-type hypersensitivity responses (require CD4+ T cells) killing of virus-infected or malignant cells (requires CD8+ cytotoxic
Nude_mouse
Apparent anti-HIV innate immune response
CD8+ cell noncytotoxic anti-HIV response appears to be an anti-HIV innate immune response because it can be observed in vitro with CD8+ cells from unexposed
CD8+ cell noncytotoxic anti-HIV response
CD8+_cell_noncytotoxic_anti-HIV_response
Subsystem of the immune system
antigens are typically displayed on MHC class I molecules, and activate CD8+ cytotoxic T-cells. With the exception of non-nucleated cells (including
Adaptive_immune_system
Dextramers offers a new method to accurately detect and quantify antigen-specific CD8+ T cells. While some of the technology is currently only sold for Research
Immudex
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
T-cell lymphoma Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma Primary cutaneous acral CD8-positive T-cell lymphoma Primary
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Protein-coding gene in the species Homo sapiens
inhibitory motif (ITIM)–like motif with the activating receptors CD4 or CD8 for binding the kinase LCK. The LAG3 gene contains 8 exons. The sequence
Lymphocyte-activation_gene_3
Medical diagnostic method
cytotoxic T lymphocyte (CTL) populations. CTLs are also called CD8+ T-cells, because they have CD8 co-receptors that bind to MHC class I molecules. Most cells
Tetramer_assay
Cell that displays antigen bound by MHC proteins on its surface
presented on MHC class I. Most cells in the body can present antigen to CD8+ cytotoxic T cells via MHC class I; however, the term "antigen-presenting
Antigen-presenting_cell
Sanchez, Camryn (October 31, 2023). "West Valley lawmakers Kern and Toma enter CD8 race". KJZZ. Retrieved November 2, 2023. Gersony, Laura (October 26, 2023)
2024 United States House of Representatives elections in Arizona
2024_United_States_House_of_Representatives_elections_in_Arizona
Type of allergic reaction
release of other Th1 cytokines, thus mediating the immune response. Activated CD8+ T cells destroy target cells on contact, whereas activated macrophages produce
Type_IV_hypersensitivity
Anti-inflammatory cytokine
and CD8+ T cell dependent anti-tumor immunity. More specifically, PEGylated recombinant human IL-10 (PEG-rHuIL-10) has been shown to enhance CD8+ T cell
Interleukin_10
Severe skin reaction involving fever, blistering, and peeling
together. It is theorized that CD8+ immune cells become overactive by stimulation from drugs or drug metabolites. CD8+ T cells then mediate keratinocyte
Toxic_epidermal_necrolysis
Abnormal formation of clumps of inflammatory cells (granulomata)
5) CD4/CD8 T cell ratio, which is indicative (but not proof) of pulmonary sarcoidosis. In at least one study, the induced sputum ratio of CD4/CD8 and the
Sarcoidosis
T cell which has not yet encountered its cognate antigen
these are the naive forms of helper T cells (CD4+) and cytotoxic T cells (CD8+). Naive T cells, unlike activated or memory T cells, have not encountered
Naive_T_cell
Medical diagnostic method
CD4:CD8 ratio) is a basic laboratory test in which the percentage of CD3-positive lymphocytes in the blood positive for CD4 (T helper cells) and CD8 (a
Helper/suppressor_ratio
One of the two types of white blood cells
the immune response (they are what becomes defective in an HIV infection). CD8+ (cytotoxic) T cells and natural killer cells are able to kill cells of the
Agranulocyte
Mammalian protein found in humans
(CC-Chemokine-activated killer) cells. It is also an HIV-suppressive factor released from CD8+ T cells The chemokine CCL5 is mainly expressed by T-cells and monocytes
CCL5
Protein-coding gene in the species Homo sapiens
pathway. During human immunodeficiency virus (HIV) infection, TIGIT expressing CD8+ T cells have been shown to be expanded and associated with clinical markers
TIGIT
Protein-coding gene in the species Homo sapiens
cells through CD8+ T cell resilience that is essential for anti-tumor activity. The research suggests that the NKG7 protein allows the CD8+ T cells to continue
NKG7
Elimination of autoreactive lymphocytes by the immune system
(MHC class I) molecules become CD4- CD8+ and thymocytes whose TCR recognize MHCII (MHC class II) become CD4+ CD8-. Subsequently, the positively selected
Central_tolerance
Immune response that does not involve antibodies
well. T-cell progenitors may differentiate into naïve CD8+ cells or naïve CD4+ cells. Naïve CD8+ cells may then further differentiate into TC1 cells upon
Cell-mediated_immunity
White blood cells of the immune system
generated in vitro. Additional regulatory T cell populations include Tr1, Th3, CD8+CD28−, and Qa-1 restricted T cells. The contribution of these populations
Regulatory_T_cell
French virologist and Nobel laureate (born 1947)
(2009). "Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses". The Journal of Immunology
Françoise_Barré-Sinoussi
Method for immune repertoire sequencing
infection, which results in the death of CD4+ T cells. and dysfunctional CD8+ T cells. Recent studies have suggested that increased TCR diversity may
Tcr-seq
Skin disease
reaction in which a drug or its metabolite stimulates cytotoxic T cells (i.e. CD8+ T cells) and T helper cells (i.e. CD4+ T cells) to initiate autoimmune reactions
Stevens–Johnson_syndrome
Suppressor-inducer T cells are a specific subset of CD4+ T helper cells that "induce" CD8+ cytotoxic T cells to become "suppressor" cells. Suppressor T cells are also
Suppressor-inducer_T_cell
Inflammatory demyelinating disease
T-cells with low numbers of CD8+ T-cells and B-cells; the dominant lymphocytes in active MS lesions are tissue resident CD8+ effector memory T-cells and
MOG_antibody_disease
Human chronic inflammatory disease
inflammatory infiltrate in oral LP is primarily composed of CD8+ T cells. A potential pathway for CD8+ T cell-mediated cytotoxicity in oral LP is described
Lichen_planus
Medical condition
cytotoxic T cells (CD8+), which rely on MHC I for proper development, leading to a deficiency of these cells. Without functional MHC I, CD8+ T cells cannot
T_cell_deficiency
Multiple strains of HIV in one person
acute HIV infection, CD8+ T-cells control viral replication and maintain it at a viral set point. Following superinfection, CD8+ T-cells lose control
HIV_superinfection
Protein found in Homo sapiens
also on dermal interstitial CD103+ dendritic cells (DC) and on resident CD8+ DC in lymph nodes. Langerin consists of a relatively short intracellular
Langerin
Immune response to CMV infection
phenomenon is the formation and maintenance of a large population of specific CD8+ T cells in reaction to cytomegalovirus (CMV) infection. CMV is a worldwide
Memory_T_cell_inflation
Oral sex on the penis by a sexual partner
unprotected sexual contact was oral sex developed systemic HIV-specific CD4+ and CD8+ T-cell immune responses, suggesting that oral exposure to HIV may be sufficient
Fellatio
Mammalian protein found in humans
IL-1. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta. CCL4 is produced
CCL4
Protein-coding gene in the species Homo sapiens
HJ (February 2012). "PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions". Journal of Immunology. 188 (4):
P-selectin glycoprotein ligand-1
P-selectin_glycoprotein_ligand-1
cell. It was also described that CD8/CD4 restriction is influenced by transcription factors Runx3, in the case of CD8 restriction, and Th-POK which directs
Cortical thymic epithelial cells
Cortical_thymic_epithelial_cells
Mammalian protein found in humans
IFN-γ, and CXCR3 mRNA in peripheral NK cells and CD8+ T cells. This suggested that IL-21 enhances the CD8+ effector functions thus leading to anti-tumor
Interleukin_21
Regulators of the immune system
during differentiation of human CD8+ T cells from the naive to effector cell phenotype, however tumor-specific human CD8+ T cells express high levels of
Immune_checkpoint
elimination phase describes a rise in infected CD4+T cells that cause a rise in CD8+T cell responses which eliminate many CD4+T cells until an equilibrium point
Immunoengineering
CD1 5 CD9 5 CD2 4 CD10 5 CD3 4 CD11 5 CD4 5 CD12 5 CD5 5 CD13 5 CD6 4 CD14 8 CD7 4 CD15 8 CD8 7 CD16 5 PLEO 17 At-large 28 Total pledged delegates 129
2000 Michigan Democratic presidential caucuses
2000_Michigan_Democratic_presidential_caucuses
Rare genetic medical disorder with abnormal lymphocyte survival
Negative T cells (DNTs) Required for diagnosis Immunophenotype: CD3+/CD4-/CD8-/TCRalpha/beta+ Measured by flow cytometry: Normal values <2.5% total T cells;
Autoimmune lymphoproliferative syndrome
Autoimmune_lymphoproliferative_syndrome
Protein-coding gene in the species Homo sapiens
domains form the binding groove that holds a peptide for presentation to CD8+ t-cells. The transmembrane region is the region that is embedded in the
HLA-A
configuration so that, unlike MHC tetramers, all of the headgroups can contact the CD8+ T cell. The headgroups are connected via flexible linkers to a coiled-coil
MHC_multimer
Autoimmune diseases of the skin
The diminished CD4+ T cell presence is thought to cause overactivation of CD8+ T cells, which are responsible for the exacerbation of psoriasis in HIV-positive
Psoriasis
disease. However, some autoreactive CD8+ T cells are intended for development into TVM. This process is controlled by CD8-Lck. The generation and maintenance
Virtual_memory_T_cell
T cells with some properties of natural killer cells
tuberculosis. NKT cells include both NK1.1+ and NK1.1−, as well as CD4+, CD4−, CD8+ and CD8− cells. Natural killer T cells can share other features with NK cells
Natural_killer_T_cell
Spectrum of conditions caused by HIV infection
with activation of CD8+ T cells, which kill HIV-infected cells, and subsequently with antibody production, or seroconversion. The CD8+ T cell response is
HIV/AIDS
Protozoan species of malaria parasite
send them for destruction by T lymphocytes (CD8+ T cells). At 48 hours after infection, Plasmodium-specific CD8+ T cells can be detected in the lymph nodes
Plasmodium_falciparum
Protein found in humans
Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160
CD160
Monoclonal antibody
2005). "TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs". The Journal of Clinical Investigation. 115
Teplizumab
Medical condition
recessive form of severe combined immunodeficiency (SCID) resulting in a lack of CD8+ T cells. People with this disease lack the capability to fight infections
ZAP70_deficiency
Cytokine with structural similarity to Interleukin-2
cytokines to compete for and negatively regulate each other's activity. CD8+ memory T cell number is controlled by a balance between IL-15 and IL-2.
Interleukin_15
of patients vaccinated against yellow fever revealed that vaccine-induced CD8+ TSCM cells specific to yellow fever antigens were stably maintained for
T_memory_stem_cell
Medical condition
seen. AITL typically has the phenotype of a mixture of CD4+ and CD8+ T-cells, with a CD4:CD8 ratio greater than unity. Polyclonal plasma cells and CD21+ follicular
Angioimmunoblastic T-cell lymphoma
Angioimmunoblastic_T-cell_lymphoma
Interface between lymphocyte and target cell
(central-SMAC) composed of the θ isoform of protein kinase C, CD2, CD4, CD8, CD28, Lck, and Fyn. p-SMAC (peripheral-SMAC) within which the lymphocyte
Immunological_synapse
Medical condition
GI tract disorder that involved T cells which expressed either the CD4, CD8, or neither surface membrane glycoprotein. The disorder resembled certain
Indolent T cell lymphoproliferative disorder of the gastrointestinal tract
Indolent_T_cell_lymphoproliferative_disorder_of_the_gastrointestinal_tract
Type of specialized cells
lack of CD4 and CD8 coreceptor expression, are proliferated and differentiated to the double positive (DP) stages. These CD4+ and CD8+ double positive
Thymic_epithelial_cell
Protein found in humans
activated by Antigen Presenting Cells (APCs), CD137 becomes embedded in CD4+ and CD8+ T cells. CD137 is a costimulatory molecule functioning to stimulate T cell
CD137
System of biological structures
T cells resembles mammalian α/β T cells. High CD8 expression precedes the dual expression of CD4 and CD8 but following clonal selection and expansion,
Avian_immune_system
CD8
CD8
CD8
CD8
Female
Scandinavian
Scandinavian form of Old Norse Ingigerðr, INGEGERD means "Ing's enclosure."
Boy/Male
Australian, British, English, German, Welsh
Carpenter
Boy/Male
Indian, Sanskrit
Dancing
Girl/Female
Tamil
Goddess Lakshmi
Girl/Female
Arabic, Muslim, Sindhi
Leader; Chief; Head
Boy/Male
Tamil
Jagadguru | ஜகதகà¯à®°à¯
Preceptor of the universe
Girl/Female
Hindu, Indian
Jewel Among the Leader
Boy/Male
Hindu, Indian, Marathi
Joyful
Boy/Male
Shakespearean
The Comedy of Errors' Duke of Ephesus.
Boy/Male
Tamil
CD8
CD8
CD8
CD8
CD8