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Protein family
Cyclophilins (CYPs) are a family of proteins named after their ability to bind to ciclosporin (cyclosporin A), an immunosuppressant which is usually used
Cyclophilin
Chemical compound
the function of lymphocytes. It does this by forming a complex with cyclophilin to block the phosphatase activity of calcineurin, which in turn decreases
Ciclosporin
Protein-coding gene in the species Homo sapiens
Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on chromosome 4. As a member
Peptidylprolyl_isomerase_D
Protein-coding gene in the species Homo sapiens
Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome
Peptidylprolyl_isomerase_A
Phylum of animals having a dorsal nerve cord
identified two conserved signature indels (CSIs) in their proteins: cyclophilin-like protein and inner mitochondrial membrane protease ATP23, which are
Chordate
Chemical compound
UNIL-025) is a cyclophilin inhibitor. Its structure is reminiscent of and synthesized from ciclosporin.[citation needed] It inhibits cyclophilin A. Alisporivir
Alisporivir
Protein-coding gene in the species Homo sapiens
as in a few archaebacteria, and thus are highly conserved. Like other cyclophilins, PPIB forms a β-barrel structure with a hydrophobic core. This β-barrel
PPIB
Pharmaceutical compound
state. To inhibit RAS, daraxonrasib first binds a chaperone molecule (cyclophilin A), which results in a complementary surface. This surface is able to
Daraxonrasib
Chemical compound
Sanglifehrin A is a polyketide natural product found to potently inhibit cyclophilins and have immunosuppressive activity. Isolation and characterisation of
Sanglifehrin
Protein-coding gene in the species Homo sapiens
conditions, such as ischemic reperfusion injury, AIDS, and cancer. Like other cyclophilins, PPIC forms a β-barrel structure with a hydrophobic core. This β-barrel
PPIC
Protein-coding gene in the species Homo sapiens
Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on chromosome 1. As a member
PPIE_(gene)
Protein family
proteins that have prolyl isomerase activity and are related to the cyclophilins in function, though not in amino acid sequence. FKBPs have been identified
FKBP
Pharmaceutical drug
combines a recombinant transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) and a fragment of human immunoglobulin G (IgG)
Telitacicept
Protein pore formed in mitochondria under pathological conditions
thought to be regulated by multiple mitochondrial proteins. Historically, Cyclophilin D and the TSPO (formerly the peripheral benzodiazepine receptor) have
Mitochondrial permeability transition pore
Mitochondrial_permeability_transition_pore
Protein-coding gene in the species Homo sapiens
encoded by the PPIL3 gene. This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide
PPIL3
Chemical compound
forms a non-covalent ligand-mediated protein-protein interaction between cyclophilin A and GTP-bound RAS. Subsequent covalent modification of the mutant Asp12
Zoldonrasib
Protein-coding gene in humans
modulating ligand (CAMLG or CAML), also known as calcium-modulating cyclophilin ligand, is a signalling protein recognized by the TNF receptor TACI.
Calcium_modulating_ligand
Drug that inhibits activity of immune system
protein cyclophilin (an immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of ciclosporin and cyclophilin inhibits
Immunosuppressive_drug
Protein-coding gene in the species Homo sapiens
Harper S, Pawson T, Anderson SK (Jan 1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin". Gene. 180 (1–2): 151–5. doi:10.1016/S0378-1119(96)00436-2
PPIG_(gene)
Protein-coding gene in the species Homo sapiens
of Medicine. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated
PPIH
Chemical compound
cyclosporin, it is a substituted cyclosporine analog that binds to cyclophilin; however, this binary complex cannot bind to calcineurin, and therefore
NIM811
Protein-coding gene in the species Homo sapiens
gene. It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a member of the peptidyl-prolyl
PPIF
Protein-coding gene in the species Homo sapiens
PPIL2 gene. This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family,
PPIL2
Enzyme
are three major classes of proteins with prolyl isomerase activity: cyclophilin and FKBPs which together are referred to as immunophilins, and parvulins
Prolyl_isomerase
Group of evolutionarily-related proteins
The human cyclophilin family, as represented by the structures of the isomerase domains of some of its members
Protein_family
American Physician and scientist
Thesis Biochemical studies on protein folding chaperones : Hsp90 and cyclophilin; and, On trypanosomal enzymes : trypanothione and glutationylspermidine
Kari_Nadeau
Protein-coding gene in the species Homo sapiens
PPIL1 gene. This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family
PPIL1
Rejection of host tissue by a transplanted organ's immune cells
the cytosolic protein peptidyl-prolyl cis-trans isomerase A (known as cyclophilin), while tacrolimus binds to the cytosolic protein peptidyl-prolyl cis-trans
Graft-versus-host_disease
Chemical compound
Rencofilstat (CRV431) is a pan-cyclophilin inhibitor and analog of cyclosporine A developed for nonalcoholic steatohepatitis and hepatocellular carcinoma
Rencofilstat
Protein-coding gene in the species Homo sapiens
the nuclear pore complex. RanBP2/Nup358 is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in controlling selective processes of
RANBP2
Bacterial protein
interface as well as outside the bacteria. SlrA shares homology with the cyclophilin-type peptidyl-prolyl isomerases (PPIases). PPIases accelerate the folding
Lipoprotein_rotamase_A
Human viral infection
C. These include vaccines to treat hepatitis, immunomodulators, and cyclophilin inhibitors, among others. These potential new treatments have come about
Hepatitis_C
Genetic muscle disorder
The investigational drug Debio-025 is a known inhibitor of the protein cyclophilin D, which regulates the swelling of mitochondria in response to cellular
Becker_muscular_dystrophy
Tissue damage after return of blood supply following ischemia or hypoxia
Cyclosporin has been confirmed in studies to inhibit the actions of cyclophilin D, a protein which is induced by excessive intracellular calcium flow
Reperfusion_injury
Protein-coding gene in the species Homo sapiens
(October 2011). "The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors". PLOS Pathogens. 7 (10) e1002331
SLC46A3
Localized enlargement of the abdominal aorta
complication. By eliminating the gene for a signaling protein called cyclophilin A (CypA) from a strain of mice, researchers were able to provide complete
Abdominal_aortic_aneurysm
this, necrosis occurs by physical interaction with the PTP regulator cyclophilin D (CypD). The mitochondrial p53-CypD axis as an important contributor
Ischemia-reperfusion injury of the appendicular musculoskeletal system
Ischemia-reperfusion_injury_of_the_appendicular_musculoskeletal_system
Immunosuppressive drug
Weissman I, Schreiber SL (August 1991). "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes". Cell. 66 (4): 807–815. doi:10
Tacrolimus
German biochemist (born 1966)
Dynamik der Cis-trans-Isomerisierung am Prolin und deren Katalyse durch Cyclophilin (1995) Academic work Discipline Biochemistry Institutions Brandeis University
Dorothee_Kern
Protein-coding gene in humans
Harper S, Pawson T, Anderson SK (1997). "RS cyclophilins: identification of an NK-TR1-related cyclophilin". Gene. 180 (1–2): 151–5. doi:10.1016/S0378-1119(96)00436-2
CLK1
Class of chemical compounds
Cyclosporin (Cyclophilin A-Calcineurin): Bridges cyclophilin A and calcineurin, inhibiting phosphatase activity via steric hindrance. RMC-7977 (Cyclophilin A-KRAS):
Molecular_glue
Mammalian protein found in Homo sapiens
type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. Basigin also serves
Basigin
Protein-coding gene in the species Homo sapiens
PPIL4 gene. This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of
PPIL4
Tool in chemical genetics
a hole-modified (S99T/F113A) cyclophilin mutant. Cyclosporin A is a chemical inducer of dimerization (CID) of cyclophilin. This first bump-and-hole pair
Bump_and_hole
Topics referred to by the same term
alpha-3 country code for Cyprus CYP, ISO 4217 code for the Cypriot pound Cyclophilin Cytochrome P450, isoenzyme Cypripedium, orchid genus This disambiguation
CYP
Protein found in humans
reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". The Journal of Biological Chemistry. 278 (9): 7459–7468. doi:10.1074/jbc
Calcitonin_receptor
Protein-coding gene in the species Homo sapiens
membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells
NKTR
Class of enzymes
unrelated, but have similar biochemical activity: cyclosporin-binding cyclophilins (CyPs) and FK506-binding proteins (FKBPs). In 2005, a group of dual-family
Immunophilins
catalyze the isomerization of prolines. PPIases are present in three types: cyclophilins, FK506-binding proteins, and the parvulins. PPIase enzymes catalyze the
Proline isomerization in epigenetics
Proline_isomerization_in_epigenetics
Protein-coding gene in the species Homo sapiens
PMID 9373149. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated
PRPF3
Protein found in humans
reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B". J. Biol. Chem. 278 (9): 7459–7468. doi:10.1074/jbc.M207976200. PMID 12397072
Apolipoprotein_B
Protein-coding gene in the species Homo sapiens
Huai Q, Kim HY, Liu Y, et al. (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug
PPP3R1
Medication
step through binding to transmembrane activator and calcium-modulating cyclophilin ligand interactor. It then causes B cells to produce autoantigen complexes
Sibeprenlimab
Mammalian protein found in humans
JD, Lane WS, et al. (August 1991). "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes". Cell. 66 (4): 807–15. doi:10
MTOR
American chemist
calcineurin by forming the ternary complexes FKBP12-FK506-calcineurin and cyclophilin-ciclosporin-calcineurin. This work, together with work by Gerald Crabtree
Stuart_Schreiber
Protein-coding gene in the species Homo sapiens
S2CID 11799731. Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin". Nature
OPN1MW
Class of enzymes
HUMAN CALCINEURIN HETERODIMER 1m63: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug
Calcineurin
Protein
Schreiber, Stuart L. (1991-08-23). "Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes". Cell. 66 (4): 807–815. Bibcode:1991Cell
Ubiquitin_ligase
Protein-coding gene in the species Homo sapiens
1093/emboj/17.6.1606. PMC 1170508. PMID 9501082. Trahey M, Weissman IL (1999). "Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates
LGALS3BP
Species of virus
polymerase, inhibitors of NSP5A, and host-targeted compounds such as cyclophilin inhibitors and silibinin. Sofosbuvir for use against chronic hepatitis
Hepatitis_C_virus
the host cell cytoplasm, the HIV-1 capsid is recognized and bound by cyclophilin A (CypA); this affinity interaction stabilizes the capsid and prevents
Viral strategies for immune response evasion
Viral_strategies_for_immune_response_evasion
Although parvulin has no homology with larger prolyl isomerases such as cyclophilin and FKBP, it does share structural features with subdomains of other
Parvulin
Necrotic cell death regulated by intracellular signaling, exerted by activated MLKL
which represses the mitochondrial permeability transition effector cyclophilin D, improves tissue survival primarily by inhibiting necrotic cell death
Necroptosis
Laboratory technique of molecular biology
molecules: tubulin, glyceraldehyde-3-phosphate dehydrogenase, albumin, cyclophilin, and ribosomal RNAs. Real-time PCR is carried out in a thermal cycler
Real-time polymerase chain reaction
Real-time_polymerase_chain_reaction
Protein-coding gene in the species Homo sapiens
Verdine GL (10 January 2017). "IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex". Cell Rep. 18 (2): 432–442. doi:10.1016/j
IMPDH2
Indian health economist and epidemiologist
2014, 52(195): 925–34 13. S Ramachandran, A Venugopal, Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests
V._Ramankutty
Type of molecules within cells
RAGE Heat-shock proteins TLR2, TLR4, CD91 ATP P2X7, P2Y2 F-actin DNGR-1 Cyclophilin A CD147 Aβ TLR2, NLRP1, NLRP3, CD36, RAGE Nuclear Histones TLR2, TLR4
Damage-associated molecular pattern
Damage-associated_molecular_pattern
FKBP1A FKBP1B FKBP2 FKBP3 FKBP4 FKBP5 FKBP6 FKBP8 FKBP9 FKBP10 FKBPL Cyclophilin Parvulin Prolyl isomerase 2-chloro-4-carboxymethylenebut-2-en-1,4-olide
List_of_enzymes
Protein-coding gene in humans
and activation. There is also experimental evidence that it binds to cyclophilin A. It is found on the cell surface of Ewing's sarcoma tumors and is positive
CD99
Medication
its effectiveness, metabolic stability, and safety. Voclosporin and cyclophilin A combine to produce a heterodimeric complex that binds to and inhibits
Voclosporin
British hepatologist
doi:10.1053/j.gastro.2008.10.026. PMID 19027013. Naoumov, N. V. (2014). "Cyclophilin inhibition as potential therapy for liver diseases". Journal of Hepatology
Nikolai_Naoumov
Dysfunction of the heart muscles due to insufficient blood flow
throughout the body. Investigations is still underway on the role of cyclophilin D in reducing the reperfusion injury. Other, less common, causes of acute
Acute_coronary_syndrome
American biochemist
"Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A". Proceedings of the National Academy of Sciences of the United States
Amy_Andreotti
Transcriptional repressor protein
9804. PMC 52809. PMID 1946405. Yang WM, Inouye CJ, Seto E (June 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity"
YY1
Protein-coding gene in the species Homo sapiens
PMID 9257651. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated
PRPF4
Protein created by joining other proteins into a single polypeptide
(such as protozoan parasites and Flavobacteria) and contain full-length cyclophilin and FKBP chaperone modules. The evolutionary origin of such chimera remains
Fusion_protein
Protein family
features a loop (amino acids 85–93) that interacts with the protein cyclophilin A (Cyp A). P24 is a structural protein that plays a crucial role in the
P24_capsid_protein
HIV/AIDS researcher
J.; Hamada, Masakazu; van Deursen, Jan; Poeschla, Eric M. (2014). "A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection". PLOS
Eric_Poeschla
though definitive evidence is still lacking. One known cofactor is Cyclophilin A, which is required for TRIM5α-mediated HIV-1 inhibition in Old World
TRIM5alpha
Protein-coding gene in the species Homo sapiens
discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral
Transmembrane activator and CAML interactor
Transmembrane_activator_and_CAML_interactor
Chemical compound
transition pore (MPTP) by inhibiting the activity of the pore regulator, cyclophilin D (CyP-D). CyP-D is a peptidyl-prolyl cis-trans isomerase or protein
Antamanide
Genetic disease in Quarter Horses, Appaloosas, and Paint Horses
"Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse". Genomics
Hereditary equine regional dermal asthenia
Hereditary_equine_regional_dermal_asthenia
Protein and coding gene in humans
FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin". Proceedings of the National Academy of Sciences of the United States
FKBP1A
Protein-coding gene in the species Homo sapiens
Interactor Consequence BSPRY N/A Calbindin-D28k N/A Calmodulin Inhibition Cyclophilin B Activation FYN PO4lyation I-MFA N/A Klotho Activation, Glycosylation
TRPV6
Mammalian protein found in Homo sapiens
BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which
B-cell_activating_factor
Prolyl 3-hydroxylase 1, P3H1, forms a larger complex with CRTAP and cyclophilin B, CyPB, in the endoplasimic reticulum. The complex hydroxylates a single
Leprecan
American molecular biologist
Research Prize 2015 Lucian Award 2019 AHA Merit Award Winner Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in
Jeffery_D._Molkentin
Protein-coding gene in the species Homo sapiens
Steve, Lu Ming Chu, Ouyang Pin (August 2004). "Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing
Pinin
Enzyme found in humans
Stagljar I, Meier P, et al. (1997). "A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II". Nucleic Acids
Caspase_10
Protein-coding gene in the species Homo sapiens
for the human FAM120AOS protein in a glioblastoma cell in regards to cyclophilin B (CypB) across 6 samples. In the control group, the expression of FAM120AOS
FAM120AOS
Protein-coding gene in the species Homo sapiens
Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor
AGTRAP
Protein-coding gene in the species Homo sapiens
Blackett J, Planelles V (Apr 2006). "Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr"
SF3B2
Gene which maintains basic cellular functions
cis-trans isomerase F PPIG Peptidyl-prolyl cis-trans isomerase G PPIH Cyclophilin H CANX Calnexin. Folding of glycoproteins within endoplasmic reticulum
Housekeeping_gene
Protein-coding gene in humans
the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B". PLOS ONE. 6 (4) e18285. Bibcode:2011PLoSO...618285M. doi:10.1371/journal
YTHDC2
Examples of separate lineages of organisms developing similar characteristics
interfaces. Examples comprise fibronectin/long chain cytokines, NEF/SH2, cyclophilin/capsid proteins. The most well-studied example is the Spike protein of
List of examples of convergent evolution
List_of_examples_of_convergent_evolution
Species of fungus
PMID 11685373. S2CID 33075098. Larson, T. G.; Nuss, D. L. (1 January 1993). "Cyclophilin-dependent stimulation of transcription by cyclosporin A." Proceedings
Tolypocladium_inflatum
Genus of viruses
Yulong; Gao, Honglei; Cui, Hongyu; Li, Kai; Liu, Changjun (2015). "Cyclophilin A Interacts with Viral VP4 and Inhibits the Replication of Infectious
Avibirnavirus
American molecular biologist
; Chaperone Machines, Molecular (1996). "Chaperone Activities of the Cyclophilin CyP-40 and the Steroid Aporeceptor Associated Protein p23". Science.
Richard_I._Morimoto
Heat shock proteins with a molecular mass around 90kDa
immunophilins FKBP51 and FKBP52, the stress induced phosphoprotein 1 (Sti1/Hop), cyclophilin-40, PP5, Tom70, and many more. The Hsp90 protein contains three functional
Hsp90
Overview of and topical guide to immunology
Teriflunomide antifolate Methotrexate Macrolides/ other IL-2 inhibitors FKBP/Cyclophilin/Calcineurin Ciclosporin Pimecrolimus Tacrolimus Voclosporin Abetimus
Outline_of_immunology
CYCLOPHILIN
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