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10.007. PMC 6299210. PMID 30503508. Sebastian S, Luban J (Jun 2005). "TRIM5alpha selectively binds a restriction-sensitive retroviral capsid". Retrovirology
TRIM5alpha
Protein-coding gene in the species Homo sapiens
effects. Other proteins that function to restrict HIV replication include TRIM5alpha and APOBEC3G. It has been demonstrated that treatment of cells with interferon
TRIM22
InterPro Family
factors—for example, with respect to retroviruses, relevant genes include TRIM5alpha, APOBEC, and Tetherin, representing directly antiviral effects Primes
Interferon_gamma
Virus that possibly infected ancient chimpanzees
Emerman M (2007). "Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein". Science. 316 (5832): 1756–1758. Bibcode:2007Sci..
Pan troglodytes endogenous retrovirus-1
Pan_troglodytes_endogenous_retrovirus-1
Antiretroviral vaginal ring
Cobicistat (c) Ritonavir (r)# Experimental agents Uncoating inhibitors TRIM5alpha (gene) Transcription inhibitors Tat antagonists Translation inhibitors
Dapivirine_Ring
investigations of host restriction factors such as Fv1,[citation needed] TRIM5alpha and other members of the tripartite motif family as well as the lentiviral
Jonathan_P._Stoye
Co-packaged antiretroviral medication
Cobicistat (c) Ritonavir (r)# Experimental agents Uncoating inhibitors TRIM5alpha (gene) Transcription inhibitors Tat antagonists Translation inhibitors
Cabotegravir/rilpivirine
Protein-coding gene in the species Homo sapiens
has been shown to interact with: ITK, CD147, P53, STAT3, Cyclophilin TRIM5alpha GRCh38: Ensembl release 89: ENSG00000196262 – Ensembl, May 2017 "Human
Peptidylprolyl_isomerase_A
TNFRSF21 TNFRSF25 Tolerance to infections Toxoid TPBG Transfer factor TRIF TRIM5alpha Trogocytosis Tuberculin Tumor necrosis factor alpha Tumor necrosis factor
Index_of_immunology_articles
Protein-coding gene in humans
PMID 16189514. S2CID 4427026. Yap MW, Nisole S, Lynch C, Stoye JP (July 2004). "Trim5alpha protein restricts both HIV-1 and murine leukemia virus". Proceedings of
MID2
Protein-coding gene in the species Homo sapiens
motif-containing 6". Li X, Gold B, O'hUigin C, et al. (2007). "Unique features of TRIM5alpha among closely related human TRIM family members". Virology. 360 (2): 419–33
TRIM6
Cellular-based anti-viral defense mechanisms
Autissier P, Sodroski J (February 2004). "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys". Nature. 427 (6977): 848–53
Intrinsic_immunity
Human gene
"Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha". The Journal of Biological Chemistry. 285 (10): 7827–7837
HSPA1B
Protein-coding gene in the species Homo sapiens
either activating or inhibiting its target protein function. For example, TRIM5alpha restriction of retroviral reverse-transcription is dependent on UBE2V2/UBE2N-mediated
UBE2V2
Experimental antibody for HIV treatment
Cobicistat (c) Ritonavir (r)# Experimental agents Uncoating inhibitors TRIM5alpha (gene) Transcription inhibitors Tat antagonists Translation inhibitors
Semzuvolimab
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