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Immunosuppressive drug
the risk of organ rejection is moderate; tacrolimus is used to lower the risk of organ rejection. Tacrolimus is also sold as a topical medication for
Tacrolimus
Immunosuppressive drug
treatment with topical calcineurin inhibitors such as tacrolimus or pimecrolimus may be tried. Both tacrolimus and pimecrolimus are effective and safe to use
Pimecrolimus
Inflammatory disease of the skin
minimal side effects. Topical immunosuppressants like pimecrolimus and tacrolimus may be better in the short term and appear equal to steroids after a year
Dermatitis
Drug that inhibits activity of immune system
structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. Contrary to ciclosporin and tacrolimus, drugs that affect
Immunosuppressive_drug
Diuretic medication
Research on Cancer (IARC) classified hydrochlorothiazide, voriconazole and tacrolimus as group 1 carcinogens. Hydrochlorothiazide is available as a generic
Hydrochlorothiazide
Class of enzymes
inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus. Calcineurin is a highly conserved protein within eukaryotic life, appearing
Calcineurin
Pharmaceutical company
shelf-life.[citation needed] Source: LCP-Tacro (tacrolimus) is a once-daily dosage version of tacrolimus for prevention of rejection in organ transplant
Veloxis_Pharmaceuticals
Corticosteroid medication
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Methylprednisolone
Protein family
trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal
FKBP
Japanese chemist and pharmacologist
Japanese chemist and pharmacologist, best known for his discovery of tacrolimus. While working for Fujisawa Pharmaceutical Company in the 1980s (Astellas
Tohru_Kino
Pharmaceutical drug
improved long-term survival using sirolimus + tacrolimus instead of mycophenolate mofetil + tacrolimus for immunosuppressive therapy starting at one year
Sirolimus
Medical condition
reported that tacrolimus successfully treats polymyositis with interstitial lung disease. Since then, many studies have suggested that tacrolimus is successful
Antisynthetase_syndrome
Medical condition
antibiotics, and calcineurin inhibitors such as cyclosporine and tacrolimus. Tacrolimus has been shown to be an effective and well-tolerated option in treating
Ear_eczema
Member of the polyomavirus family
immunosuppressants in BKVAN Most common methods: Withdrawal of MMF or tacrolimus Replacement of tacrolimus by cyclosporine Overall reduction of immunosuppressive load
BK_virus
Long-term form of skin inflammation
inhibitors, such as tacrolimus or pimecrolimus, are also recommended as first-line therapies for managing atopic dermatitis. Both tacrolimus and pimecrolimus
Atopic_dermatitis
Mountain in Tsukuba, Ibaraki Prefecture, Japan
medication and immunomodulator tacrolimus is produced by a soil bacterium, Streptomyces tsukubensis. The name tacrolimus is derived from "Tsukuba macrolide
Mount_Tsukuba
Medical condition
is unspecific. Treatment includes topical corticosteroids and topical tacrolimus 0.1% ointment. Atrophic skin with a mixture of superficial erosions, crusts
Erosive pustular dermatosis of the scalp
Erosive_pustular_dermatosis_of_the_scalp
Japanese pharmaceutical company
vedotin) - Bladder cancer Prograf (tacrolimus) – Prevention of post-transplant organ rejection Protopic (tacrolimus ointment) – Atopic dermatitis (eczema)
Astellas_Pharma
Medication against high blood pressure
drugs to increase in levels, including cyclosporine, simvastatin, and tacrolimus (the increase in the last one being more likely in people with CYP3A5*3
Amlodipine
Indian multinational pharmaceutical company
American military by the independent laboratory Valisure found that generic tacrolimus produced by Intas did not perform as an equivalent substitute for the
Intas_Pharmaceuticals
Medical procedure
prednisolone. These include: azathioprine and mycophenolate, and ciclosporin and tacrolimus. The indication for kidney transplantation is end-stage renal disease
Kidney_transplantation
Physiological molecule and therapeutic drug
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Hyaluronic_acid
Species of bacterium
Ibaraki in Japan. Streptomyces tsukubensis produces the immunosuppressant tacrolimus. List of Streptomyces species "Species Streptomyces tsukubensis". LPSN
Streptomyces_tsukubensis
Species of bacterium
has been isolated from deer dung. Streptomyces tacrolimicus produces tacrolimus. List of Streptomyces species "Species Streptomyces tacrolimicus". LPSN
Streptomyces_tacrolimicus
Medical condition
disease after surgery and treatment with prednisone was treated with tacrolimus. Tacrolimus (FK-506) was administered at an initial dosage of 1 mg every 12
Kimura's_disease
Skin thinning due to prolonged exposure to topical steroids
treatment of choice for atopic dermatitis. However, topical immunomodulators (tacrolimus, pimecrolimus) and biologics are available options. The mechanism of these
Steroid-induced_skin_atrophy
Medical condition
Reitamo, Sakari (2001). "Treatment of lichenified atopic eczema with tacrolimus ointment" (PDF). Acta Dermato-Venereologica. 81 (4): 314–315. doi:10
Lichenification
Drug interactions with grapefruit juice
leads to serious adverse events (e.g., nephrotoxicity). Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as ciclosporin
Grapefruit–drug_interactions
Monoclonal antibody
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Nemolizumab
Pharmaceutical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Suvomipic
Rejection of host tissue by a transplanted organ's immune cells
reduced incidence and severity of GvHD. Methotrexate, cyclosporin and tacrolimus are common drugs used for GvHD prophylaxis. Further research is necessary
Graft-versus-host_disease
Autoimmune skin condition
steroids or steroids injected into the lesions. Other topical treatments, tacrolimus or pimecrolimus can also be used. If this does not help the patient, his
Discoid_lupus_erythematosus
Antiseptic solution
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Povidone-iodine
Triazole antifungical drug
Research on Cancer (IARC) classified hydrochlorothiazide, voriconazole and tacrolimus as group 1 carcinogens. Being metabolized by hepatic cytochrome P450,
Voriconazole
Indian multinational biopharmaceutical company
+ Metformin), CANMAb (Trastuzumab), Evertor (Everolimus), TACROGRAF (Tacrolimus), ALZUMAb (Itolizumab) and KRABEVA (Bevacizumab). Syngene International
Biocon
Surgical procedure in which a patient's diseased lungs are partially or totally replaced
long-term survival using sirolimus + tacrolimus (median survival 8.9 years) instead of mycophenolate mofetil + tacrolimus (median survival 7.1 years) for immunosuppressive
Lung_transplantation
Increase in size of the gums
avoid this deleterious side effect. In the case of immunosuppression, tacrolimus is an available alternative which results in much less severe gingival
Gingival_enlargement
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Magnesium sulfate (medication)
Magnesium_sulfate_(medication)
Pharmaceutical drug classification
D11AC09 Xenysalate D11AC30 Others D11AE01 Metandienone Empty group D11AH01 Tacrolimus D11AH02 Pimecrolimus D11AH03 Cromoglicic acid D11AH04 Alitretinoin D11AH05
ATC_code_D11
Class of natural products
Included are not only 12-16 membered macrocycles but also larger rings as in tacrolimus. The first macrolide discovered was erythromycin, which was first used
Macrolide
Neurodegenerative disease caused by prions
2013). "Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents". Proceedings of the National Academy
Creutzfeldt–Jakob_disease
Quaternary ammonium cation
1016/j.biopha.2019.109002. PMID 31154270. Abushammala I (October 2021). "Tacrolimus and herbs interactions: a review". Pharmazie. 76 (10): 468–472. doi:10
Berberine
Autoimmune disease in which the immune system attacks healthy tissue
antimalarials may be used. Medications such as prednisone, mycophenolic acid and tacrolimus have been used in the past. Disease-modifying antirheumatic drugs (DMARDs)
Lupus
Sudden decrease in kidney function that develops within seven days
(e.g. amoxicillin/clavulanic acid) and calcineurin inhibitors (e.g., tacrolimus) can also directly damage the tubular cells of the kidney and result in
Acute_kidney_injury
Excessive production of lymphocytes by the immune system
by the prolonged use of T cell suppressant drugs, such as sirolimus, tacrolimus, or ciclosporin. The Epstein-Barr virus, which infects >90% of the world
Lymphoproliferative_disorders
Inflammatory skin disease with painful pustules and ulcers
application of clobetasol, mupirocin, and gentamicin alternated with tacrolimus can be effective. Pyoderma gangrenosum ulcers demonstrate pathergy, that
Pyoderma_gangrenosum
Chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Cromoglicic_acid
Swelling of gums due to side effect of medications
immunosuppressive drugs linked to gingival hyperplasia are cyclosporin and tacrolimus. The most frequently used immunosuppressive drug is cyclosporin, which
Drug-induced gingival enlargement
Drug-induced_gingival_enlargement
Antiandrogen and hormone replacement medication
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Dutasteride
Immunosuppressant medication
immunosuppressants, also including a calcineurin inhibitor (ciclosporin or tacrolimus) and a glucocorticoid (e.g. dexamethasone or prednisone). Mycophenolate
Mycophenolic_acid
Thyroid hormone medication
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Levothyroxine
Medical condition
against the surrounding normal skin. Cosmetic camouflage may be required. Tacrolimus has been reported as speeding resolution. In exceptionally severe cases
Pityriasis_alba
Form of arthritis causing swollen joints
ritonavir, and pyrazinamide. The immunosuppressive drugs ciclosporin and tacrolimus are also associated with gout, the former more so when used in combination
Gout
Breed of cat
respond favourably to topical steroid treatments such as prednisolone and tacrolimus ointment. A UK study looking at veterinary records found the Bengal to
Bengal_cat
Investigational hair loss drugs
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
List of investigational hair loss drugs
List_of_investigational_hair_loss_drugs
Autoimmune disease of skin and muscle
as corticosteroids, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, and cyclosporine, with intravenous immunoglobulin (IVIG) widely used
Dermatomyositis
Antiretroviral medication
amiodarone, propafenone and disopyramide, immunosuppressants such as tacrolimus, voclosporin and sirolimus, neuroleptics like lurasidone and pimozide
Ritonavir
Medication used for epilepsy, bipolar disorder and migraine
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Valproate
Skin disease characterized by red, raised, and itchy bumps
CU include cyclosporine, tacrolimus, sirolimus, and mycophenolate. Calcineurin inhibitors, such as cyclosporine and tacrolimus, inhibit cell responsiveness
Hives
Medication to treat gastroesophageal reflux disease and other conditions
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Omeprazole
Chemical compound
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Dehydroepiandrosterone
Medical condition
therapy. Immunosuppressive drugs, such as sirolimus, mycophenolate mofetil, tacrolimus, ciclosporin, leflunomide and TNF inhibitors, have leukopenia as a known
Leukopenia
Medical condition
treatment with the immunomodulator pimecrolimus or the immunosuppressant tacrolimus can prevent all visible symptoms of this disease.[citation needed] Since
Balanitis_circinata
Crusting or scaling of a baby's scalp
used but may have drawbacks.[clarification needed] The immunomodulators tacrolimus/Protopic and pimecrolimus/Elidel have not been approved for children under
Cradle_cap
Antifungal medication used for dermatophytoses
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Griseofulvin
Chronic disease of the liver, characterized by fibrosis
Transplantation necessitates the use of immune suppressants (ciclosporin or tacrolimus). Manifestations of decompensation in cirrhosis include gastrointestinal
Cirrhosis
Human disease
Khare AK (January 2013). "Treatment of nodular scabies with topical tacrolimus". Indian Dermatology Online Journal. 4 (1): 52–53. doi:10.4103/2229-5178
Scabies
Antibiotic medication
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Rifaximin
Itchy skin rash usually affecting the genitals
Recent studies have shown that topical calcineurin inhibitors such as tacrolimus can have an effect similar to corticosteroids, but its effects on cancer
Lichen_sclerosus
Antibiotic derived from Penicillin
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Flucloxacillin
Medication and insecticide
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Permethrin
Typical antipsychotic medication
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Chlorpromazine
Medication of the barbiturate type
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Phenobarbital
Enzyme that metabolizes substances by oxidation
substrates of CYP3A4 are: some immunosuppressants: ciclosporin (cyclosporin), tacrolimus, sirolimus, upadacitinib; many chemotherapeutics: docetaxel, tamoxifen
CYP3A4
Class of enzymes
immunosuppressive drugs such as sirolimus (rapamycin), cyclosporin (such as CsA) and tacrolimus (FK506), which inhibit the prolyl isomerase activity of the immunophilins
Immunophilins
Opioid medication
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Fentanyl
Chemical compound
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Meclizine
Chemical compound
Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched
Ascomycin
Chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Turosteride
Group of drugs used against malaria
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Artemisinin
Medical study concerned with the kidneys
agents are prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and sirolimus. Newer, so-called "biologic drugs"
Nephrology
Form of scleroderma involving isolated patches of hardened skin
have been used. Other immunomodulators such as methotrexate, topical tacrolimus, and penicillamine have been tried. Children and teenagers with active
Morphea
Medication
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Atinvicitinib
Substance used to diagnose, cure, treat, or prevent disease
to prevent organ rejection or treat autoimmune disease Cyclosporine, tacrolimus, adalimumab Vaccines Stimulate the immune system to prevent infectious
Medication
Chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Alitretinoin
Experimental surgical operation
Odeyemi, I; Pollock, RF (2016). "Systematic Review and Meta-Analysis of Tacrolimus versus Ciclosporin as Primary Immunosuppression After Liver Transplant"
Head_transplant
Antihistamine medication
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Loratadine
Skin condition where patches lose pigment
clobetasol or 0.10% betamethasone) and calcineurin inhibitors (such as tacrolimus or pimecrolimus) are considered to be first-line treatments for vitiligo
Vitiligo
Chemical compound
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Clotrimazole
Antifungal chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Ketoconazole
Skin disease
evidence for the effectiveness of topical calcineurin inhibitors like tacrolimus and pimecrolimus as well as lithium salt therapy. Calcineurin inhibitors
Seborrhoeic_dermatitis
Chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Zinc_pyrithione
Chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
4-Aminobenzoic_acid
Inflammation of the membranes lining the chest cavity (pleurae)
be a role for the use of corticosteroids (for tuberculous pleurisy), tacrolimus (Prograf) and methotrexate (Trexall, Rheumatrex) in the treatment of pleurisy
Pleurisy
Chemical compound
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Fenbendazole
Antibiotic
Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal
Tetracycline
Chemical compound
zinc) Antihistamines Calcineurin inhibitors Cyclosporin Pimecrolimus Tacrolimus Isotretinoin Keratolytics Coal tar Resorcinol Salicylic acid Sulfur Urea
Hydroquinone
Rare brain condition, leading to severe swelling
are: immunosuppression (especially for organ transplantation, e.g. with tacrolimus), severe infection and/or sepsis, chemotherapy, autoimmune disease, and
Posterior reversible encephalopathy syndrome
Posterior_reversible_encephalopathy_syndrome
Medical procedure involving an incision in a vein
ESR, Coombs test, platelet antibodies, flow cytometry, blood levels of tacrolimus and cyclosporin Pink K2 EDTA (chelator / anticoagulant) Blood typing and
Phlebotomy
Medical condition
or corticosteroids. Topical medications may include corticosteroids, tacrolimus, pimecrolimus, or Derma-Smooth/FS scalp oil. Triamcinolone acetonide,
Scarring_hair_loss
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