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Rejection of host tissue by a transplanted organ's immune cells
Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants
Graft-versus-host_disease
Rejection of host cells by the immune cells of transplanted blood
In hematology, transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the immunologically competent
Transfusion-associated graft-versus-host disease
Transfusion-associated_graft-versus-host_disease
Medical procedure to replace blood or immune stem cells
radiation or chemotherapy before the transplantation. Infection and graft-versus-host disease are major complications of allogeneic HSCT. HSCT remains a dangerous
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
Antibodies to prevent and treat transplant rejection
acute graft versus host disease in recipients receiving progenitor cell transplants. While higher doses (15 mg/kg) reduced acute graft versus host this
Anti-thymocyte_globulin
Medication used as chemotherapy and to suppress the immune system
people who are ill-suited for autologous stem cell transplant. Graft-versus-host disease (GVHD) is a major barrier for allogeneic stem cell transplant
Cyclophosphamide
Pharmaceutical drug
DA (June 1998). "Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production
Sirolimus
myeloma and possibly breast cancer. It is closely linked with graft-versus-host disease (GvHD), as the underlying principle of alloimmunity is the same
Graft-versus-tumor_effect
Transplantation between individuals of the same species
transplant can result in an immune attack on the recipient, called graft-versus-host disease. Material is obtained from a donor who is a living person, or
Allotransplantation
Human chronic inflammatory disease
lichenoid reactions. They can also occur in association with graft versus host disease. Lichen planus lesions are so called because of their "lichen-like"
Lichen_planus
Type of signaling molecule
involved the detrimental effects of renal fibrosis.[citation needed] Graft-versus-host disease (GvHD) targets JAK 1 and 2, the human tyrosine kinase protein
Inflammatory_cytokine
Frequently fatal immune reaction
group A streptococcus, and non-infectious conditions such as graft-versus-host disease. The viruses can invade lung epithelial cells and alveolar macrophages
Cytokine_storm
Chemical compound
among others, is a medication used for the treatment of chronic graft versus host disease (cGvHD). It is in the class of drugs known as serine/threonine
Belumosudil
Protein complex
therapeutics. LPAM-1 integrin is involved in the development of graft-versus-host disease (GVHD). Donor-derived CTL cells use α4β7 integrin to migrate to
LPAM-1
Rejection of transplanted tissue by the recipient's immune system
rejection via the CD4 and CD8 T cells. Complication (medicine) Graft-versus-host disease Graft-versus-tumor effect Immunosuppression Transplant engineering Li
Transplant_rejection
Form of organ transplantation
Theoretically, thymus transplantation could cause two types of graft-versus-host disease (GVHD): First, it could cause a donor T cell-related GVHD, because
Thymus_transplantation
Immunomodulatory drug
currently used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such
Thalidomide
Medication
to or intolerance of hydroxyurea; and steroid-refractory acute graft-versus-host disease. Ruxolitinib is a Janus kinase inhibitor. It was developed and
Ruxolitinib
First person known to have been cured of HIV/AIDS
that when a transplant recipient has graft-versus-host disease, the transplanted cells may kill off the host's HIV-infected immune cells. In July 2012
Timothy_Ray_Brown
Medication
(no controls) with severe steroid-resistant acute intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (HSCT)
Alemtuzumab
Australian pharmaceutical company
sold it as an allogeneic cell product for the treatment of acute graft versus host disease (aGVHD) in children and adults in Japan. TEMCELL is the first
Mesoblast
Biological communication between cells involving purine nucleosides and their receptors
in patients with Graft-versus-host disease (GVHD), ATP is released into the peritoneal fluid. It binds onto the P2RX7 receptors of host antigen-presenting
Purinergic_signalling
Medication used in cancer treatment
macroglobulinemia (WM), marginal zone lymphoma (MZL), and chronic graft versus host disease (cGVHD). Very common (>10% frequency) adverse effects include
Ibrutinib
Cancer of plasma cells
donor (allograft). Allografts come with a particular risk of a graft-versus-host-disease. Mesenchymal stromal cells may reduce all-cause mortality if they
Multiple_myeloma
Blood cancer characterized by overproduction of lymphoblasts
treating graft-versus-host disease after stem cell transplantation on all-cause mortality and the complete disappearance of chronic acute graft-versus-host disease
Acute_lymphoblastic_leukemia
Genetic disorder
cognitive function, and physical symptoms. Patients can develop graft versus host disease; this is more likely in non-sibling donors. In a 1998 study, children
Hurler_syndrome
Autoimmune disease
immunodeficiency syndrome, sarcoidosis, amyloidosis, graft-versus-host disease, and IgG4-related disease. Patients using anticholinergic drugs must stop using
Sjögren's_disease
Type of blood and immune-system cancer
stromal cells as treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with
Hodgkin_lymphoma
Monoclonal antibody
Niktimvo, is a monoclonal antibody used for the treatment of chronic graft-versus-host disease. It is a blocker of the colony stimulating factor-1 receptor.
Axatilimab
Medical techniques to separate one or more components of blood
the units tested and that the product be irradiated to avoid graft-versus-host disease (inactivate lymphocytes). Irradiation does not affect PMN function
Apheresis
Pharmacologic substance
marrow-derived mesenchymal stromal cell therapy used for the treatment of graft-versus-host disease. Remestemcel contains mesenchymal stromal cells, which are a type
Remestemcel
Skin rash of small, raised red bumps
may also have this appearance. Maculopapular rash is seen in graft-versus-host disease (GVHD) developed after a hematopoietic stem cell transplant (bone
Maculopapular_rash
Decreased resistance to infection
it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as systemic lupus erythematosus
Immunosuppression
Surgical transplantation of skin
forms. Risks for the skin graft surgery are: Bleeding Infection Loss of grafted skin Nerve damage Graft-versus-host disease Marjolin's ulcer Rejection
Skin_grafting
Multipotent adult stem cells present in multiple tissues
treating diseases are in clinical development around the world, particularly treating autoimmune diseases, graft versus host disease, Crohn's disease, multiple
Mesenchymal_stem_cell
Chemical compound
developed for ulcerative colitis, eczema, alopecia areata, and graft-versus-host disease. Chen, Baili; Zhong, Jie; Li, Xiuling; Pan, Feng; Ding, Yijuan;
Ivarmacitinib
be induced for treatment purposes. TCD can reduce the risk of graft-versus-host disease (GvHD), which is a common issue in transplants. The idea that
T-cell_depletion
immune system. Furthermore, there is virtually no incidence of graft-versus-host disease. In 1993 a research article demonstrated that islet isografts
Isograft
Type of cancer of lymph nodes
participants receive stem-cell transplants, they can develop a graft-versus-host disease. When compared with placebo for treating immune mediated inflammation
Non-Hodgkin_lymphoma
Alternative medical procedure
suggests that photopheresis might be effective in the treatment of graft-versus-host disease, though controlled trials are needed to support this use. The
Blood_irradiation_therapy
allogeneic‐transplantation biology, prevention of graft-versus-host disease, conditioning regimen innovation, using the graft-versus-tumor effect as an early form of immunotherapy
Rainer_F._Storb
Chemical compound
number of disease models such as atherosclerosis, ischemia, lung disease, surgical adhesions, endometriosis and pulmonary graft-versus-host disease. It has
NR58-3.14.3
Monoclonal antibody
monoclonal antibody developed as an immunosuppressive drug against graft-versus-host disease. Its target is the alpha chain of the interleukin-2 receptor.
Inolimomab
Rare immune disorder where the thymus is missing at birth
opportunistic infections, and a tendency to develop autologous graft-versus-host disease (GVHD) or, in the case of complete DiGeorge syndrome, an "atypical"
Congenital_athymia
American haematologist and physician scientist
bone marrow patients by better understanding the chronic form of graft-versus-host disease. Lee is the former president of the American Society of Hematology
Stephanie_Lee_(scientist)
Collection of tissues with similar functions
often requires immunosuppression to prevent organ rejection or graft-versus-host disease. There is considerable interest throughout the world in creating
Organ_(biology)
Subclass of HLA-D antigens that consist of alpha and beta chains
were originally defined as cell surface antigens that mediate graft-versus-host disease. Identification of these antigens has led to greater success and
HLA-DR
Reaction occurring within an organism as a defence against a pathogen
(for example, blood) or organ can cause graft-versus-host disease. A type of immune reactivity known as Rh disease can be observed in pregnant women. These
Immune_response
German-American physician
known for his work in hematopoietic stem cell transplantation, graft-versus-host disease, and the treatment of bone marrow failure syndromes, myelodysplastic
H._Joachim_Deeg
This article provides a list of autoimmune diseases. These conditions, where the body's immune system mistakenly attacks its own cells, affect a range
List_of_autoimmune_diseases
Medical condition
HSCT can include graft-versus-host disease, failure of the graft, and other toxicity related to the transplant. Sickle cell disease is most prevalent
Sickle_cell_disease
Bone transplant
Medicine portal Bone healing CNT Network Bio-Stress Sensors Graft-versus-host disease Hydroxyapatite Oral and Maxillofacial Surgery Orthopedic surgery
Bone_grafting
Medical intervention
lymphoma. Evidence suggests that this treatment might help treat graft-versus-host disease, though this evidence is largely observational; controlled trials
Photopheresis
Excess number of eosinophil cells in the blood
fungi and viruses. They also participate in transplant rejection, Graft-versus-host disease, and the killing of tumor cells. In conducting these functions
Eosinophilia
Reddening, swelling, numbness and skin peeling due to chemotherapy
three weeks) graft-versus-host disease. It is important to differentiate PPE, which is benign, from the more dangerous graft-versus-host disease. As time
Chemotherapy-induced acral erythema
Chemotherapy-induced_acral_erythema
Experimental leukemia treatment
simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectors"
TK_cell_therapy
Cell surface receptor protein found on antigen-presenting cells
these D antigens, originally HL-A4 antigens, are involved in graft-versus-host disease when lymphoid tissues are transplanted between people. Serological
HLA-DQ
Experimental drug
investigated as a treatment for tenosynovial giant cell tumor, chronic graft-versus-host-disease (cGVHD), and pancreatic cancer. Vaynrub A, Healey JH, Tap W, Vaynrub
Pimicotinib
Intravenous transference of blood products
treatment can also replace gamma-irradiation as a method to prevent graft-versus-host disease (TA-GvHD). Before a recipient receives a transfusion, compatibility
Blood_transfusion
British biologist
and their roles in the generation of immunological tolerance, graft versus host disease, and transplant rejection. Elizabeth Simpson was born in London
Elizabeth_Simpson_(biologist)
Medical condition
autoimmune enteropathy is graft-versus-host disease, Crohn's disease, and food sensitivity enteropathies such as celiac disease and lactose intolerance
Autoimmune_enteropathy
Abnormal membrane in the esophagus
Syndrome, bullous dermatologic disorders, inlet patch, graft-versus-host disease, and celiac disease. The postulated mechanisms are sideropenic anemia (mechanism
Esophageal_web
Lichenoid trikeratosis Lichenoid dermatitis Lichenoid reaction of graft-versus-host disease Linear lichen planus Mucosal lichen planus Peno-gingival syndrome
List_of_skin_conditions
Natural killer T cells genetically engineered to combat cancer
advantages such as reduced risk of cytokine release syndrome (CRS) and graft-versus-host disease (GVHD), enabling "off-the-shelf" allogeneic use. As of 2025, CAR-NK
CAR-NK
Monoclonal antibody
as a possible treatment for psoriasis and in the prevention of graft-versus-host disease. Podestà, Manuel A.; Binder, Christian; Sellberg, Felix; DeWolf
Siplizumab
Chemical compound
lymphocytic leukemia (CLL), diffuse large B cell lymphoma (DLBCL), graft-versus-host disease (GvHD), hematological malignancies, mantle cell lymphoma (MCL)
Entospletinib
developing consensus guidelines for clinical trials in chronic Graft-versus-host disease (GVHD). Pavletic (born Živko Pavletić) was born in Zagreb, Croatia
Steven_Z._Pavletic
Inflammatory bowel disease that causes ulcers in the colon
on histology. In patients who have undergone transplantation, graft versus host disease may also be a differential diagnosis. This response to transplantation
Ulcerative_colitis
Medical condition
cirrhosis Primary sclerosing cholangitis Hodgkin's lymphoma Chronic graft-versus-host disease Drugs(chlorpromazine)/Toxins Ischemia Treatment is dependent upon
Vanishing_bile_duct_syndrome
Antiretroviral drug
graft-versus-host disease". N. Engl. J. Med. 367 (2): 135–145. doi:10.1056/NEJMoa1201248. PMC 3568501. PMID 22784116. "HIV Drug Reduces Graft-versus-Host
Maraviroc
Medical condition
Darier's disease and lichen planus but has also occasionally been associated with acantholytic epidermolysis bullosa, no association, graft-versus-host disease
Longitudinal_erythronychia
Ultraviolet light therapy treatment
ultraviolet light therapy treatment for skin diseases: vitiligo, eczema, psoriasis, graft-versus-host disease, mycosis fungoides, large plaque parapsoriasis
PUVA_therapy
American singer and rapper (1974–2010)
to complications from medicine he was taking to offset GVHD (graft-versus-host disease), which he had been struggling with after having a stem cell transplant
Rich_Cronin
Drug that inhibits activity of immune system
immunosuppressants to prevent the acute transplant rejection and graft-versus-host disease. Nevertheless, they do not prevent an infection and also inhibit
Immunosuppressive_drug
Medical research company
Prochymal or remestemcel-L, which was approved for pediatric Graft-versus-Host Disease (GvHD). Prochymal is a mesenchymal stem cell therapy derived from
Osiris_Therapeutics
ductopenia include failing liver transplant, Hodgkin's lymphoma, graft-versus-host disease (GVHD), sarcoid, cytomegalovirus infection, HIV, and medication
Ductopenia
Permanent enlargement of the lung airways
ulcerative colitis and Crohn's disease also have an association with bronchiectasis. Additionally, graft-versus-host disease in patients who have undergone
Bronchiectasis
Mouth-lining mucous membrane
is done for definitive diagnosis of lichen planus. Graft-versus-host disease: An autoimmune disease developed following bone marrow transplant in which
Oral_mucosa
Tissue compatibility between individuals
require higher degrees of matching due to the increased risk of graft-versus-host disease, in which the donor's immune system recognizes the recipient's
Histocompatibility
Presence of cells originating from another individual
might trigger a graft-versus-host reaction leading to autoimmune disease. This offers a potential explanation for why many autoimmune diseases are more prevalent
Microchimerism
Monoclonal antibody
immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147. Gavilimomab proved slightly less
Gavilimomab
Blood antigen set classification systems
disease of the newborn. It is also used before hematopoietic stem cell transplantation, as it may be responsible for some cases of acute graft-versus-host
Human_blood_group_systems
American hematologist
failed series of experimental treatments for leukemia and for Graft-versus-host disease at Seattle's Fred Hutchinson Cancer Research Center from 1981
E._Donnall_Thomas
Transfer of spleen or its fragments from one individual to another
Splenectomy – Surgical removal of the spleen Wu; et al. (January 2011). "Graft-versus-host disease after intestinal and multivisceral transplantation". Transplantation
Spleen_transplantation
Medical condition
red patches or spots on a white background. Sjögren's syndrome Graft-versus-host disease Post-irradiation sialadenitis Sarcoidosis—there may be parotitis
Salivary_gland_disease
Species of virus
to life-threatening lung disease characterized by immune dysregulation. RSV has evolved numerous strategies to evade the host's antiviral response, with
Respiratory_syncytial_virus
Genetic disorder leading to severe impairment of the immune system
be depleted of all mature T cells to avoid the occurrence of graft-versus-host disease (GVHD). Consequently, a functional immune system takes longer
Severe combined immunodeficiency
Severe_combined_immunodeficiency
Allogenic cord blood cell therapy
blood. The most common adverse reactions include infections, graft-versus-host disease, and infusion reactions. Omidubicel is composed of human allogeneic
Omidubicel
Red blood cells separated for blood transfusion
transfusion reactions including fatal transfusion-associated graft-versus-host disease (TA-GvHD), irradiation is damaging to the red blood cell membrane
Packed_red_blood_cells
Human antigen receptor of the HLA group
HLA-DP is a protein/peptide-antigen receptor and graft-versus-host disease antigen that is composed of 2 subunits, DPα and DPβ. DPα and DPβ are encoded
HLA-DP
Medical condition
aspects of disease. However, SDS patients have an elevated occurrence of BMT-related adverse events, including graft-versus-host disease (GVHD) and toxicity
Shwachman–Diamond_syndrome
transplant-related mortality. Practices of microtransplantation has shown none graft-versus-host disease (GVHD) till present, thus immunosuppressive drugs for relieving
Microtransplantation
Experimental cancer drug
lymphomas and T cell driven autoimmune diseases, including multiple sclerosis, and graft-versus-host disease following stem cell or bone marrow transplant
Resimmune
Protein-coding gene in the species Homo sapiens
extensive number of cancers, neurodegenerative diseases, cell senescence and aging, and Graft-versus-host disease. This gene encodes a 70kDa heat shock protein
HSPA1L
Monoclonal antibody
investigated for the treatment of systemic lupus erythematosus and graft-versus-host disease, but the studies failed to show positive effects of the drug.
Zolimomab_aritox
Medication and metabolite of cholesterol
atresia. It is not effective in liver allograft rejection, and in graft-versus-host disease involving the liver.[medical citation needed] Diarrhea was the
Ursodeoxycholic_acid
Chemical compound
PMC 7033370. PMID 31880771. Tugues S, et al. (2018). "Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid
Lenzilumab
Benign lesion on the side of the tongue due to Epstein-Barr virus
immunosuppressive medication. OHL may also accompany chronic graft versus host disease. Even more rare are reports of OHL in persons with competent immune
Hairy_leukoplakia
all prostate cancers Developing new potential treatments for graft-versus-host disease Creating new mouse models to facilitate research in cancer biology
University of Michigan Rogel Cancer Center
University_of_Michigan_Rogel_Cancer_Center
Immunosuppressive drug
Cai C, Tang Y, et al. (June 2020). "Comparative efficacy of 20 graft-versus-host disease prophylaxis therapies for patients after hematopoietic stem-cell
Tacrolimus
Endocrine gland
condition is virtually indistinguishable from graft versus host disease. Myasthenia gravis is an autoimmune disease most often caused by antibodies that block
Thymus
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