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CYCLIN E

  • Cyclin E
  • Member of the cyclin family

    Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle

    Cyclin E

    Cyclin E

    Cyclin_E

  • Cyclin
  • Group of proteins

    Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally

    Cyclin

    Cyclin

    Cyclin

  • Cyclin E/Cdk2
  • The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). Similar to other cyclin/Cdk complexes

    Cyclin E/Cdk2

    Cyclin E/Cdk2

    Cyclin_E/Cdk2

  • Cyclin D
  • Member of the cyclin protein family

    Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during

    Cyclin D

    Cyclin D

    Cyclin_D

  • Cyclin-dependent kinase 2
  • Protein found in humans

    complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required

    Cyclin-dependent kinase 2

    Cyclin-dependent kinase 2

    Cyclin-dependent_kinase_2

  • Cell cycle
  • Events leading to cell division

    various genes like cyclin E, cyclin A, DNA polymerase, thymidine kinase, etc. Cyclin E thus produced binds to CDK2, forming the cyclin E-CDK2 complex, which

    Cell cycle

    Cell cycle

    Cell_cycle

  • Cyclin A
  • Protein family

    Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes

    Cyclin A

    Cyclin_A

  • Cyclin D1
  • Protein found in humans

    Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the

    Cyclin D1

    Cyclin D1

    Cyclin_D1

  • Cell cycle checkpoint
  • Control mechanism in the eukaryotic cell cycle

    largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at

    Cell cycle checkpoint

    Cell cycle checkpoint

    Cell_cycle_checkpoint

  • Cyclin E1
  • Protein-coding gene in the species Homo sapiens

    G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family

    Cyclin E1

    Cyclin E1

    Cyclin_E1

  • Cyclin-dependent kinase
  • Class of enzymes

    Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases involved in the regulation of the cell cycle. These enzymes function as

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • Cyclin-dependent kinase 1
  • Mammalian protein found in Homo sapiens

    Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • Cyclin D/Cdk4
  • Multi-protein structure

    The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine

    Cyclin D/Cdk4

    Cyclin_D/Cdk4

  • Cyclin-dependent kinase complex
  • of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex

    Cyclin-dependent kinase complex

    Cyclin-dependent kinase complex

    Cyclin-dependent_kinase_complex

  • RNA-induced silencing complex
  • Multiprotein complex

    transfected with Drosophila cyclin E dsRNA. Cyclin E is an essential gene for cell cycle progression into the S phase. Cyclin E dsRNA arrested the cell cycle

    RNA-induced silencing complex

    RNA-induced_silencing_complex

  • CDKN1B
  • Protein-coding gene in humans

    family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes

    CDKN1B

    CDKN1B

    CDKN1B

  • MAPK/ERK pathway
  • Cell signaling pathway

    transcriptional activity, preventing expression of S-phase entry genes including Cyclin E, Cyclin A2 and Emi1. ERK1/2 activation downstream of mitogen induced Ras signaling

    MAPK/ERK pathway

    MAPK/ERK_pathway

  • Ubiquitin
  • Regulatory protein found in most eukaryotic tissues

    SKP2 targets p27Kip-1, an inhibitor of cyclin-dependent kinases (CDKs). CDKs2/4 partner with the cyclins E/D, respectively, forming a family of cell

    Ubiquitin

    Ubiquitin

    Ubiquitin

  • Endoreduplication
  • Replication of the nuclear genome without mitosis

    endoreduplication these events are facilitated by an oscillation in cyclin E-Cdk2 activity. Cyclin E-Cdk2 activity drives the recruitment and activation of the

    Endoreduplication

    Endoreduplication

  • Restriction point
  • Animal cell cycle checkpoint

    feature of the restriction point is the activation of G1/S- and S-phase cyclin-CDK complexes, which in turn phosphorylate proteins that initiate DNA replication

    Restriction point

    Restriction point

    Restriction_point

  • Stem cell
  • Unspecialized biological cell that can become specialized

    phases: Cyclin D and Cdk4/6 are active in the G1 phase, while Cyclin E and Cdk2 are active during the late G1 phase and S phase; and Cyclin A and Cdk2

    Stem cell

    Stem cell

    Stem_cell

  • Centrosome cycle
  • Centrioles are nine triplets microtubules

    in S phase. It has also been shown that Cdk2 complexes with both cyclin A and cyclin E and this complex is critical for centrosome duplication. Three Cdk2

    Centrosome cycle

    Centrosome cycle

    Centrosome_cycle

  • Histone
  • Protein family around which DNA winds to form nucleosomes

    transcription on chromosomes 1 and 6 of human cells. NPAT is also a substrate of cyclin E-Cdk2, which is required for the transition between G1 phase and S phase

    Histone

    Histone

    Histone

  • Mantle cell lymphoma
  • Type of blood cancer

    over-expression of cyclin D2, cyclin D3 or cyclin E, which also lead to cell cycle hyperactivity and have a similar prognosis to the main cyclin-D1 variant of

    Mantle cell lymphoma

    Mantle cell lymphoma

    Mantle_cell_lymphoma

  • Cyclin B
  • Protein family

    Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk

    Cyclin B

    Cyclin B

    Cyclin_B

  • Retinoblastoma protein
  • Mammalian protein found in humans

    example of E2F-regulated genes repressed by pRb are cyclin E and cyclin A. Both of these cyclins are able to bind to Cdk2 and facilitate entry into the

    Retinoblastoma protein

    Retinoblastoma protein

    Retinoblastoma_protein

  • CIP/KIP
  • proteins bind a wide range of G1/S and S-phase cyclin-CDK complexes including cyclin D-CDK4,6 and cyclin E-, A-CDK2 complexes. Traditionally it was assumed

    CIP/KIP

    CIP/KIP

  • G1/S transition
  • Stage in cell cycle

    E2F drives the expression of other cyclins, including cyclin E and A, and genes necessary for DNA replication. Cyclin E either phosphorylates more pRb, thereby

    G1/S transition

    G1/S transition

    G1/S_transition

  • Tegtociclib
  • Experimental CDK2-selective inhibitor for hormone receptor-positive breast cancer

    the activity of cyclin-dependent kinase 2 (CDK2), a key regulator of cell cycle progression. CDK2 is activated by cyclin E and cyclin A during the G1/S

    Tegtociclib

    Tegtociclib

  • G0 phase
  • Quiescent stage of the cell cycle in which the cell does not divide

    involves downregulation of cell cycle progression genes, such as cyclin A2, cyclin B1, cyclin E2, and survivin, and upregulation of genes involved in the regulation

    G0 phase

    G0 phase

    G0_phase

  • Embryonic diapause
  • Evolutionary reproductive strategy of mammals

    the dacapo gene in the fruit fly. This gene inhibits the formation of Cyclin E/Cdk2 complexes, which is necessary for DNA synthesis. Another known regulator

    Embryonic diapause

    Embryonic_diapause

  • SCF complex
  • Type of protein

    substrates of SCF complexes include: cyclin family proteins: Cyclin D, Cyclin E transcriptional regulators: Myc, E2f1, p130 cyclin-dependent kinase inhibitors

    SCF complex

    SCF complex

    SCF_complex

  • INK4
  • INK4 is a family of cyclin-dependent kinase inhibitors (CKIs). The members of this family (p16INK4a, p15INK4b, p18INK4c, p19INK4d) are inhibitors of CDK4

    INK4

    INK4

  • Cyclin B1
  • Protein-coding gene in the species Homo sapiens

    G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein involved in mitosis. The gene

    Cyclin B1

    Cyclin B1

    Cyclin_B1

  • S phase
  • Second subphase of interphase

    for instance, cell growth induces accumulation of Cln3 cyclin, which complexes with the cyclin dependent kinase CDK2. The Cln3-CDK2 complex promotes transcription

    S phase

    S phase

    S_phase

  • FBXW7
  • Protein-coding gene in the species Homo sapiens

    contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Other well established

    FBXW7

    FBXW7

    FBXW7

  • P21
  • Protein

    (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that

    P21

    P21

    P21

  • G2 phase
  • Third subphase of interphase

    threshold level of active cyclin-B1/CDK1 complex, also known as cyclin-B1/Cdc2 or the maturation promoting factor (MPF). Active cyclin-B1/CDK1 triggers irreversible

    G2 phase

    G2 phase

    G2_phase

  • Neuronal cell cycle
  • regulated by cyclins binding their respective cyclin dependent kinases (Cdks) which then activate the kinases (Fisher, 2012). During G1, cyclin D is synthesized

    Neuronal cell cycle

    Neuronal_cell_cycle

  • Biochemical cascade
  • Series of chemical reactions resulting in a cell response

    p19Arf-p53-P21Cip1 signaling pathways. Embryonic stem cells have constitutive cyclin E-CDK2 activity, which hyperphosphorylates and inactivates Rb. This leads

    Biochemical cascade

    Biochemical_cascade

  • Cyclin A2
  • Protein-coding gene in the species Homo sapiens

    Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis

    Cyclin A2

    Cyclin A2

    Cyclin_A2

  • Basal-like carcinoma
  • Breast cancer subtype

    expression of RB and CyclinD1 gene and high expression of E2F Transcription Factor 3 (E2F-3) as well as Cyclin E genes. The Cyclin D-CDK4/CDK6 complex

    Basal-like carcinoma

    Basal-like carcinoma

    Basal-like_carcinoma

  • Cell cycle analysis
  • Biological measurement technique

    multiparameter analysis that includes measurement of expression of cyclin D1, cyclin E, cyclin A and cyclin B1, each in relation to DNA content Concurrent measurement

    Cell cycle analysis

    Cell_cycle_analysis

  • Cyclin B3
  • Cell cycle protein

    G2/mitotic-specific cyclin-B3 is a protein encoded by the CCNB3 gene located on the X chromosome in humans. Cyclin B3 has features of both A type cyclins and B type

    Cyclin B3

    Cyclin B3

    Cyclin_B3

  • Gene duplication
  • Duplication of a gene sequence within a genome

    translated amino acid sequences (e.g. BLASTp, tBLASTx) to identify ancient duplications or on DNA nucleotide sequences (e.g. BLASTn, megablast) to identify

    Gene duplication

    Gene_duplication

  • Hippo signaling pathway
  • Signaling pathway that controls organ size

    for the expression of several genes that promote organ growth, such as cyclin E, which promotes cell cycle progression, and diap1 (Drosophila inhibitor

    Hippo signaling pathway

    Hippo signaling pathway

    Hippo_signaling_pathway

  • Cyclin K
  • Protein-coding gene in the species Homo sapiens

    Cyclin-K is a protein that in humans is encoded by the CCNK gene. The protein encoded by this gene is a member of the transcription cyclin family. These

    Cyclin K

    Cyclin K

    Cyclin_K

  • Oncovirus
  • Viruses that can cause cancer

    (proto-oncogenes) in the genome. For example, it has been shown that vFLIP and vCyclin interfere with the TGF-β signaling pathway indirectly by inducing oncogenic

    Oncovirus

    Oncovirus

    Oncovirus

  • RICTOR
  • Protein-coding gene in the species Homo sapiens

    (outside of mTORC2) to mediate the ubiquitination of growth-promoting factors cyclin E and c-Myc. Furthermore, elevated growth factor signaling may suppress the

    RICTOR

    RICTOR

    RICTOR

  • S-phase-promoting factor
  • Introduction: S-phase-promoting factor(SPF) is varying Cdk/cyclin complexes in eukaryotes that initiates the S-phase in the cell cycle. SPF is at its peak

    S-phase-promoting factor

    S-phase-promoting_factor

  • Cyclin-dependent kinase 4
  • Human protein

    Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • DMTF1
  • Protein-coding gene in the species Homo sapiens

    Cyclin-D-binding Myb-like transcription factor 1 is a protein that in humans is encoded by the DMTF1 gene. GRCh38: Ensembl release 89: ENSG00000135164

    DMTF1

    DMTF1

    DMTF1

  • Cyclin-dependent kinase 7
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene

    Cyclin-dependent kinase 7

    Cyclin-dependent kinase 7

    Cyclin-dependent_kinase_7

  • Embryonic stem cell
  • Type of pluripotent blastocystic stem cell

    development. In ESCs, cyclin A and cyclin E proteins involved in the G1/S transition are always expressed at high levels. Cyclin-dependent kinases such

    Embryonic stem cell

    Embryonic stem cell

    Embryonic_stem_cell

  • Mir-223
  • RNA molecule

    that the RhoB mRNA is a bona fide miR-223 target. miR-223 also regulates cyclin E activity by modulating expression of the FBXW7 protein. In particular,

    Mir-223

    Mir-223

    Mir-223

  • Induced cell cycle arrest
  • Artificial stopping of the cell cycle

    Measurement of the cyclins from an extract of an arrested cell can determine what phase the cell is in. For example, a peak of cyclin E protein would indicate

    Induced cell cycle arrest

    Induced_cell_cycle_arrest

  • CREB-binding protein
  • Nuclear protein that binds to CREB

    post-translational modifications. It turned out that administration of cyclin E/CDK2 inhibitors did in fact inhibit the enzymatic activity of CBP's KAT

    CREB-binding protein

    CREB-binding protein

    CREB-binding_protein

  • Merkel-cell carcinoma
  • Rare and highly aggressive skin cancer

    that LT may also preserve cell proliferation signals such as c-Myc and cyclin E and cause DNA injury to the p53 tumor suppressor. Meanwhile, sT has been

    Merkel-cell carcinoma

    Merkel-cell carcinoma

    Merkel-cell_carcinoma

  • GAK (protein)
  • Protein-coding gene in the species Homo sapiens

    Cyclin G-associated kinase (GAK) is a serine/threonine kinase that in humans is encoded by the GAK gene. In all eukaryotes, the cell cycle is governed

    GAK (protein)

    GAK (protein)

    GAK_(protein)

  • E2F
  • Family of transcription factors

    The phosphorylation of pRB is initiated by cyclin D/cdk4, cdk6 complex and continued by cyclin E/cdk2. Cyclin D/cdk4,6 itself is activated by the MAPK signaling

    E2F

    E2F

  • Biochemical switches in the cell cycle
  • properly completed before progression to the next phase. For example, Cdk, or cyclin dependent kinase, is a major control switch for the cell cycle and it allows

    Biochemical switches in the cell cycle

    Biochemical_switches_in_the_cell_cycle

  • DREAM complex
  • Protein complex

    affected by similar growth stimuli and subsequent cyclin-CDK activity. Increasing cyclin D-CDK4 and cyclin E-CDK2 activity dissociates the DREAM complex from

    DREAM complex

    DREAM_complex

  • Mesothelin
  • Protein found in humans

    "Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein

    Mesothelin

    Mesothelin

    Mesothelin

  • Retinoblastoma-like protein 2
  • Protein-coding gene in the species Homo sapiens

    Retinoblastoma-like protein 2 has been shown to interact with: BRCA1, BRF1 C-Raf, Cyclin E1, Cyclin-dependent kinase 2, HDAC1, Prohibitin, and RBBP8. Mutations in RBL2

    Retinoblastoma-like protein 2

    Retinoblastoma-like protein 2

    Retinoblastoma-like_protein_2

  • Inhibitor of CDK, cyclin A1 interacting protein 1
  • Protein-coding gene in the species Homo sapiens

    Inhibitor of CDK, cyclin A1 interacting protein 1 is a protein that in humans is encoded by the INCA1 gene. GRCh38: Ensembl release 89: ENSG00000196388

    Inhibitor of CDK, cyclin A1 interacting protein 1

    Inhibitor of CDK, cyclin A1 interacting protein 1

    Inhibitor_of_CDK,_cyclin_A1_interacting_protein_1

  • Fusome
  • Throughout the cell cycle, different cyclins associate with the fusome to induce synchronous cell divisions. Cyclin A and Cyclin E localize to the fusome in female

    Fusome

    Fusome

    Fusome

  • Tim Hunt
  • British biochemist

    studying fertilized sea urchin eggs in the early 1980s, Hunt discovered cyclin, a protein that cyclically aggregates and is depleted during cell division

    Tim Hunt

    Tim Hunt

    Tim_Hunt

  • Cyclin-dependent kinase inhibitor 1C
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent

    Cyclin-dependent kinase inhibitor 1C

    Cyclin-dependent kinase inhibitor 1C

    Cyclin-dependent_kinase_inhibitor_1C

  • Ovarian follicle activation
  • Follicles moving from inactive to growing phase

    inhibits cell cycle progression at the G1 phase by preventing the action of cyclin E-Cdk2. Due to its important role in the cell cycle, it is found within the

    Ovarian follicle activation

    Ovarian_follicle_activation

  • DNA re-replication
  • Undesirable occurrence in eukaryotic cells

    fully rereplicated in a given cell cycle. These control mechanisms rely on cyclin-dependent kinase (CDK) activity. DNA replication control mechanisms cooperate

    DNA re-replication

    DNA re-replication

    DNA_re-replication

  • CCNC (gene)
  • Protein-coding gene in humans

    Cyclin-C is a protein that in humans is encoded by the CCNC gene. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded

    CCNC (gene)

    CCNC (gene)

    CCNC_(gene)

  • AP-1 transcription factor
  • Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)

    (August 2001). "Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes". Molecular Biology of the Cell. 12 (8): 2352–63

    AP-1 transcription factor

    AP-1 transcription factor

    AP-1_transcription_factor

  • Galectin
  • Protein family binding to β-galactoside sugars

    It can also regulate some of the proteins of the cell cycle, such as cyclin E and c-myc, which may give it additional tumorigenic properties. The concentration

    Galectin

    Galectin

    Galectin

  • List of MeSH codes (D12.776)
  • cerevisiae MeSH D12.776.167.200.067.875 – cyclin-dependent kinase 5 MeSH D12.776.167.200.067.900 – cyclin-dependent kinase 9 MeSH D12.776.167.200.580

    List of MeSH codes (D12.776)

    List_of_MeSH_codes_(D12.776)

  • Cyclin-dependent kinase 9
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent

    Cyclin-dependent kinase 9

    Cyclin-dependent kinase 9

    Cyclin-dependent_kinase_9

  • NPAT (gene)
  • Protein-coding gene in the species Homo sapiens

    Zhao J, Dynlacht B, Imai T, Hori T, Harlow E (Feb 1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry". Genes & Development

    NPAT (gene)

    NPAT (gene)

    NPAT_(gene)

  • Cyclin D2
  • Protein-coding gene in humans

    G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. The protein encoded by this gene belongs to the highly conserved cyclin family

    Cyclin D2

    Cyclin D2

    Cyclin_D2

  • Cyclin-dependent kinase inhibitor protein
  • Protein which inhibits cyclin-dependent kinase

    A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and

    Cyclin-dependent kinase inhibitor protein

    Cyclin-dependent kinase inhibitor protein

    Cyclin-dependent_kinase_inhibitor_protein

  • CCNY (gene)
  • Protein-coding gene in humans

    Cyclin-Y is a protein that in humans is encoded by the CCNY gene. GRCh38: Ensembl release 89: ENSG00000108100 – Ensembl, May 2017 GRCm38: Ensembl release

    CCNY (gene)

    CCNY (gene)

    CCNY_(gene)

  • Control of chromosome duplication
  • origins. Removal of cyclin E with antibodies blocks replication. Cyclin E-CDk2 is also important in Drosophila. Levels of cyclin E rise during S phase

    Control of chromosome duplication

    Control of chromosome duplication

    Control_of_chromosome_duplication

  • Fasudil
  • Chemical compound

    rate of p27Kip1. p27Kip1 is a cyclin-dependent kinase (CDK) inhibitor which down-regulates cell cycle by binding cyclin-CDK complex. Human pulmonary arterial

    Fasudil

    Fasudil

    Fasudil

  • CUL3
  • Protein-coding gene in humans

    suppressor protein RhoBTB2. CUL3 has been shown to interact with: CAND1, Cyclin E1, DCUN1D1, KEAP1, and KLHL12. GRCh38: Ensembl release 89: ENSG00000036257

    CUL3

    CUL3

    CUL3

  • SMARCA4
  • Protein-coding gene in the species Homo sapiens

    PMID 11085541. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian

    SMARCA4

    SMARCA4

    SMARCA4

  • CCNE
  • Topics referred to by the same term

    Cisco Career Certifications Commission on Collegiate Nursing Education Cyclin E This disambiguation page lists articles associated with the title CCNE

    CCNE

    CCNE

  • Parkin (protein)
  • Mammalian protein found in humans

    [citation needed] Putative substrates of parkin include synphilin-1, CDC-rel1, cyclin E, p38 tRNA synthase, Pael-R, synaptotagmin XI, sp22 and parkin itself (see

    Parkin (protein)

    Parkin (protein)

    Parkin_(protein)

  • CIZ1
  • Protein-coding gene in humans

    factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. An

    CIZ1

    CIZ1

    CIZ1

  • Maturation promoting factor
  • Biological factor

    also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin–Cdk complex that was discovered first in frog eggs. It stimulates the mitotic

    Maturation promoting factor

    Maturation_promoting_factor

  • S phase index
  • SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation", Journal of Cell Science 116, 2321-2332 (2003). v t e

    S phase index

    S_phase_index

  • TSG101
  • Protein-coding gene in the species Homo sapiens

    (2002). "TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins". Cell. Mol. Biol. (Noisy-le-grand). 47 (7):

    TSG101

    TSG101

    TSG101

  • Cell division
  • Biological process

    controlled by cyclin and cyclin-dependent kinases. The progression of interphase is the result of the increased amount of cyclin. As the amount of cyclin increases

    Cell division

    Cell division

    Cell_division

  • MIZF
  • Protein-coding gene in the species Homo sapiens

    van Wijnen AJ, Stein JL, Stein GS (2005). "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell

    MIZF

    MIZF

    MIZF

  • Dinaciclib
  • Chemical compound

    Dinaciclib (SCH-727965) is an experimental drug that inhibits cyclin-dependent kinases (CDKs). It is being evaluated in clinical trials for various cancer

    Dinaciclib

    Dinaciclib

    Dinaciclib

  • Cyclin dependent kinase like 1
  • Protein-coding gene in the species Homo sapiens

    Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. This gene product is a member of a large family of CDC2-related

    Cyclin dependent kinase like 1

    Cyclin dependent kinase like 1

    Cyclin_dependent_kinase_like_1

  • CUL4A
  • Protein-coding gene in humans

    regulated by the SCFSkp2 complex. CRL4-mediated destruction of p21 relieves cyclin E-Cdk2 inhibition and promotes S phase entry. Loss of Cdt2 expression increases

    CUL4A

    CUL4A

    CUL4A

  • TP53-inducible glycolysis and apoptosis regulator
  • Protein-coding gene in the species Homo sapiens

    called cyclin dependent kinases (cdks) bound to cyclin proteins. The specific complexes that phosphorylate Rb are cyclin D-cdk4 and cyclin E-cdk2. When

    TP53-inducible glycolysis and apoptosis regulator

    TP53-inducible glycolysis and apoptosis regulator

    TP53-inducible_glycolysis_and_apoptosis_regulator

  • CCNG2
  • Protein-coding gene in humans

    whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino

    CCNG2

    CCNG2

    CCNG2

  • CDC25A
  • Protein-coding gene in humans

    cells and is degraded upon metaphase exit akin to Cyclin B. It is competent to activate the G1/S cyclin-dependent kinases CDK4 and CDK2 by removing inhibitory

    CDC25A

    CDC25A

    CDC25A

  • Cyclin-dependent kinase 6
  • Protein found in humans

    encoded by the CDK6 gene. It is regulated by cyclins, more specifically by cyclin D proteins and cyclin-dependent kinase inhibitor proteins. The protein

    Cyclin-dependent kinase 6

    Cyclin-dependent kinase 6

    Cyclin-dependent_kinase_6

  • CCT7
  • Protein-coding gene in humans

    Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular

    CCT7

    CCT7

    CCT7

  • CSNK1D
  • Protein-coding gene in humans

    protein kinase A (PKA), protein kinase B (Akt), cyclin-dependent kinase 2/cyclin E (CDK2/E) and cyclin-dependent kinase 5/p35 (CDK5/p35), CDC-like kinase

    CSNK1D

    CSNK1D

    CSNK1D

AI & ChatGPT searchs for online references containing CYCLIN E

CYCLIN E

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CYCLIN E

  • CAYLIN
  • Female

    English

    CAYLIN

    Variant spelling of English Kaylin, CAYLIN means "girl."

    CAYLIN

  • Colin
  • Boy/Male

    African, American, Australian, British, Chinese, Christian, Danish, English, French, Gaelic, German, Greek, Indian, Irish, Jamaican, Scottish, Tamil

    Colin

    Victory of the People; Young Boy; Abbreviation of Nicholas People's Victory; Young Creature; Victor; People's Victory; Cub; Pup; Dove; Oak Meadow

    Colin

  • Collin
  • Boy/Male

    American, Australian, British, Celtic, Christian, Dutch, English, French, Gaelic, German, Greek, Irish, Portuguese

    Collin

    Creative; Victory of the People; Form of Colin; Victor; Abbreviation of Nicholas; Young Creature; People's Victory; Dove; One who had Travelled to Rome; Young Pup

    Collin

  • CARLIN
  • Female

    English

    CARLIN

    Irish Gaelic unisex name CARLIN means "little champion."

    CARLIN

  • Curlin
  • Surname or Lastname

    English

    Curlin

    English : variant of Curling.Swedish : from an unexplained first element + the adjectival suffix -(l)in, derivative of Latin -enius.Probably also an Americanized spelling of German Gerling.

    Curlin

  • Collin
  • Surname or Lastname

    English and French

    Collin

    English and French : from a pet form of English Coll 1, French Colle.Probably an altered spelling of German Kollin.Danish : variant of Colding.Swedish : ornamental name from an unexplained first element, probably from a place name, + the the suffix -in, from Latin -in(i)us ‘descendant of’.

    Collin

  • COLLIN
  • Male

    English

    COLLIN

    Variant spelling of English Colin, COLLIN means "whelp; young pup."

    COLLIN

  • Bhawar
  • Boy/Male

    Indian, Sikh

    Bhawar

    Cyclone

    Bhawar

  • Carlin
  • Boy/Male

    Gaelic German Irish

    Carlin

    Small champion.

    Carlin

  • Colin
  • Male

    English

    Colin

    People's Victory

    Colin

  • Carlin
  • Girl/Female

    British, Christian, English, German

    Carlin

    Female Version of Carl; Charles

    Carlin

  • Catlin
  • Surname or Lastname

    English

    Catlin

    English : from the medieval female personal name Cat(e)lin(e), Anglo-Norman French form of Catherine.

    Catlin

  • Colin
  • Boy/Male

    Greek American English French Gaelic Scottish

    Colin

    People's victory.

    Colin

  • Caplin
  • Surname or Lastname

    English

    Caplin

    English : occupational name for a chantry priest (or the servant of one), a priest endowed to sing mass daily on behalf of the souls of the dead (Late Latin capellanus). Compare Chaplin.Americanized spelling of Swiss German Kaeppelin, a diminutive of Kappel.

    Caplin

  • Colin
  • Surname or Lastname

    French

    Colin

    French : from a reduced pet form of the personal name Nicolas (see Nicholas).English : variant spelling of Collin.A Colin from Brittany, France, is documented in St. Ours, Quebec, in 1669, with the secondary surname LaLiberté, which is often translated Liberty; Colin is often Americanized as Collins.

    Colin

  • Cocklin
  • Surname or Lastname

    English

    Cocklin

    English : from a diminutive of Middle English cok ‘cock’ (see Cocke).Perhaps also an Americanized spelling of Swiss and South German Köchlin, Koechlin, or Köchling, all diminutives of Koch.

    Cocklin

  • Collin
  • Boy/Male

    Gaelic American Irish English French

    Collin

    child.

    Collin

  • AYLIN
  • Female

    Turkish

    AYLIN

    Turkish name AYLIN means "moon halo."

    AYLIN

  • Cullin
  • Surname or Lastname

    English and Irish

    Cullin

    English and Irish : variant spelling of Cullen.

    Cullin

  • Caelin
  • Boy/Male

    Anglo, Australian, British, English

    Caelin

    Powerful Warrior

    Caelin

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CYCLIN E

Follow users with usernames @CYCLIN E or posting hashtags containing #CYCLIN E

CYCLIN E

Online names & meanings

  • Satayu | ஸதாயு
  • Boy/Male

    Tamil

    Satayu | ஸதாயு

    (Brother of amavasu and vivasu)

  • Mooaz
  • Boy/Male

    Arabic

    Mooaz

    Lucky

  • Sharef
  • Boy/Male

    Afghan, Arabic

    Sharef

    Kind Hearted

  • Joseba
  • Boy/Male

    Australian, Basque, French, Hebrew

    Joseba

    God will Multiply; God will Add

  • Gaushi
  • Girl/Female

    Indian

    Gaushi

    Goddess of Kindness

  • Damodar
  • Boy/Male

    Hindi

    Damodar

    Rope belt.

  • ALLOWN
  • Male

    Hebrew

    ALLOWN

    (אַלוֹן) Hebrew name ALLOWN means "oak tree." In the bible, this is the name of a son of Simeon.

  • Bedwyr
  • Boy/Male

    British, Celtic, English

    Bedwyr

    Returns Excalibur to the Lady of the Lake

  • Suprema
  • Girl/Female

    Christian, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu

    Suprema

    Loving

  • Hug
  • Surname or Lastname

    English

    Hug

    English : variant of Huck.German and Dutch : from the personal name Hug or Hugo, equivalent of English Hugh.

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CYCLIN E

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CYCLIN E

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CYCLIN E

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Other words and meanings similar to

CYCLIN E

AI search in online dictionary sources & meanings containing CYCLIN E

CYCLIN E

  • Cyclamin
  • n.

    A white amorphous substance, regarded as a glucoside, extracted from the corm of Cyclamen Europaeum.

  • Myolin
  • n.

    The essential material of muscle fibers.

  • Cyclic
  • a.

    Alt. of Cyclical

  • Cyclas
  • n.

    A long gown or surcoat (cut off in front), worn in the Middle Ages. It was sometimes embroidered or interwoven with gold. Also, a rich stuff from which the gown was made.

  • Cyclical
  • a.

    Of or pertaining to a cycle or circle; moving in cycles; as, cyclical time.

  • Cycled
  • imp. & p. p.

    of Cycle

  • Cycle
  • n.

    One entire round in a circle or a spire; as, a cycle or set of leaves.

  • Cyclone
  • n.

    A violent storm, often of vast extent, characterized by high winds rotating about a calm center of low atmospheric pressure. This center moves onward, often with a velocity of twenty or thirty miles an hour.

  • Wheeling
  • n.

    The act or practice of using a cycle; cycling.

  • Cycling
  • p. pr. & vb. n.

    of Cycle

  • Cycle
  • n.

    An interval of time in which a certain succession of events or phenomena is completed, and then returns again and again, uniformly and continually in the same order; a periodical space of time marked by the recurrence of something peculiar; as, the cycle of the seasons, or of the year.

  • Cycling
  • n.

    The act, art, or practice, of riding a cycle, esp. a bicycle or tricycle.

  • Cycle
  • v. i.

    To ride a bicycle, tricycle, or other form of cycle.

  • Cyclist
  • n.

    A cycler.

  • Lollard
  • n.

    One of the followers of Wyclif in England.

  • Circular
  • a.

    Adhering to a fixed circle of legends; cyclic; hence, mean; inferior. See Cyclic poets, under Cyclic.

  • Cycle
  • v. i.

    To pass through a cycle of changes; to recur in cycles.

  • Cyclonic
  • a.

    Pertaining to a cyclone.

  • Wheelman
  • n.

    One who rides a bicycle or tricycle; a cycler, or cyclist.