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Member of the cyclin family
Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle
Cyclin_E
Group of proteins
Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally
Cyclin
The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). Similar to other cyclin/Cdk complexes
Cyclin_E/Cdk2
Mammalian protein found in Homo sapiens
Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine
Cyclin-dependent_kinase_1
Events leading to cell division
various genes like cyclin E, cyclin A, DNA polymerase, thymidine kinase, etc. Cyclin E thus produced binds to CDK2, forming the cyclin E-CDK2 complex, which
Cell_cycle
Protein found in humans
complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required
Cyclin-dependent_kinase_2
Member of the cyclin protein family
Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during
Cyclin_D
Protein family
Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes
Cyclin_A
Control mechanism in the eukaryotic cell cycle
largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at
Cell_cycle_checkpoint
Class of enzymes
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases involved in the regulation of the cell cycle. These enzymes function as
Cyclin-dependent_kinase
Protein-coding gene in the species Homo sapiens
G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family
Cyclin_E1
Multi-protein structure
The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine
Cyclin_D/Cdk4
Protein found in humans
Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the
Cyclin_D1
Protein-coding gene in humans
family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes
CDKN1B
of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex
Cyclin-dependent kinase complex
Cyclin-dependent_kinase_complex
Cell signaling pathway
transcriptional activity, preventing expression of S-phase entry genes including Cyclin E, Cyclin A2 and Emi1. ERK1/2 activation downstream of mitogen induced Ras signaling
MAPK/ERK_pathway
Regulatory protein found in most eukaryotic tissues
SKP2 targets p27Kip-1, an inhibitor of cyclin-dependent kinases (CDKs). CDKs2/4 partner with the cyclins E/D, respectively, forming a family of cell
Ubiquitin
Unspecialized biological cell that can become specialized
phases: Cyclin D and Cdk4/6 are active in the G1 phase, while Cyclin E and Cdk2 are active during the late G1 phase and S phase; and Cyclin A and Cdk2
Stem_cell
Replication of the nuclear genome without mitosis
endoreduplication these events are facilitated by an oscillation in cyclin E-Cdk2 activity. Cyclin E-Cdk2 activity drives the recruitment and activation of the
Endoreduplication
Multiprotein complex
transfected with Drosophila cyclin E dsRNA. Cyclin E is an essential gene for cell cycle progression into the S phase. Cyclin E dsRNA arrested the cell cycle
RNA-induced_silencing_complex
Protein-coding gene in the species Homo sapiens
Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis
Cyclin_A2
Centrioles are nine triplets microtubules
in S phase. It has also been shown that Cdk2 complexes with both cyclin A and cyclin E and this complex is critical for centrosome duplication. Three Cdk2
Centrosome_cycle
Protein-coding gene in humans
Cyclin-Y is a protein that in humans is encoded by the CCNY gene. GRCh38: Ensembl release 89: ENSG00000108100 – Ensembl, May 2017 GRCm38: Ensembl release
Cyclin-Y
Protein-coding gene in the species Homo sapiens
G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein involved in mitosis. The gene
Cyclin_B1
Animal cell cycle checkpoint
feature of the restriction point is the activation of G1/S- and S-phase cyclin-CDK complexes, which in turn phosphorylate proteins that initiate DNA replication
Restriction_point
INK4 is a family of cyclin-dependent kinase inhibitors (CKIs). The members of this family (p16INK4a, p15INK4b, p18INK4c, p19INK4d) are inhibitors of CDK4
INK4
Stage in cell cycle
E2F drives the expression of other cyclins, including cyclin E and A, and genes necessary for DNA replication. Cyclin E either phosphorylates more pRb, thereby
G1/S_transition
Protein
(alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that
P21
Type of blood cancer
over-expression of cyclin D2, cyclin D3 or cyclin E, which also lead to cell cycle hyperactivity and have a similar prognosis to the main cyclin-D1 variant of
Mantle_cell_lymphoma
Protein-coding gene in the species Homo sapiens
contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Other well established
FBXW7
Mammalian protein found in humans
example of E2F-regulated genes repressed by pRb are cyclin E and cyclin A. Both of these cyclins are able to bind to Cdk2 and facilitate entry into the
Retinoblastoma_protein
Protein family around which DNA winds to form nucleosomes
transcription on chromosomes 1 and 6 of human cells. NPAT is also a substrate of cyclin E-Cdk2, which is required for the transition between G1 phase and S phase
Histone
proteins bind a wide range of G1/S and S-phase cyclin-CDK complexes including cyclin D-CDK4,6 and cyclin E-, A-CDK2 complexes. Traditionally it was assumed
CIP/KIP
Second subphase of interphase
for instance, cell growth induces accumulation of Cln3 cyclin, which complexes with the cyclin dependent kinase CDK2. The Cln3-CDK2 complex promotes transcription
S_phase
Protein family
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk
Cyclin_B
Introduction: S-phase-promoting factor(SPF) is varying Cdk/cyclin complexes in eukaryotes that initiates the S-phase in the cell cycle. SPF is at its peak
S-phase-promoting_factor
Protein-coding gene in humans
Cyclin-C is a protein that in humans is encoded by the CCNC gene. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded
Cyclin-C
Quiescent stage of the cell cycle in which the cell does not divide
involves downregulation of cell cycle progression genes, such as cyclin A2, cyclin B1, cyclin E2, and survivin, and upregulation of genes involved in the regulation
G0_phase
Human protein
Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member
Cyclin-dependent_kinase_4
Third subphase of interphase
threshold level of active cyclin-B1/CDK1 complex, also known as cyclin-B1/Cdc2 or the maturation promoting factor (MPF). Active cyclin-B1/CDK1 triggers irreversible
G2_phase
Breast cancer subtype
expression of RB and CyclinD1 gene and high expression of E2F Transcription Factor 3 (E2F-3) as well as Cyclin E genes. The Cyclin D-CDK4/CDK6 complex
Basal-like_carcinoma
RNA molecule
that the RhoB mRNA is a bona fide miR-223 target. miR-223 also regulates cyclin E activity by modulating expression of the FBXW7 protein. In particular,
Mir-223
regulated by cyclins binding their respective cyclin dependent kinases (Cdks) which then activate the kinases (Fisher, 2012). During G1, cyclin D is synthesized
Neuronal_cell_cycle
Evolutionary reproductive strategy of mammals
the dacapo gene in the fruit fly. This gene inhibits the formation of Cyclin E/Cdk2 complexes, which is necessary for DNA synthesis. Another known regulator
Embryonic_diapause
Undesirable occurrence in eukaryotic cells
fully rereplicated in a given cell cycle. These control mechanisms rely on cyclin-dependent kinase (CDK) activity. DNA replication control mechanisms cooperate
DNA_re-replication
Throughout the cell cycle, different cyclins associate with the fusome to induce synchronous cell divisions. Cyclin A and Cyclin E localize to the fusome in female
Fusome
Type of protein
substrates of SCF complexes include: cyclin family proteins: Cyclin D, Cyclin E transcriptional regulators: Myc, E2f1, p130 cyclin-dependent kinase inhibitors
SCF_complex
Protein-coding gene in the species Homo sapiens
Zhao J, Dynlacht B, Imai T, Hori T, Harlow E (Feb 1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry". Genes & Development
NPAT_(gene)
Protein-coding gene in humans
factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. An
CIZ1
Protein-coding gene in the species Homo sapiens
Cyclin-K is a protein that in humans is encoded by the CCNK gene. The protein encoded by this gene is a member of the transcription cyclin family. These
Cyclin_K
properly completed before progression to the next phase. For example, Cdk, or cyclin dependent kinase, is a major control switch for the cell cycle and it allows
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Biological measurement technique
multiparameter analysis that includes measurement of expression of cyclin D1, cyclin E, cyclin A and cyclin B1, each in relation to DNA content Concurrent measurement
Cell_cycle_analysis
Protein complex
affected by similar growth stimuli and subsequent cyclin-CDK activity. Increasing cyclin D-CDK4 and cyclin E-CDK2 activity dissociates the DREAM complex from
DREAM_complex
Rare and highly aggressive skin cancer
that LT may also preserve cell proliferation signals such as c-Myc and cyclin E and cause DNA injury to the p53 tumor suppressor. Meanwhile, sT has been
Merkel-cell_carcinoma
Topics referred to by the same term
Cisco Career Certifications Commission on Collegiate Nursing Education Cyclin E This disambiguation page lists articles associated with the title CCNE
CCNE
Duplication of a gene sequence within a genome
translated amino acid sequences (e.g. BLASTp, tBLASTx) to identify ancient duplications or on DNA nucleotide sequences (e.g. BLASTn, megablast) to identify
Gene_duplication
Type of pluripotent blastocystic stem cell
development. In ESCs, cyclin A and cyclin E proteins involved in the G1/S transition are always expressed at high levels. Cyclin-dependent kinases such
Embryonic_stem_cell
Protein-coding gene in the species Homo sapiens
called cyclin dependent kinases (cdks) bound to cyclin proteins. The specific complexes that phosphorylate Rb are cyclin D-cdk4 and cyclin E-cdk2. When
TP53-inducible glycolysis and apoptosis regulator
TP53-inducible_glycolysis_and_apoptosis_regulator
Protein-coding gene in the species Homo sapiens
(outside of mTORC2) to mediate the ubiquitination of growth-promoting factors cyclin E and c-Myc. Furthermore, elevated growth factor signaling may suppress the
RICTOR
Viruses that can cause cancer
(proto-oncogenes) in the genome. For example, it has been shown that vFLIP and vCyclin interfere with the TGF-β signaling pathway indirectly by inducing oncogenic
Oncovirus
Protein-coding gene in humans
whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino
CCNG2
Protein-coding gene in the species Homo sapiens
Inhibitor of CDK, cyclin A1 interacting protein 1 is a protein that in humans is encoded by the INCA1 gene. GRCh38: Ensembl release 89: ENSG00000196388
Inhibitor of CDK, cyclin A1 interacting protein 1
Inhibitor_of_CDK,_cyclin_A1_interacting_protein_1
Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent
Cyclin-dependent_kinase_9
Protein found in humans
"Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein
Mesothelin
cerevisiae MeSH D12.776.167.200.067.875 – cyclin-dependent kinase 5 MeSH D12.776.167.200.067.900 – cyclin-dependent kinase 9 MeSH D12.776.167.200.580
List_of_MeSH_codes_(D12.776)
Cell cycle protein
G2/mitotic-specific cyclin-B3 is a protein encoded by the CCNB3 gene located on the X chromosome in humans. Cyclin B3 has features of both A type cyclins and B type
Cyclin_B3
British biochemist
studying fertilized sea urchin eggs in the early 1980s, Hunt discovered cyclin, a protein that cyclically aggregates and is depleted during cell division
Tim_Hunt
Protein-coding gene in humans
Cyclin M2 is a protein in humans that is encoded by the CNNM2 gene. This gene encodes a member of the ancient conserved domain containing protein family
CNNM2
Protein-coding gene in humans
Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene. The protein encoded by this gene belongs to the dual specificity
CDKN3
Mammalian protein found in humans
[citation needed] Putative substrates of parkin include synphilin-1, CDC-rel1, cyclin E, p38 tRNA synthase, Pael-R, synaptotagmin XI, sp22 and parkin itself (see
Parkin_(protein)
Protein-coding gene in the species Homo sapiens
Retinoblastoma-like protein 2 has been shown to interact with: BRCA1, BRF1 C-Raf, Cyclin E1, Cyclin-dependent kinase 2, HDAC1, Prohibitin, and RBBP8. Mutations in RBL2
Retinoblastoma-like_protein_2
Protein-coding gene in the species Homo sapiens
PMID 11085541. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian
SMARCA4
Artificial stopping of the cell cycle
Measurement of the cyclins from an extract of an arrested cell can determine what phase the cell is in. For example, a peak of cyclin E protein would indicate
Induced_cell_cycle_arrest
Protein family binding to β-galactoside sugars
It can also regulate some of the proteins of the cell cycle, such as cyclin E and c-myc, which may give it additional tumorigenic properties. The concentration
Galectin
Follicles moving from inactive to growing phase
inhibits cell cycle progression at the G1 phase by preventing the action of cyclin E-Cdk2. Due to its important role in the cell cycle, it is found within the
Ovarian_follicle_activation
Series of chemical reactions resulting in a cell response
p19Arf-p53-P21Cip1 signaling pathways. Embryonic stem cells have constitutive cyclin E-CDK2 activity, which hyperphosphorylates and inactivates Rb. This leads
Biochemical_cascade
Protein-coding gene in the species Homo sapiens
Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene
Cyclin-dependent_kinase_7
Protein-coding gene in humans
cells and is degraded upon metaphase exit akin to Cyclin B. It is competent to activate the G1/S cyclin-dependent kinases CDK4 and CDK2 by removing inhibitory
CDC25A
Protein-coding gene in the species Homo sapiens
(2002). "TSG101 expression in gynecological tumors: relationship to cyclin D1, cyclin E, p53 and p16 proteins". Cell. Mol. Biol. (Noisy-le-grand). 47 (7):
TSG101
SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation", Journal of Cell Science 116, 2321-2332 (2003). v t e
S_phase_index
Protein-coding gene in the species Homo sapiens
Activating Protein): an effector of RhoC to enhance expression of cyclin E and cyclin D1. This resulted in cells being promoted to enter S phase more rapidly
RhoC
Chemical compound
rate of p27Kip1. p27Kip1 is a cyclin-dependent kinase (CDK) inhibitor which down-regulates cell cycle by binding cyclin-CDK complex. Human pulmonary arterial
Fasudil
Nuclear protein that binds to CREB
post-translational modifications. It turned out that administration of cyclin E/CDK2 inhibitors did in fact inhibit the enzymatic activity of CBP's KAT
CREB-binding_protein
origins. Removal of cyclin E with antibodies blocks replication. Cyclin E-CDk2 is also important in Drosophila. Levels of cyclin E rise during S phase
Control of chromosome duplication
Control_of_chromosome_duplication
Protein-coding gene in humans
suppressor protein RhoBTB2. CUL3 has been shown to interact with: CAND1, Cyclin E1, DCUN1D1, KEAP1, and KLHL12. GRCh38: Ensembl release 89: ENSG00000036257
CUL3
Protein-coding gene in the species Homo sapiens
van Wijnen AJ, Stein JL, Stein GS (2005). "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell
MIZF
Protein domain
involved in the self-efficient binding of Fbw7 and stable dimerization of cyclin E T380 phospho-degron to Fbw7. Dimerization of β-TrCP1 and β-TrCP2 also found
D_domain
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
(August 2001). "Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes". Molecular Biology of the Cell. 12 (8): 2352–63
AP-1_transcription_factor
transformed into a sharply thresholded output. The development of B-type cyclin–cyclin-dependent kinase activity, as well as the onset of DNA replication,
Cell division control protein 4
Cell_division_control_protein_4
Family of transcription factors
The phosphorylation of pRB is initiated by cyclin D/cdk4, cdk6 complex and continued by cyclin E/cdk2. Cyclin D/cdk4,6 itself is activated by the MAPK signaling
E2F
Protein found in humans
encoded by the CDK6 gene. It is regulated by cyclins, more specifically by cyclin D proteins and cyclin-dependent kinase inhibitor proteins. The protein
Cyclin-dependent_kinase_6
Human protein and coding gene
PMID 8895581. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian
SMARCD3
Protein
G1/S-specific cyclin Cln3 is a protein that is encoded by the CLN3 gene. The Cln3 protein is a budding yeast G1 cyclin that controls the timing of Start
Cln3
Mammalian protein found in Homo sapiens
Retinoblastoma-like protein 1 has been shown to interact with: BEGAIN, BRCA1, BRF1, Cyclin A2, Cyclin-dependent kinase 2, E2F1, HDAC1, MYBL2 Mothers against decapentaplegic
Retinoblastoma-like_protein_1
Protein found in humans
Kung H, Matera AG (2000). "Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies". J. Cell Sci. 113 (9): 1543–52. doi:10
Coilin
Protein-coding gene in the species Homo sapiens
G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene. The protein encoded by this gene belongs to the highly conserved cyclin family
Cyclin_D3
Protein kinase gene
CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase protein
CDK12
Protein found in the human body
Gurian-West M, Clurman B, Roberts JM (September 1999). "Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells". Genes & Development
NEDD8
Protein-coding gene in humans
Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene. The protein encoded by this gene is a neuron-specific
CDK5R2
Protein-coding gene in the species Homo sapiens
PMC 317164. PMID 9744861. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (1999). "Cyclin E Associates with BAF155 and BRG1, Components of the Mammalian SWI-SNF
SMARCC1
CYCLIN E
CYCLIN E
Female
Turkish
Turkish name AYLIN means "moon halo."
Female
English
Variant spelling of English Kaylin, CAYLIN means "girl."
Surname or Lastname
French
French : from a reduced pet form of the personal name
Nicolas (see Nicholas).English : variant spelling of
Collin.A Colin from Brittany, France, is documented in St. Ours, Quebec,
in 1669, with the secondary surname LaLiberté, which is
often translated Liberty; Colin is often Americanized as
Boy/Male
African, American, Australian, British, Chinese, Christian, Danish, English, French, Gaelic, German, Greek, Indian, Irish, Jamaican, Scottish, Tamil
Victory of the People; Young Boy; Abbreviation of Nicholas People's Victory; Young Creature; Victor; People's Victory; Cub; Pup; Dove; Oak Meadow
Boy/Male
Gaelic American Irish English French
child.
Girl/Female
British, Christian, English, German
Female Version of Carl; Charles
Male
English
Variant spelling of English Colin, COLLIN means "whelp; young pup."
Surname or Lastname
English and Irish
English and Irish : variant spelling of Cullen.
Surname or Lastname
English and French
English and French : from a pet form of English Coll 1, French Colle.Probably an altered spelling of German Kollin.Danish : variant of Colding.Swedish : ornamental name from an unexplained first element, probably from a place name, + the the suffix -in, from Latin -in(i)us ‘descendant of’.
Surname or Lastname
English
English : from a diminutive of Middle English cok ‘cock’ (see Cocke).Perhaps also an Americanized spelling of Swiss and South German Köchlin, Koechlin, or Köchling, all diminutives of Koch.
Boy/Male
Greek American English French Gaelic Scottish
People's victory.
Boy/Male
Gaelic German Irish
Small champion.
Boy/Male
Indian, Sikh
Cyclone
Female
English
Irish Gaelic unisex name CARLIN means "little champion."
Surname or Lastname
English
English : occupational name for a chantry priest (or the servant of one), a priest endowed to sing mass daily on behalf of the souls of the dead (Late Latin capellanus). Compare Chaplin.Americanized spelling of Swiss German Kaeppelin, a diminutive of Kappel.
Surname or Lastname
English
English : from the medieval female personal name Cat(e)lin(e), Anglo-Norman French form of Catherine.
Surname or Lastname
English
English : variant of Curling.Swedish : from an unexplained first element + the adjectival suffix -(l)in, derivative of Latin -enius.Probably also an Americanized spelling of German Gerling.
Boy/Male
Anglo, Australian, British, English
Powerful Warrior
Boy/Male
American, Australian, British, Celtic, Christian, Dutch, English, French, Gaelic, German, Greek, Irish, Portuguese
Creative; Victory of the People; Form of Colin; Victor; Abbreviation of Nicholas; Young Creature; People's Victory; Dove; One who had Travelled to Rome; Young Pup
Male
English
People's Victory
CYCLIN E
CYCLIN E
CYCLIN E
CYCLIN E
CYCLIN E
CYCLIN E
CYCLIN E