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Rare and highly aggressive skin cancer
Merkel cell carcinoma (MCC) is an aggressive skin cancer occurring in about three thousand persons per year in the United States. It is also known as
Merkel-cell_carcinoma
Receptors in the skin of vertebrates
Merkel cells, also known as Merkel–Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and
Merkel_cell
Species of virus
University of Pittsburgh Cancer Institute in 2008. Approximately 80% of Merkel cell carcinoma (MCC) tumors have been found to be infected with MCV. MCV appears
Merkel_cell_polyomavirus
Medical condition
penile cancers are squamous-cell carcinomas. Other types of penile cancer, such as Merkel-cell carcinoma, small-cell carcinoma, and melanoma, are generally
Penile_cancer
Most common type of skin cancer
Basal-cell carcinoma (BCC), also known as basal-cell cancer, basalioma, or rodent ulcer, is the most common type of skin cancer. It often appears as a
Basal-cell_carcinoma
Medication
name Zynyz, is an anti-cancer medication used for the treatment of Merkel cell carcinoma. Retifanlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal
Retifanlimab
Type of malignant cancer
Small-cell carcinoma is a type of highly aggressive cancer that most commonly arises within the lungs, but can also occasionally arise in the cervix, prostate
Small-cell_carcinoma
Cancer medication
antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Common side effects include fatigue, musculoskeletal
Avelumab
Medical condition
Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal
Cutaneous squamous-cell carcinoma
Cutaneous_squamous-cell_carcinoma
Human disease
squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374
Human papillomavirus infection
Human_papillomavirus_infection
Viral disease affecting humans
virus to invade the cell. The cycle of infection within a cell covers approximately 24 hours, during this time, the infected cell generates progressively
Measles
Viruses that can cause cancer
a recently discovered analogue called Merkel cell polyomavirus has been associated with Merkel cell carcinoma, a form of skin cancer. The Rb binding
Oncovirus
Skin rash resulting from excess exposure to heat
there is a possibility that a squamous cell carcinoma, or a neuroendocrine carcinoma, such as a Merkel cell carcinoma, may form. If there is a persistent
Erythema_ab_igne
Autoimmune diseases of the skin
increases the risk of developing squamous cell carcinoma of the skin by 431% and increases the risk of basal cell carcinoma by 100%. There is no increased risk
Psoriasis
Viral infection of the skin
Henderson-Patterson bodies) in the epidermis, above the stratum basale, which consist of cells with abundant large granular eosinophilic cytoplasmic inclusion bodies (accumulated
Molluscum_contagiosum
Austrian jazz keyboardist and composer (1932–2007)
died a little over a month later from a rare form of skin cancer (Merkel cell carcinoma) on 11 September 2007. He was cremated at Feuerhalle Simmering and
Joe_Zawinul
Oncologist
and non-melanoma skin cancers (such as squamous cell and basal cell, skin cancer, merkel cell carcinoma), and sarcoma. Samlowski joined Nevada Oncology
Wolfram_Samlowski
Human disease (bacterial infection)
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Impetigo
American entrepreneur (1944–2008)
treatment for a malignant tumor of the salivary glands, caused by Merkel cell carcinoma, a rare form of cancer. Copeland had sought experimental treatments
Al_Copeland
Form of cancer immunotherapy
Opdivo in combination with Yervoy for first-line esophageal squamous cell carcinoma indications". Food and Drug Administration. Archived from the original
Checkpoint_inhibitor
Adrenocortical carcinoma Carcinoid Gastrinoma Glucagonoma Insulinoma Islet cell carcinoma (endocrine pancreas) Merkel cell carcinoma Multiple endocrine
List_of_cancer_types
Eradicated viral disease
phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found
Smallpox
Benign cyst usually found on the skin
malignant transformation is exceedingly rare. The incidence of squamous cell carcinoma developing from an epidermal inclusion cyst has been estimated to range
Epidermoid_cyst
Cancer
Kangri cancer is a type of squamous-cell carcinoma of the skin. It is found only in Kashmir in the northwest of the Indian subcontinent. It occurs on the
Kangri_cancer
Loss of hair from areas on the body
underlying mechanism involves failure by the body to recognize its own cells, with subsequent immune-mediated destruction of the hair follicle. No cure
Alopecia_areata
Australian chef (1963–2025)
following relationship. She died of an aggressive form of skin cancer, Merkel-cell carcinoma, on 22 November 2025, at the age of 62. Gyngell, Skye; Lowe, Jason
Skye_Gyngell
Skin condition where patches lose pigment
vitiligo had a statistically significant decreased incidence of squamous-cell carcinoma, a cancer that develops from the skin. There is no cure for vitiligo
Vitiligo
Tumors of the endocrine and nervous systems
neuroendocrine carcinoma ovary neuroendocrine tumor of the cervix Prostate tumor with neuroendocrine differentiation testes Merkel cell carcinoma of skin (trabecular
Neuroendocrine_tumor
Autoimmune disease in which the immune system attacks healthy tissue
scavenger cell, they named the antibody that causes one cell to ingest another the LE factor and the two nuclei cell result in the LE cell. The LE cell, it
Lupus
Alleged condition of hair suddenly turning white
over-activation of the sympathetic nervous system was causing stem cells to stop producing pigment cells in hair follicles. According to some versions of the escape
Canities_subita
Medical condition involving uncontrolled growth of skin cells
include: Merkel cell carcinoma, Paget's disease of the breast, atypical fibroxanthoma, porocarcinoma, spindle cell tumors, sebaceous carcinomas, microcystic
Skin_cancer
Medical condition
Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise ocular surface squamous neoplasia (OSSN). SCC is
Conjunctival squamous cell carcinoma
Conjunctival_squamous_cell_carcinoma
Artificial stimulation of the immune system to treat cancer
antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Common side effects include fatigue, musculoskeletal
Cancer_immunotherapy
differentiation of small cell and non-small cell carcinomas, i.e. adenocarcinoma and squamous carcinoma. Merkel cell carcinoma Lung cancer "VM618 Glossary". Archived
Nuclear_moulding
Viral disease caused by the varicella zoster virus
chickenpox has resolved, the virus can remain dormant (inactive) in human nerve cells (dorsal root ganglia or cranial nerves) for years or decades, after which
Shingles
Surgery used to treat skin cancers
protuberans, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal carcinoma, merkel cell carcinoma, Paget's disease of the breast
Mohs_surgery
American pharmaceutical company
sickle cell disease and cerebral adrenoleukodystrophy. It is also developing T cell product candidates to treat acute myeloid leukemia, Merkel-cell carcinoma
Bluebird_bio
Family of viruses
2009). "Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas". The American
Polyomaviridae
Infectious agent that replicates in cells
virus is a polyomavirus (Merkel cell polyomavirus) that causes most cases of a rare form of skin cancer called Merkel cell carcinoma. Hepatitis viruses can
Virus
Pharmaceutical drug used in cancer treatment
cervical cancer, hepatocellular carcinoma, biliary tract cancer, Merkel-cell carcinoma, renal cell carcinoma, endometrial carcinoma, tumor mutational burden-high
Pembrolizumab
American football coach and executive (1929–2011)
undergone heart surgery in 1996. Davis was also afflicted with Merkel-cell carcinoma, a rare skin cancer, and had undergone throat surgery in the days
Al_Davis
Melanin spots on skin
"Melanocortin-1 Receptor Genotype is a Risk Factor for Basal and Squamous Cell Carcinoma". Journal of Investigative Dermatology. 116 (2): 224–229. doi:10.1046/j
Freckle
Benign skin tumor originating in keratocytes
other skin conditions, including basal cell carcinoma. Sometimes, seborrheic keratosis and basal cell carcinoma occur at the same location. At clinical
Seborrheic_keratosis
Inflammation of skin surrounding a nail
of acrokeratosis paraneoplastica, which is associated with squamous-cell carcinoma of the larynx. Paronychia can occur with diabetes, drug-induced immunosuppression
Paronychia
Sexually transmitted infection
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Syphilis
Benign tumor of smooth muscle
rehabilitation required. Associated with papillary variant of renal cell carcinoma and multiple cutaneous leiomyoma. Defect is in the fumarate hydratase
Leiomyoma
5858/2003-127-1231-TAP. PMID 12951999. Vazmitel M, Michal M, Kazakov DV (2007). "Merkel cell carcinoma and Azzopardi phenomenon". Am J Dermatopathol. 29 (3): 314–5. doi:10
Azzopardi_phenomenon
Chronic disease caused by bacterial infection
adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection". Cell. 152 (1–2): 51–67. doi:10.1016/j.cell.2012.12.014
Leprosy
Medical disorders that destroy blood vessels by inflammation
Lamprecht, P.; Langford, C. A.; Luqmani, R. A.; Mahr, A. D.; Matteson, E. L.; Merkel, P. A.; Ozen, S.; Pusey, C. D.; Rasmussen, N.; Rees, A. J.; Scott, D. G
Vasculitis
Skin disease characterized by red, raised, and itchy bumps
such as cyclosporine and tacrolimus, inhibit cell responsiveness to mast cell products and inhibit T cell activity. They are preferred by some experts
Hives
Viral infection of sheep and goats
Papular purpuric gloves and socks syndrome Polyomaviridae Merkel cell polyomavirus Merkel cell carcinoma RNA virus Paramyxoviridae MeV Measles Matonaviridae
Orf_(disease)
Human disease
skin produces an intense itch, which has the characteristics of a delayed cell-mediated inflammatory response to allergens. IgE antibodies are present in
Scabies
polyomaviruses, such as Merkel cell polyomavirus, which causes Merkel cell carcinoma in humans, STag appears to be important for replication and to be
Small_tumor_antigen
Cancer of the skin, integumentary lymph nodes, or other organs
fill with blood cells, giving the tumor its characteristic bruise-like appearance. KSHV proteins are uniformly detected in KS cancer cells.[citation needed]
Kaposi's_sarcoma
Skin cancer originating in melanocytes
and UVB even at lower SPFs. Sunscreen also protects against squamous cell carcinoma, another skin cancer. Concerns have been raised that sunscreen might
Melanoma
Skin condition characterized by pimples
acne vulgaris, is a long-term skin condition that occurs when dead skin cells and sebum clog hair follicles. Typical features of the condition include
Acne
activity. Merkel cell polyomavirus (MCPyV), also known as Human polyomavirus 5, naturally infects humans and is associated with Merkel cell carcinoma (MCC)
Large_tumor_antigen
Long-term form of skin inflammation
activation of plasma cells and B lymphocytes, which release antigen-specific IgE, contributing to further inflammation. Other CD4+ helper T-cell pathways thought
Atopic_dermatitis
Medical condition
methods are common surgical treatments, which act by freezing the external cell structure of the warts, destroying the live tissue.[citation needed] Electrodesiccation
Plantar_wart
Solid, non-blisterform elevated areas in or under the skin
ultrasound (R) of thyroid colloid nodule with calcification Lung nodule Merkel cell carcinoma Pyogenic granuloma Lipoma "Nodule Definition – NCI Dictionary of
Nodule_(medicine)
Human viral disease
A (IgA) antibodies; IgG antibodies persist for life and confer immunity. Cell-mediated immune responses are also important in limiting the scope and the
Chickenpox
Viral disease caused by herpes simplex viruses
infection, the viruses are transported along sensory nerves to the nerve cell bodies, where they reside lifelong. Causes of recurrence may include decreased
Herpes
Common human disease caused by a group of viruses
Papular purpuric gloves and socks syndrome Polyomaviridae Merkel cell polyomavirus Merkel cell carcinoma RNA virus Paramyxoviridae MeV Measles Matonaviridae
Hand,_foot,_and_mouth_disease
Precancerous white or grey lesion within the mouth
leukoplakia and 70–100% of proliferative leukoplakia developing into squamous cell carcinoma. Leukoplakia is a descriptive term that should only be applied after
Leukoplakia
Rough skin induced by UV exposure
skin cancer called squamous cell carcinoma. Untreated lesions have up to a 20% risk of progression to squamous cell carcinoma, so treatment by a dermatologist
Actinic_keratosis
Chemical compound
(July 2022). "Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma". JCI Insight. 7 (13) e160513. doi:10.1172/jci.insight.160513. PMC 9310528
Milademetan
Skin disease
The yeast is thought to feed on skin oils (lipids), as well as dead skin cells. Infections are more common in people who have seborrheic dermatitis, dandruff
Tinea_versicolor
Species of virus
meegid.2005.01.004. PMID 16376841. Burrel S, Boutolleau D, Ryu D, Agut H, Merkel K, Leendertz FH, et al. (July 2017). "Ancient Recombination Events between
Herpes_simplex_virus
Group of autoimmune diseases resulting in abnormal growth of connective tissue
B cells mature into plasma cells, which furthers the autoimmune component of the condition. T cells differentiate into subsets, including Th2 cells, which
Scleroderma
Protein found in humans
is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous
Keratin_20
Human and animal disease of follicles
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Folliculitis
Rash in several vector-borne diseases
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Erythema_migrans
rare and constitutes only 2% of all granular cell tumors. List of cutaneous conditions Glassy cell carcinoma Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo
Granular_cell_tumor
American radio broadcasting personality (1940–2004)
United States as well as Canada. On December 9, 2004, he died from Merkel cell carcinoma after it had metastasized to his lungs and kidneys. Born in Minneapolis
David_Brudnoy
Human chronic inflammatory disease
stricture. It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus. Genital lichen planus, which may cause lesions on
Lichen_planus
Red rash due to infection with parvovirus B19
is a single stranded DNA virus, replication can only occur in dividing cells. This is also why populations other than children can become infected with
Fifth_disease
Any medical condition that affects the integumentary system
blood supply. The epidermis contains four cell types: keratinocytes, melanocytes, Langerhans cells, and Merkel cells. Of these, keratinocytes are the major
Skin_condition
American politician (1926–2012)
marriage to Patricia Derwinski. Derwinski died in a nursing home from Merkel cell carcinoma, on January 15, 2012, at age 85. He was buried in Arlington National
Ed_Derwinski
Species of virus
membrane. To enter the cell, the membrane of MV fuses to the plasma membrane, specifically glycosaminoglycans, of the host cell and then enters via macropinocytosis
Molluscum_contagiosum_virus
Mole or birthmark; visible, circumscribed, chronic skin lesion
Melanocytic nevi can be categorized based on the location of melanocytic cells Junctional: epidermis Intradermal: dermis Compound: epidermis and dermis
Nevus
Genital ulcer
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Chancre
Medical condition
difficult to manage, and treat. The prognosis is not reassuring. Squamous cell carcinoma is often a concern with NL. However, this occurs very late into the
Necrobiosis_lipoidica
Human disease caused by human herpesviruses
confirmed with blood tests (PCR or antigen). Low numbers of white blood cells may also be present. Treatment includes sufficient fluids and medications
Roseola
Virus that causes digestive upset and sometimes heart damage
echovirus and mumps virus). The entry of coxsackievirus into cells, especially endothelial cells, is mediated by coxsackievirus and adenovirus receptor. Coxsackieviruses
Coxsackievirus
American historian of modern China (1931–2023)
children and were married until his death in 2017. Goldman died from Merkel cell carcinoma at her home in Cambridge, Massachusetts, on November 16, 2023, at
Merle_Goldman
Small, rough growth resembling a cauliflower or a solid blister
after carbon dioxide laser treatment. Keratolysis, of dead surface skin cells usually using salicylic acid, blistering agents, immune system modifiers
Wart
Fingertip skin lesion due to infection by the herpes virus
Papular purpuric gloves and socks syndrome Polyomaviridae Merkel cell polyomavirus Merkel cell carcinoma RNA virus Paramyxoviridae MeV Measles Matonaviridae
Herpetic_whitlow
Autoimmune disease of skin and connective tissue characterized by large blisters
targeting, a cascade of immunomodulators results in a variable surge of immune cells, including neutrophils, lymphocytes, and eosinophils coming to the affected
Bullous_pemphigoid
Genus of viruses (poxes)
170–250 kb in length. Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans
Orthopoxvirus
Medical condition (infection)
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Boil_(infection)
American racing driver (1917–2012)
Christopher (Kip) and Stephen. Fitch died on October 31, 2012, of Merkel cell carcinoma at his home in Connecticut. (key) Allen Brown. "John Fitch". oldracingcars
John_Fitch_(racing_driver)
Immune hypersensitivity reaction causing rash
CD4+ helper T cells and CD8+ cytotoxic T cells, which orchestrate a type IV hypersensitivity reaction. Upon activation, these T cells release proinflammatory
Erythema_multiforme
Chemical compound
positive cancers (e.g. small-cell lung cancer, ovarian cancer). It has been granted Orphan drug status for Merkel cell carcinoma. It has reported encouraging
Lorvotuzumab_mertansine
Sexually transmitted infection caused by certain types of human papillomaviruses
by the body within two years of infection, it is possible for infected cells to undergo a latency (quiet) period, with the first occurrence or a recurrence
Genital_wart
Human virus that infects RBC precursors
may contribute to lifelong persistence. In one case involving pulmonary carcinoma, a B19V integration junction was found in the colon, indicating possible
Parvovirus_B19
Medical condition
Papular purpuric gloves and socks syndrome Polyomaviridae Merkel cell polyomavirus Merkel cell carcinoma RNA virus Paramyxoviridae MeV Measles Matonaviridae
Laryngeal_papillomatosis
Area of the human head
including: Actinic keratosis Basal-cell carcinoma Epidermoid cyst Merkel-cell carcinoma Pilar cyst Squamous cell carcinoma Dandruff – a common problem caused
Scalp
Medical condition
Molluscum contagiosum Actinic keratosis Squamous-cell carcinoma Basal-cell carcinoma Merkel-cell carcinoma Nevus sebaceous Trichoepithelioma Pigmented Freckles
Pityriasis_alba
Medical condition
necks, backs, ankles and wrists. Bumps are caused by the clustering of T cells below the skin. These papules start as very small, pimple looking bumps
Granuloma_annulare
Topics referred to by the same term
disorder MCC (gene), a candidate colorectal tumor suppressor gene Merkel cell carcinoma, a rare and aggressive cancer of the skin Microcrystalline cellulose
MCC
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MERKEL CELL-CARCINOMA
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MERKEL CELL-CARCINOMA
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MERKEL CELL-CARCINOMA
MERKEL CELL-CARCINOMA
MERKEL CELL-CARCINOMA
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