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CYCLIN C

  • Cyclin
  • Group of proteins

    Cyclins are proteins that control the progression of a cell through the cell cycle by activating cyclin-dependent kinases (CDK). Cyclins were originally

    Cyclin

    Cyclin

    Cyclin

  • Cyclin-C
  • Protein-coding gene in humans

    Cyclin-C is a protein that in humans is encoded by the CCNC gene. The protein encoded by this gene is a member of the cyclin family of proteins. The encoded

    Cyclin-C

    Cyclin-C

    Cyclin-C

  • G0 phase
  • Quiescent stage of the cell cycle in which the cell does not divide

    Immunoprecipitation kinase assays revealed that cyclin C has Rb kinase activity. Furthermore, unlike cyclins D and E, cyclin C's Rb kinase activity is highest during

    G0 phase

    G0 phase

    G0_phase

  • Cyclin-dependent kinase
  • Class of enzymes

    Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases involved in the regulation of the cell cycle. These enzymes function as

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • Cyclin E1
  • Protein-coding gene in the species Homo sapiens

    G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family

    Cyclin E1

    Cyclin E1

    Cyclin_E1

  • Cyclin D1
  • Protein found in humans

    Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the

    Cyclin D1

    Cyclin D1

    Cyclin_D1

  • Cyclin-dependent kinase 4
  • Human protein

    Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • Cyclin-dependent kinase 1
  • Mammalian protein found in Homo sapiens

    Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine

    Cyclin-dependent kinase 1

    Cyclin-dependent kinase 1

    Cyclin-dependent_kinase_1

  • Cyclin-dependent kinase 8
  • Protein-coding gene in the species Homo sapiens

    protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate with the mediator complex and regulate

    Cyclin-dependent kinase 8

    Cyclin-dependent kinase 8

    Cyclin-dependent_kinase_8

  • Cyclin D
  • Member of the cyclin protein family

    Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during

    Cyclin D

    Cyclin D

    Cyclin_D

  • Cyclin-dependent kinase 2
  • Protein found in humans

    Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein

    Cyclin-dependent kinase 2

    Cyclin-dependent kinase 2

    Cyclin-dependent_kinase_2

  • Cyclin-dependent kinase complex
  • of a protein kinase, cyclin-dependent kinase (CDK), with a regulatory subunit, cyclin. Once cyclin-dependent kinases bind to cyclin, the formed complex

    Cyclin-dependent kinase complex

    Cyclin-dependent kinase complex

    Cyclin-dependent_kinase_complex

  • Cyclin B1
  • Protein-coding gene in the species Homo sapiens

    G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein involved in mitosis. The gene

    Cyclin B1

    Cyclin B1

    Cyclin_B1

  • Cyclin-dependent kinase 9
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb. The protein encoded by this gene is a member of the cyclin-dependent

    Cyclin-dependent kinase 9

    Cyclin-dependent kinase 9

    Cyclin-dependent_kinase_9

  • Cyclin E
  • Member of the cyclin family

    Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle

    Cyclin E

    Cyclin E

    Cyclin_E

  • Cyclin D2
  • Protein-coding gene in humans

    G1/S-specific cyclin-D2 is a protein that in humans is encoded by the CCND2 gene. The protein encoded by this gene belongs to the highly conserved cyclin family

    Cyclin D2

    Cyclin D2

    Cyclin_D2

  • Cyclin A
  • Protein family

    Cyclin A is a member of the cyclin family, a group of proteins that function in regulating progression through the cell cycle. The stages that a cell passes

    Cyclin A

    Cyclin_A

  • Cyclin B
  • Protein family

    Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk

    Cyclin B

    Cyclin B

    Cyclin_B

  • Cell cycle
  • Events leading to cell division

    that cyclin D-Cdk4/6 binds to a C-terminal alpha-helix region of Rb that is only distinguishable to cyclin D rather than other cyclins, cyclin E, A and

    Cell cycle

    Cell cycle

    Cell_cycle

  • G2 phase
  • Third subphase of interphase

    threshold level of active cyclin-B1/CDK1 complex, also known as cyclin-B1/Cdc2 or the maturation promoting factor (MPF). Active cyclin-B1/CDK1 triggers irreversible

    G2 phase

    G2 phase

    G2_phase

  • ProtCID
  • the ordered Pfam assignments for that sequence, e.g. (Pkinase) or (Cyclin_N)_(Cyclin_C). Homodimeric interfaces in all crystals that contain particular

    ProtCID

    ProtCID

    ProtCID

  • Cyclin-dependent kinase 3
  • Protein-coding gene in the species Homo sapiens

    CDK3 can phosphorylate histone H1 and interacts with an unknown type of cyclin. GRCh38: Ensembl release 89: ENSG00000250506 – Ensembl, May 2017 "Human

    Cyclin-dependent kinase 3

    Cyclin-dependent kinase 3

    Cyclin-dependent_kinase_3

  • Cyclin E/Cdk2
  • The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). Similar to other cyclin/Cdk complexes

    Cyclin E/Cdk2

    Cyclin E/Cdk2

    Cyclin_E/Cdk2

  • P21
  • Protein

    (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that

    P21

    P21

    P21

  • Cyclin A2
  • Protein-coding gene in the species Homo sapiens

    Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis

    Cyclin A2

    Cyclin A2

    Cyclin_A2

  • Cyclin K
  • Protein-coding gene in the species Homo sapiens

    Cyclin-K is a protein that in humans is encoded by the CCNK gene. The protein encoded by this gene is a member of the transcription cyclin family. These

    Cyclin K

    Cyclin K

    Cyclin_K

  • Tim Hunt
  • British biochemist

    studying fertilized sea urchin eggs in the early 1980s, Hunt discovered cyclin, a protein that cyclically aggregates and is depleted during cell division

    Tim Hunt

    Tim Hunt

    Tim_Hunt

  • Cyclin D3
  • Protein-coding gene in the species Homo sapiens

    G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene. The protein encoded by this gene belongs to the highly conserved cyclin family

    Cyclin D3

    Cyclin D3

    Cyclin_D3

  • Inhibitor of CDK, cyclin A1 interacting protein 1
  • Protein-coding gene in the species Homo sapiens

    Serve H, Koschmieder S, Müller-Tidow C (August 2011). "Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation

    Inhibitor of CDK, cyclin A1 interacting protein 1

    Inhibitor of CDK, cyclin A1 interacting protein 1

    Inhibitor_of_CDK,_cyclin_A1_interacting_protein_1

  • Cyclin-dependent kinase 6
  • Protein found in humans

    encoded by the CDK6 gene. It is regulated by cyclins, more specifically by cyclin D proteins and cyclin-dependent kinase inhibitor proteins. The protein

    Cyclin-dependent kinase 6

    Cyclin-dependent kinase 6

    Cyclin-dependent_kinase_6

  • Cyclin B3
  • Cell cycle protein

    (NLS) of chicken cyclin B3 appears to be in the 26 C-terminal residues, consistent with A type cyclins. Human cyclin B3 is the largest cyclin, 1395 amino acids

    Cyclin B3

    Cyclin B3

    Cyclin_B3

  • CIP/KIP
  • proteins bind a wide range of G1/S and S-phase cyclin-CDK complexes including cyclin D-CDK4,6 and cyclin E-, A-CDK2 complexes. Traditionally it was assumed

    CIP/KIP

    CIP/KIP

  • CCNY (gene)
  • Protein-coding gene in humans

    Cyclin-Y is a protein that in humans is encoded by the CCNY gene. GRCh38: Ensembl release 89: ENSG00000108100 – Ensembl, May 2017 GRCm38: Ensembl release

    CCNY (gene)

    CCNY (gene)

    CCNY_(gene)

  • Cyclin D/Cdk4
  • Multi-protein structure

    The Cyclin D/Cdk4 complex is a multi-protein structure consisting of the proteins Cyclin D and cyclin-dependent kinase 4, or Cdk4, a serine-threonine

    Cyclin D/Cdk4

    Cyclin_D/Cdk4

  • CCNC
  • Topics referred to by the same term

    Carolina, a gated golf community in Pinehurst, North Carolina, United States Cyclin-C, encoded by the CCNC gene This disambiguation page lists articles associated

    CCNC

    CCNC

  • CDKN2C
  • Protein-coding gene in humans

    Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene. The protein encoded by this gene is a member of the INK4

    CDKN2C

    CDKN2C

    CDKN2C

  • RNA polymerase II holoenzyme
  • Form of eukaryotic RNA polymerase II

    of serine 5 and is, thus, seen in middle to late elongation. CDK8 and cyclin C (CCNC) are components of the RNA polymerase II holoenzyme that phosphorylate

    RNA polymerase II holoenzyme

    RNA_polymerase_II_holoenzyme

  • CDKN1B
  • Protein-coding gene in humans

    family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes

    CDKN1B

    CDKN1B

    CDKN1B

  • Motifs targeted by APC/C
  • subunit of APC/C. This then triggers the degradation of Cdc20 and leads to the activation of APC/CCdh1 through G1 to suppress S- phase cyclin-Cdk activity

    Motifs targeted by APC/C

    Motifs targeted by APC/C

    Motifs_targeted_by_APC/C

  • Cell cycle checkpoint
  • Control mechanism in the eukaryotic cell cycle

    largely determined by the activation of cyclin-dependent kinases by regulatory protein subunits called cyclins, different forms of which are produced at

    Cell cycle checkpoint

    Cell cycle checkpoint

    Cell_cycle_checkpoint

  • Cyclin-dependent kinase 7
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. The protein encoded by this gene

    Cyclin-dependent kinase 7

    Cyclin-dependent kinase 7

    Cyclin-dependent_kinase_7

  • Anaphase-promoting complex
  • Cell-cycle regulatory complex

    APC/C appear to be securin and the B type cyclins. This is conserved between mammals and yeast. In fact, yeast are viable in the absence of the APC/C if

    Anaphase-promoting complex

    Anaphase-promoting complex

    Anaphase-promoting_complex

  • Pierre Léopold
  • French scientist

    O'Farrell, UCSF). This work allowed him to identify a new cdk complex, cyclin C/Cdk8, involved in the function of the mediator, controlling transcription

    Pierre Léopold

    Pierre_Léopold

  • GAK (protein)
  • Protein-coding gene in the species Homo sapiens

    Cyclin G-associated kinase (GAK) is a serine/threonine kinase that in humans is encoded by the GAK gene. In all eukaryotes, the cell cycle is governed

    GAK (protein)

    GAK (protein)

    GAK_(protein)

  • Cell division
  • Biological process

    controlled by cyclin and cyclin-dependent kinases. The progression of interphase is the result of the increased amount of cyclin. As the amount of cyclin increases

    Cell division

    Cell division

    Cell_division

  • Cyclin-dependent kinase inhibitor protein
  • Protein which inhibits cyclin-dependent kinase

    A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and

    Cyclin-dependent kinase inhibitor protein

    Cyclin-dependent kinase inhibitor protein

    Cyclin-dependent_kinase_inhibitor_protein

  • Cyclin-dependent kinase 5
  • Protein found in humans

    Cyclin-dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago,[when?] and it

    Cyclin-dependent kinase 5

    Cyclin-dependent kinase 5

    Cyclin-dependent_kinase_5

  • Cyclin A1
  • Protein-coding gene in the species Homo sapiens

    Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose

    Cyclin A1

    Cyclin A1

    Cyclin_A1

  • CDK12
  • Protein kinase gene

    CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. This enzyme is a member of cyclin-dependent kinase protein

    CDK12

    CDK12

    CDK12

  • Cytokeratin 5/6 antibodies
  • usually negative. Cyclin D1 and CK5/6 staining could be used in concert to distinguish between the diagnosis of papilloma (Cyclin D1 < 4.20%, CK 5/6

    Cytokeratin 5/6 antibodies

    Cytokeratin 5/6 antibodies

    Cytokeratin_5/6_antibodies

  • P16
  • Mammalian protein found in humans

    p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that

    P16

    P16

    P16

  • APC/C activator protein CDH1
  • Fungal protein found in Saccharomyces cerevisiae S288c

    (like mitotic cyclins) which contain a destruction box (D-box) and an additional degradation signal (KEN box), Cdh1 recruits them in a C-box-dependent

    APC/C activator protein CDH1

    APC/C activator protein CDH1

    APC/C_activator_protein_CDH1

  • Mediator (coactivator)
  • Multiprotein complex involved in transcription in eukaryotes

    09.016. PMID 21983542. Xu W, Ji JY (2011). "Dysregulation of CDK8 and Cyclin C in tumorigenesis". J Genet Genomics. 38 (10): 439–52. doi:10.1016/j.jgg

    Mediator (coactivator)

    Mediator (coactivator)

    Mediator_(coactivator)

  • Endoreduplication
  • Replication of the nuclear genome without mitosis

    (G1-S-G2-M) in which mitosis is circumvented entirely, due to modulation of cyclin-dependent kinase (CDK) activity. Examples of endoreduplication characterised

    Endoreduplication

    Endoreduplication

  • CCNG2
  • Protein-coding gene in humans

    are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly

    CCNG2

    CCNG2

    CCNG2

  • Cyclin-dependent kinase inhibitor 1C
  • Protein-coding gene in the species Homo sapiens

    Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent

    Cyclin-dependent kinase inhibitor 1C

    Cyclin-dependent kinase inhibitor 1C

    Cyclin-dependent_kinase_inhibitor_1C

  • Sandra Quackenbush
  • American virologist

    1015. PMID 6755614. Birkenheuer, C; Brewster, C; Quackenbush, S; Rovnak, J (2015). "Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription

    Sandra Quackenbush

    Sandra_Quackenbush

  • SCF complex
  • Type of protein

    Polo-like kinase 1 or Cyclin B-CDK1. Fbw7, which is the human homolog of cdc4 in yeast, is an FBP that targets Cyclin E, Myc, Notch and c-Jun for degradation

    SCF complex

    SCF complex

    SCF_complex

  • Cyclin B2
  • Protein-coding gene in the species Homo sapiens

    G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The

    Cyclin B2

    Cyclin B2

    Cyclin_B2

  • G2-M DNA damage checkpoint
  • Cell cycle checkpoint in eukaryotic organisms

    specific cyclin-CDK complexes. CyclinB-CDK1 activity is specific to the G2/M checkpoint. Accumulation of cyclin B increases the activity of the cyclin dependent

    G2-M DNA damage checkpoint

    G2-M DNA damage checkpoint

    G2-M_DNA_damage_checkpoint

  • Mitotic exit
  • checkpoints. Many factors including cyclins, cyclin-dependent kinases (CDKs), ubiquitin ligases, inhibitors of cyclin-dependent kinases, and reversible

    Mitotic exit

    Mitotic_exit

  • CDKN3
  • Protein-coding gene in humans

    "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69

    CDKN3

    CDKN3

    CDKN3

  • Restriction point
  • Animal cell cycle checkpoint

    feature of the restriction point is the activation of G1/S- and S-phase cyclin-CDK complexes, which in turn phosphorylate proteins that initiate DNA replication

    Restriction point

    Restriction point

    Restriction_point

  • Clb 5,6 (Cdk1)
  • box motif is found on the C terminus of both cyclins, and includes the conserved FLRRISK sequence characterizing B-type cyclins. Clb5 and Clb6 are part

    Clb 5,6 (Cdk1)

    Clb_5,6_(Cdk1)

  • G1/S transition
  • Stage in cell cycle

    transformation and disease states such as cancer. During this transition, G1 cyclin D-Cdk4/6 dimer phosphorylates retinoblastoma releasing transcription factor

    G1/S transition

    G1/S transition

    G1/S_transition

  • Cyclin T2
  • Protein-coding gene in the species Homo sapiens

    Cyclin-T2 is a protein that in humans is encoded by the CCNT2 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose

    Cyclin T2

    Cyclin T2

    Cyclin_T2

  • Maturation promoting factor
  • Biological factor

    also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin–Cdk complex that was discovered first in frog eggs. It stimulates the mitotic

    Maturation promoting factor

    Maturation_promoting_factor

  • Seliciclib
  • Chemical compound

    CYC202) is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors that inhibit multiple enzyme targets including

    Seliciclib

    Seliciclib

    Seliciclib

  • CCNG1
  • Protein-coding gene in humans

    Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene. The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose

    CCNG1

    CCNG1

    CCNG1

  • CDKN2A
  • Protein-coding gene in humans

    CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed

    CDKN2A

    CDKN2A

    CDKN2A

  • Induced cell cycle arrest
  • Artificial stopping of the cell cycle

    to the cyclin mRNA and prevent the mRNA from being translated into cyclin protein. This can actually be used to destroy phase-specific cyclins beyond

    Induced cell cycle arrest

    Induced_cell_cycle_arrest

  • Neuronal cell cycle
  • regulated by cyclins binding their respective cyclin dependent kinases (Cdks) which then activate the kinases (Fisher, 2012). During G1, cyclin D is synthesized

    Neuronal cell cycle

    Neuronal_cell_cycle

  • CDKN2B
  • Protein-coding gene in humans

    Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4b is a protein that is encoded by the CDKN2B gene in

    CDKN2B

    CDKN2B

    CDKN2B

  • CDK13
  • Protein-coding gene in humans

    Cyclin dependent kinase 13 is an enzyme that in humans is encoded by the CDK13 gene. The protein encoded by this gene is a member of the cyclin-dependent

    CDK13

    CDK13

    CDK13

  • Protein c-Fos
  • Mammalian protein found in Homo sapiens

    induce any malignant tumors. Activation of the c-Fos transgene in mice results in overexpression of cyclin D1, A and E in osteoblasts and chondrocytes,

    Protein c-Fos

    Protein c-Fos

    Protein_c-Fos

  • Cherry angioma
  • Small bright red dome-shaped bump on the skin

    MEK1 and cyclin E1. By inhibiting mir-424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin E1 which

    Cherry angioma

    Cherry angioma

    Cherry_angioma

  • CCNF
  • Protein-coding gene in humans

    G2/mitotic-specific cyclin-F is a protein that in humans is encoded by the CCNF gene. This gene encodes a member of the cyclin family. Cyclins are important

    CCNF

    CCNF

    CCNF

  • CCNI (gene)
  • Protein-coding gene in humans

    Cyclin-I is a protein that in humans is encoded by the CCNI gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose

    CCNI (gene)

    CCNI (gene)

    CCNI_(gene)

  • P-TEFb
  • Protein complex regulating transcription in eukaryotes

    Drosophila cells. It is a cyclin dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T in Drosophila. In humans

    P-TEFb

    P-TEFb

    P-TEFb

  • Protein kinase C
  • Family of enzymes

    In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling

    Protein kinase C

    Protein_kinase_C

  • Stem cell
  • Unspecialized biological cell that can become specialized

    phases: Cyclin D and Cdk4/6 are active in the G1 phase, while Cyclin E and Cdk2 are active during the late G1 phase and S phase; and Cyclin A and Cdk2

    Stem cell

    Stem cell

    Stem_cell

  • MAPK/ERK pathway
  • Cell signaling pathway

    transcriptional activity, preventing expression of S-phase entry genes including Cyclin E, Cyclin A2 and Emi1. ERK1/2 activation downstream of mitogen induced Ras signaling

    MAPK/ERK pathway

    MAPK/ERK_pathway

  • Centrosome cycle
  • Centrioles are nine triplets microtubules

    in S phase. It has also been shown that Cdk2 complexes with both cyclin A and cyclin E and this complex is critical for centrosome duplication. Three

    Centrosome cycle

    Centrosome cycle

    Centrosome_cycle

  • Meiosis
  • Cell division producing haploid gametes

    WEE1 as well as regulation of cyclin B levels facilitated by the anaphase-promoting complex (APC). CDK1 is regulated by cyclin B, whose synthesis peaks at

    Meiosis

    Meiosis

    Meiosis

  • Metaphase
  • Third stage of mitosis and meiosis

    (cyclosome or APC/C), a ubiquitin ligase which targets securin and cyclin B for degradation via the proteosome. As long as securin and cyclin B remain active

    Metaphase

    Metaphase

    Metaphase

  • Cyclin H
  • Protein-coding gene in the species Homo sapiens

    Cyclin-H is a protein that in humans is encoded by the CCNH gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose

    Cyclin H

    Cyclin H

    Cyclin_H

  • Sic1
  • inhibitor of Cdk1-Clb (B-type cyclins) complexes in the budding yeast Saccharomyces cerevisiae. Because B-type cyclin-Cdk1 complexes are the drivers

    Sic1

    Sic1

  • MED13
  • Protein-coding gene in the species Homo sapiens

    The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. GRCh38:

    MED13

    MED13

    MED13

  • Retinoblastoma-like protein 2
  • Protein-coding gene in the species Homo sapiens

    Retinoblastoma-like protein 2 has been shown to interact with: BRCA1, BRF1 C-Raf, Cyclin E1, Cyclin-dependent kinase 2, HDAC1, Prohibitin, and RBBP8. Mutations in

    Retinoblastoma-like protein 2

    Retinoblastoma-like protein 2

    Retinoblastoma-like_protein_2

  • Palbociclib
  • Medication for HR+ HER2– breast cancer

    HR-positive and HER2-negative breast cancer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor

    Palbociclib

    Palbociclib

    Palbociclib

  • Novak–Tyson model
  • relationships between cyclin and MPF in interphase-arrested frog egg extracts. The first was Solomon's 1990 Cell paper, titled "Cyclin activation of p34cdc2"

    Novak–Tyson model

    Novak–Tyson_model

  • FBXW7
  • Protein-coding gene in the species Homo sapiens

    directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Other well established pro-proliferative targets of FBXW7 are c-Myc and

    FBXW7

    FBXW7

    FBXW7

  • Dinaciclib
  • Chemical compound

    Dinaciclib (SCH-727965) is an experimental drug that inhibits cyclin-dependent kinases (CDKs). It is being evaluated in clinical trials for various cancer

    Dinaciclib

    Dinaciclib

    Dinaciclib

  • MyoD
  • Mammalian protein found in Homo sapiens

    repression of the D1 cyclin. Both MyoD and pRb are necessary for the repression of cyclin D1, but rather than acting directly on cyclin D1, they act on Fra-1

    MyoD

    MyoD

    MyoD

  • CDK inhibitor
  • Any chemical that inhibits the function of CDKs

    A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs. They are used to treat cancers by preventing overproliferation

    CDK inhibitor

    CDK_inhibitor

  • G1 phase
  • First subphase of interphase

    of S phase cyclin genes; anaphase-promoting complex (APC) is activated, which targets and degrades S and M cyclins (but not G1/S cyclins); and a high

    G1 phase

    G1 phase

    G1_phase

  • CDK5R1
  • Protein-coding gene in humans

    Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene. The protein encoded by this gene (p35) is a neuron-specific

    CDK5R1

    CDK5R1

    CDK5R1

  • Cyclin dependent kinase like 1
  • Protein-coding gene in the species Homo sapiens

    Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. This gene product is a member of a large family of CDC2-related

    Cyclin dependent kinase like 1

    Cyclin dependent kinase like 1

    Cyclin_dependent_kinase_like_1

  • Mantle cell lymphoma
  • Type of blood cancer

    surrounds normal germinal center follicles. MCL cells generally over-express cyclin D1 due to the t(11:14) translocation, a chromosomal translocation in the

    Mantle cell lymphoma

    Mantle cell lymphoma

    Mantle_cell_lymphoma

  • CCNL2
  • Protein-coding gene in humans

    Cyclin-L2 is a protein that in humans is encoded by the CCNL2 gene. The protein encoded by this gene belongs to cyclin family. Table Source: genecards

    CCNL2

    CCNL2

    CCNL2

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CYCLIN C

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CYCLIN C

  • Curlin
  • Surname or Lastname

    English

    Curlin

    English : variant of Curling.Swedish : from an unexplained first element + the adjectival suffix -(l)in, derivative of Latin -enius.Probably also an Americanized spelling of German Gerling.

    Curlin

  • Cullin
  • Surname or Lastname

    English and Irish

    Cullin

    English and Irish : variant spelling of Cullen.

    Cullin

  • Caplin
  • Surname or Lastname

    English

    Caplin

    English : occupational name for a chantry priest (or the servant of one), a priest endowed to sing mass daily on behalf of the souls of the dead (Late Latin capellanus). Compare Chaplin.Americanized spelling of Swiss German Kaeppelin, a diminutive of Kappel.

    Caplin

  • Chulin
  • Girl/Female

    Hindu, Indian, Mexican, Russian

    Chulin

    Crisp; Calm; Reserved

    Chulin

  • Carlin
  • Boy/Male

    Gaelic German Irish

    Carlin

    Small champion.

    Carlin

  • Cailin
  • Boy/Male

    Scottish

    Cailin

    Contemporary'Child.

    Cailin

  • Catlin
  • Surname or Lastname

    English

    Catlin

    English : from the medieval female personal name Cat(e)lin(e), Anglo-Norman French form of Catherine.

    Catlin

  • AYLIN
  • Female

    Turkish

    AYLIN

    Turkish name AYLIN means "moon halo."

    AYLIN

  • CARLIN
  • Female

    English

    CARLIN

    Irish Gaelic unisex name CARLIN means "little champion."

    CARLIN

  • COLLIN
  • Male

    English

    COLLIN

    Variant spelling of English Colin, COLLIN means "whelp; young pup."

    COLLIN

  • Carlin
  • Boy/Male

    Australian, Celtic, French, Gaelic, German, Irish

    Carlin

    Little Champion

    Carlin

  • Collin
  • Boy/Male

    Gaelic American Irish English French

    Collin

    child.

    Collin

  • Cocklin
  • Surname or Lastname

    English

    Cocklin

    English : from a diminutive of Middle English cok ‘cock’ (see Cocke).Perhaps also an Americanized spelling of Swiss and South German Köchlin, Koechlin, or Köchling, all diminutives of Koch.

    Cocklin

  • Cailin
  • Boy/Male

    Australian, Scottish

    Cailin

    Contemporary Similar to Cailean Child

    Cailin

  • Collin
  • Surname or Lastname

    English and French

    Collin

    English and French : from a pet form of English Coll 1, French Colle.Probably an altered spelling of German Kollin.Danish : variant of Colding.Swedish : ornamental name from an unexplained first element, probably from a place name, + the the suffix -in, from Latin -in(i)us ‘descendant of’.

    Collin

  • Carlin
  • Girl/Female

    British, Christian, English, German

    Carlin

    Female Version of Carl; Charles

    Carlin

  • Colin
  • Surname or Lastname

    French

    Colin

    French : from a reduced pet form of the personal name Nicolas (see Nicholas).English : variant spelling of Collin.A Colin from Brittany, France, is documented in St. Ours, Quebec, in 1669, with the secondary surname LaLiberté, which is often translated Liberty; Colin is often Americanized as Collins.

    Colin

  • Colin
  • Boy/Male

    African, American, Australian, British, Chinese, Christian, Danish, English, French, Gaelic, German, Greek, Indian, Irish, Jamaican, Scottish, Tamil

    Colin

    Victory of the People; Young Boy; Abbreviation of Nicholas People's Victory; Young Creature; Victor; People's Victory; Cub; Pup; Dove; Oak Meadow

    Colin

  • CAYLIN
  • Female

    English

    CAYLIN

    Variant spelling of English Kaylin, CAYLIN means "girl."

    CAYLIN

  • Collin
  • Boy/Male

    American, Australian, British, Celtic, Christian, Dutch, English, French, Gaelic, German, Greek, Irish, Portuguese

    Collin

    Creative; Victory of the People; Form of Colin; Victor; Abbreviation of Nicholas; Young Creature; People's Victory; Dove; One who had Travelled to Rome; Young Pup

    Collin

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CYCLIN C

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CYCLIN C

Online names & meanings

  • Sachindev
  • Boy/Male

    Hindu

    Sachindev

    Lord Indra Dev

  • Sarah
  • Biblical

    Sarah

    lady; mother of the multitude

  • Rheta
  • Girl/Female

    Greek

    Rheta

    Speaker.

  • Nirmala
  • Girl/Female

    Assamese, Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Sanskrit, Sindhi, Tamil, Telugu

    Nirmala

    Clean; Virtuous; Pure; Clear; Calm

  • Nehru
  • Boy/Male

    Hindu, Indian, Tamil

    Nehru

    Canal

  • Thadina
  • Girl/Female

    Hebrew

    Thadina

    Given praise.

  • Srisurya
  • Boy/Male

    Hindu

    Srisurya

  • Maksim
  • Boy/Male

    Australian, Finnish, Latin, Swedish

    Maksim

    Greatest

  • Bedar |
  • Boy/Male

    Muslim

    Bedar |

    Wakeful, Attentive, Alert

  • Britni
  • Girl/Female

    American, Australian, Latin

    Britni

    From England; From Brittany or Great Britain

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CYCLIN C

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CYCLIN C

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CYCLIN C

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Other words and meanings similar to

CYCLIN C

AI search in online dictionary sources & meanings containing CYCLIN C

CYCLIN C

  • Cycling
  • p. pr. & vb. n.

    of Cycle

  • Caplin
  • n.

    See Capelin.

  • Cycle
  • n.

    An interval of time in which a certain succession of events or phenomena is completed, and then returns again and again, uniformly and continually in the same order; a periodical space of time marked by the recurrence of something peculiar; as, the cycle of the seasons, or of the year.

  • Cyclical
  • a.

    Of or pertaining to a cycle or circle; moving in cycles; as, cyclical time.

  • Cycle
  • n.

    One entire round in a circle or a spire; as, a cycle or set of leaves.

  • Cycle
  • v. i.

    To pass through a cycle of changes; to recur in cycles.

  • Cycloidian
  • a. & n.

    Same as 2d and 3d Cycloid.

  • Caplin
  • n.

    Alt. of Capling

  • Wheeling
  • n.

    The act or practice of using a cycle; cycling.

  • Cyclist
  • n.

    A cycler.

  • Wheelman
  • n.

    One who rides a bicycle or tricycle; a cycler, or cyclist.

  • Cycle
  • v. i.

    To ride a bicycle, tricycle, or other form of cycle.

  • Cyclic
  • a.

    Alt. of Cyclical

  • Cycloidal
  • a.

    Pertaining to, or resembling, a cycloid; as, the cycloidal space is the space contained between a cycloid and its base.

  • Cycling
  • n.

    The act, art, or practice, of riding a cycle, esp. a bicycle or tricycle.

  • Circler
  • n.

    A mean or inferior poet, perhaps from his habit of wandering around as a stroller; an itinerant poet. Also, a name given to the cyclic poets. See under Cyclic, a.

  • Circular
  • a.

    Adhering to a fixed circle of legends; cyclic; hence, mean; inferior. See Cyclic poets, under Cyclic.

  • Cyclonic
  • a.

    Pertaining to a cyclone.

  • Cycled
  • imp. & p. p.

    of Cycle