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NEDD8

  • NEDD8
  • Protein found in the human body

    NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL)

    NEDD8

    NEDD8

    NEDD8

  • Neddylation
  • Post-translational modifications involving the protein NEDD8

    to the post-translational modification in which ubiquitin-like protein NEDD8 is covalently attached to the lysine residue of a target protein, which

    Neddylation

    Neddylation

    Neddylation

  • Cullin
  • Hydrophobic scaffold protein

    in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine

    Cullin

    Cullin

    Cullin

  • Pevonedistat
  • Chemical compound

    (MLN4924) is a selective NEDD8 inhibitor. It is being investigated as a cancer treatment, e.g. for mantle cell lymphoma (MCL). NEDD8-activating enzyme (NAE)

    Pevonedistat

    Pevonedistat

    Pevonedistat

  • UBE2M
  • Protein-coding gene in the species Homo sapiens

    NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene. The modification of proteins with ubiquitin is an important cellular

    UBE2M

    UBE2M

    UBE2M

  • APPBP1
  • Protein-coding gene in the species Homo sapiens

    NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene. The protein encoded by this gene binds to the beta-amyloid

    APPBP1

    APPBP1

    APPBP1

  • UBA1
  • Protein-coding gene in the species Homo sapiens

    is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological

    UBA1

    UBA1

    UBA1

  • Ubiquitin-like protein
  • Family of small proteins

    SENP1) reported around the same time by a variety of investigators in 1996, NEDD8 in 1997, and Apg12 in 1998. A systematic survey has since identified over

    Ubiquitin-like protein

    Ubiquitin-like protein

    Ubiquitin-like_protein

  • Protein folding
  • Change of a linear protein chain to a 3D structure

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Protein folding

    Protein folding

    Protein_folding

  • UBE1C
  • Protein-coding gene in the species Homo sapiens

    NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an

    UBE1C

    UBE1C

    UBE1C

  • Chromosome 2
  • Human chromosome

    titin TUBA4B: encoding protein Tubulin alpha 4b UBE2F: encoding protein NEDD8-conjugating enzyme UBE2F UBXD2: UBX domain-containing protein 4 UXS1: UDP-glucuronic

    Chromosome 2

    Chromosome 2

    Chromosome_2

  • Signal peptide
  • Short peptide present at N-terminal of newly synthesized proteins

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Signal peptide

    Signal_peptide

  • Aryl hydrocarbon receptor
  • Vertebrate receptor protein and transcription factor

    also been shown to interact with the following: AIP ARNTL CCNT1 ESR1 NCOA1 NEDD8 NRIP1 RELA RELB RP GRCh38: Ensembl release 89: ENSG00000106546 – Ensembl

    Aryl hydrocarbon receptor

    Aryl hydrocarbon receptor

    Aryl_hydrocarbon_receptor

  • Ubiquitin conjugating enzyme E2 F (putative)
  • Protein-coding gene in the species Homo sapiens

    NEDD8-conjugating enzyme UBE2F is a protein that in humans is encoded by the UBE2F gene. NEDD8 Neddylation GRCh38: Ensembl release 89: ENSG00000184182

    Ubiquitin conjugating enzyme E2 F (putative)

    Ubiquitin conjugating enzyme E2 F (putative)

    Ubiquitin_conjugating_enzyme_E2_F_(putative)

  • Rub
  • Topics referred to by the same term

    preparation Massage, the rubbing or kneading of the body's soft tissues NEDD8, a protein in Saccharomyces cerevisiae known as Rub1 Rubredoxin A (RubA)

    Rub

    Rub

  • RBX1
  • Protein-coding gene in the species Homo sapiens

    DC, Hunt HW, Hammel M, Schulman BA (Sep 2008). "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation"

    RBX1

    RBX1

    RBX1

  • Post-translational modification
  • Chemical changes in proteins following their translation from mRNA

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Post-translational modification

    Post-translational modification

    Post-translational_modification

  • CUL3
  • Protein-coding gene in humans

    the complex is regulated by the attachment of the ubiquitin-like protein NEDD8 to a conserved Lys residue in the cullin-homology domain, the process called

    CUL3

    CUL3

    CUL3

  • Heat shock protein
  • Family of proteins

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Heat shock protein

    Heat_shock_protein

  • Ubiquitin
  • Regulatory protein found in most eukaryotic tissues

    neuronal-precursor-cell-expressed developmentally downregulated protein-8 (NEDD8, also called Rub1 in S. cerevisiae), human leukocyte antigen F-associated

    Ubiquitin

    Ubiquitin

    Ubiquitin

  • Succinylation
  • Addition of a succinyl group to a lysine group of a protein

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Succinylation

    Succinylation

  • Deubiquitinating enzyme
  • Protein family

    role of DUBs is the cleavage of ubiquitin-like proteins such as SUMO and NEDD8. Some DUBs may have the ability to cleave isopeptide bonds between these

    Deubiquitinating enzyme

    Deubiquitinating enzyme

    Deubiquitinating_enzyme

  • SENP8
  • Protein-coding gene in the species Homo sapiens

    Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene. NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the

    SENP8

    SENP8

    SENP8

  • Raymond J. Deshaies
  • American biochemist and cell biologist

    regulating SCF and other CRL enzymes by removing the ubiquitin-like protein NEDD8 from their cullin subunit. In 2013, they showed that Cand1 has the unusual

    Raymond J. Deshaies

    Raymond_J._Deshaies

  • NUB1
  • Protein-coding gene in the species Homo sapiens

    NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene. NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like

    NUB1

    NUB1

    NUB1

  • Protein targeting
  • Biological mechanism for routing proteins

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Protein targeting

    Protein_targeting

  • Chaperone (protein)
  • Proteins assisting in protein folding

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Chaperone (protein)

    Chaperone (protein)

    Chaperone_(protein)

  • CUL4B
  • Protein-coding gene in humans

    of CRL4B complexes. CUL4B is also modified by covalent attachment of a NEDD8 molecule at a highly conserved lysine residue in the C-terminal region.

    CUL4B

    CUL4B

    CUL4B

  • Brenda Schulman
  • American biochemist

    proteins (UBLs), a class of proteins that are similar to ubiquitin, such as NEDD8. She has also extensively studied enzymes that for which ubiquitin and UBLs

    Brenda Schulman

    Brenda Schulman

    Brenda_Schulman

  • List of EC numbers (EC 2)
  • EC 2.3.2.32: cullin-RING-type E3 NEDD8 transferase EC 2.3.2.33: RCR-type E3 ubiquitin transferase EC 2.3.2.34: E2 NEDD8-conjugating enzyme EC 2.3.2.35:

    List of EC numbers (EC 2)

    List_of_EC_numbers_(EC_2)

  • Ubiquitin ligase
  • Protein

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Ubiquitin ligase

    Ubiquitin ligase

    Ubiquitin_ligase

  • Heat shock protein 47
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Heat shock protein 47

    Heat shock protein 47

    Heat_shock_protein_47

  • Signalosome
  • induce T-cell responses. COP9 signalosome: Catalyses the hydrolysis of NEDD8 protein from the Cullin subunit of Cullin-RING ubiquitin ligases (CRL).

    Signalosome

    Signalosome

  • CAND1
  • Protein-coding gene in humans

    Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene. CAND1 has been shown to interact with: CUL1, CUL2

    CAND1

    CAND1

    CAND1

  • CUL4A
  • Protein-coding gene in humans

    core of CRL4 complexes. CUL4A is also modified by covalent attachment of a NEDD8 molecule at a highly conserved lysine residue in the C-terminal region.

    CUL4A

    CUL4A

    CUL4A

  • COP9 signalosome
  • protein complex with isopeptidase activity. It catalyses the hydrolysis of NEDD8 protein from the cullin subunit of Cullin-RING ubiquitin ligases (CRL).

    COP9 signalosome

    COP9 signalosome

    COP9_signalosome

  • Survival of motor neuron
  • Protein in animal cells

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Survival of motor neuron

    Survival of motor neuron

    Survival_of_motor_neuron

  • Ubiquitin-conjugating enzyme
  • Protein family

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Ubiquitin-conjugating enzyme

    Ubiquitin-conjugating_enzyme

  • Chaperonin
  • Family of heat shock proteins

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Chaperonin

    Chaperonin

    Chaperonin

  • CUL1
  • Protein-coding gene in humans

    "Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293

    CUL1

    CUL1

    CUL1

  • ATG8
  • Protein in budding yeast

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    ATG8

    ATG8

    ATG8

  • NAE
  • Topics referred to by the same term

    acid excretion, the net amount of acid excreted in the urine per unit time NEDD8 activating enzyme North American English, a generalized variety of the English

    NAE

    NAE

  • DNAJC1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    DNAJC1

    DNAJC1

    DNAJC1

  • Carnitine O-acetyltransferase
  • Enzyme

    for Type 2 diabetes and other diseases. CRAT is known to interact with NEDD8, PEX5, SUMO1. GRCm38: Ensembl release 89: ENSMUSG00000026853 – Ensembl,

    Carnitine O-acetyltransferase

    Carnitine O-acetyltransferase

    Carnitine_O-acetyltransferase

  • Heat shock protein 90kDa alpha (cytosolic), member A1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Heat shock protein 90kDa alpha (cytosolic), member A1

    Heat shock protein 90kDa alpha (cytosolic), member A1

    Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1

  • SUMO protein
  • Family of proteins which attach to other proteins to modify them

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    SUMO protein

    SUMO protein

    SUMO_protein

  • CDC34
  • Protein-coding gene in humans

    Gladysheva TB, Hottelet M, Parent LA, Coggins MB, et al. (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination

    CDC34

    CDC34

    CDC34

  • DNAJA3
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    DNAJA3

    DNAJA3

    DNAJA3

  • UFM1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    UFM1

    UFM1

    UFM1

  • Ubiquitin-binding domain
  • Type of protein domain

    Santonico, Elena (7 April 2020). "Old and New Concepts in Ubiquitin and NEDD8 Recognition". Biomolecules. 10 (4): 566. doi:10.3390/biom10040566. PMC 7226360

    Ubiquitin-binding domain

    Ubiquitin-binding domain

    Ubiquitin-binding_domain

  • Lysine malonylation
  • Post-translational modification

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Lysine malonylation

    Lysine malonylation

    Lysine_malonylation

  • UBE2V2
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    UBE2V2

    UBE2V2

    UBE2V2

  • URM1
  • Protein family

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    URM1

    URM1

    URM1

  • Target peptide
  • Type of peptide chain

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Target peptide

    Target_peptide

  • List of EC numbers (EC 6)
  • 6.2.1.63: L-arginine—[L-arginyl-carrier protein] ligase EC 6.2.1.64: E1 NEDD8-activating enzyme EC 6.2.1.65: salicylate—CoA ligase EC 6.2.1.66: glyine—[glycyl-carrier

    List of EC numbers (EC 6)

    List_of_EC_numbers_(EC_6)

  • Hsp70
  • Family of heat shock proteins

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Hsp70

    Hsp70

    Hsp70

  • UBE2E1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    UBE2E1

    UBE2E1

    UBE2E1

  • List of human protein-coding genes 5
  • Q8NHV4 10409 NEDD4 HGNC:7727; P46934 10410 NEDD4L HGNC:7728; Q96PU5 10411 NEDD8 HGNC:7732; Q15843 10412 NEDD9 HGNC:7733; Q14511 10413 NEFH HGNC:7737; P12036

    List of human protein-coding genes 5

    List_of_human_protein-coding_genes_5

  • Mdm2
  • Protein-coding gene in humans

    complex binding protein N-terminus binding ubiquitin protein ligase activity NEDD8 ligase activity disordered domain specific binding protein domain specific

    Mdm2

    Mdm2

    Mdm2

  • ISG15
  • Protein found in humans

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    ISG15

    ISG15

    ISG15

  • COPS4
  • Protein-coding gene in humans

    reference expression data Gene ontology Molecular function protein binding NEDD8-specific protease activity Cellular component cytoplasm COP9 signalosome

    COPS4

    COPS4

    COPS4

  • SMN1
  • Protein-coding gene in humans

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    SMN1

    SMN1

    SMN1

  • S-phase kinase-associated protein 1
  • Protein-coding gene in the species Homo sapiens

    Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination

    S-phase kinase-associated protein 1

    S-phase kinase-associated protein 1

    S-phase_kinase-associated_protein_1

  • Von Hippel–Lindau tumor suppressor
  • Mammalian protein found in humans

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Von Hippel–Lindau tumor suppressor

    Von Hippel–Lindau tumor suppressor

    Von_Hippel–Lindau_tumor_suppressor

  • James A. Wells
  • American chemical biologist and protein engineer

    Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase". Journal of the American Chemical Society. 138 (40): 13123–13126

    James A. Wells

    James_A._Wells

  • RNF7
  • Protein-coding gene in the species Homo sapiens

    C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1". Mol. Cell. Biol. 20

    RNF7

    RNF7

    RNF7

  • Ubiquitin-activating enzyme
  • Class of enzymes

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Ubiquitin-activating enzyme

    Ubiquitin-activating enzyme

    Ubiquitin-activating_enzyme

  • Binding immunoglobulin protein
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Binding immunoglobulin protein

    Binding immunoglobulin protein

    Binding_immunoglobulin_protein

  • CUL2
  • Protein-coding gene in humans

    PMC 108784. PMID 9447969. Wada H, Yeh ET, Kamitani T (1999). "Identification of NEDD8-conjugation site in human cullin-2". Biochem. Biophys. Res. Commun. 257

    CUL2

    CUL2

    CUL2

  • HSPA12A
  • Human gene

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    HSPA12A

    HSPA12A

  • HSPA8
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    HSPA8

    HSPA8

    HSPA8

  • TRAP1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    TRAP1

    TRAP1

    TRAP1

  • UBE2K
  • Protein-coding gene in the species Homo sapiens

    Hill CP (1999). "Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes". J. Biol. Chem. 273 (52):

    UBE2K

    UBE2K

    UBE2K

  • CUL5
  • Protein-coding gene in humans

    Hammel Michal, Schulman Brenda A (Sep 2008). "Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation"

    CUL5

    CUL5

    CUL5

  • UBA2
  • Protein-coding gene in the species Homo sapiens

    ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8". Nature. 422 (6929): 330–4. Bibcode:2003Natur.422..330W. doi:10.1038/nature01456

    UBA2

    UBA2

    UBA2

  • DNAJC19
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    DNAJC19

    DNAJC19

    DNAJC19

  • Hsp33
  • InterPro Family

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Hsp33

    Hsp33

  • CBL (gene)
  • Mammalian gene

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    CBL (gene)

    CBL (gene)

    CBL_(gene)

  • Ubiquitin carboxy-terminal hydrolase L1
  • Protein-coding gene in the species Homo sapiens

    Caskey LS, Yeh ET, Kamitani T (Oct 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochemical and Biophysical Research Communications. 251 (3):

    Ubiquitin carboxy-terminal hydrolase L1

    Ubiquitin carboxy-terminal hydrolase L1

    Ubiquitin_carboxy-terminal_hydrolase_L1

  • Ubiquitin-protein ligase E3B
  • Protein-coding gene in Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Ubiquitin-protein ligase E3B

    Ubiquitin-protein ligase E3B

    Ubiquitin-protein_ligase_E3B

  • BTRC (gene)
  • Protein-coding gene in the species Homo sapiens

    MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination

    BTRC (gene)

    BTRC (gene)

    BTRC_(gene)

  • HSP90B1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    HSP90B1

    HSP90B1

    HSP90B1

  • Prokaryotic ubiquitin-like protein
  • Protein family

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Prokaryotic ubiquitin-like protein

    Prokaryotic ubiquitin-like protein

    Prokaryotic_ubiquitin-like_protein

  • Hsp27
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Hsp27

    Hsp27

    Hsp27

  • Fuzzy complex
  • Hidenori; Yeh, Edward T. H; Kamitani, Tetsu (2003). "Regulation of the NEDD8 Conjugation System by a Splicing Variant, NUB1L". Journal of Biological

    Fuzzy complex

    Fuzzy complex

    Fuzzy_complex

  • Hsp90
  • Heat shock proteins with a molecular mass around 90kDa

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Hsp90

    Hsp90

    Hsp90

  • UCHL3
  • Human gene and enzyme

    humans is encoded by the UCHL3 gene. UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule

    UCHL3

    UCHL3

    UCHL3

  • Helen Walden
  • English structural biologist

    in the mechanisms of ubiquitination, solving the structure of the E1 for Nedd8. In London, Walden studied the specificity and regulation of E3 ubiquitin

    Helen Walden

    Helen Walden

    Helen_Walden

  • GroEL
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    GroEL

    GroEL

    GroEL

  • CYLD (gene)
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    CYLD (gene)

    CYLD (gene)

    CYLD_(gene)

  • TP53BP2
  • Protein-coding gene in the species Homo sapiens

    Y, Liu W, Naumovski L, Neve RL (2003). "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation

    TP53BP2

    TP53BP2

    TP53BP2

  • UBR1
  • Mammalian protein found in Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    UBR1

    UBR1

    UBR1

  • USP6
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    USP6

    USP6

    USP6

  • HSP90AB1
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    HSP90AB1

    HSP90AB1

    HSP90AB1

  • Clusterin
  • Protein found in humans

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    Clusterin

    Clusterin

    Clusterin

  • OTUB2
  • Protein-coding gene in the species Homo sapiens

    thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity NEDD8-specific protease activity ubiquitin binding protein binding hydrolase activity

    OTUB2

    OTUB2

    OTUB2

  • RNF8
  • Protein-coding gene in the species Homo sapiens

    of Ku80, allowing it to be released from the Ku protein ring, or else by NEDD8 promoted ubiquitination of Ku protein, causing its release from DNA. UV-induced

    RNF8

    RNF8

    RNF8

  • UBE2O
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    UBE2O

    UBE2O

    UBE2O

  • HSPA14
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    HSPA14

    HSPA14

    HSPA14

  • DNAJC13
  • Protein-coding gene in the species Homo sapiens

    enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like

    DNAJC13

    DNAJC13

    DNAJC13

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Online names & meanings

  • Eleanora
  • Girl/Female

    American, Australian, British, Christian, Dutch, English, German, Greek, Irish, Italian, Spanish

    Eleanora

    Light; Form of Eleanor; Sun-ray; Shinning Light; Variant of Helen; Foreign

  • Ambily
  • Girl/Female

    Indian, Malayalam

    Ambily

    Moon

  • Reule
  • Boy/Male

    French

    Reule

    Famous wolf.

  • Subodh
  • Boy/Male

    Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu

    Subodh

    Good Knowledge; Sound Advice; Easily Understood; Good; Intelligent; Spiritual Intelligence

  • MENTU-RA
  • Male

    Egyptian

    MENTU-RA

    , a priest of Amen Ra.

  • Lingley
  • Surname or Lastname

    English

    Lingley

    English : variant of Lindley.

  • Arda
  • Boy/Male

    Australian, Dutch, Farsi, Parsi

    Arda

    Truthful

  • Zanna
  • Girl/Female

    Hebrew

    Zanna

    God's gift.

  • Dharesh | தாரேஷ 
  • Boy/Male

    Tamil

    Dharesh | தாரேஷ 

    Lord of land

  • Akshra
  • Girl/Female

    Indian

    Akshra

    Letters

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