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CDKN2A

  • CDKN2A
  • Protein-coding gene in humans

    CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed

    CDKN2A

    CDKN2A

    CDKN2A

  • Dysplastic nevus syndrome
  • Medical condition

    inherited in an autosomal dominant pattern, and caused by mutations in the CDKN2A gene. In addition to melanoma, individuals with the condition are at increased

    Dysplastic nevus syndrome

    Dysplastic nevus syndrome

    Dysplastic_nevus_syndrome

  • P16
  • Mammalian protein found in humans

    p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that

    P16

    P16

    P16

  • Myocardial infarction
  • Interruption of cardiac blood supply

    with chromosome 9 on the short arm p at locus 21, which contains genes CDKN2A and 2B, although the single nucleotide polymorphisms that are implicated

    Myocardial infarction

    Myocardial infarction

    Myocardial_infarction

  • Melanoma
  • Skin cancer originating in melanocytes

    transmitted autosomal dominantly and mostly associated with the CDKN2A mutations. People who have a CDKN2A mutation associated with FAMMM have a 38-fold increased

    Melanoma

    Melanoma

    Melanoma

  • Pancreatic cancer
  • Type of endocrine gland cancer

    multiple mole and melanoma syndrome, FAMMM-PC) due to mutations in the CDKN2A tumor suppressor gene; autosomal recessive ATM and autosomal dominantly

    Pancreatic cancer

    Pancreatic cancer

    Pancreatic_cancer

  • Anaplastic astrocytoma
  • Type of brain cancer

    microvascular proliferation and necrosis (features that, along with homozygous CDKN2A/B deletion, define grade 4) The MIB-1 (Ki-67) labelling index is usually

    Anaplastic astrocytoma

    Anaplastic astrocytoma

    Anaplastic_astrocytoma

  • Oropharyngeal cancer
  • Pharynx cancer that is located in the oropharynx

    Asbestos-related diseases); Certain genetic changes including: P53 mutation and CDKN2A (p16) mutations; Poor nutrition; Plummer–Vinson syndrome. Erythroplakia;

    Oropharyngeal cancer

    Oropharyngeal cancer

    Oropharyngeal_cancer

  • Endometrial cancer
  • Uterine cancer that is located in tissues lining the uterus

    point mutation unknown 17–41% CDH1 loss of heterozygosity unknown 80–90% CDKN2A loss of heterozygosity or epigenetic silencing 20% 40% PIK3CA (oncogene)

    Endometrial cancer

    Endometrial cancer

    Endometrial_cancer

  • P14arf
  • Human protein

    suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus). p14ARF is induced in response to elevated

    P14arf

    P14arf

  • Chordoma
  • Type of spinal cancer

    respectively. The CDKN2A (p16) and CDKN2B (p15) loci on chromosome 9p21 are frequently deleted in chordomas Another study found CDKN2A immunoreactivity

    Chordoma

    Chordoma

    Chordoma

  • Barrett's esophagus
  • Precancerous tissue formation in the esophagus

    Maley CC, Sanchez CA, Odze RD, et al. (February 2007). "NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma"

    Barrett's esophagus

    Barrett's esophagus

    Barrett's_esophagus

  • Neoplasm
  • Tumor or other abnormal growth of tissue

    Kolios G (July 2010). "Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas". World J. Gastroenterol. 16 (28): 3553–60. doi:10

    Neoplasm

    Neoplasm

    Neoplasm

  • Bernese Mountain Dog
  • Swiss breed of dog

    role in this are mutations to genes that help suppress tumours, including: CDKN2A/B, PTEN, and RB1. Another related mutation is to the PTPN11 gene, which

    Bernese Mountain Dog

    Bernese Mountain Dog

    Bernese_Mountain_Dog

  • Sex-linked barring
  • identified four mutations located in or around the tumor suppressor locus CDKN2A, which appear to be associated with sex-linked barring. The four mutations

    Sex-linked barring

    Sex-linked_barring

  • Ovarian cancer
  • Cancer originating in or on the ovary

    CCND2 upregulation 15% CCNE1 amplification 20% CDK12 high-grade serous CDKN2A downregulation (30%) and deletion (2%) 32% CTNNB1 clear-cell DICER1 missense

    Ovarian cancer

    Ovarian cancer

    Ovarian_cancer

  • Vero cell
  • Cell lineage used in cell cultures

    the type I interferon gene cluster and cyclin-dependent kinase inhibitors CDKN2A and CDKN2B in the genome. Although African green monkeys were previously

    Vero cell

    Vero cell

    Vero_cell

  • COSMIC cancer database
  • Online biology database

    (tissue) summary page provides lists of mutated genes. The figure shows the CDKN2A gene, which is a tumor suppressor that leads to cancer when it is inactivated

    COSMIC cancer database

    COSMIC_cancer_database

  • Astrocytoma
  • Type of brain tumor

    volume, or increased cerebrospinal fluid volume. Homozygous deletion of CDKN2A/B is the main feature of high grade astrocytoma. In addition, a genome-wide

    Astrocytoma

    Astrocytoma

    Astrocytoma

  • Squamous-cell carcinoma of the lung
  • Medical condition

    observed in tumor suppressors such as CDKN2A, PTEN and NF1. Some alterations such as the ones affecting TP53 and CDKN2A are shared by lung SCC and the other

    Squamous-cell carcinoma of the lung

    Squamous-cell carcinoma of the lung

    Squamous-cell_carcinoma_of_the_lung

  • Dysplastic nevus
  • Mole in the skin with an abnormal appearance

    40-50% of cases, the disorder has been linked with germline mutations in the CDKN2A gene, which codes for p16 (a regulator of cell division). Low magnification

    Dysplastic nevus

    Dysplastic nevus

    Dysplastic_nevus

  • Acute lymphoblastic leukemia
  • Blood cancer characterized by overproduction of lymphoblasts

    more mutations. Common inherited risk factors include mutations in ARID5B, CDKN2A/2B, CEBPE, IKZF1, GATA3, PIP4K2A and, more rarely, TP53. These genes play

    Acute lymphoblastic leukemia

    Acute lymphoblastic leukemia

    Acute_lymphoblastic_leukemia

  • T-cell acute lymphoblastic leukemia
  • Type of acute lymphoblastic leukemia

    but specific genetic mutations (commonly including those in NOTCH1 and CDKN2A) may be passed along, increasing susceptibility to cases of T-ALL. Some

    T-cell acute lymphoblastic leukemia

    T-cell acute lymphoblastic leukemia

    T-cell_acute_lymphoblastic_leukemia

  • Abemaciclib
  • Anti-breast cancer medication

    20 July 2023. "Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6". www.clinicaltrials.gov. Retrieved

    Abemaciclib

    Abemaciclib

    Abemaciclib

  • The Cancer Genome Atlas
  • Project to catalogue genetic mutations responsible for cancer

    heterogeneous, with alterations to CDKN2A, SETD2, TFE3, or increased expression of the NRF2–ARE pathway; loss of expression of CDKN2A and CpG island methylation

    The Cancer Genome Atlas

    The_Cancer_Genome_Atlas

  • DNA repair
  • Cellular mechanism

    K, et al. (July 2010). "Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas". World Journal of Gastroenterology. 16 (28):

    DNA repair

    DNA repair

    DNA_repair

  • Adenomatoid tumor
  • Medical condition

    Unlike some malignant mesotheliomas, adenomatoid tumors do not harbor CDKN2A deleterious mutations. In order to see adenomatoid tumors multiple imaging

    Adenomatoid tumor

    Adenomatoid tumor

    Adenomatoid_tumor

  • Norman Sharpless
  • American cancer researcher (born 1966)

    Kingsmore, D; Stevenson, KS; Koppelstaetter, C; et al. (2013). "Pre-Transplant CDKN2A Expression in Kidney Biopsies Predicts Renal Function and Is a Future Component

    Norman Sharpless

    Norman Sharpless

    Norman_Sharpless

  • Cutaneous B-cell lymphoma
  • Medical condition

    have or do not have, respectively, inactivating mutations in both of their CDKN2A genes. Magro CM, Porcu P, Ahmad N, Klinger D, Crowson AN, Nuovo G (September

    Cutaneous B-cell lymphoma

    Cutaneous B-cell lymphoma

    Cutaneous_B-cell_lymphoma

  • Richter's transformation
  • Medical condition

    beta-2-microglobulin levels; CLL/SLL cells which develop deletions in the CDKN2A gene, disruptions of the TP53 gene, activation of the C-MYC gene, trisomy

    Richter's transformation

    Richter's_transformation

  • Genetic causes of type 2 diabetes
  • Genes such as CDKN2A, CDKN2B, and HNF1B exhibit increase the risk phenotype with SNPs in their 3' UTR miRNA binding sites. As CDKN2A and B regulate the

    Genetic causes of type 2 diabetes

    Genetic_causes_of_type_2_diabetes

  • List of Johnson & Johnson products and services
  • FiercePharma. 7 December 2020. Retrieved 2021-10-01. "Dual Targeting of CDKN2A and PIK3CA May Offer Better Outcomes in Urothelial Carcinoma". Targeted

    List of Johnson & Johnson products and services

    List_of_Johnson_&_Johnson_products_and_services

  • Diabetes in Japan
  • Health issue in Japan

    allelic frequencies between these populations. Genes such as CDKAL1, IGF2BP2, CDKN2A/CDKN2B, HHEX, SLC30A8, and KCNJ11 have shown risk alleles persistent to

    Diabetes in Japan

    Diabetes_in_Japan

  • Bhramar Mukherjee
  • Indian-American biostatistician, data scientist

    ; DeLancey, J. O.; Raskin, L. (2012). "Risk of Non-Melanoma Cancers in CDKN2A Mutation Carriers". Journal of the National Cancer Institute. 104 (12):

    Bhramar Mukherjee

    Bhramar Mukherjee

    Bhramar_Mukherjee

  • Neuroblastoma
  • Genetically inherited cancer of certain nerve tissues

    primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene". BMC Genomics. 9: 353. doi:10.1186/1471-2164-9-353. PMC 2527340. PMID 18664255

    Neuroblastoma

    Neuroblastoma

    Neuroblastoma

  • HPV-positive oropharyngeal cancer
  • Cancer of the throat

    the pRb pathway is inactivated by E7 instead of Cyclin D1 amplification. CDKN2A is a tumour suppressor gene that encodes a tumor suppressor protein, p16

    HPV-positive oropharyngeal cancer

    HPV-positive_oropharyngeal_cancer

  • Head and neck cancer
  • Cancer arises in the head or neck region

    patterns. In HPV-negative disease, genes frequently mutated include TP53, CDKN2A and PIK3CA. In HPV-positive disease, these genes are less frequently mutated

    Head and neck cancer

    Head and neck cancer

    Head_and_neck_cancer

  • CDKN2B
  • Protein-coding gene in humans

    CDKN2B gene in humans. This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated, deleted, or disregulated in a wide

    CDKN2B

    CDKN2B

    CDKN2B

  • CDKN2BAS
  • Non-coding RNA in humans

    spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms

    CDKN2BAS

    CDKN2BAS

    CDKN2BAS

  • Primary testicular diffuse large B-cell lymphoma
  • Medical condition

    neoplastic cells in PT-DLBCL have deletions in one or both copies of the CDKN2A gene which can lead to genome instability, i.e. a high rate of acquisition

    Primary testicular diffuse large B-cell lymphoma

    Primary_testicular_diffuse_large_B-cell_lymphoma

  • Cyclin-dependent kinase 4
  • Human protein

    as well as in its related proteins including D-type cyclins, p16(INK4a), CDKN2A and Rb were all found to be associated with tumorigenesis of a variety of

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • Lewis lung carcinoma
  • 1951 mouse tumour still used in research

    present in 30 cancer genes including Kras, Nras, Trp53, Dcc, and Cacna1d. Cdkn2a and Cdkn2b are biallelically deleted from the genome. Five pathways (RTK/RAS

    Lewis lung carcinoma

    Lewis_lung_carcinoma

  • Adrenocortical carcinoma
  • Cancer of the adrenal cortex

    and DAXX. The telomerase gene TERT is often amplified while ZNRF3 and CDKN2A are often homozygously deleted. The genes h19, insulin-like growth factor

    Adrenocortical carcinoma

    Adrenocortical carcinoma

    Adrenocortical_carcinoma

  • Methylated-DNA–protein-cysteine methyltransferase
  • Mammalian protein found in Homo sapiens

    Seferiadis K, et al. (2010). "Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas". World Journal of Gastroenterology. 16 (28):

    Methylated-DNA–protein-cysteine methyltransferase

    Methylated-DNA–protein-cysteine methyltransferase

    Methylated-DNA–protein-cysteine_methyltransferase

  • Epigenetics and melanoma
  • Form of cancer

    Glendening, J.M., Flores, J.F., Walker, G.J., et al. 1997. "Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation

    Epigenetics and melanoma

    Epigenetics_and_melanoma

  • Papillary renal cell carcinoma
  • Medical condition

    pathways, which includes CDKN2A silencing, mutation in chromatin-modifying genes, and a GpG island methylator phenotype (CIMP). CDKN2A is a tumor suppressor

    Papillary renal cell carcinoma

    Papillary renal cell carcinoma

    Papillary_renal_cell_carcinoma

  • Cyclin-dependent kinase inhibitor protein
  • Protein which inhibits cyclin-dependent kinase

    Protein Gene Target p16 CDKN2A Cyclin-dependent kinase 4, Cyclin-dependent kinase 6 p15 CDKN2B Cyclin-dependent kinase 4 p18 CDKN2C Cyclin-dependent kinase

    Cyclin-dependent kinase inhibitor protein

    Cyclin-dependent kinase inhibitor protein

    Cyclin-dependent_kinase_inhibitor_protein

  • Nutritional epigenetics
  • Study of how diet changes gene expression

    (2020-06-01). "Genistein inhibited the proliferation of kidney cancer cells via CDKN2a hypomethylation: role of abnormal apoptosis". International Urology and

    Nutritional epigenetics

    Nutritional_epigenetics

  • Adenocarcinoma of the lung
  • Lung cancer of glandular origin or characteristics

    have been reported, as well as deletions of tumor suppressor genes such as CDKN2A. Frequent alterations occur in genes belonging to the receptor tyrosine

    Adenocarcinoma of the lung

    Adenocarcinoma of the lung

    Adenocarcinoma_of_the_lung

  • Follicular lymphoma
  • Cancer originating in lymph nodes

    function-associated antigen 3, that is involved in activating T-cells), CDKN2A (encoding p16INK4a and p14arf tumor suppressor proteins) or CDKN2B (encoding

    Follicular lymphoma

    Follicular lymphoma

    Follicular_lymphoma

  • C2C12
  • Mouse myoblast cell line

    this in C2C12 skeletal muscle cells is believed to be in the INK4a gene (CDKN2A). Electrical pulse stimulation (EPS) is an in vitro method used to mimic

    C2C12

    C2C12

    C2C12

  • List of genes mutated in cutaneous conditions
  • Hemochromatosis C7orf11 Trichothiodystrophy CBS Cystathionine synthase Homocystinuria CDKN2A Familial melanoma syndrome CHS1 (LYST) Chédiak–Higashi syndrome CXCR4 WHIM

    List of genes mutated in cutaneous conditions

    List_of_genes_mutated_in_cutaneous_conditions

  • STK35L1
  • Protein-coding gene in the species Homo sapiens

    and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA

    STK35L1

    STK35L1

    STK35L1

  • CDKN2C
  • Protein-coding gene in humans

    Moretti A, Basso G, Borriello A, Della Ragione F (1998). "Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma". Hepatology

    CDKN2C

    CDKN2C

    CDKN2C

  • Auto-sexing
  • Type of poultry breed

    Leif Andersson (2010). Sex-linked barring in chickens is controlled by the CDKN2A/B tumour suppressor locus. Pigment Cell and Melanoma Research. 23 (4): 521–530

    Auto-sexing

    Auto-sexing

    Auto-sexing

  • Neurofibroma
  • Benign nerve-sheath tumor in the peripheral nervous system

    cancers from neurofibromas is associated with the loss of expression of the CDKN2A or TP53 gene in nonmyelinating Schwann cells that also exhibit biallelic

    Neurofibroma

    Neurofibroma

    Neurofibroma

  • Wound healing assay
  • Laboratory assessment of re-epithelialization in cell cultures

    Iwei; Bastian, Boris C.; Judson, Robert L. (July 2018). "Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation". Cancer Cell. 34 (1): 56–68

    Wound healing assay

    Wound healing assay

    Wound_healing_assay

  • List of human protein-coding genes 2
  • P38936 2673 CDKN1B HGNC:1785; P46527 2674 CDKN1C HGNC:1786; P49918 2675 CDKN2A HGNC:1787; P42771, Q8N726 2676 CDKN2AIP HGNC:24325; Q9NXV6 2677 CDKN2AIPNL

    List of human protein-coding genes 2

    List_of_human_protein-coding_genes_2

  • Antisense RNA
  • Single stranded RNA

    induce DNA methylation, can also repress the neighboring gene of CDKN2B, CDKN2A, by recruiting polycomb repressive complex 2 (PRC2) which leads to histone

    Antisense RNA

    Antisense RNA

    Antisense_RNA

  • Erica Golemis
  • American oncologist

    TP53 and CDKN2A in order to show that patterns of hotspot mutations in TP53 differed depending on the presence or absence of a co-occurring CDKN2A mutation

    Erica Golemis

    Erica Golemis

    Erica_Golemis

  • MTAP
  • Enzymes responsible for polyamine metabolism

    "Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line". Cancer Research

    MTAP

    MTAP

    MTAP

  • Amelanotic melanoma
  • Medical condition

    Linda; Sini, Maria C.; Palmieri, Giuseppe; Scarrà, Giovanna Bianchi (2009). "CDKN2A and MC1R analysis in amelanotic and pigmented melanoma". Melanoma Research

    Amelanotic melanoma

    Amelanotic melanoma

    Amelanotic_melanoma

  • Gastrointestinal stromal tumor
  • Human disease (cancer)

    potential responsiveness to immunotherapy. The C3 subtype, with frequent CDKN2A aberrations, could benefit from a combination of KIT and CDK4/6 inhibitors

    Gastrointestinal stromal tumor

    Gastrointestinal stromal tumor

    Gastrointestinal_stromal_tumor

  • Primary cutaneous diffuse large B-cell lymphoma, leg type
  • Medical condition

    Hypermethylated of the promoters for two tumor suppressor genes, CDKN2B and CDKN2A (11 and 44% of cases, respectively) stops the genes from expressing their

    Primary cutaneous diffuse large B-cell lymphoma, leg type

    Primary_cutaneous_diffuse_large_B-cell_lymphoma,_leg_type

  • IFNA16
  • Protein-coding gene in the species Homo sapiens

    and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Fam. Cancer. 9 (4): 625–33. doi:10.1007/s10689-010-9356-3. PMC 3233727

    IFNA16

    IFNA16

    IFNA16

  • Monomorphic epitheliotropic intestinal T cell lymphoma
  • Medical condition

    chromosomes 9. This results in a loss of heterozygosity for two genes, the CDKN2A gene which encodes cyclin-dependent kinase Inhibitor 2A, a protein that

    Monomorphic epitheliotropic intestinal T cell lymphoma

    Monomorphic_epitheliotropic_intestinal_T_cell_lymphoma

  • Pediatric ependymoma
  • homolog of p53, and deletion of the p53 pathway gene p14arf/p16/INK4A (CDKN2A) have also been found in pediatric ependymomas. Over-expression of components

    Pediatric ependymoma

    Pediatric_ependymoma

  • Pharmacoepigenetics
  • Field of study

    genes frequently observed are APC, CDH1, CDKN2A, MGMT, and RASSF1A (a tumor suppressor). In the cases of CDKN2A and RASSF1A DNA these genes are methylated

    Pharmacoepigenetics

    Pharmacoepigenetics

  • Blastic plasmacytoid dendritic cell neoplasm
  • Medical condition

    the disease: 1) mutations in NRAS, ASXL1, and TP53; 2) deletions of the CDKN2A-ARF-CDKN2B locus on the short arm of chromosome 9, CDKN1B locus on the short

    Blastic plasmacytoid dendritic cell neoplasm

    Blastic plasmacytoid dendritic cell neoplasm

    Blastic_plasmacytoid_dendritic_cell_neoplasm

  • Radiosensitivity
  • Susceptibility of cells to radiation

    with radiosensitivity in normal tissues: γH2AX, TP53BP1, VEGFA, CASP3, CDKN2A, IL6, and IL1B. Stochastic effects do not have a threshold of irradiation

    Radiosensitivity

    Radiosensitivity

  • Mir-423 microRNA precursor family
  • Short RNA molecule

    Lindholm PM, Salmenkivi K, Bagwan I, Nicholson AG, Knuutila S (July 2009). "CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant

    Mir-423 microRNA precursor family

    Mir-423_microRNA_precursor_family

  • ATM serine/threonine kinase
  • Mammalian protein found in Homo sapiens

    A, Franco MF, Esteves EB, Scherrer L, Gallo CV, et al. (October 2015). "CDKN2A (p14(ARF)/p16(INK4a)) and ATM promoter methylation in patients with impalpable

    ATM serine/threonine kinase

    ATM serine/threonine kinase

    ATM_serine/threonine_kinase

  • Myxofibrosarcoma
  • Medical condition

    deletions in the NF1 gene occur ~10% of MFS cases while mutations in the CDKN2A/CDKN2B and amplifications in the CDK6, CCND1, and MDM2 genes occur in rare

    Myxofibrosarcoma

    Myxofibrosarcoma

  • Ankyrin repeat
  • Protein domain

    BAT8; BCL3; BCOR; BCORL1; BTBD11; CAMTA1; CAMTA2; CASKIN1; CASKIN2; CCM1; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CENTB1; CENTB2; CENTB5; CENTG1; CENTG2; CENTG3;

    Ankyrin repeat

    Ankyrin repeat

    Ankyrin_repeat

  • CDKAL1
  • Protein-coding gene in humans

    Kashiwagi A, Kaku K, et al. (March 2008). "Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a

    CDKAL1

    CDKAL1

    CDKAL1

  • Cancer epigenetics
  • Field of study in cancer research

    genes are epigenetically altered in sarcomas. These include APC, CDKN1A, CDKN2A, CDKN2B, Ezrin, FGFR1, GADD45A, MGMT, STK3, STK4, PTEN, RASSF1A, WIF1, as

    Cancer epigenetics

    Cancer epigenetics

    Cancer_epigenetics

  • DNA (cytosine-5)-methyltransferase 3A
  • Protein-coding gene in the species Homo sapiens

    Tanzawa H (June 2003). "Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity".

    DNA (cytosine-5)-methyltransferase 3A

    DNA (cytosine-5)-methyltransferase 3A

    DNA_(cytosine-5)-methyltransferase_3A

  • CCDC180
  • Protein-coding gene in humans

    gov. Retrieved 2016-05-10. "www.genecards.org/cgi-bin/carddisp.pl?gene=CDKN2A". www.genecards.org. Retrieved 2016-05-10. "www.genecards.org/cgi-bin/carddisp

    CCDC180

    CCDC180

  • BMI1
  • Human protein

    ER (2008). "BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression". Cancer Res. 68 (16): 6507–15. doi:10.1158/0008-5472.CAN-07-6152

    BMI1

    BMI1

    BMI1

  • CDKN2D
  • Protein-coding gene in humans

    (mouse) or the human equivalent p14ARF, which are alternative products of the CDKN2A gene. GRCh38: Ensembl release 89: ENSG00000129355 – Ensembl, May 2017 GRCm38:

    CDKN2D

    CDKN2D

    CDKN2D

  • ZBTB48
  • Protein-coding gene in the species Homo sapiens

    of target genes, including mitochondrial fission process 1 (MTFP1) and CDKN2A. ZBTB48 localizes to chromosome 1p36, a region that is frequently rearranged

    ZBTB48

    ZBTB48

    ZBTB48

  • Enteropathy-associated T-cell lymphoma
  • Complication of celiac disease

    on the short or "p" arm of chromosome 17; genomic alterations around the CDKN2A tumor suppressor and CDKN2B cell proliferation regulator at position p21

    Enteropathy-associated T-cell lymphoma

    Enteropathy-associated T-cell lymphoma

    Enteropathy-associated_T-cell_lymphoma

  • MiR-125
  • cyclin-dependent kinase inhibitor 2A (CDKN2A), a negative regulator of the cell cycle. On the other hand, downregulation of CDKN2A correlates with chronic neurological

    MiR-125

    MiR-125

  • Central nervous system prophylaxis
  • of CNS relapse. ABC subtype DLBCL, characterized by gene alterations (at CDKN2A) affecting NF-κB signaling, is associated with worse survival outcomes and

    Central nervous system prophylaxis

    Central_nervous_system_prophylaxis

  • EZH2
  • Protein-coding gene in the species Homo sapiens

    of EZH2-mediated transcriptional repression include HOXA9, HOXC8, MYT1, CDKN2A and retinoic acid target genes. In cancer, EZH2 may play a role in activation

    EZH2

    EZH2

    EZH2

  • Mir-584 microRNA precursor family
  • RNA molecule

    Lindholm PM, Salmenkivi K, Bagwan I, Nicholson AG, Knuutila S (July 2009). "CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant

    Mir-584 microRNA precursor family

    Mir-584_microRNA_precursor_family

  • Epitranscriptome
  • Biochemical changes to RNA

    regulation of tumor suppressors like cyclin-dependent kinase inhibitor 2A (CDKN2A) and breast cancer 2 (BRCA2). On the other hand, increased m6A levels inhibit

    Epitranscriptome

    Epitranscriptome

  • IFNK
  • Protein-coding gene

    and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Familial Cancer. 9 (4): 625–633. doi:10.1007/s10689-010-9356-3

    IFNK

    IFNK

    IFNK

  • 2017 in science
  • the University of Rochester Medical Center identify four genes – KRAS, CDKN2A, SMAD4, and TP53 – responsible for how long patients survive with pancreatic

    2017 in science

    2017_in_science

  • Somatic evolution in cancer
  • Accumulation of mutations

    confirmed although mutations in some tumor suppressor genes, including CDKN2A (p16), predispose to clonal expansions that encompass large numbers of crypts

    Somatic evolution in cancer

    Somatic_evolution_in_cancer

  • Epigenetic therapy
  • Use of epigenome-influencing techniques to treat medical conditions

    tumor-suppressor genes which can cause transcriptional inactivation of genes (i.e. CDKN2A) encoding for other regulatory proteins (i.e. p14 and p16) that play a vital

    Epigenetic therapy

    Epigenetic therapy

    Epigenetic_therapy

  • Porocarcinoma
  • Medical condition

    in a single case, and, in individual cases, mutations in the TP53, RB1, CDKN2A and HRAS tumor suppressor genes. Further studies are needed to determine

    Porocarcinoma

    Porocarcinoma

  • Mir-32 microRNA precursor family
  • Precursor microRNA family

    Lindholm PM, Salmenkivi K, Bagwan I, Nicholson AG, Knuutila S (July 2009). "CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant

    Mir-32 microRNA precursor family

    Mir-32_microRNA_precursor_family

  • HHIPL1
  • Protein-coding gene in the species Homo sapiens

    Sato N, Sawabe M, Muramatsu M (2014-01-01). "Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis

    HHIPL1

    HHIPL1

    HHIPL1

  • Mir-885 microRNA precursor family
  • RNA family

    M.; Salmenkivi, K.; Bagwan, I.; Nicholson, A. G.; Knuutila, S. (2009). "CDKN2A,NF2, andJUNare dysregulated among other genes by miRNAs in malignant mesothelioma-A

    Mir-885 microRNA precursor family

    Mir-885_microRNA_precursor_family

  • List of OMIM disorder codes
  • neural system tumor syndrome; 155755; CDKN2A Melanoma; 609048; CDK4 Melanoma, cutaneous malignant, 2; 155601; CDKN2A Meleda disease; 248300; SLURP1 Melnick–Needles

    List of OMIM disorder codes

    List_of_OMIM_disorder_codes

  • Mir-455 microRNA precursor family
  • RNA family

    Lindholm PM, Salmenkivi K, Bagwan I, Nicholson AG, Knuutila S (July 2009). "CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant

    Mir-455 microRNA precursor family

    Mir-455_microRNA_precursor_family

  • Epigenetic priming
  • Type of modification to a cell's epigenome

    successful. The epigenetic intervention was fruitful in demethylating loci (i.e. CDKN2A, ESR1, HPP1, MGMT, TIMP3) abnormally methylated in gastric carcinomas. A

    Epigenetic priming

    Epigenetic priming

    Epigenetic_priming

  • Mir-340 microRNA precursor family
  • RNA family

    Lindholm PM, Salmenkivi K, Bagwan I, Nicholson AG, Knuutila S (July 2009). "CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant

    Mir-340 microRNA precursor family

    Mir-340_microRNA_precursor_family

  • Virtual karyotype
  • Digital information reflecting an individual's karyotype

    (acquired uniparental disomy) has been reported at key loci in ALL, such as CDKN2A gene at 9p, which have prognostic significance. SNP array virtual karyotyping

    Virtual karyotype

    Virtual_karyotype

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Online names & meanings

  • Sumedha
  • Girl/Female

    Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Tamil, Telugu

    Sumedha

    Wise; Intelligent

  • Speake
  • Surname or Lastname

    English

    Speake

    English : nickname for someone thought to resemble a woodpecker in some way, Middle English spek(e) (a reduced form of Old French espeche(e), of Germanic origin).

  • Khairun Nisa |
  • Girl/Female

    Muslim

    Khairun Nisa |

    Best of women epithet of kh

  • Ziarmal
  • Boy/Male

    Arabic, Muslim

    Ziarmal

    Hardworker

  • Gavrilovich
  • Boy/Male

    Russian

    Gavrilovich

    Worships God.

  • Naitee
  • Girl/Female

    Hindu

    Naitee

    Little gift, End less

  • AGHADREENA
  • Female

    Irish

    AGHADREENA

    Irish name AGHADREENA means "from the field of the sloe bushes."

  • Tony
  • Boy/Male

    Christian & English(British/American/Australian)

    Tony

    Beyond Praise

  • Sudiksha
  • Girl/Female

    Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sindhi, Tamil, Telugu

    Sudiksha

    Goddess Lakshmi

  • LEELA
  • Female

    Hindi/Indian

    LEELA

    (लीला) Hindi name LEELA means "play."

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Other words and meanings similar to

CDKN2A

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