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Protein-coding gene in the species Homo sapiens
regulatory factor 7, also known as IRF7, is a member of the interferon regulatory factor family of transcription factors. IRF7 encodes interferon regulatory
IRF7
Cytokine
macrophages and NK cells to elicit an anti-viral response, involving IRF3/IRF7 antiviral pathways, and are also active against tumors. Plasmacytoid dendritic
Interferon_type_I
Chemical element with atomic number 77 (Ir)
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_tetroxide
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_compounds
Specific genus of RNA viruses
suppressing the activity of the interferon regulatory proteins IRF3, IRF5, and IRF7. The levels of IgG and IgA in the blood and IgA in the gut correlate with
Rotavirus
Alloy of iridium and osmium
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Osmiridium
Protein
capacity. ICP0 also inhibits the activity of IFN regulatory factors (IRF3) and IRF7, which are key transcription factors that induce production of antiviral
HHV infected cell polypeptide 0
HHV_infected_cell_polypeptide_0
Protein found in humans
antiviral signaling and the induction of type I interferon by targeting IRF7, a key player in the antiviral signal pathways. AIP consists of an N-terminal
AH receptor-interacting protein
AH_receptor-interacting_protein
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Tetrairidium_dodecacarbonyl
American biologist and Nobel laureate (1938–2025)
Promotes a Type I Interferon Response by Countering Intron Retention in Irf7". Molecular Cell. 73 (4): 803–814.e6. doi:10.1016/j.molcel.2018.11.038. PMID 30639243
David_Baltimore
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(III)_bromide
Vertebrate receptor protein and transcription factor
Harhaj EW (June 2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon".
Aryl_hydrocarbon_receptor
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Cyclooctadiene iridium chloride dimer
Cyclooctadiene_iridium_chloride_dimer
Protein-coding gene in the species Homo sapiens
post-myocardial infarction cardioprotection. IRF3 has been shown to interact with IRF7. GRCh38: Ensembl release 89: ENSG00000126456 – Ensembl, May 2017 GRCm38:
IRF3
Protein family
PRR activation phosphorylate ubiquitously expressed IRFs (IRF1, IRF3, and IRF7) through IRF kinases, such as TANK-binding kinase 1 (TBK1). Phosphorylated
Interferon_regulatory_factors
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Crabtree's_catalyst
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_acetylacetonate
Immunity strategy in living beings
IKKε/TBK-1 complex, inducing dimerization of transcription factors IRF3 and IRF7, which are translocated in the nucleus, where they induce IFN production
Innate_immune_system
Mammalian protein found in Homo sapiens
and the transport of the interferon regulatory factors 3 and 7 (IRF3 and IRF7) into the cell's nucleus. Once there, the regulatory factors induce the transcription
MDA5
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Chlorobis(cyclooctene)iridium dimer
Chlorobis(cyclooctene)iridium_dimer
deficiency STAT1 deficiency, gain-of-function mutation STAT2 deficiency IRF7 deficiency CD16 deficiency IRF8 deficiency IFNAR2 deficiency TLR pathway
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Raman A, Rust AG, Bergthaler A, Aitchison JD, Aderem A. (2012) A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
John_D._Aitchison
ENSG00000117595 IRF Known motif – High-throughput in vitro [431] RGTWTCRNNNNNNCGAWACY IRF7 ENSG00000185507 IRF Known motif – High-throughput in vitro [432] CGAAAVYGAAANY
List of human transcription factors
List_of_human_transcription_factors
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_tetrachloride
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(II)_chloride
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_trifluoride
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Cyclooctadiene iridium methoxide dimer
Cyclooctadiene_iridium_methoxide_dimer
Viral nonstructural protein
ubiquitin ligase. NSP1 could mediates the degradation of IRF3, IRF5, and IRF7 by recognizing a common element of IRF proteins, thereby allowing NSP1 to
NSP1_(rotavirus)
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(IV)_oxide
complex consisting of MyD88, TRAF6 and the interferon regulatory factor 7 (IRF7). IRF7 is a transcription factor that translocates into the nucleus when activated
Interleukin-1 receptor associated kinase
Interleukin-1_receptor_associated_kinase
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(IV)_iodide
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Sodium_hexachloroiridate(III)
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Vaska's_complex
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_tetrabromide
Human protein and coding gene
response. Upon viral infection, FADD is needed to increase the levels of Irf7 a molecule which is needed for the production of IFN-α. IFN-α is a key molecule
FADD
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(III)_sulfide
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(III)_chloride
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Trimesityliridium
Protein found in humans
SINTBAD Transcription factors activated upon TBK1 activation include IRF3, IRF7 and ZEB1. Deregulation of TBK1 activity and mutations in this protein are
TANK-binding_kinase_1
Sendai virus, virus of rodents
"SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection". The Journal of Biological Chemistry
Murine_respirovirus
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_disulfide
Mammalian protein found in Homo sapiens
activate by phosphorylation the IFN regulatory factors (IRF), IRF3 and IRF7. IRF3 and IRF7 are themselves transcription factors that translocate into the nucleus
IFNA2
Interaction motifs found in a wide array of proteins
TBK1 and IKBKE are responsible for phosphorylating and activating IRF3 and IRF7 (Fitzgerald et al., 2003; Hemmi et al., 2004; Matsui et al., 2006). Various
CARD_(domain)
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_tetrafluoride
W. (2015-06-05). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon".
Tax_gene_product
PMID 21592361. Ersing, I; Bernhardt, K; Gewurz, BE (Jun 21, 2013). "NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1". Viruses
Epstein–Barr virus latent membrane protein 1
Epstein–Barr_virus_latent_membrane_protein_1
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Ammonium hexachloroiridate(IV)
Ammonium_hexachloroiridate(IV)
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(V)_fluoride
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium(III)_iodide
Protein-coding gene in the species Homo sapiens
(Jul 2014). "Serum amyloid A induces interleukin-33 expression through an IRF7-dependent pathway". European Journal of Immunology. 44 (7): 2153–64. doi:10
Serum_amyloid_A1
Enzymes that catalyze acyl group transfer from acetyl-CoA to histones
(chromatin remodeler), NF-κB (p65), TAL1/SCL, Beta2/NeuroD, C/EBPβ, IRF2, IRF7, YY1, KLF13, EVI1, AME, ER81, and the androgen receptor (AR). PCAF has also
Histone_acetyltransferase
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Iridium_hexafluoride
Receptor family
activation of the transcription factors interferon regulatory factor 3 (IRF3) and IRF7 which induce type I (including IFNα and IFNβ) and type III interferons (IFN)
RIG-I-like_receptor
Chemical compound
IrCl4 IrI 4 IrO2 IrS2 (NH4)2[IrCl6] Li2IrO3 Iridium(V) IrF5 Iridium(VI) IrF6 Sr2MgIrO6 Sr2CaIrO6 Ir(O2)O2 Iridium(VII) IrF7 Iridium(VIII/IX) IrO4 IrO+4
Lithium_iridate
Protein-coding gene in humans
DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear
IKBKE
Protein-coding gene in the species Homo sapiens
(Ctenopharyngodon idella) GPATCH3 initiates IFN 1 expression via the activation of STING-IRF7 signal axis". Developmental and Comparative Immunology. 112 103781. doi:10
GPATCH2L
HGNC:6119; Q15306 7780 IRF5 HGNC:6120; Q13568 7781 IRF6 HGNC:6121; O14896 7782 IRF7 HGNC:6122; Q92985 7783 IRF8 HGNC:5358; Q02556 7784 IRF9 HGNC:6131; Q00978
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Protein found in humans
also indicate a role for PMSB9, in a panel with 9 other genes (Zbp1, Mx2, Irf7, Lfi47, Tapbp, Timp1, Trafd1, Tap2) in the development of influenza vaccines
PSMB9
IRF7
IRF7
IRF7
IRF7
Surname or Lastname
English
English : unexplained. Perhaps a Huguenot name, an altered form of French Poitras.
Boy/Male
Indian, Sanskrit
Evening
Female
Hebrew
Variant spelling of Hebrew Yediydah, YEDIDA means "friend" or "beloved."Â
Girl/Female
Hindu, Indian, Tamil
Beauty of Flower
Boy/Male
Hindu, Indian, Kannada, Marathi, Telugu
Fearless
Girl/Female
French
Victorious.
Boy/Male
Hindu, Indian
Lord of Money; Lord Kuber
Surname or Lastname
English
English : variant of Daughtry.
Girl/Female
Tamil
Basil, Radha, Holy
Male
English
Anglicized form of Hebrew Chaggiy, HAGGI means "festive." In the bible, this is the name of a son of Gad.Â
IRF7
IRF7
IRF7
IRF7
IRF7