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Search references for STAT5. Phrases containing STAT5
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Protein family
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered
STAT5
Biological signaling pathway h
STATs to dissociate from the receptor. At least STAT5 requires glycosylation at threonine 92 for strong STAT5 tyrosine phosphorylation. These activated STATs
JAK-STAT_signaling_pathway
Genetic abnormality in leukemia cancer cells
targets. JAK2, STAT1, STAT3 and STAT5 have been shown to be constitutively active in CML models. Where JAK2 and STAT5 being the main components, where
Philadelphia_chromosome
Protein-coding gene in the species Homo sapiens
sites for a variety of intracellular pathway activators and Stats (such as Stat5). In addition to activating Ras/AKT and ERK/MAP kinase, phosphatidylinositol
Erythropoietin_receptor
Protein family
JAK/STAT pathway, resulting in the activation of transcription factor, STAT5. These two functions—retinol transporter and cytokine receptor—while using
Receptor for retinol uptake STRA6
Receptor_for_retinol_uptake_STRA6
Protein-coding gene in the species Homo sapiens
with: Glucocorticoid receptor, Janus kinase 1, Janus kinase 2, and PTPN11. STAT5 GRCh38: Ensembl release 89: ENSG00000173757 – Ensembl, May 2017 GRCm38:
STAT5B
Cytokine with structural similarity to Interleukin-2
activation of signal transducer and activator of transcription 3 (STAT3) and STAT5. Due to sharing of receptor subunits between IL-2 and IL-15, both of these
Interleukin_15
Pharmaceutical compound
Tison K, Zhou H, Bai L, Acharyya RK, McEachern D, et al. (July 2025). "STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity". Nature
SD36
Protein that stimulates red blood cell production
progenitor surface and activates a JAK2 signalling cascade. This initiates the STAT5, PIK3 and Ras MAPK pathways. This results in differentiation, survival and
Erythropoietin
Mammalian protein found in Homo sapiens
surface. GM-CSF signals via signal transducer and activator of transcription, STAT5. In macrophages, it has also been shown to signal via STAT3. The cytokine
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Group of cytokine proteins
stimulation by T-cell receptor of these cells. IL-33 in combination with some STAT5 activators, such as IL-2, IL-7 or TSLP, up-regulates expression of its own
Interleukin-1_family
Mammalian protein found in Homo sapiens
stimulated by erythropoietin binding to its receptor and activating the Jak2/Stat5 signaling pathway. The clinical significance in humans is becoming clear
Erythroferrone
Protein-coding gene in the species Homo sapiens
focus on STAT5a/b, targeting and inhibiting different mediators of the JAK2-STAT5 pathway. STAT5A has been shown to interact with: CRKL, Epidermal growth
STAT5A
Chemical compound
enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases
Aurintricarboxylic_acid
Protein in the species Homo sapiens
kinases are activated which phosphorylate and activate STAT1, STAT3, and STAT5. The OSMR portion of the IL-31 binding complex contains intracellular motifs
Interleukin_31
Rare congenital neuromuscular disorder
and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway". The Journal of Clinical Investigation. 121 (8): 3042–50. doi:10
Spinal_muscular_atrophy
Protein-coding gene in humans
capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic
CRLF2
Signaling proteins released by host cells in response to the presence of pathogens
of the CRK family of adaptor proteins called CRKL, a nuclear adaptor for STAT5 that also regulates signaling through the C3G/Rap1 pathway. Type I IFNs
Interferon
Centromere- and microtubule-associated protein
centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway and also as a coactivator of NF-kappaB-mediated transcription
CENPJ
Disease causing insufficient blood cells of all types
lower expression of CD45RA (mean age: 45 years); and expression of the IL-2/STAT5 pathway. Higher frequency of HLA-DR2 and HLA-DR15 may cause augmented presentation
Aplastic_anemia
Lymphocyte protein
(January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". The Journal of Biological Chemistry. 275 (1):
Tyrosin-protein_kinase_Lck
hypermutation Specific granule Specol STAT protein STAT1 STAT2 STAT3 STAT4 STAT5 STAT6 Stem cell educator Stimulator of interferon genes Stromal cell-derived
Index_of_immunology_articles
Non-receptor tyrosine kinase and coding gene in humans
TEC TNFRSF1A VAV1 YES1 Prolactin signals through JAK2 are dependent on STAT5, and on the RUSH transcription factors. Janus kinase inhibitor, medical
Janus_kinase_2
Artificial stimulation of the immune system to treat cancer
avidity and sustained tumor immunity. Surprisingly no changes in activity of STAT5, CISH's purported target. Thus CISH represents a new class of T-cell intrinsic
Cancer_immunotherapy
Mammalian protein found in Homo sapiens
with the erythropoietin receptor and may play a role in activation of the Stat5 pathway". Blood. 91 (10): 3734–3745. doi:10.1182/blood.V91.10.3734. PMID 9573010
LYN
Subset of T lymphocytes
mainly because of high level of phosphorylation on key transcription factor STAT5. In mice, TCM proved to confer more powerful immunity against viruses, bacteria
Memory_T_cell
Medical condition
with Y177 of BCR. Through AKT/PKB, PI3-K pathway could also be activated. STAT5, 1, and 6 has been reported that is a major molecular signaling event activated
Biphenotypic_acute_leukaemia
Sub-population of CD4+T cells
TCR-induced interleukin-9 production by TH9 cells. STAT5, downstream factor of IL-2, induce TH9 cells IL-9. STAT5 directly bind to Il-9 gene promoter, although
Th_9_cell
Protein controlling mammalian coloration
showed that neutralizing antibodies to MC1R prevented phosphorylation of STAT5 by erythropoietin, and that MC2R and MC5R were also involved, as shown in
Melanocortin_1_receptor
Protein-coding gene in the species Homo sapiens
lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain". Leukemia. 10 (8):
Interleukin-7_receptor-α
Protein-coding gene in humans
phosphorylate downstream molecules such as Bcr/Abl, PI3K/AKT, MAPK/ERK or STAT5 which then participate in myeloid cell polarization, proliferation and migration
HCK
Protein-coding gene in the species Homo sapiens
(December 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry.
Suppressor of cytokine signaling 1
Suppressor_of_cytokine_signaling_1
American surgical oncologist
aberrations in breast cancer. Together, they also demonstrated that the loss of STAT5 in estrogen-receptor-positive breast cancer is associated with increased
Anne_Rosenberg
Pharmaceutical compound
experimental drug which acts as an inhibitor of the proteins STAT3 and STAT5. This blocks the transcription of the enzyme Tet methylcytosine dioxygenase
UC-514321
Austrian pharmacologist and toxicologist
Wikidata Q45859851. R Moriggl; D J Topham; S Teglund; et al. (February 1999). "Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells"
Veronika_Sexl
Form of cancer immunotherapy
Surprisingly there was no changes in activity of Cish's purported target, STAT5. CISH knock out in T cells increased PD-1 expression and the adoptive transfer
Checkpoint_inhibitor
Professor of pathology, immunology, biology, and surgery
02.003(2022). Zhou, J. et al. 2021. The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity. Nat Immunol, doi:10
Weiping_Zou
Protein-coding gene in the species Homo sapiens
on 21 February 2020. Retrieved 2 August 2020. "ELM - Detail for LIG_SH2_STAT5". elm.eu.org. Archived from the original on 22 February 2020. Retrieved
ISLR
Protein-coding gene in the species Homo sapiens
Acetyltransferases CBP and p300 bind to the transactivation domain. AP1, STAT5 and VDR bind to C-terminal domain. Also, ETS1 has been shown to interact
ETS1
Protein found on the surface of cells
a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation [citation needed]. Knockout studies in mice suggest
Interleukin-7_receptor
Mammalian protein found in humans
This phosphorylation recruits STAT transcription factors, predominantly STAT5, which dimerize and migrate to the cell nucleus where they bind to DNA.
Interleukin_2
Transmembrane molecule in the mitochondria
order to survive and become red cells. Bcl-xL promoter contains GATA-1 and Stat5 sites. This protein accumulates throughout the differentiation, ensuring
Bcl-xL
Family of intracellular transcription factors
STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in type II
STAT_protein
Protein-coding gene in humans
proximal section is known to be responsible for proliferation by activating STAT5 and c-myc. Membrane distal section is then required for differentiation
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Protein-coding gene in humans
(January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". Journal of Biological Chemistry. 275 (1):
PTPN11
Mammalian protein found in humans
regulatory (Tr1) cells or Th17 cells from naïve T cells via STAT1, STAT4, and STAT5 phosphorylation. Several studies have shown that tumor-associated macrophages
CXCL9
Protein-coding gene in humans
long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells". Oncogene. 19 (17): 2086–2097
ETS2
Medical condition
phosphorylation of Signal Transducer and Activator of Transcription 5, STAT5. The STAT5 proteins dimerize and translocate to the nucleus, controlling subsequent
X-linked severe combined immunodeficiency
X-linked_severe_combined_immunodeficiency
Transmembrane proteins
IL10RA IL10RB TYK2, JAK1 Stat3, Stat1, Stat5 ? Doubled. IL-20R, II IL-19/20/24 IL20RB IL20RA TYK2, JAK1 Stat3, Stat5 ? β is high-affinity. IL-20R, I IL-20/24
Type_II_cytokine_receptor
Cytokine, alarmin, and growth factor
Trobridge PA, Farr AG, Levin SD, Ziegler SF (December 1999). "Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction". Journal of
Thymic_stromal_lymphopoietin
Control of DNA to RNA conversion in cells
Metser G, Hennighausen L (August 2016). "Hierarchy within the mammary STAT5-driven Wap super-enhancer". Nat Genet. 48 (8): 904–911. doi:10.1038/ng.3606
Transcriptional_regulation
American immunologist
and signaling functions, as well as roles for the signal transducers STAT5 and STAT5 in erythropoiesis. In her final year as director, Watowich was the
Stephanie_S._Watowich
Receptor to which cortisol and other glucocorticoids bind
Gouilleux F, Groner B (October 1996). "Functional interactions between Stat5 and the glucocorticoid receptor". Nature. 383 (6602): 726–728. Bibcode:1996Natur
Glucocorticoid_receptor
Novatchkova M, Delogu A, Bouillet P, et al. (February 2010). "Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during
Organization and expression of immunoglobulin genes
Organization_and_expression_of_immunoglobulin_genes
Mammalian protein found in Homo sapiens
apoptotic pathway. Many of the genes affected by PIP appear to be regulated by STAT5. A mitogenic effect of this protein on experimental breast cells lines MCF10A
Prolactin-induced_protein
American computational chemist
BOMB-facilitated library growth and FEP scans identified diaminotriazoles that inhibit STAT5 phosphorylation (IC50 < 10 nM) and show cell-active potency against hyperproliferative
William_L._Jorgensen
Medical condition
negatively regulates STAT3 and inhibits other STAT proteins like STAT5 and STAT1. STAT5 is important for regulatory T cell (Treg) differentiation and function
STAT3_GOF
Protein-coding gene in the species Homo sapiens
are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish. In human tumor-infiltrating lymphocytes
CISH_(protein)
Family of interleukins
Stat3, Stat1, Stat5 IL-19/20/24 IL-20RA IL-20RB Stat3, Stat5 IL-20/24 IL-22R IL-20RB Stat3, Stat5 IL-22 IL-22R IL-10RB Stat3, Stat1, Stat5 IL-22BP (antagonist)
IL-10_family
Protein involved in the binding of the growth hormone
(December 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry.
Growth_hormone_receptor
Protein found in humans
gene (Pkare); protein kinase MysPDZ 110-kDa myosin XVIIIA STAT1, STAT3, STAT5 Signal transducers and activators of transcription-1, -2, -3; transcription
Colony stimulating factor 1 receptor
Colony_stimulating_factor_1_receptor
Mammalian protein found in Homo sapiens
activators of transcription participate in this signalling cascade, namely STAT5, STAT1 and STAT3. After dimerisation, they translocate to nucleus to perform
IL2RA
Protein and coding gene in humans
Berg M, Leonard WJ (January 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell. 96 (1): 121–130
STAT6
Type I cytokine receptor and coding gene in humans
there have been 4 STAT proteins identified as transducer molecules of PRLR, STAT5 is recognised as the most important transducer of PRLR isoforms, with a
Prolactin_receptor
Member of the cyclin protein family
growth factor or oncogene induced expression by Src, Ras, ErbB2, STAT3, STAT5, impaired protein degradation, or chromosomal translocation. Gene amplification
Cyclin_D
Protein-coding gene in the species Homo sapiens
of the positive feedback loop of IL-2. It positively affects the IL-2Rα-STAT5 pathway. IL-2 maintains Helios expression. IL-2 is probably not the only
IKZF2
Protein-coding gene in the species Homo sapiens
fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation". J Biol Chem. 277 (18): 15962–70. doi:10.1074/jbc.M102777200
SH2B1
Protein-coding gene in the species Homo sapiens
"Growth hormone (GH) induces the formation of protein complexes involving Stat5, Erk2, Shc and serine phosphorylated proteins". Mol. Cell. Endocrinol. 166
MAPK1
Protein-coding gene in the species Homo sapiens
progenitors, basophils, and eosinophils. IL-3/Receptor complex induces JAK2/STAT5 cell signalization pathway. It can stimulate transcription factor c‑myc
Interleukin_3
Heterodimeric receptor
recruit STAT proteins (classically STAT1, STAT2, or STAT3, although STAT4, STAT5, and STAT6 may play a role in certain cell types) via their SH2 domains
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Protein-coding gene in the species Homo sapiens
signal transducer and activator (STAT) proteins namely STAT1, STAT3 and STAT5 and thus connects this cytokine to various biological processes. The gene
Interleukin_9
Protein-coding gene in the species Homo sapiens
the JAK/STAT pathway. Direct binding of transcription factors STAT3 and STAT5 to the Pim-1 promoter results in the transcription of Pim-1. The Pim-1 gene
PIM1
Mammalian protein found in Homo sapiens
transcription of different genes. IL-2 and IL-4 activate JAK1, JAK3 and STAT5. JAK3 activating mutations are found in 16% of T-cell acute lymphoblastic
Janus_kinase_3
Protein found in humans
are no changes in activity or phosphorylation of Cish's purported target, STAT5 in either the presence or absence of Cish. In vitro studies have shown signs
PLCG1
Group of blood-based disorders
blood cells types through RAS p21 protein activator 1, Phospholipase Cβ, STAT5, and extracellular signal-regulated kinases. The FLT3 gene is located on
Clonal_hypereosinophilia
Protein-coding gene in the species Homo sapiens
cells the growth hormone prolactin induces HSP90AA1 expression through STAT5. NF-κB or RELA also induces HSP90AA1 expression possibly explaining the
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
Protein-coding gene in the species Homo sapiens
migration of the metastatic cancer cells. KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for
KIAA1958
Mammalian protein found in Homo sapiens
Paxillin phosphorylation at S272 and S274 activates ADAM10 protease, and STAT5 phosphorylation at S779 modulates BCL-ABL-mediated leukemogenesis. PAK2
PAK2
Protein-coding gene in humans
(January 2000). "Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation". J. Biol. Chem. 275 (1): 599–604. doi:10.1074/jbc
PTPN6
Protein-coding gene in humans
degradation; and c) therefore over-stimulates cell signaling pathways such as STAT5, NF-κB, and extracellular signal-regulated kinases which promote cell growth
PDGFRB
Protein complex
activation that subsequently phosphorylates STAT3 via the β chain and JAK3/STAT5 activation via its γ chain. Once tyrosine-phosphorylated, STAT transcription
Interleukin-15_receptor
Protein
Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry.
SOCS3
Protein-coding gene in the species Homo sapiens
et al. (2005). "Physical and functional interactions between STAP-2/BKS and STAT5". J. Biol. Chem. 280 (9): 8188–96. doi:10.1074/jbc.M411692200. hdl:2115/28113
STAP2
Protein-coding gene in the species Homo sapiens
(December 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". The Journal of Biological Chemistry.
SOCS2
Protein-coding gene in the species Homo sapiens
M, Shimamura S, Motoyoshi K (November 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating
CRKL
Protein-coding gene in the species Homo sapiens
translocator-like, homodimer 1.000 MZF1 Myeloid zinc finger protein 0.992 STAT STAT5: signal transducer and activator of transcription 5 0.944 ETSF ETS-like
C9orf85
Protein-coding gene in humans
differentiate along the eosinophil lineage by causing the activation of NF-κB, STAT5, and protein kinase B cell signaling pathways. The FIP1L1 component of FIP1L1-PDGFRA
FIP1L1
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Chemical compound
is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells".
Lenzilumab
American physician and immunologist
the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5". Nature Immunology. 12 (3): 247–54. doi:10.1038/ni.1995. PMC 3182404. PMID 21278738
John_J._O'Shea
Population (SP) SOX10 SOX2 SOX9 SP phenotype SSEA-1 SSEA-3 SSEA-4 Stat3 Stat5 Stella Stra8 Stro-1 Tartrate-resistant acid phosphatase (TRAcP) TdT telomerase
Stem_cell_marker
Chemical compound
2008). "Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients
Lestaurtinib
Protein-coding gene in the species Homo sapiens
angiogenesis by modulating VEGF receptor 2 (VEGFR2) expression through STAT5 and GATA2 in endothelial cells. Mouse models have shown GPR126 deletion
GPR126
Segment of nucleic acid that affects the expression of associated genes
Metser G, Hennighausen L (August 2016). "Hierarchy within the mammary STAT5-driven Wap super-enhancer". Nat Genet. 48 (8): 904–911. doi:10.1038/ng.3606
Regulatory_sequence
Protein-coding gene in the species Homo sapiens
Bouvier G, Bertoglio J (January 2000). "Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2
IL2RB
Protein-coding gene in humans
contrast, heterodimerization with p19 can promote cell proliferation and STAT5 activation. AIM generally promotes inflammation in tissues such as liver
CD5L
Medical therapy involving transplant of cells expanded ex vivo
avidity and sustained tumor immunity. Surprisingly no changes in activity of STAT5, CISH's purported target. Thus CISH represents a new class of T-cell intrinsic
Adoptive_cell_transfer
Protein-coding gene in the species Homo sapiens
edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase". J. Immunol. 179 (6): 3402–6. doi:10.4049/jimmunol
DUSP3
Protein found in humans
(March 1999). "Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells". The
Cyclin_D1
Protein-coding gene in the species Homo sapiens
John S, Berg M, Leonard WJ (Mar 1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling". Cell. 96 (1): 121–30
N-myc-interactor
STAT5
STAT5
STAT5
STAT5
Girl/Female
Celebrity, Hindu, Indian, Malayalam, Marathi, Sanskrit, Tamil, Telugu
Goddess Lakshmi
Boy/Male
Arabic
Guard; Protector
Girl/Female
Arabic, Muslim
Sun of the Women
Girl/Female
Australian, French, German, Hebrew, Hungarian, Slovenia
Gift from God; Female Version of John; The Lord is Gracious
Boy/Male
American, Australian, Danish, French, German, Latin
Little Warrior; Mars; Roman God of War; Brave
Boy/Male
Hindu
Soft natured
Boy/Male
Tamil
God is gracious, Swan like
Male
Greek
(Φίλητος) Greek name PHILETOS means "beloved." In the bible, this is the name of a heretic.
Girl/Female
Arabic, Muslim
Good Fortune
Boy/Male
Hindu, Indian, Tamil
Strongest
STAT5
STAT5
STAT5
STAT5
STAT5