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Protein-coding gene in the species Homo sapiens
of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete
STAT5B
Medical condition
but can also be caused by defective post-receptor signal transduction (STAT5B), abnormalities of the IGF-1 gene or IGF-1 receptor. Secondary (acquired)
Laron_syndrome
Protein family
related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins. Though STAT5A and STAT5B are encoded by separate genes
STAT5
Subtype of acute myeloid leukaemia characterised by accumulation of promyelocytes
matrix associated, signal transducer and activator of transcription 5b (STAT5B), protein kinase A regulatory subunit 1α (PRKAR1A), factor interacting with
Acute_promyelocytic_leukemia
Medical condition
pathway component gain promotes cell proliferation and survival unknown STAT5B STAT5B ~2–6% JAK-STAT signaling pathway component gain promotes cell proliferation
Extranodal NK/T-cell lymphoma, nasal type
Extranodal_NK/T-cell_lymphoma,_nasal_type
Medical condition
diagnosis sees that the following should be considered: CD25 deficiency STAT5B deficiency Severe combined immunodeficiency X linked thrombocytopenia Immunosuppressive
Autoimmune polyendocrine syndrome
Autoimmune_polyendocrine_syndrome
Protein-coding gene in the species Homo sapiens
the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind
STAT4
mutations in CIITA, RFXANK, RFX5, or RFXAP) CD25 deficiency CD27 deficiency STAT5b deficiency ITK deficiency SH2D1A deficiency (XLP1) MAGT1 deficiency DOCK2
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Biochemical process involving the production of fats
mechanism suggests that growth hormones may phosphorylate with STAT5A and STAT5B, transcription factors that are a part of the Signal Transducer And Activator
Lipogenesis
Human chromosome
SLFN11, SLFN12, SLFN12L, SLFN13, SLFN14 STAT proteins: STAT3, STAT5A, STAT5B Tubulins: TUBD1, TUBG1, TUBG2 Ubiquitin-conjugating enzymes: UBE2G1, UBE2O
Chromosome_17
Family of intracellular transcription factors
that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in type II interferon signalling
STAT_protein
Medical condition
also be caused by mutations in the STAT genes, particularly STAT5B and STAT1. Because STAT5B is involved in the formation of regulatory T cells, mutations
Autoimmune_enteropathy
Protein-coding gene in the species Homo sapiens
acids unique to its C-terminal domain and is 96% similar to its homolog, STAT5b. The six functional domains and their corresponding amino acid positions
STAT5A
P40763 15954 STAT4 HGNC:11365; Q14765 15955 STAT5A HGNC:11366; P42229 15956 STAT5B HGNC:11367; P51692 15957 STAT6 HGNC:11368; P42226 15958 STATH HGNC:11369;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Mammalian protein found in Homo sapiens
GNB2L1 IL6ST, Grb2, IL2RB, IRS1, IL10RA, PTPN11, STAM2, STAT3, STAT5A, STAT5B, and TNFRSF1A. Janus kinase inhibitor GRCh38: Ensembl release 89: ENSG00000162434
Janus_kinase_1
ENSG00000126561 STAT Known motif – In vivo/Misc source [889] YTTCYNRGAAHY STAT5B ENSG00000173757 STAT Known motif – In vivo/Misc source [890] ADTTCYHRGAAA
List of human transcription factors
List_of_human_transcription_factors
Biological signaling pathway h
proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains, each with a different
JAK-STAT_signaling_pathway
Receptor to which cortisol and other glucocorticoids bind
NCOA1, NCOA2, NCOA3, POU2F1, RANBP9, RELA, SMAD3, SMARCD1, SMARCA4 STAT3, STAT5B, Thioredoxin, TRIM28, and YWHAH. Membrane glucocorticoid receptor Selective
Glucocorticoid_receptor
Protein-coding gene in humans
PDGFRB, PI3K → Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3, SOS1, STAT3, STAT5A, and STAT5B. Inhibitors Batoprotafib SHP099 Sitneprotafib Vociprotafib (RMC-4630) AUTACs
PTPN11
Protein domain
SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK VAV1; VAV2; VAV3
SH2_domain
Hormone pathway
prolactin receptors (PRLR) expressed on TIDA neurons, activating the JAK2–STAT5B signalling cascade. This feedback has two temporal components. Within minutes
Hypothalamic–pituitary–prolactin axis
Hypothalamic–pituitary–prolactin_axis
Protein found in humans
2634_2634_2642. PMID 9531570. Dong S, Tweardy DJ (April 2002). "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic
Retinoic_acid_receptor_alpha
Protein involved in the binding of the growth hormone
prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B". Molecular Endocrinology. 14 (9): 1338–50. doi:10.1210/mend.14.9.0513.
Growth_hormone_receptor
Membrane receptor protein found in humans
(January 2002). "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth & Differentiation
Tumor necrosis factor receptor 1
Tumor_necrosis_factor_receptor_1
Non-receptor tyrosine kinase and coding gene in humans
IL12RB2 IL5RA PIK3R1 PPP2R4 PTK2 PTPN11 PTPN6 PRMT5 SH2B1 SHC1 SOCS3 STAT5A STAT5B STAM SOCS1 TEC TNFRSF1A VAV1 YES1 Prolactin signals through JAK2 are dependent
Janus_kinase_2
Group of disorders
genes regulate cell growth and survival. Other genes (e.g. JAK3, STAT3, and STAT5B ) that are mutated in far lower percentages of cases also regulate these
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
Italian hematologist, academic and researcher
and Reed-Sternberg tumor cells discovered recurrent mutations of STAT3, STAT5B, JAK1, JAK2 and PTPN1 that support the pivotal role of aberrant activation
Brunangelo_Falini
Complication of celiac disease
subpopulations that have mutations: in other JAK-STAT pathway genes viz., STAT5B, JAK3, and SOCS1 (SOCS1 inhibits STAT signaling); tumor suppressor genes
Enteropathy-associated T-cell lymphoma
Enteropathy-associated_T-cell_lymphoma
Medical condition
T cells that may have mutations or other genetic abnormalities in their STAT5B, JAK3, TP53, SETD2, BRAF, KRAS, GNA12, CREBBP, and/or Myc genes. Indolent
Natural killer cell enteropathy
Natural_killer_cell_enteropathy
Medical condition
when TK gene fusions are negative (mutations in TET2, ASXL1, EHZ2, SETBP1, STAT5B) Detecting novel gene fusions not identified by standard methods Distinguishing
Acute_eosinophilic_leukemia
Protein-coding gene in the species Homo sapiens
mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Molecular Endocrinology. 16 (6): 1394–1406. doi:10.1210/mend.16.6.0845
SOCS2
commonly observed in peripheral T cell lymphomas (PTCL), while STAT3 and STAT5B mutations are unique to large granular lymphocytic (LGL) leukemia. Furthermore
Precision_diagnostics
Medical condition
formation. Mutations in JAK-STAT signaling pathway genes (i.e. JAK3 and STAT5B). This pathway regulates cell proliferation, death, and tumor formation
Monomorphic epitheliotropic intestinal T cell lymphoma
Monomorphic_epitheliotropic_intestinal_T_cell_lymphoma
173100; GH1 Growth hormone insensitivity with immunodeficiency; 245590; STAT5B Growth retardation with deafness and mental retardation due to IGF1 deficiency;
List_of_OMIM_disorder_codes
Protein-coding gene in humans
Moreover, the authors observed a reduced T cell proliferation and an impaired STAT5B phosphorylation upon IL2 stimulation of the patients' lymphocytes. DOCK11
Dedicator of cytokinesis protein 11
Dedicator_of_cytokinesis_protein_11
Protein found in humans
PMC 88789. PMID 11113190. Dong S, Tweardy DJ (April 2002). "Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic
Nuclear receptor co-repressor 2
Nuclear_receptor_co-repressor_2
Protein-coding gene in the species Homo sapiens
up-regulated 1) V$STAT Signal transducer and activator of transcription V$STAT5B.01 Signal transducer and activator of transcription 5B V$ZF03 C2H2 zinc
FAM214B
STAT5B
STAT5B
STAT5B
STAT5B
Boy/Male
Christian, German
High Born Ruler; Ruler of All; Powerful
Girl/Female
English
Modern feminine of John and Jon.
Boy/Male
Hindu
Arnik
Boy/Male
Hindu
Joy of winning
Girl/Female
Biblical
That makes fruitful.
Boy/Male
Indian, Punjabi, Sikh
An Auspicious Lamp
Girl/Female
Italian
consecrated to God.
Boy/Male
Hebrew
Praised.
Biblical
a parable; governing
Boy/Male
Afghan, Arabic, French, German, Gujarati, Hindu, Indian, Kannada, Marathi, Muslim, Sindhi
Studious Person; One who Instruct; Lord; A Prophet's Name; Eager Lord; Impulsive; Lord of Fiery; Prophet's Name
STAT5B
STAT5B
STAT5B
STAT5B
STAT5B