AI & ChatGPT searches , social queriess for SPHINGOMYELIN
Search references for SPHINGOMYELIN. Phrases containing SPHINGOMYELIN
See searches and references containing SPHINGOMYELIN!
Search references for SPHINGOMYELIN. Phrases containing SPHINGOMYELIN
See searches and references containing SPHINGOMYELIN!SPHINGOMYELIN
Class of chemical compounds
Sphingomyelin (SM, /ˌsfɪŋɡoʊˈmaɪəlɪn/) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath that surrounds
Sphingomyelin
Class of enzymes
Sphingomyelin phosphodiesterase D (EC 3.1.4.41, sphingomyelinase D) is an enzyme of the sphingomyelin phosphodiesterase family with systematic name sphingomyelin
Sphingomyelin phosphodiesterase D
Sphingomyelin_phosphodiesterase_D
Class of enzymes
Sphingomyelin phosphodiesterase (EC 3.1.4.12, also known as neutral sphingomyelinase, sphingomyelinase, or SMase; systematic name sphingomyelin cholinephosphohydrolase)
Sphingomyelin phosphodiesterase
Sphingomyelin_phosphodiesterase
Test of fetal amniotic fluid to assess for lung immaturity
The lecithin–sphingomyelin ratio (L/S ratio or L-S ratio) is a test of fetal amniotic fluid to assess for fetal lung immaturity. Lungs require surfactant
Lecithin–sphingomyelin_ratio
Substance of biological origin that is soluble in nonpolar solvents
phospholipids (cephalin), glycolipids (cerebroside) and sphingolipids (sphingomyelin). The terms lipoid, lipin, lipide and lipid have been used with varied
Lipid
Medical condition
varying severity. These are inherited metabolic disorders in which sphingomyelin accumulates in lysosomes in cells of many organs. NP types A, A/B, and
Niemann–Pick_disease
Family of waxy lipid molecules
membrane of eukaryotic cells, since they are component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer. Contrary to previous
Ceramide
In enzymology, a sphingomyelin synthase (EC 2.7.8.27) is an enzyme that catalyzes the chemical reaction a ceramide + a phosphatidylcholine ⇌ {\displaystyle
Sphingomyelin_synthase
Enzyme found in humans
Sphingomyelin phosphodiesterase 1 (SMPD1), also known as acid sphingomyelinase (ASM), is an enzyme that in humans is encoded by the SMPD1 gene. Sphingomyelin
Sphingomyelin phosphodiesterase 1
Sphingomyelin_phosphodiesterase_1
Family of chemical compounds
bonded to the terminal oxygen atom include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides
Sphingolipid
Class of lipids
Sphingolipid Ceramide phosphorylcholine (Sphingomyelin) (SPH) Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) Ceramide phosphoryllipid Phospholipids
Phospholipid
Chemical compound and essential nutrient
Fat-soluble choline-containing compounds (phosphatidylcholines and sphingomyelins) are either hydrolyzed by phospholipases or enter the lymph incorporated
Choline
Enzyme that hydrolyzes sphingomyelin
sphingomyelinase (SMase) family, responsible for catalyzing the breakdown of sphingomyelin to ceramide and phosphorylcholine. They are organized into alkaline
Acid_sphingomyelinase
Species of annelid worm
membranes contain significant amounts of sphingomyelin. (Lysenin is also toxic to organisms lacking sphingomyelin in their cell walls, including Bacillus
Eisenia_fetida
Sphingomyelin deacylase (EC 3.5.1.109, SM deacylase, GcSM deacylase, glucosylceramide sphingomyelin deacylase, sphingomyelin glucosylceramide deacylase
Sphingomyelin_deacylase
Class of phospholipids
component of the pulmonary surfactant, and is often used in the lecithin–sphingomyelin ratio to calculate fetal lung maturity. While phosphatidylcholines are
Phosphatidylcholine
Structure surrounding milk fat globules
a source of multiple bioactive compounds, including phospholipids, sphingomyelins, gangliosides, glycolipids, glycoproteins, and carbohydrates that have
Milk_fat_globule_membrane
Combination in the membranes of cells
surrounding bilayer. Also, lipid rafts are enriched in sphingolipids such as sphingomyelin, which is typically elevated by 50% compared to the plasma membrane
Lipid_raft
Class of lipids
brain, as it helps with reduced stress and improved memory. Sphingomyelin Sphingomyelin is a type of sphingolipid, which contains a backbone of sphingoid
Glycerophospholipid
SSRI antidepressant
sphingomyelinase, a key regulator of ceramide levels which derives ceramide from sphingomyelin. While it is unclear how fluoxetine exerts its effect on mood, it has
Fluoxetine
Lipid molecules on cell membrane
hydrocarbon chain. In sphingomyelin and glycolipids, the amino group of sphingosine is linked to FAs by an amide bond. In sphingomyelin the primary hydroxyl
Membrane_lipid
Chemical compound
part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid. Sphingosine can be phosphorylated in vivo
Sphingosine
Hollow cavity found in the lungs
infants causes infant respiratory distress syndrome (IRDS). The lecithin–sphingomyelin ratio is a measure of fetal amniotic fluid to indicate lung maturity
Pulmonary_alveolus
Fluid surrounding a fetus within the amnion
L/S ratio test (lecithin/sphingomyelin). This test is used to determine fetal lung maturity. Both lecithin and sphingomyelin are lung surfactants that
Amniotic_fluid
Chemical compound
termed a glycerophospholipid and the other a sphingomyelin, or more specifically within the sphingomyelin class, a sphingophospholipid. Phosphorylethanolamine
Phosphorylethanolamine
Protein-coding gene in the species Homo sapiens
1073/pnas.97.11.5895. PMC 18530. PMID 10823942. "Entrez Gene: SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)"
SMPD3
Chemical compound
neuroprotective effects due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and
Citicoline
Class of enzymes
of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which
Phosphodiesterase
Choline occurs in the head groups of phosphatidylcholine and sphingomyelin, which are abundant in cell membranes. It is the precursor for the neurotransmitter
Carbon-11-choline
Treatment of cancer using drugs that inhibit cell division or kill cells
(S1P) has shown similar effect, but its mechanism of inhibiting the sphingomyelin apoptotic pathway may also interfere with the apoptosis action of chemotherapy
Chemotherapy
Set of chemical reactions in organisms
the basic structure exist, including backbones such as sphingosine in sphingomyelin, and hydrophilic groups such as phosphate in phospholipids. Steroids
Metabolism
Protein-coding gene in the species Homo sapiens
pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase
ENPP7
Toxin found in earthworms
as a soluble monomer that binds specifically to a membrane receptor, sphingomyelin in the case of lysenin. After attaching to the membrane, the oligomerization
Lysenin
Human disease affecting newborns
point-of-care method for predicting IRDS by measuring the lecithin-sphingomyelin ratio (L/S) in gastric aspirate (GA). The new method, which is based
Infant respiratory distress syndrome
Infant_respiratory_distress_syndrome
Topics referred to by the same term
SMS2 may refer to: Sphingomyelin synthase, an enzyme Small Multitasking System 2 SMS-2 weather satellite SMS (disambiguation) This disambiguation page
SMS2
Oxygen-delivering blood cell and the most common type of blood cell
disposed, as shown below: Outer monolayer Phosphatidylcholine (PC); Sphingomyelin (SM). Inner monolayer Phosphatidylethanolamine (PE); Phosphoinositol
Red_blood_cell
Chemical compound
synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells"
Monensin
Family of enzymes
phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as some
Calcineurin-like phosphoesterase
Calcineurin-like_phosphoesterase
Chemical compound
platelet-activating factor; the phospholipid phosphatidylcholine and sphingomyelin, the only phospholipid of the membrane that is not built with a glycerol
Phosphorylcholine
Class of enzymes
with eukaryotic cell membranes and hydrolyzing phosphatidylcholine and sphingomyelin, leading to cell lysis. Zinc-metallophospholipases C: Clostridium perfringens
Phospholipase_C
Model of cell membranes
Christie, William (Bill) W. "Sphingolipids, Membrane Rafts and Caveolae - sphingomyelin and cholesterol - structure, occurrence, biochemistry and function"
Fluid_mosaic_model
Protein-coding gene in the species Homo sapiens
"Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells". The Journal
SGMS1
This enzyme is mainly located within the lysosome, where it cleaves sphingomyelin to ceramide and sphingosine, the latter of which is then phosphorylated
FIASMA
Genus of recluse spiders
dermonecrotic venom that contains sphingomyelinase D, an enzyme in the sphingomyelin phosphodiesterase family. It is somewhat unique to them, otherwise only
Sicarius_(spider)
Protein family
highly basic peptides. These cytolysins form cation-selective pores in sphingomyelin-containing membranes. Examples include equinatoxins (from Actinia equina)
Sea_anemone_cytotoxic_protein
showed that stressed but otherwise intact phagosome membranes expose sphingomyelin on their cytosolic surface, providing an early indicator of impending
Felix_Armin_Randow
5-MTHF deficiency in the brain
S-adenosyl homocysteine; SAM: S-adenosyl-methionine; Ser: Serine; SHMT: serine-hydroxy methyl transferase; SM: sphingomyelin. Figure 1 from Mafi et al., 2020.
Cerebral_folate_deficiency
Subspecies of rod-shaped bacterium
called damselysin (Dly). Dly is a phospholipase D with activity against sphingomyelin. This toxin exerts strong hemolytic activity in the erythrocytes across
Photobacterium damselae subsp. damselae
Photobacterium_damselae_subsp._damselae
Topics referred to by the same term
SMS1 may refer to: Sphingomyelin synthase, an enzyme SMS-1, weather satellite, part of the NASA program Synchronous Meteorological Satellite SMS (disambiguation)
SMS1
Species of bacterium
mechanisms, skin commensals interact with infectious agents like pathogens. Sphingomyelin phosphodiesterase is the main driver in the S. epidermidis production
Staphylococcus_epidermidis
Species of bacterium
bond–cleaving exotoxin that provides the bacterium with the ability to cleave sphingomyelin, which is a glycerophospholipid eukaryotic cell-wall component, so by
Corynebacterium pseudotuberculosis
Corynebacterium_pseudotuberculosis
phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and sphingomyelin are some of the most common lipids most animal cell membranes. These
Unilamellar_liposome
Topics referred to by the same term
MediaWorks Small penis humiliation Smoothed particle hydrodynamics Sphingomyelin Self-propelled howitzer, a type of self-propelled artillery This disambiguation
SPH
Fatty substance insulating nerve cell axons
glycolipid called galactocerebroside. The intertwining hydrocarbon chains of sphingomyelin strengthen the myelin sheath. Cholesterol is an essential lipid component
Myelin
Substance that lowers surface tension
phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, and sphingomyelins. Lauryldimethylamine oxide and myristamine oxide are two commonly used
Surfactant
German-born biochemist and physician (1829–1901)
and characterized numerous compounds of the brain, such as cephalin, sphingomyelin, galactose, lactic acid and sphingosine. In 1884 he explained his findings
Johann Ludwig Wilhelm Thudichum
Johann_Ludwig_Wilhelm_Thudichum
J. Clin. Nutr. 32, 58–83 (1979). Kummerow FA. Interaction between sphingomyelin and oxysterols contributes to atherosclerosis and sudden death. Am.
Fred_Kummerow
Protein-coding gene in the species Homo sapiens
Sphingomyelin phosphodiesterase 4 is an enzyme that in humans is encoded by the SMPD4 gene. GRCh38: Ensembl release 89: ENSG00000136699 – Ensembl, May
SMPD4
Nervonic acid has 24 carbons, is found in brain glycolipids (Nervon) and sphingomyelin, and is a cis-15-mono-unsaturated fatty acid. C23H45CO2H, IUPAC organization
List of unsaturated fatty acids
List_of_unsaturated_fatty_acids
Species of spider
evidence was circumstantial and an assay of the venom did not find Sphingomyelin phosphodiesterase D. While there have been reports of bites being harmful
Ctenus_captiosus
Medical condition
required to metabolize the lipid sphingomyelin. If sphingomyelinase is absent or not functioning properly, sphingomyelin cannot be metabolized properly
SMPD1-associated Niemann–Pick disease
SMPD1-associated_Niemann–Pick_disease
Protein
outer-leaflet, facing the outside environment, contains phosphatidylcholine and sphingomyelin. Scramblase is an enzyme, present in the cell membrane, that can transport
Phospholipid_scramblase
Medium (C12–C14) and long (C22–C24) chain fatty acids are less than 1%. Sphingomyelin (4.42% of the total phospholipids), phosphatidyl ethanolamine (12.8%)
Ambadi_seed_oil
Human chromosome
solute carrier family 40 (iron-regulated transporter), member 1 SMPD4: Sphingomyelin phosphodiesterase 4 SP140: encoding protein SP140 nuclear body protein
Chromosome_2
Protein family
on phosphatidylcholine, it also shows weak catalytic activity with sphingomyelin and phosphatidylinositol. Sequence studies have shown the protein to
Zinc-dependent phospholipase C
Zinc-dependent_phospholipase_C
Medical specialty concerning pregnancy and childbirth
factor for infant respiratory distress syndrome. Typically, a lecithin:sphingomyelin ratio greater than 1.5 is associated with increased lung maturity. Nonstress
Obstetrics
Medical condition
accepted treatments Prognosis Niemann-Pick disease Sphingomyelinase Sphingomyelin in brain and RBCs Mental retardation Spasticity Seizures Hepatosplenomegaly
Sphingolipidoses
Membrane-bound extracellular vesicles
lipid- dependent mechanisms. Exosomes are enriched in cholesterol, sphingomyelin, saturated phosphatidylcholine and phosphatidylethanolamine as compared
Exosome_(vesicle)
Form of vitamin B-12
used for DNA methylation and to make phospholipid membranes, choline, sphingomyelin, acetylcholine, and other neurotransmitters. The metabolism of propionyl-CoA
Cyanocobalamin
Species of venomous spider
vitro and ex vivo, and like Loxosceles, it is capable and hydrolyzes sphingomyelin, induce cell death of keratinocytes and complement-dependent hemolysis
Sicarius_ornatus
bifunctional enzyme that produces both CPE and sphingomyelin, thus also functioning as a sphingomyelin synthase. Both mammalian CPE synthases, SMS2 and
Ceramide phosphoethanolamine synthase
Ceramide_phosphoethanolamine_synthase
Protein-coding gene in the species Homo sapiens
Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene. GRCh38: Ensembl release 89: ENSG00000135587 – Ensembl, May
SMPD2
Class of enzymes
metabolic process negative regulation of cell population proliferation sphingomyelin biosynthetic process phosphatidylcholine biosynthetic process blastocyst
Phosphatidylethanolamine N-methyltransferase
Phosphatidylethanolamine_N-methyltransferase
Rare genetic disorder
precursor to several essential compounds, including phosphatidylserine, sphingomyelin, glycine, and D-serine. Diagnosis of SPATCCM generally relies on whole
SPATCCM
American biochemist and developmental biologist (1935–2024)
chemistry and biochemistry from University of Vienna in 1960, focused on sphingomyelin structure. He continued his studies of biochemistry in postdoctoral
Igor_B._Dawid
+ sphingomyelin Thus, the two substrates of this enzyme are CDP-choline and N-acylsphingosine, whereas its two products are CMP and sphingomyelin. This
Ceramide cholinephosphotransferase
Ceramide_cholinephosphotransferase
Process where substrates are converted into more complex products in living organisms
are particularly abundant in the central nervous system. For example, sphingomyelin is part of the myelin sheath of nerve fibers. Sphingolipids are formed
Biosynthesis
Protein-coding gene in the species Homo sapiens
YH, Bielawski J, Kraveka JM, et al. (2008). "Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced
Ceramide_synthase_5
combining cholesterol with a phospholipid and/or sphingolipids e.g. sphingomyelin. This phase has been related to lipid rafts that may exist in plasma
Liquid_ordered_phase
Molecule destroying the membrane of red blood cells
mechanism was discovered to be the hydrolysis of a specific membrane lipid, sphingomyelin, which accounts for 50% of the cell's membrane. This degradation was
Hemolysin
German biochemist (1896–1971)
cause of Niemann-Pick’s lipidosis as the storage of large amounts of sphingomyelin in the brain, liver and spleen. He found that cerebroside accumulated
Ernst_Klenk
Biological membrane structure
the outer (extracellular) leaflet is based on phosphatidylcholine, sphingomyelin and a variety of glycolipids. In some cases, this asymmetry is based
Lipid_bilayer
Rare metabolic disease
in particular lipid-mediated signaling. ceramides are reduced, while sphingomyelin—a plasma membrane component that contributes to the efficiency of signal
Combined malonic and methylmalonic aciduria
Combined_malonic_and_methylmalonic_aciduria
Family of fluorescent dyes
M.; Kobayashi, T. (25 September 2018). "Protein Probes to Visualize Sphingomyelin and Ceramide Phosphoethanolamine". Chem. Phys. Lipids. 216: 132–141
Alexa_Fluor
diacylglycerol-lyase EC 3.1.4.11: phosphoinositide phospholipase C EC 3.1.4.12: sphingomyelin phosphodiesterase EC 3.1.4.13: serine-ethanolaminephosphate phosphodiesterase
List_of_EC_numbers_(EC_3)
Chemical compound
shown to form noncovalent complexes with various biomolecules including sphingomyelin and other associated glycolipids. Woods AS, Moyer SC, Wang HY, Wise
Chlorisondamine
Family of toxins from bacteria
that CDC would associate with lipid rafts. A later study showed that sphingomyelin, a necessary component of lipid raft formation, inhibited rather than
Cholesterol-dependent cytolysin
Cholesterol-dependent_cytolysin
Species of bacterium
"Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein
Thermotoga_maritima
Index of articles on biophysics
cell adhesion molecules Solute pumping Sorting and assembly machinery Sphingomyelin Spinal locomotion Sports biomechanics Steady state (biochemistry) Stephen
Index_of_biophysics_articles
Class of toxic sphingolipids involved in neurological and metabolic disorders
ceramide transporter protein is involved, it will go to the TGN to form sphingomyelin. If the vesicles are the ones in charge of transport, it will reach
1-Deoxysphingolipids
Class of peptides that have antimicrobial activity
membranes are usually made of zwitterionic phosphatidylcholine and sphingomyelin, even though a small portion of the membrane's outer surfaces contain
Antimicrobial_peptides
Lipid with a carbohydrate attached to a ceramide
certain species of bacteria, such as members of the genus Sphingomonas. Sphingomyelin Charles Chalfant; Maurizio Del Poeta (2010). Sphingolipids as signaling
Glycosphingolipid
Human chromosome
22 SMAP1: small acidic protein SMCO4: encoding protein SMCO4 SMPD1: sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) SNHG1: encoding
Chromosome_11
American lipid and cancer researcher
12604-9. Accessed 19 May 2020. T. Okazaki, R. Bell. and Y.A. Hannun "Sphingomyelin turnover induced by vitamin D3 in HL-60 cells: Role in cell differentiation"
Yusuf_A._Hannun
Neuroimmunologist
including steroids, intravenous immunoglobulin, plasmapheresis, and sphingomyelin." Singh V. K., Lin SX, Newell E, Nelson C. (2002). "Abnormal measles-mumps-rubella
Vijendra_K._Singh
Novel drug delivery system
these surfactants. Biological membrane lipids, such as phospholipids, sphingomyelins, bile salts (sodium taurocholate), and sterols (cholesterol) are used
Lipid-based_nanoparticle
Biological signaling using lipid molecules
proteins in serum. Ceramide (Cer) can be generated by the breakdown of sphingomyelin (SM) by sphingomyelinases (SMases), which are enzymes that hydrolyze
Lipid_signaling
Type of lecithin derived from eggs
cell membrane. Other components include phosphatidylethanolamine and sphingomyelin. Egg lecithin is usually extracted chemically using ethanol, acetone
Egg_lecithin
German pathologist (1868–1944)
Niemann–Pick disease: A biochemical disorder affecting a lipid fat called sphingomyelin, which usually results in progressive enlargement of the liver and spleen
Ludwig_Pick
Enzyme
phosphocholine The bacterial enzyme is a zinc protein. It also acts on sphingomyelin and phosphatidylinositol. Druzhinina KV, Kritsman MG (1952). "[Lecithinase
Lecithinase_C
SPHINGOMYELIN
SPHINGOMYELIN
SPHINGOMYELIN
SPHINGOMYELIN
Girl/Female
British, English
Island of Linden Trees
Female
English
Feminine variant spelling of English unisex Angel, ANGELL means "angel, messenger."
Girl/Female
Arabic, Muslim, Sindhi
Treasure; She was the Daughter of Khalid Bin Jafar Bin Qurt
Girl/Female
Indian
Fate, Happiness, Goddess Lakshmi
Male
English
Old English Arthurian legend name of a Knight of the Round Table who was the illegitimate son and traitor of King Arthur, possibly MORDRED means "sea counsel." He was brother (or half-brother) to Agravain, Gaheris, Gareth, and Gawain, and noted for having crowned himself and married Guinevere while Arthur was waging war on Emperor Lucius of Rome. He was killed by Arthur at the Battle of Camlann.Â
Girl/Female
Assamese, Bengali, Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Tamil, Telugu
Eternal
Boy/Male
Tamil
Brilliant
Girl/Female
Australian, Vietnamese
Fog
Boy/Male
Hindu, Indian
Strong; Healthy; Name of Lord Shiva; Youth; Sky; Young Generation
Boy/Male
Gaelic
Dark hero.
SPHINGOMYELIN
SPHINGOMYELIN
SPHINGOMYELIN
SPHINGOMYELIN
SPHINGOMYELIN