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Dopamine-releasing portion of the substantia nigra
The pars compacta (SNpc, SNc) is one of two subdivisions of the substantia nigra of the midbrain (the other being the pars reticulata); it is situated
Pars_compacta
Structure in the basal ganglia of the brain
different connections and functions: the pars compacta (SNpc) and the pars reticulata (SNpr). The pars compacta serves mainly as a projection to the basal
Substantia_nigra
Bilateral pathway in the brain
hemisphere. It has two distinct parts, the pars compacta (SNc) and the pars reticulata (SNr). The pars compacta contains dopaminergic neurons from the A9
Nigrostriatal_pathway
GABA-releasing portion of the substantia nigra
The pars reticulata (SNpr) is a portion of the substantia nigra and is located lateral to the pars compacta. Most of the neurons that project out of the
Pars_reticulata
Group of subcortical nuclei involved in the motor and reward systems
the cortex, as well as dopaminergic inputs from the substantia nigra pars compacta. The dorsal striatum is generally considered to be involved in sensorimotor
Basal_ganglia
Topics referred to by the same term
set Pars compacta, a portion of the substantia nigra in anatomy Compactum This disambiguation page lists articles associated with the title Compacta. If
Compacta
Part of the nervous system in primates
made up of two parts, the pars compacta (SNpc) and the pars reticulata (SNpr), sometimes there is a reference to the pars lateralis but that is usually
Primate_basal_ganglia
Nucleus in the basal ganglia of the brain
substantia nigra pars reticulata. The striosomes receive input from the prefrontal cortex and give outputs to the substantia nigra pars compacta. There are
Striatum
Projection neurons in the brain that synthesize and release dopamine
women. The dopaminergic pathways that project from the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) into the striatum (i.e., the
Dopaminergic_pathways
Classification of disease severity
nigra. In particular, this death occurs in the ventral part of the pars compacta, with up to 70% of the cells affected by the time the patient dies.
Braak_staging
Dark pigment found in the brain
large quantities in catecholaminergic cells of the substantia nigra pars compacta and locus coeruleus, giving a dark color to the structures. Neuromelanin
Neuromelanin
Organic chemical that functions both as a hormone and a neurotransmitter
area called the pars reticulata and an output area called the pars compacta. The dopaminergic neurons are found mainly in the pars compacta (cell group A8)
Dopamine
Collection of neurons in the brainstem
peduncle. It has two divisions of subnuclei; the pars compacta, containing mainly cholinergic neurons, and the pars dissipata, containing mainly glutamatergic
Pedunculopontine_nucleus
Treatment method for Parkinson's disease
discovery that the death of dopaminergic neurons in the substantia nigra pars compacta resulted in the motor symptoms of the disease. Thus, cell transplantation
Cell-based therapies for Parkinson's disease
Cell-based_therapies_for_Parkinson's_disease
System of neural circuits in the brain
primarily consists of modulatory dopaminergic projections from the pars compacta of the substantia nigra, and ventral tegmental area as well as excitatory
Cortico-basal ganglia-thalamo-cortical loop
Cortico-basal_ganglia-thalamo-cortical_loop
Progressive neurodegenerative disease
and the degeneration of dopaminergic neurons in the substantia nigra pars compacta. The death of these neurons reduces available dopamine in the striatum
Parkinson's_disease
Protein-coding gene in humans
expressed in endothelial cell prefrontal cortex external globus pallidus pars compacta superior vestibular nucleus Brodmann area 9 right frontal lobe occipital
CALHM1
Round structure at the base of the forebrain
substantia nigra contains two parts: the substantia nigra pars compacta (SNpc) and the substantia nigra pars reticulata (SNpr). The SNpc obtains input from the
Putamen
Structure of the basal ganglia of the brain
pallidal nuclei and the two parts of the substantia nigra (the pars compacta and pars reticulata) constitute a high-frequency autonomous pacemaker. (see
Globus_pallidus
Chemical compound
animals by lesioning the dopaminergic neurons of the substantia nigra pars compacta, in order to develop and test new medicines and treatments for Parkinson's
Oxidopamine
linear nucleus of the raphe Interfascicular nucleus Substantia nigra Pars compacta Pars reticulata Interpeduncular nucleus Cerebral peduncle Crus cerebri
List of regions in the human brain
List_of_regions_in_the_human_brain
Forward-most portion of the brainstem
nigra – one where neurons are densely packed (the pars compacta) and one where they are not (the pars reticulata), which serve a different role from one
Midbrain
Protein involved in multiple prion diseases
spinal ganglia trigeminal ganglion pons Epithelium of choroid plexus pars compacta Top expressed in nucleus of stria terminalis CA3 field entorhinal cortex
Major_prion_protein
Topics referred to by the same term
Supply Network Collaboration, SAP business software Substantia nigra pars compacta, or SNc, a region of the brain Air Cargo Carriers ICAO code General
SNC
Protein-coding gene in the species Homo sapiens
pallidus entorhinal cortex Brodmann area 23 tendon of biceps brachii pars compacta Top expressed in gastrula cumulus cell internal carotid artery zygote
RNF12
Mental state of being in love
neurons which produce dopamine (the other being the substantia nigra pars compacta). Projections from the VTA innervate the NAc, where dopamine activity
Romantic_love_(mental_state)
group of thalamus orbitofrontal cortex superior vestibular nucleus pars compacta Brodmann area 23 amygdala n/a More reference expression data BioGPS
Centrosomal_protein_15
Mitochondrial protein involved in iron–sulfur cluster biosynthesis
superior vestibular nucleus pars compacta external globus pallidus right adrenal cortex myocardium left adrenal cortex pars reticulata Top expressed in
ISCU
Endogenous GABA precursor
hippocampus, cerebellum, striatum, cerebral cortex, and substantia nigra pars compacta (SNpc). These findings may warrant a rethinking of the actions of MAO-B
N-Acetylputrescine
Protein-coding gene in the species Homo sapiens
thoracic aorta cardia monocyte vena cava lateral nuclear group of thalamus pars compacta n/a More reference expression data BioGPS n/a Gene ontology Molecular
Deoxyribonuclease II, lysosomal
Deoxyribonuclease_II,_lysosomal
Posterior part of the brain, adjoining and structurally continuous
sends a descending tract to the lower motor neurons. Substantia nigra pars compacta: This is a concentration of neurons in the ventral portion of the midbrain
Brainstem
Protein-coding gene in the species Homo sapiens
tissue of biceps brachii spinal ganglia trigeminal ganglion pars compacta skin of thigh pars reticulata right adrenal cortex vulva gums gingival epithelium
ME1_(gene)
Protein-coding gene in the species Homo sapiens
frontal pole spinal ganglia pars compacta superior vestibular nucleus Brodmann area 10 Brodmann area 23 orbitofrontal cortex pars reticulata Top expressed
Tubulin_beta-2A_chain
Protein-coding gene in the species Homo sapiens
lateral nuclear group of thalamus right frontal lobe anterior pituitary pars compacta pars reticulata right hemisphere of cerebellum Brodmann area 9 nucleus
HARS
Protein-coding gene in the species Homo sapiens
endothelial cell retinal pigment epithelium corpus callosum Brodmann area 23 pars compacta germinal epithelium pons ganglionic eminence Top expressed in tail of
Signal transducing adaptor molecule
Signal_transducing_adaptor_molecule
Protein-coding gene in the species Homo sapiens
metanephric glomerulus Epithelium of choroid plexus pars reticulata endothelial cell kidney tubule pars compacta Top expressed in interventricular septum neural
WWOX
Unanswered question in the study of consciousness
shown that ferritin and neuromelanin in fixed human substantia nigra pars compacta (SNc) tissue are able to support widespread electron tunneling. Further
Binding_problem
Protein-coding gene in the species Homo sapiens
Brodmann area 23 bronchial epithelial cell epithelium of nasopharynx pars compacta caput epididymis superior vestibular nucleus Top expressed in olfactory
Store-operated calcium entry-associated regulatory factor
Store-operated_calcium_entry-associated_regulatory_factor
Chemical substance that enables neurotransmission
dopamine due to the loss of dopaminergic neurons in substantia nigra pars compacta. Schizophrenia, a highly heterogeneous and complicated disorder has
Neurotransmitter
Protein-coding gene in humans
ganglia tail of epididymis pars reticulata germinal epithelium seminal vesicula ventricular zone trigeminal ganglion pars compacta Top expressed in yolk sac
Telomeric repeat-binding factor 1
Telomeric_repeat-binding_factor_1
Protein-coding gene in the species Homo sapiens
expressed in lateral nuclear group of thalamus cerebellar vermis pars reticulata pars compacta parotid gland subthalamic nucleus external globus pallidus inferior
DNER
Non-coding RNA in the species Homo sapiens
seminal vesicula Achilles tendon external globus pallidus spinal ganglia pars compacta n/a More reference expression data BioGPS n/a Orthologs Species Human
MALAT1
Fringe hypothesis
observed experimentally, such as electron tunneling in substantia nigra pars compacta (SNc) tissue and the presence of disordered arrays of ferritin in SNc
Quantum_mind
Protein-coding gene in humans
muscle tissue of rectus abdominis postcentral gyrus prefrontal cortex pars compacta pons right ventricle Top expressed in medial ganglionic eminence molar
PPP2CA
Protein-coding gene in the species Homo sapiens
vermis postcentral gyrus entorhinal cortex pons middle temporal gyrus pars compacta superior frontal gyrus Top expressed in barrel cortex substantia nigra
GDAP1
Protein-coding gene in humans
orbitofrontal cortex postcentral gyrus corpus epididymis trabecular bone pars compacta Top expressed in stroma of bone marrow habenula pontine nuclei medial
CLTC
Protein-coding gene in humans
subthalamic nucleus inferior ganglion of vagus nerve Brodmann area 46 pars reticulata pars compacta external globus pallidus Top expressed in deep cerebellar nuclei
NIPA1
Models used in Parkinson's disease research
characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The loss of the dopamine neurons in the brain, results in motor
Animal models of Parkinson's disease
Animal_models_of_Parkinson's_disease
Protein-coding gene in the species Homo sapiens
pallidus corpus callosum subthalamic nucleus pars reticulata medulla oblongata ventral tegmental area pars compacta pons superior vestibular nucleus Top expressed
Tweety_family_member_2
Protein-coding gene in the species Homo sapiens
prefrontal cortex Brodmann area 10 orbitofrontal cortex frontal pole pars compacta dorsolateral prefrontal cortex superior vestibular nucleus Top expressed
ATP6V1B2
Protein-coding gene in the species Homo sapiens
cell right uterine tube spinal ganglia olfactory zone of nasal mucosa pars compacta mucosa of ileum orbitofrontal cortex Brodmann area 46 Top expressed
Tubulin_beta-4B_chain
Proposed disorder of problematic passion & distress
neurons which produce dopamine (the other being the substantia nigra pars compacta). Projections from the VTA innervate the NAc, where dopamine activity
Love_addiction
Genetic brain disorder
synthesized by nuclei located in the mesencephalon. The substantia nigra pars compacta (SNpc), the ventral tegmental area (VTA) and the retrorubral field (RRF)
Rett_syndrome
Protein-coding gene in the species Homo sapiens
(ortholog) Top expressed in superior vestibular nucleus pars reticulata spinal ganglia pars compacta middle temporal gyrus lateral nuclear group of thalamus
LARP1
Protein-coding gene in the species Homo sapiens
group of thalamus ventricular zone external globus pallidus pars compacta right frontal lobe pars reticulata anterior cingulate cortex Brodmann area 9 prefrontal
CSTPP1
Tetrahydropyridine, a chemical causing Parkinson's disease symptoms
primarily dopamine-producing neurons in a part of the brain called the pars compacta of the substantia nigra (SNc). MPP+ interferes with complex I of the
MPTP
Neurological ramifications of and for the Binding Problem in the study of consciousness
observed experimentally, such as electron tunneling in substantia nigra pars compacta (SNc) tissue and the presence of disordered arrays of ferritin in SNc
Neural_binding
nerve external globus pallidus pars reticulata C1 segment medulla oblongata pons superior vestibular nucleus pars compacta n/a More reference expression
SOX2OT
Protein-coding gene in the species Homo sapiens
epididymis internal globus pallidus pars reticulata caput epididymis renal medulla bronchial epithelial cell pars compacta mucosa of paranasal sinus corpus
Musashi-2
Protein-coding gene in the species Homo sapiens
pancreatic ductal cell endothelial cell germinal epithelium bone marrow cell pars compacta superficial temporal artery Brodmann area 23 parietal pleura Top expressed
PLDN
Protein-coding gene in the species Homo sapiens
frontal gyrus primary visual cortex right hemisphere of cerebellum pars compacta postcentral gyrus paraflocculus of cerebellum Top expressed in neural
STXBP1
Protein-coding gene in the species Homo sapiens
expressed in tibia synovial joint retinal pigment epithelium pars compacta endothelial cell pars reticulata lateral nuclear group of thalamus tendon of biceps
Branched chain amino acid transaminase 1
Branched_chain_amino_acid_transaminase_1
Protein-coding gene in the species Homo sapiens
pallidus right auricle of heart tendon of biceps brachii entorhinal cortex pars compacta vena cava Top expressed in epithelium of lens ciliary body iris neural
DKK3
Protein-coding gene in the species Homo sapiens
atrium skin of arm mucosa of ileum pons superior vestibular nucleus pars compacta ventral tegmental area Top expressed in motor neuron mammillary body
DYNLL2
Protein-coding gene in the species Homo sapiens
(ortholog) Top expressed in endothelial cell pons body of pancreas pars compacta right ventricle pars reticulata postcentral gyrus entorhinal cortex lateral nuclear
BNIP3
Brain pathway
accumbens and olfactory tubercle Nigrostriatal pathway: Substantia nigra pars compacta → Caudate nucleus and putamen Tuberoinfundibular pathway: Hypothalamus
Mesolimbic_pathway
Mammalian protein found in humans
paraflocculus of cerebellum pars compacta frontal pole superior frontal gyrus middle temporal gyrus postcentral gyrus primary visual cortex pars reticulata Top expressed
SV2A
Protein-coding gene in the species Homo sapiens
nucleus inferior ganglion of vagus nerve pons external globus pallidus pars compacta Top expressed in superior frontal gyrus primary visual cortex dentate
GRIK5
Hypothesis that decreased glutamatergic signalling is involved in schizophrenia
the striatum into the globulus pallidus internal and substantia nigra pars compacta. This core input to the basal ganglia is combined with input from the
Glutamate hypothesis of schizophrenia
Glutamate_hypothesis_of_schizophrenia
Israeli neuroscientist and pharmacologist
identified accumulation of iron in the dopamine neurons of substantia nigra pars compacta of Parkinsonian brains and role of iron initiated oxidative stress induced
Moussa_B._H._Youdim
Protein-coding gene in the species Homo sapiens
trigeminal ganglion spinal ganglia pars reticulata parietal pleura corpus epididymis lactiferous duct pars compacta nipple left uterine tube cardia Top
GFRA1
Perception that only seems real
Parkinson's disease is usually associated with a degraded substantia nigra pars compacta, but recent evidence suggests that PD affects a number of sites in the
Hallucination
Protein-coding gene in the species Homo sapiens
epithelial cell pons endometrium skin of thigh middle temporal gyrus pars compacta Top expressed in olfactory epithelium transitional epithelium of urinary
PGRMC1
Protein-coding gene in the species Homo sapiens
(ortholog) Top expressed in superior vestibular nucleus pars compacta pons external globus pallidus pars reticulata parietal lobe lateral nuclear group of thalamus
EPB41L1
Mammalian protein found in Homo sapiens
vestibular nucleus entorhinal cortex pons pars compacta parietal lobe postcentral gyrus middle temporal gyrus pars reticulata Top expressed in anterior amygdaloid
Microtubule-associated protein 2
Microtubule-associated_protein_2
Protein-coding gene in the species Homo sapiens
in testicle pons lateral nuclear group of thalamus pars compacta Epithelium of choroid plexus pars reticulata subthalamic nucleus superior vestibular
HLTF
Evolution and neuroscience of romantic love
neurons which produce dopamine (the other being the substantia nigra pars compacta). Projections from the VTA innervate the NAc, where dopamine activity
Biology_of_romantic_love
Protein-coding gene in humans
subthalamic nucleus lateral nuclear group of thalamus orbitofrontal cortex pars compacta pars reticulata inferior ganglion of vagus nerve Top expressed in dorsal
Reticulon_4
Protein-coding gene in the species Homo sapiens
paranasal sinus palpebral conjunctiva retinal pigment epithelium pons pars compacta pars reticulata tibia epithelium of nasopharynx external globus pallidus
ARL3
Protein-coding gene in the species Homo sapiens
Human Mouse (ortholog) Top expressed in endothelial cell pars compacta Brodmann area 23 pars reticulata lateral nuclear group of thalamus pancreatic epithelial
Mitoguardin_1
Protein-coding gene in humans
Top expressed in spinal ganglia pars compacta pons superior vestibular nucleus lateral nuclear group of thalamus pars reticulata bronchial epithelial
KIF21A
Protein-coding gene in humans
(ortholog) Top expressed in pons pars compacta spinal ganglia lateral nuclear group of thalamus superior vestibular nucleus pars reticulata right lobe of liver
SOD1
Protein-coding gene in the species Homo sapiens
expression pattern Bgee Human Mouse (ortholog) Top expressed in pons pars reticulata pars compacta endothelial cell lateral nuclear group of thalamus middle temporal
Ubiquitin_B
pituitary gland hypothalamus nucleus accumbens pars compacta middle temporal gyrus anterior pituitary pars reticulata Top expressed in islet of Langerhans
SCG2
Protein-coding gene in humans
(ortholog) Top expressed in lateral nuclear group of thalamus pars compacta sperm pars reticulata Brodmann area 23 external globus pallidus parietal lobe
DNM1L
Protein-coding gene in the species Homo sapiens
expressed in external globus pallidus pars reticulata internal globus pallidus entorhinal cortex caudate nucleus pars compacta lateral nuclear group of thalamus
HEPACAM
Protein-coding gene in the species Homo sapiens
Top expressed in inferior ganglion of vagus nerve pars reticulata subthalamic nucleus pars compacta superior vestibular nucleus external globus pallidus
DPYSL2
Protein-coding gene in the species Homo sapiens
(ortholog) Top expressed in paraflocculus of cerebellum pars compacta Brodmann area 10 pars reticulata lateral nuclear group of thalamus frontal pole
MAP1LC3B
Protein-coding gene in the species Homo sapiens
epithelial cell Brodmann area 10 middle frontal gyrus frontal pole pars compacta corpus callosum dorsal motor nucleus of vagus nerve lactiferous duct
FTO_gene
Small lens-shaped nucleus in the brain
neuromodulatory inputs, notably dopaminergic axons from the substantia nigra pars compacta. It also receives inputs from the pedunculopontine nucleus. The axons
Subthalamic_nucleus
Protein-coding gene in the species Homo sapiens
expressed in renal medulla optic nerve pars reticulata trabecular bone superior surface of tongue pars compacta pylorus lateral nuclear group of thalamus
ATP5F1E
Protein-coding gene in humans
nasopharynx germinal epithelium cerebellar vermis pars reticulata subthalamic nucleus pars compacta trabecular bone Top expressed in Gonadal ridge human
RAD21
Mammalian protein found in Homo sapiens
patterns in the adult mouse show high expression in the substantia nigra pars compacta. DAT in the mesocortical pathway, labeled with radioactive antibodies
Dopamine_transporter
Effects of cigarettes on the developing human brain
midbrain dopaminergic neurons situated in the ventral tegmental area and pars compacta. Nicotine negatively affects the prefrontal cortex of the developing
Effects of nicotine on human brain development
Effects_of_nicotine_on_human_brain_development
Spinal trigeminal nucleus
Sources Dopaminergic nuclei Ventral tegmental area Substantia nigra pars compacta Noradrenergic nuclei Locus coeruleus Dorsolateral pontine reticular
Reticular_formation
Protein-coding gene in the species Homo sapiens
cell lateral nuclear group of thalamus spinal ganglia Brodmann area 46 pars compacta pons superior frontal gyrus entorhinal cortex Top expressed in dorsomedial
Atlastin-1
Type of GABAergic neuron in the striatum
dynorphinergic MSNs connect the striatum with the substantia nigra (pars compacta and reticulata) and the entopeduncular nucleus (medial globus pallidus)
Medium_spiny_neuron
Protein-coding gene in the species Homo sapiens
lateral nuclear group of thalamus spinal ganglia prefrontal cortex pars compacta superior vestibular nucleus dorsolateral prefrontal cortex hypothalamus
Ubiquitin carboxy-terminal hydrolase L1
Ubiquitin_carboxy-terminal_hydrolase_L1
Protein-coding gene in the species Homo sapiens
group of thalamus Brodmann area 23 pars compacta endothelial cell pons middle temporal gyrus postcentral gyrus pars reticulata entorhinal cortex Top expressed
KvLQT3
Group of neural structures responsible for motivation and desire
the caudate nucleus and putamen), substantia nigra (i.e., the pars compacta and pars reticulata), prefrontal cortex, anterior cingulate cortex, insular
Reward_system
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