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Protein in human genes
Monocyte to macrophage differentiation factor also known as PAQR11 is a protein that in humans is encoded by the MMD gene. It is a member of the progestin
Monocyte to macrophage differentiation factor
Monocyte_to_macrophage_differentiation_factor
Mammalian protein found in Homo sapiens
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages,
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Protein-coding gene in humans
granulocyte-macrophage colony-stimulating factor receptor, also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating
Granulocyte-macrophage colony-stimulating factor receptor
Granulocyte-macrophage_colony-stimulating_factor_receptor
Mammalian protein found in humans
a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor
Macrophage colony-stimulating factor
Macrophage_colony-stimulating_factor
Subtype of leukocytes
Monocytes are a type of leukocyte or white blood cell. They are the largest type of leukocyte in the blood and can differentiate into macrophages and
Monocyte
Protein found in humans
stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is
Colony stimulating factor 1 receptor
Colony_stimulating_factor_1_receptor
Type of white blood cell
phenotype. Human macrophages are about 21 micrometres (0.00083 in) in diameter and are produced by the differentiation of monocytes in tissues. They can
Macrophage
Biological process
Macrophage polarization is a process by which macrophages adopt different functional programs in response to the signals from their microenvironment. This
Macrophage_polarization
Fat-laden M2 macrophages seen in atherosclerosis
inflammation processes induce the differentiation of monocytes into mature macrophages. There are two main subtypes of macrophages, M1 (pro-inflammatory) and
Foam_cell
Classification in immunology
surface receptors for growth factors. Recently, the marker CD47 was found to have anti-phagocytic signals to macrophages and inhibit natural killer (NK)
Cluster_of_differentiation
Macrophages located in the liver
allowing for cell populations to replenish themselves: this is in complete contrast to monocyte-derived macrophages that have no proliferative potential
Kupffer_cell
Skin macrophages used for wound repair and hair growth
facilitating the differentiation of monocytes into tissue-resident dermal macrophages and their survival. Therefore, the differentiation of monocytes to dermal
Dermal_macrophage
Bone-marrow-derived macrophage (BMDM) refers to macrophage cells that are generated in a research laboratory from mammalian bone marrow cells. BMDMs can differentiate into
Bone marrow-derived macrophage
Bone_marrow-derived_macrophage
Mammalian protein found in humans
"Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
American immunologist
her postdoctoral work, Randolph characterized monocyte differentiation to dendritic cells and macrophages and made advances in our understanding of dendritic
Gwendalyn_J._Randolph
Vertebrate cell
"histocytes" do not appear to derive from monocytic-macrophage lines. The term Histiocyte can also simply refer to a cell from monocyte origin outside the blood
Histiocyte
Protein found in humans
proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. Platelet derived growth factor is a major inducer of CCL2 gene. CCR2
CCL2
Inflammatory disease involving a buildup of lesions in the walls of arteries
required for the differentiation of monocytes into macrophages. The monocytes differentiate into macrophages, which proliferate locally, ingest oxidized LDL
Atherosclerosis
utilized is zwitterionic buffer – HEPES. Induction of differentiation of U-937 into monocytes or macrophages can be achieved by various agents such as PMA (phorbol
U937_(cell_line)
Category of small signaling proteins
the term "lymphokine" to describe proteins secreted from lymphocytes and later, proteins derived from macrophages and monocytes in culture were called
Cytokine
Cytokine
function in differentiation, chemotaxis, proliferation, and activation of many immune cells. TGF-β is secreted by many cell types, including macrophages, in a
Transforming growth factor beta
Transforming_growth_factor_beta
Mammalian protein found in humans
CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating
CD68
Group of cytokines
T-lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and
Interleukin
Sufan (2017). "Macrophage Differentiation in Normal and Accelerated Wound Healing". Macrophages. Results and Problems in Cell Differentiation. Vol. 62. pp
Immune system contribution to regeneration
Immune_system_contribution_to_regeneration
Cell that removes bone tissue
necessary for osteoclastogenesis and are widely involved in the differentiation of monocyte/macrophage derived cells. RANKL is a member of the tumour necrosis
Osteoclast
Immune system messenger protein which induces inflammation
by activated macrophages, and induces inflammation by binding to its receptors on other cells. It is a member of the tumor necrosis factor superfamily
Tumor_necrosis_factor
Instance of defined set in Homo sapiens with Reactome ID (R-HSA-6806560)
AP-1 transcription factor has been shown to have a hand in a wide range of cellular processes, including cell growth, differentiation, and apoptosis. AP-1
AP-1_transcription_factor
Human monocytic cell line
used as a models to study the monocyte-macrophage differentiation process, antigen presentation and as a model to examine some macrophage-related physiological
THP-1_cell_line
Series of events that restore integrity to damaged tissue after an injury
are in the wound site, monocytes mature into macrophages. Macrophages also secrete a number of factors such as growth factors and other cytokines, especially
Wound_healing
Family of biomolecules
(IL-8), macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and neurotactin. "Neurotrophic factors". Nature
Neurotrophic_factors
Macrophage subset
toll-like receptor ligands. The first signal promotes the differentiation of monocytes to macrophages and the second signal promotes immunosuppressive functions
Regulatory_macrophages
Protein family
(CMPs) and the inhibition of granulocytic differentiation during the divergence of granulocytes and monocytes. IRF8 and IRF4 are also involved in the regulation
Interferon_regulatory_factors
Mammalian protein found in humans
expressed on monocytes and macrophages, and at lower levels on neutrophils and dendritic cells. CD14 exists in two forms, one anchored to the membrane
CD14
Formation of blood cellular components
myeloid lineage, which include granulocytes, megakaryocytes, monocytes, and macrophages, are derived from common myeloid progenitors, and are involved
Haematopoiesis
Biological system protecting an organism against disease
innate immune system, such as dendritic cells, macrophages, monocytes, neutrophils, and epithelial cells, to identify two classes of molecules: pathogen-associated
Immune_system
Cell that matures into a monocyte
hematopoiesis. They are the first developmental stage in the monocyte series leading to a macrophage. Their myeloid cell fate is induced by the concentration
Monoblast
Protein-coding gene in humans
the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Molecular and Cellular Biology. 22 (11): 3744–3756. doi:10
GRB2 associated binding protein 3
GRB2_associated_binding_protein_3
Mammalian protein found in humans
"Expression of Tmem119/Sall1 and Ccr2/CD69 in FACS-Sorted Microglia- and Monocyte/Macrophage-Enriched Cell Populations After Intracerebral Hemorrhage". Front
CCR2
Macrophage found in the lungs
An alveolar macrophage, pulmonary macrophage, (or dust cell, or dust eater) is a type of macrophage, a professional phagocyte, found in the airways and
Alveolar_macrophage
Accessory cell of the mammalian immune system
adherence of monocytes. Treatment of these monocytes with interleukin 4 (IL-4) and granulocyte-macrophage colony stimulating factor (GM-CSF) leads to differentiation
Dendritic_cell
Process which produces red blood cells
progenitor (CLP). CMPs are the cells that go on to become red blood cells as well as platelets, macrophages, monocytes, and granulocytes. The common myeloid progenitor
Erythropoiesis
Class of proteins
peritubular cells of kidney. Granulocyte-macrophage colony-stimulating factor and granulocyte CSF are given to stimulate white blood cell formation in
Hemopoietic_growth_factor
Protein-coding gene in the species Homo sapiens
chemoattractant, directing an immune response to certain pathogens. Likewise, macrophages and monocytes respond to low levels of TGF-β1 in a chemotactic manner
TGF_beta_1
Protein-coding gene in the species Homo sapiens
The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded
Granulocyte colony-stimulating factor receptor
Granulocyte_colony-stimulating_factor_receptor
Protein involved in blood vessel growth
, stimulation monocyte/macrophage migration, neurons, cancer cells, kidney and epithelial cells ). In vitro, VEGF-A has been shown to stimulate endothelial
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
Type of cells of the immunological system
basophils, and monocytes. Monocytes are further subdivided into dendritic cells and macrophages. Monocytes, macrophages, and neutrophils are phagocytic
White_blood_cell
Protein-coding gene in the species Homo sapiens
Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. Bibcode:2005PNAS
PDE1B
Cells that ingest harmful matter within the body
They include monocytes, macrophages, neutrophils, tissue dendritic cells, and mast cells. Their name comes from the Greek phagein, "to eat" or "devour"
Phagocyte
Protein-coding gene in the species Homo sapiens
growth or survival of monocytes. In cancer, IL-34 was shown to drive the migration of monocyte-derived tumor-associated macrophages in the tumor microenvironment
Interleukin_34
Immune response that does not involve antibodies
induce the differentiation into TC2 cells and IL-1 or IL-23 can induce the differentiation into TC17 cells. Naïve CD4+ cells may differentiate into TH1
Cell-mediated_immunity
Mass resulting from the fusion of many cells
response to an infection, such as tuberculosis, herpes, or HIV, or as part of a foreign body reaction. These MGCs are cells of monocyte or macrophage lineage
Giant_cell
Marker on immune cells
is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was
CD4
Protein-coding gene in the species Homo sapiens
(August 2004). "Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1". The Journal of Clinical Investigation
FOXP1
Protein-coding gene in the species Homo sapiens
regulatory T cells. Allograft Inflammatory Factor 1 is found in activated macrophages. Activated macrophages are found in tissues with inflammation. AIF1
Allograft inflammatory factor 1
Allograft_inflammatory_factor_1
Multipotent adult stem cells present in multiple tissues
Mao N (May 2005). "Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells". Blood. 105 (10): 4120–6. doi:10
Mesenchymal_stem_cell
Mammalian protein found in humans
constituvely expressed on mouse Ly6Clo nonclassical monocytes in steady state. Moreover, PD-L1+ macrophages might also show cross-organ enrichment (e.g., lymph
PD-L1
Feeling of pain from stimuli which do not normally elicit pain
the spinal cord by the recruitment of immune system cells such as monocytes/macrophages and T lymphocytes. There is a substantial body of evidence that
Allodynia
Damage to nervous tissue
C, Morell P (July 1998). "Monocyte chemoattractant protein 1 is responsible for macrophage recruitment following injury to sciatic nerve". Journal of
Nerve_injury
Protein-coding gene in the species Homo sapiens
The adipose differentiation related protein (ADRP) was first characterized as an mRNA molecule that express early in adipocyte differentiation. The full
Perilipin-2
Cell-surface glycoprotein
and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression". The Journal
CD44
Physical effects resulting from activation of the immune system
phagocytosis by macrophages, leading to neutrophil clearance and release of anti-inflammatory and reparative cytokines such as transforming growth factor-β1. The
Inflammation
Tumour-promoting cell type
recruitment of monocytes and induce their differentiation into pro-tumorigenic macrophage subset M2. In breast cancer secretion of monocyte chemotactic protein-1
Cancer-associated_fibroblast
Mammalian protein found in Homo sapiens
cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene
RANKL
Protein-coding gene in humans
tissue macrophages of the spleen, liver, lungs, lymph nodes, and proximal tubules of the kidney. Expression was also found in circulating monocytes, B lymphocytes
CD5L
Lilly USA". "hcdm, Human Cell Differentiation Molecules". www.hcdm.org. Retrieved 2015-10-15. "hcdm, Human Cell Differentiation Molecules". www.hcdm.org.
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Protein-coding gene in the species Homo sapiens
"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–255. PMID 2107490. "Entrez Gene: FOSL1
FOSL1
Protein that stimulates cell division and differentiation
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has
Epidermal_growth_factor
Mammalian protein found in humans
cyclooxygenase. CCL3 has been shown to interact with CCL4. Attracts macrophages, monocytes and neutrophils. Macrophage inflammatory proteins ENSG00000277632
CCL3
Protein-coding gene in the species Homo sapiens
J, et al. (1990). "CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity". J. Clin. Invest. 85 (5): 1468–76. doi:10.1172/JCI114593
Azurocidin_1
Protein-coding gene in the species Homo sapiens
monocytes, and dendritic cells), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF)
Interleukin_3
Medical condition
and granulocyte-macrophage colony-stimulating factor. Each of these genes functions to promote the proliferation and differentiation of eosinophil precursor
Familial_eosinophilia
Protein-coding gene in the species Homo sapiens
PMID 18178554. Jin Z, Zheng E, Sareli C, Kolattukudy PE, Niu J (2021). "Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player of Host Defense
ZC3H12A
Mammalian protein found in Homo sapiens
convertase) to form mature IL-1β. IL-1β is a member of the interleukin 1 family of cytokines. This cytokine is produced by activated macrophages, monocytes, and
Interleukin_1_beta
Type of immune cell
cells of Th1 immunity are macrophages as well as CD8 T cells, IgG B cells, and IFN-γ CD4 T cells. The key Th1 transcription factors are STAT4 and T-bet. IFN-γ
T_helper_cell
Protein-coding gene in the species Homo sapiens
transglutaminase Coagulation factor XIII) is also known to bind and probably inhibit Macrophage migration inhibitory factor; though S19 oligomers themselves
40S_ribosomal_protein_S19
Colony forming unit that generates myeloid cells in the bone marrow
monocyte, megakaryocyte. The common myeloid progenitor (CMP) and the common lymphoid progenitor (CLP) are the first branch of cell differentiation in
CFU-GEMM
Protein-coding gene in the species Homo sapiens
humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are
TREM2
Protein-coding gene in the species Homo sapiens
dendritic cells (DCs) and macrophages. The transcription factors IRF4 and IRF8 work in concert to achieve DC differentiation. IRF4 expression is responsible
IRF4
Cell surface receptor found in humans
immunity essential to fight infectious diseases. TLR4 is expressed in immune cells mainly of myeloid origin, including monocytes, macrophages and dendritic
Toll-like_receptor_4
Mammalian protein found in humans
previously known as macrophage inflammatory protein (MIP-1β), is a protein which in humans is encoded by the CCL4 gene. CCL4 belongs to a cluster of genes
CCL4
Family of transcription factor protein complexes
the differentiation of osteoclasts from monocytes. Disulfiram, olmesartan and dithiocarbamates can inhibit the NF-κB signaling cascade. Effort to develop
NF-κB
Mammalian protein found in humans
CD74. CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). The nascent MHC class II protein in the rough endoplasmic
CD74
Protein-coding gene in the species Homo sapiens
granulocyte differentiation, and excessive macrophage formation. SNPs located near the 3' region of IKZF1 in humans have been linked to susceptibility to childhood
IKZF1
Cytokine protein
and glycogen/p38 MAPK pathways. Thus, when IL-6 is signalling in monocytes or macrophages, it creates a pro-inflammatory response, whereas IL-6 activation
Interleukin_6
Medical condition
spikes in monocyte- and macrophage-associated inflammatory mediators and temporary increases in the proteins vascular endothelial growth factors (VEGF) and
Capillary_leak_syndrome
Signaling glycoprotein regulating cell proliferation
and differentiation, MSCs were shown to have stronger osteogenic differentiation into bone-forming cells when stimulated by epidermal growth factor (EGF)
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein-coding gene in the species Homo sapiens
active secretion from macrophages, natural killer cells, and dendritic cells. The interaction between RAGE and its ligands is thought to result in pro-inflammatory
RAGE_(receptor)
Type of tissue in the spleen
the total number of monocytes present in circulation. These stored monocytes, contrary to previous belief, are not progenitors to the self-sustaining
Red_pulp
residues from polypeptides. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the
Carboxypeptidase_M
Mammalian protein found in humans
innate immune system response. IL-8, also known as monocyte-derived neutrophil chemotactic factor (MDNCF), has two primary functions. It induces chemotaxis
Interleukin_8
Immunity strategy in living beings
tissues, organ-specific macrophages are differentiated from phagocytic cells present in the blood called monocytes. Macrophages are the most efficient
Innate_immune_system
Protein-coding gene in humans
putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1
CMKLR1
Protein-coding gene in the species Homo sapiens
"Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation". Oncogene. 5 (3): 249–55. PMID 2107490. Molven A, Houge
FOSL2
Mammalian protein found in humans
sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be
CD43
Protein-coding gene in the species Homo sapiens
Akkad N, Ochi A, Heindel DW, et al. (May 2017). "Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance"
Galectin-9
Protein-coding gene in the species Homo sapiens
family transcription factor PU.1 in hematopoietic cell differentiation, proliferation and apoptosis". Cell Death and Differentiation. 6 (7): 599–608. doi:10
SPI1
Protein-coding gene in the species Homo sapiens
YV (January 2018). "The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2". Immunobiology. 223 (1):
IRF5
Immune cells that responds to any antigen
immune system. Macrophages are produced through the differentiation of monocytes, and after ingestion of bacteria, secrete enzymes to destroy the ingested
Nonspecific_immune_cell
Pharmaceutical drug
name Leukine among others, is a recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) that functions as an immunostimulator. It is administered
Sargramostim
Stem cells that give rise to other blood cells
cells give rise to different types of blood cells, in lines called myeloid and lymphoid. Myeloid cells include monocytes, macrophages, neutrophils, basophils
Hematopoietic_stem_cell
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
Boy/Male
Muslim
Distinguisher. Differentiator.
Boy/Male
Australian, Danish, Finnish, German, Norse, Swedish
Rescue; To Save; To Help; To Protect
Boy/Male
Hindu
To possess, To hav power to rule, To govern, To be master
Female
Egyptian
, the wife of Simouth.
Female
Egyptian
, the wife of the priest Anhur-mes.
Boy/Male
Indian, Sanskrit
Without Differentiation
Female
Egyptian
, a daughter of King Amenhotep I.
Boy/Male
Tamil
To possess, To hav power to rule, To govern, To be master
Female
Egyptian
, another form of Ratta or Ritho.
Boy/Male
Tamil
Pallavit | பலà¯à®²à®µà®¿à®¤
To sprout, To grow
Pallavit | பலà¯à®²à®µà®¿à®¤
Male
Chamoru
, to concern, to pertain to.
Boy/Male
Hindu, Indian, Kashmiri, Oriya, Sanskrit, Tamil, Telugu
To Rejoice; To Celebrate; To Praise; To Bless; Delight
Female
Egyptian
, the wife of Kauta.
Boy/Male
Tamil
To help, To support
Girl/Female
Arabic, Australian, Muslim
To Flower; To Blossom; To Glow
Boy/Male
Arabic, Hindu, Indian, Muslim
One who Distinguishes Truth from Falsehood; Distinguishes; Differentiator
Girl/Female
Indian
To see, To perceive, To have vision
Girl/Female
Assamese, Bihari, Gujarati, Hindu, Indian, Telugu
Prosperity; To be Successful; To Succeed; To Grow; To Increase; To Make Gain
Girl/Female
Tamil
To see, To perceive, To have vision
Girl/Female
Indian, Sanskrit
Without Differentiation
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
Boy/Male
Hindu
Cupid, Lord of Love
Surname or Lastname
English
English : unexplained.
Girl/Female
Norse
Wife of Loki.
Girl/Female
Muslim
Learned. Wise.
Male
German
Contracted form of Old High German Hrodwulf, HRODULF means "famous wolf."
Girl/Female
Gujarati, Indian
Fairy; Goddess
Girl/Female
Indian
Helper, Publisher, Diffuser, Spreader, Protector
Girl/Female
English, Indian
Peace
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Punjabi, Sikh, Sindhi, Tamil, Telugu
Brave; Winner; Smart; Strong; Uncountable; Infinite God
Male
Greek
(ΒαÏιησοÏ) Greek form of Aramaic Bar-Yesu, BARIESOU means "son of Jesus." In the New Testament bible, this is the name of a false prophet.
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
MONOCYTE TO-MACROPHAGE-DIFFERENTIATION-FACTOR
prep.
An obsolete intensive prefix used in the formation of compound verbs; as in to-beat, to-break, to-hew, to-rend, to-tear. See these words in the Vocabulary. See the Note on All to, or All-to, under All, adv.
adv.
In the way of differentiation.
a.
Alt. of Monotypic
prep.
Effect; end; consequence; as, the prince was flattered to his ruin; he engaged in a war to his cost; violent factions exist to the prejudice of the state.
a.
Having a definite organic structure; showing differentiation of parts.
prep.
Apposition; connection; antithesis; opposition; as, they engaged hand to hand.
prep.
Extent; limit; degree of comprehension; inclusion as far as; as, they met us to the number of three hundred.
n.
The gradual formation or production of organs or parts by a process of evolution or development, as when the seed develops the root and the stem, the initial stem develops the leaf, branches, and flower buds; or in animal life, when the germ evolves the digestive and other organs and members, or when the animals as they advance in organization acquire special organs for specific purposes.
prep.
The preposition to primarily indicates approach and arrival, motion made in the direction of a place or thing and attaining it, access; and also, motion or tendency without arrival; movement toward; -- opposed to from.
prep.
Comparison; as, three is to nine as nine is to twenty-seven; it is ten to one that you will offend him.
prep.
In many phrases, and in connection with many other words, to has a pregnant meaning, or is used elliptically.
prep.
In a very general way, and with innumerable varieties of application, to connects transitive verbs with their remoter or indirect object, and adjectives, nouns, and neuter or passive verbs with a following noun which limits their action. Its sphere verges upon that of for, but it contains less the idea of design or appropriation; as, these remarks were addressed to a large audience; let us keep this seat to ourselves; a substance sweet to the taste; an event painful to the mind; duty to God and to our parents; a dislike to spirituous liquor.
prep.
Hence, it indicates motion, course, or tendency toward a time, a state or condition, an aim, or anything capable of being regarded as a limit to a tendency, movement, or action; as, he is going to a trade; he is rising to wealth and honor.
prep.
Accord; adaptation; as, an occupation to his taste; she has a husband to her mind.
prep.
As sign of the infinitive, to had originally the use of last defined, governing the infinitive as a verbal noun, and connecting it as indirect object with a preceding verb or adjective; thus, ready to go, i.e., ready unto going; good to eat, i.e., good for eating; I do my utmost to lead my life pleasantly. But it has come to be the almost constant prefix to the infinitive, even in situations where it has no prepositional meaning, as where the infinitive is direct object or subject; thus, I love to learn, i.e., I love learning; to die for one's country is noble, i.e., the dying for one's country. Where the infinitive denotes the design or purpose, good usage formerly allowed the prefixing of for to the to; as, what went ye out for see? (Matt. xi. 8).
n.
The supposed act or tendency in being of every kind, whether organic or inorganic, to assume or produce a more complex structure or functions.
prep.
Accompaniment; as, she sang to his guitar; they danced to the music of a piano.
n.
The act of distinguishing or describing a thing, by giving its different, or specific difference; exact definition or determination.
n.
The act of differentiating.
n.
One who, or that which, differentiates.