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Stem cells that give rise to other blood cells
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the first
Hematopoietic_stem_cell
Medical procedure to replace blood or immune stem cells
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
Hematopoietic stem cell (HSC) mobilization is the medical process of stimulating hematopoietic stem cells to move (or "mobilize") from their native microenvironment
Hematopoietic stem cell mobilization
Hematopoietic_stem_cell_mobilization
Unspecialized biological cell that can become specialized
others, hematopoietic stem cells, which replenish blood and immune cells, basal cells, which maintain the skin epithelium, and mesenchymal stem cells, which
Stem_cell
Use of stem cells to treat or prevent a disease or condition
is hematopoietic stem cell transplantation. This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can
Stem-cell_therapy
Ability of a cell to differentiate into other cell types
progenitor cells have the gene activation potential to differentiate into discrete cell types. For example, a hematopoietic stem cell – and this cell type can
Cell_potency
Biological term
blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC)
Hematopoietic_stem_cell_niche
Semi-solid tissue in the spongy portions of bones
stem cells are related to bone marrow. Hematopoietic stem cells in the bone marrow can give rise to hematopoietic lineage cells, and mesenchymal stem
Bone_marrow
Multipotent stem cell in the adult body
Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate
Adult_stem_cell
Colony forming unit that generates myeloid cells in the bone marrow
cell differentiation in hematopoiesis after the hemocytoblast (hematopoietic stem cell). In current terminology, CFU-S refers to the pluripotent stem
CFU-GEMM
Cell produced by hematopoiesis
Blood cells with differentiation potential are called hematopoietic cells; the ones with the most such potential are hematopoietic stem cells. Red blood
Blood_cell
Medical condition
curative treatment currently available is a hematopoietic stem cell transplant (HCT). In this procedure, stem cells are harvested from umbilical cord blood
Wiskott–Aldrich_syndrome
all hematopoietic stem cells in the adult hematopoietic system. The aorta gonad mesonephros region has been shown to harbour multipotent hematopoietic colony-forming
Aorta-gonad-mesonephros
Disease causing insufficient blood cells of all types
globulin—combined with corticosteroids, chemotherapy, and ciclosporin. Hematopoietic stem cell transplantation is also used, especially for patients under 30
Aplastic_anemia
Bone marrow cell which produces platelets
cells that give rise to the mature megakaryocyte subtypes. The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast)
Megakaryocyte
Type of cells of the immunological system
cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including
White_blood_cell
Obstruction of the lungs' small airways (bronchioles) due to inflammation
syndrome (BOS) in the setting of post lung transplantation and hematopoietic stem cell transplant (HSCT). Patients who develop BOS post lung transplant
Bronchiolitis_obliterans
Child conceived to provide stem cells
such as cancer or Fanconi anemia, that can best be treated by hematopoietic stem cell, or other transplant. The saviour sibling is conceived through
Savior_sibling
Hereditary blood disorder causing anemia
recommended. Hematopoietic stem cells (HSC) are cells in the bone marrow that can develop into all types of blood cells, including red blood cells, white blood
Beta_thalassemia
Family of inherited blood disorders
recommended. Hematopoietic stem cells (HSC) are cells in the bone marrow that can develop into all types of blood cells, including red blood cells, white blood
Thalassemia
Mammalian protein found in Homo sapiens
guidance cues that direct hematopoietic stem cells (HSCs) to their stem cell niche (the microenvironment in which a stem cell resides), and it plays an
Stem_cell_factor
Organs that make blood cells
(spelled hematopoietic system in American English) is the system in the body involved in the creation of the cells of blood. Haematopoietic stem cells (HSCs)
Haematopoietic_system
Medical procedure
performed with hematopoietic stem cells (precursors of blood-forming cells) in hematopoietic stem cell transplantation, cardiac cells have also been used
Autologous stem-cell transplantation
Autologous_stem-cell_transplantation
Inherited blood disorder causing anemia
Sodani, Pietro; Gaziev, Javid (1 May 2012). "Hematopoietic Stem Cell Transplantation in Thalassemia and Sickle Cell Anemia". Cold Spring Harbor Perspectives
Alpha-thalassemia
Diverse collection of blood-related cancers
the changes in the blood cells and bone marrow. Treatments may include supportive care, drug therapy, and hematopoietic stem cell transplantation. Supportive
Myelodysplastic_syndrome
Method of replacing blood-forming stem cells
better outcome in terms of the number of hematopoietic stem cell (CD34+ cells) yield. Immature hematopoietic stem cells in the circulating blood that are similar
Peripheral stem cell transplantation
Peripheral_stem_cell_transplantation
Formation of blood cellular components
Cells". Molecular Cell Biology (4th ed.). New York: W. H. Freeman. Figure 24-8: Formation of differentiated blood cells from hematopoietic stem cells
Haematopoiesis
Blood that has been modified for therapeutic or other purposes
from sickle cell disease can now receive targeted gene therapies using hematopoietic stem cells. Hematopoietic stem cells are stem cells which differentiate
Gene therapy for blood diseases
Gene_therapy_for_blood_diseases
The list of human cell types provides an enumeration and description of the various specialized cells found within the human body, highlighting their
List_of_human_cell_types
Blood in the placenta and umbilical cord after birth
childbirth. Cord blood is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders. Cord blood is composed of
Cord_blood
Multipotent adult stem cells present in multiple tissues
These bone marrow stem cells do not contribute to the formation of blood cells, and so do not express the hematopoietic stem cell marker CD34. They are
Mesenchymal_stem_cell
Chemical compound
and improved body composition. Dietary valine is essential for hematopoietic stem cell (HSC) self-renewal, as demonstrated by experiments in mice. Dietary
Valine
Cancer arises in the head or neck region
susceptibility to throat cancer.[citation needed] People after hematopoietic stem cell transplantation (HSCT) are at a higher risk for oral cancer. Post-HSCT
Head_and_neck_cancer
Hematopoietic stem cell transplantation may be used to treat a number of conditions both congenital and acquired. Malignancies Hematological Leukemias
List of conditions treated with hematopoietic stem cell transplantation
List_of_conditions_treated_with_hematopoietic_stem_cell_transplantation
Protein found in humans
identifies cell surface antigens. CD34 was first described as a cell surface glycoprotein on hematopoietic stem cells and functions as a cell-cell adhesion
CD34
HIV functional cure without medication
HIV remission have occurred in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) to treat underlying hematologic malignancies
HIV_remission
Tissue or organ used in transplantation
of the stem cell growth factors GM-CSF and G-CSF, most hematopoietic stem cell transplantation procedures are now performed using stem cells collected
Transplantable organs and tissues
Transplantable_organs_and_tissues
Hereditary disease group
therapy has been the standard treatment for CGD for several years. Hematopoietic stem cell transplantation from a matched donor is curative although not without
Chronic_granulomatous_disease
Surgically moving tissue to a different part of the same body
for complex renal conditions), and autologous stem-cell transplantation where the patient’s own cells are collected and later reinfused. Examples include
Autotransplantation
Culture of stem cells that can be propagated indefinitely
differentiated cell types (unlike pluripotent embryonic stem cells). Types of adult stem cells include hematopoietic stem cells and mesenchymal stem cells. Hematopoietic
Stem-cell_line
Medical condition
sponsor's decision. Hematopoietic stem cell transplantation (HSCT) involves replacing the dysfunctional stem cells from a person with sickle cell disease with
Sickle_cell_disease
Cell type
the process in which hematopoietic stem cells (HSCs) differentiate into mature blood cell types. MEPs and other progenitor cells are characterized based
Megakaryocyte–erythroid progenitor cell
Megakaryocyte–erythroid_progenitor_cell
Chemical compound
an immunostimulant used to mobilize hematopoietic stem cells in cancer patients into the bloodstream. The stem cells are then extracted from the blood and
Plerixafor
Protein-coding gene in the species Homo sapiens
pluripotent stem cell model of NHEJ1 deficiency, it was shown that NHEJ1 has an important role in promoting survival of the primitive hematopoietic progenitors
Non-homologous end-joining factor 1
Non-homologous_end-joining_factor_1
Type of white blood cell
of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate
T_cell
Ethical concerns about embryonic stem cell research and medical use
stem cells. Not all stem cell research involves human embryos. For example, adult stem cells, amniotic stem cells, and induced pluripotent stem cells
Stem_cell_controversy
German-American Immunologist and Hematologist
heterogeneity of hematopoietic stem cells (HSCs). Muller-Sieburg is known for her contributions to the purification of hematopoietic stem cells, the characterization
Christa_Muller-Sieburg
Human disease
effective line of treatment for malignant infantile osteopetrosis is hematopoietic stem cell transplantation. It has been shown to provide long-term disease-free
Malignant infantile osteopetrosis
Malignant_infantile_osteopetrosis
Expansion of blood cells
is a common aging-related phenomenon in which hematopoietic stem cells (HSCs) or other early blood cell progenitors contribute to the formation of a genetically
Clonal_hematopoiesis
myeloid cells Endothelial progenitor cell Endothelial colony forming cell Endothelial stem cell Angioblast/Mesoangioblast Pericyte Mural cell Mesothelial
List of human cell types derived from the germ layers
List_of_human_cell_types_derived_from_the_germ_layers
Group of disorders
followed by hematopoietic stem cell transplantation. Epstein–Barr virus–associated aggressive NK cell leukemia (EBV+ ANKL) is a rare NK cell malignancy
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
German charity
of blood cancer and hematopoietic stem cell transplantation and raises awareness of the need for donors for hematopoietic stem cell transplantation which
DKMS
Specific location in the body containing stem cells
Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate
Stem-cell_niche
Tissue of bone marrow
leukemia Hematopoietic stem cell Lymphocyte Myelocyte Kawamoto H, Minato N (2004). "Myeloid cells". The International Journal of Biochemistry & Cell Biology
Myeloid_tissue
Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can also be identified by functional
Stem_cell_marker
Gene therapy medication
adrenoleukodystrophy. Elivaldogene autotemcel is a form of autologous hematopoietic stem cell therapy where stem cells are mobilized and collected from the patient and genetically
Elivaldogene_autotemcel
Facility which stores umbilical cord blood for future use
contains hematopoietic stem cells (which can differentiate only into blood cells), and should not be confused with embryonic stem cells or pluripotent stem cells
Cord_blood_bank
Medication
Yartemlea, is a monoclonal antibody used for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Narsoplimab is
Narsoplimab
Therapy in which cellular material is injected into a patient
Stem cell Stem cell therapy Allotransplantation Autotransplantation Xenotransplantation Regenerative medicine Mesenchymal stem cell Hematopoietic stem
Cell_therapy
Lymphocytes without surface receptors
Predominantly, these include natural killer cells (NK cells), with a lesser portion being hematopoietic stem cells traversing freely within the bloodstream
Null_cell
Rare disease of the bones
counselling, and timely institution of appropriate treatment, namely hematopoietic stem cell transplantation (HSCT), which offers a satisfactory treatment modality
Osteopetrosis
Early form of hematopoietic stem cells
KSL cells in cell biology are an early form of mouse/murine hematopoietic stem cells. Characteristics are Kit (+), Sca-1 (+) and Lin (-). HSCs [Hematopoietic
KSL_cells
Medical condition
AK2 protein allows hematopoietic stem cells to differentiate and proliferate. Hematopoietic stem cells give rise to blood cells. Differentiation and
Reticular_dysgenesis
Deterioration of function with age
effort to replace the somatic cells may cause exhaustion of stem cells. Hematopoietic stem cell aging Hematopoietic stem cells (HSCs) regenerate the blood
Senescence
Cancer of plasma cells
of stem cell transplants to treat multiple myeloma. In autologous hematopoietic stem-cell transplantation (ASCT) – the patient's stem cells are collected
Multiple_myeloma
American stem cell researcher and inventor
human hematopoietic stem cells. Tsukamoto’s research and contributions in the medical field have led to groundbreaking advancements in stem cell research
Ann_Tsukamoto
Immune cells found in lymph nodes
the lymphoid tissue. Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. Possible
Follicular_dendritic_cells
Medication
used for the treatment of multiple myeloma. Motixafortide is a hematopoietic stem cell mobilizer and a CXCR4 antagonist. It is given by subcutaneous injection
Motixafortide
Transformation of a stem cell to a more specialized cell
of neurogenesis. Hematopoietic stem cells (adult stem cells) from the bone marrow that give rise to red blood cells, white blood cells, and platelets.
Cellular_differentiation
Hematological malignancy
did not, even though the drug elevated their white blood cell counts. Hematopoietic stem cell transplantation for HCL does not improve relapse-free survival
Hairy_cell_leukemia
American scientist
Montana State University in 1961. His research has since focused on hematopoietic stem cell biology. Weissman was not an exceptionally good student in high
Irving_Weissman
Mammalian protein found in humans
the number of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem cell transplantation
Granulocyte colony-stimulating factor
Granulocyte_colony-stimulating_factor
Progenitor cell to a red blood cell
unit-erythroid) denotes a hematopoietic stem cell in the bone marrow which eventually matures into a red blood cell (also called an erythroid cell). It arises from
CFU-E
Human disease
chemotherapy, zidovudine plus interferon-a (AZT/IFN), and allogeneic hematopoietic stem cell transplantation (alloHSCT). ATL is usually a highly aggressive
Adult T-cell leukemia/lymphoma
Adult_T-cell_leukemia/lymphoma
Medical technology
2022. Cartier N, Aubourg P (July 2010). "Hematopoietic stem cell transplantation and hematopoietic stem cell gene therapy in X-linked adrenoleukodystrophy"
Gene_therapy
Medication
umbilical cord-derived CD34- cells, non-expanded/dorocubicel is an cancer treatment for use in hematopoietic stem cell transplantation. It is composed
Allogeneic umbilical cord-derived CD34- cells, non-expanded/dorocubicel
Allogeneic_umbilical_cord-derived_CD34-_cells,_non-expanded/dorocubicel
Medical techniques to separate one or more components of blood
extracorporeal therapy. One of the uses of apheresis is for collecting hematopoietic stem cells. Depending on the substance that is being removed, different processes
Apheresis
Group of disorders characterised by degeneration of white matter in the brain
a decade after onset. Treatment options are limited, although hematopoietic stem cell transplantations using bone marrow or cord blood seem to help in
Leukodystrophy
transplanting more hematopoietic stem cells. This procedure is called 'megadose transplantation,' and can prevent rejection because the stem cells have the ability
T-cell_depletion
Medical condition
thrombopoietin receptor, which is expressed in pluripotent hematopoietic stem cells and cells of the megakaryocyte lineage. CAMT is diagnosed by a bone
Congenital amegakaryocytic thrombocytopenia
Congenital_amegakaryocytic_thrombocytopenia
effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains donor T cells (T lymphocytes) that can be beneficial
Graft-versus-tumor_effect
Theory of aging
stem cell pools requires several conditions. Balancing proliferation and quiescence along with homing (See niche) and self-renewal of hematopoietic stem
Stem_cell_theory_of_aging
Type of white blood cell
extremely specific, with all BCRs on a B cell recognizing the same epitope. B cells develop from hematopoietic stem cells (HSCs) that originate from bone marrow
B_cell
Indian research Institute
Institute for Stem Cell Science and Regenerative Medicine (inStem) is an Indian research organisation focused on stem cell science and regenerative medicine
Institute for Stem Cell Science and Regenerative Medicine
Institute_for_Stem_Cell_Science_and_Regenerative_Medicine
monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS). T cell receptor V(D)J recombination "Archived copy"
T-cell receptor excision circles
T-cell_receptor_excision_circles
Stem cell in bone marrow that gives rise to endothelial cells
Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. They are multipotent, which describes the ability to give rise
Endothelial_stem_cell
Cell that differentiates into one or a few cell types
A progenitor cell is a biological cell that can differentiate into a specific cell type. Stem cells and progenitor cells have this ability in common.
Progenitor_cell
Gene therapy medication
gene and for whom hematopoietic stem cell transplantation is appropriate and no suitable human leukocyte antigen-matched related stem cell donor is available
Etuvetidigene_autotemcel
Group of disorders of bone and cartilage development
dysplasias include enzyme replacement therapy, small molecule therapy, hematopoietic stem cell transplantation and gene therapy. These therapies aim at preventing
Osteochondrodysplasia
Pharmaceutical compound
disease (VOD) also known as sinusoidal obstructive syndrome (SOS) in hematopoietic stem-cell transplantation (HSCT) therapy for adults, adolescents, children
Defibrotide
for significant contributions to the fields of gene therapy and hematopoietic stem cell biology and in 2009 was awarded the Tobias Prize by The Royal Swedish
Stefan_Karlsson_(professor)
Quiescent stage of the cell cycle in which the cell does not divide
in hematopoietic stem cells. Lack of p53 has been shown to prevent differentiation of these stem cells due to the cells' inability to exit the cell cycle
G0_phase
American scientist
other scientists to isolate other types of stem cells, and allowed her lab to isolate hematopoietic stem cells (HSCs) with distinct functional characteristics
Margaret_Goodell
Connective tissue cell of any organ
differentiation of hematopoietic cells and forming necessary blood elements. The interaction between stromal cells and tumor cells is known to play a
Stromal_cell
stem cell factor. There are many differences between the human and murine hematopoietic cell markers for the commonly accepted type of hematopoietic stem
Techniques to isolate haematopoietic stem cells
Techniques_to_isolate_haematopoietic_stem_cells
Infertile cow with XX/XY chromosomes
example of microchimerism. The chimerism is mainly present in the hematopoietic stem cells. The phenomenon of sterile cows being born as twins to bulls is
Freemartin
Blood production outside of the bone marrow
hematopoiesis cannot work properly in the bone marrow and the hematopoietic stem cells (HSC) have to migrate to other tissues in order to continue with
Extramedullary_hematopoiesis
Immune cell found in connective tissue
that hematopoietic stem cells (HSCs) were the basis for such development. In the classical sequence of hematopoiesis, hematopoietic stem cells (HSCs)
Mast_cell
Rare type of blood cancer
the production of blood cells arising from hematopoietic stem cells. The V617F subsustition also renders hematopoietic cells more sensitive to growth
Primary_myelofibrosis
Dutch oncologist and researcher
is a Dutch oncologist and researcher known for his research in hematopoietic stem cell transplantation for cancer patients. van den Brink obtained his
Marcel_R.M._van_den_Brink
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