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Type of protein or peptide
A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). Mitogenesis
Mitogen
Cell signaling pathway
cell, such as cell division. The pathway includes many proteins, such as mitogen-activated protein kinases (MAPKs), originally called extracellular signal-regulated
MAPK/ERK_pathway
Type of protein
Pokeweed mitogen is a mitogen derived from the roots of Phytolacca americana. It functions as a lectin and a mitotic stimulus for the division of lymphocytes
Pokeweed_mitogen
P38 mitogen-activated protein kinases
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Class of enzymes
"extracellular signal-regulated kinases", is sometimes used as a synonym for mitogen-activated protein kinase (MAPK), but has more recently been adopted for
Extracellular signal-regulated kinases
Extracellular_signal-regulated_kinases
Protein family
p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines
P38 mitogen-activated protein kinases
P38_mitogen-activated_protein_kinases
Kinase enzyme
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein
Mitogen-activated protein kinase kinase
Mitogen-activated_protein_kinase_kinase
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. MAPK14 encodes p38α mitogen-activated
MAPK14
Species of bacterium
effects. YopJ, which shares an operon with YpkA, "...interferes with the mitogen-activated protein (MAP) kinase activities of c-Jun N-terminal kinase (JNK)
Yersinia_pseudotuberculosis
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this
MAPK1
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene
MAP2K1
Pharmaceutical compound
various types of cancer. It is a selective, orally administered inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/MEK2), developed by Fosun
Luvometinib
Enzyme catalyzing transfer of phosphate groups onto specific substrates
Mohamed S.H.; Sebaiy, Mahmoud M.; Elgawish, Mohamed Saleh (2024), "p38 mitogen-activated protein kinase inhibitors", Current Molecular Targets of Heterocyclic
Kinase
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene. The protein encoded by this gene is a member
MAP3K15
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this
MAPK3
Protein-produced toxins that create pores in cell membrane
zinc-metalloprotease, which shows specificity for a conserved family of mitogen-activated protein kinases. The loss of these proteins results in a breakdown
Pore-forming_toxin
Animal cell cycle checkpoint
cycle completion is no longer dependent on the presence of mitogens. Sustained mitogen signaling promotes cell cycle entry largely through regulation
Restriction_point
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic
MAP4K1
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene
MAP2K3
Chemical compounds
Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli,
C-Jun_N-terminal_kinases
Protein found in humans
also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein
ASK1
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this
MAPK8
Protein-coding gene in humans
Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene. The protein encoded by this gene is
MAP4K2
Class of enzymes
Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP
MAP_kinase_kinase_kinase
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2
MAP2K2
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. The gene was identified by its oncogenic transforming
MAP3K8
(MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate
MAPK_phosphatase
the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires
RAF_kinase
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. The protein encoded by
TAB1
Species of flowering plant in the family Phytolaccaceae
for some utility in biomedical research (e.g., in studies of pokeweed mitogen). In the wild, it is easily found growing in pastures, recently cleared
Phytolacca_americana
Enzyme
Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene. The protein encoded by this gene is a member of serine/threonine
MAP3K12
Mammalian protein found in Homo sapiens
Drosophila ortholog of the mammalian NLK gene. This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated
NLK
Chemical compound
drug in development by Eli Lilly. Although originally thought to be a p38 mitogen-activated protein kinase (MAPK) inhibitor, it has since been reported that
Ralimetinib
American actress
pharmacology from Yale University, where she studied regulation of oncogenic mitogen-activated protein kinase signaling. Her Erdős-Bacon number is 5. Little
Eunice_Cho
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 is a member of the MAP kinase
MAPK7
Protein-coding gene in the species Homo sapiens
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene. The
MAP3K2
compared to sigmoidal curves for cooperative (ultrasensitive) enzymes. In mitogen-activated protein kinase (MAPK) signaling (see example below), the ultrasensitivity
Ultrasensitivity
Enzyme found in humans
Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene is a member of the MAP kinase
Mitogen-activated protein kinase 9
Mitogen-activated_protein_kinase_9
Peptide hormone in animals
Regulation of the CGRP gene is in part controlled by the expression of the mitogen-activated protein kinase (MAPK) signaling pathway and cytokines like TNFα
Calcitonin gene-related peptide
Calcitonin_gene-related_peptide
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is a signal transduction enzyme that in humans is encoded by the autosomal MAP3K1 gene. MAP3K1
MAP3K1
Family of proteins
Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. MAP4K1 (aka HPK1) MAP4K2
MAP kinase kinase kinase kinase
MAP_kinase_kinase_kinase_kinase
Pharmaceutical drug classification
ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes
ATC_code_L01
Putative drug class for treating cancer
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
Aurora_inhibitor
Chemical compound
PH-797804 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiinflammatory effects and
PH-797804
Topics referred to by the same term
MKK is mitogen-activated protein kinase kinase, an enzyme. MKK may also refer to: Malmö KK, Swedish swim team from Malmö Main-Kinzig-Kreis, a kreis (district)
MKK_(disambiguation)
Protein-coding gene in the species Homo sapiens
regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein
PRKD3
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene. The protein encoded by this gene
MAP2K5
Protein family
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
Phosphatidylinositol 3-kinase-related kinase
Phosphatidylinositol_3-kinase-related_kinase
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome
MAP3K3
System of signaling molecules within a cell
original first messenger signal. For example, RasGTP signals link with the mitogen activated protein kinase (MAPK) cascade to amplify the allosteric activation
Second_messenger_system
Signaling glycoprotein regulating cell proliferation
two B subunits (PDGF-BB), or one of each (PDGF-AB). PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene. The protein encoded by this gene is a member of the MAP
MAPK11
Protein-coding gene in the species Homo sapiens
2 diabetes. MAPK8IP1 has been shown to interact with MAP3K10, DUSP16, Mitogen-activated protein kinase 9, MAPK8, LRP2, LRP1, MAP3K12, MAP2K7, MAPK8IP2
MAPK8IP1
Energy-carrying molecule in living cells
Phosphorylation of a protein by a kinase can activate a cascade such as the mitogen-activated protein kinase cascade. ATP is also a substrate of adenylate
Adenosine_triphosphate
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. The protein encoded by this gene is a member of the Ser/Thr
MAPK6
Species of bacterium
cycle is also modulated by the toxin, which can act as an intracellular mitogen. P. multocida has been observed invading and replicating inside host amoebae
Pasteurella_multocida
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene. The protein encoded by this gene is a member
MAP3K13
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. TAK1 is an evolutionarily
MAP3K7
Peptide hormone that stimulates growth
increases the concentration of glucose and free fatty acid. It is a type of mitogen which is specific only to the receptors on certain types of cells. GH is
Growth_hormone
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the
MAPK13
Topics referred to by the same term
Methyl ethyl ketone or butanone, a solvent, used also to weld some plastics Mitogen-activated protein kinase kinase, an important enzyme in biochemical MAPK/ERK
Mek
Topics referred to by the same term
a closed United States Air Force radar station in Tennessee MAPK1, p42 mitogen-activated protein kinase Papyrus 42, a biblical manuscript Phosphorus-42
P42
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 19 is a protein that in humans is encoded by the MAP3K19 gene. GRCh38: Ensembl release 89: ENSG00000176601
MAP3K19
Process of obtaining intravenous access
Green, Yellow, Purple QuantiFERON 1. Grey (nil) tube 2. Green (TB1 antigen) tube 3. Yellow (TB2 antigen) tube 4. Purple (mitogen) tube Tuberculosis
Venipuncture
Protein-coding gene in humans
Molecular function MDM2/MDM4 family protein binding NF-kappaB binding mitogen-activated protein kinase binding protein binding ubiquitin-like protein
CDK5RAP3
Medical condition
findings on the disease's genomic structure, especially mutations in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway
Erdheim–Chester_disease
Protein-coding gene in humans
Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. The protein encoded by this gene is called
MAP3K11
Medication used to treat allergic reactions
glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen-activated protein kinase phosphatase-1-dependent mechanism in mice". Basic
Anti-allergic_agent
Protein-coding gene in the species Homo sapiens
protein kinases including those activated by cAMP, calcium/calmodulin, mitogen, and cyclin. Both isoforms have the same six phosphorylation sites: The
Synapsin_I
Lectin (carbohydrate-binding protein)
physiological function in plants, however, is still unknown. ConA is a plant mitogen, and is known for its ability to stimulate mouse T-cell subsets giving
Concanavalin_A
Protein-coding gene in the species Homo sapiens
member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases
MAPKAPK3
Mammalian protein found in Homo sapiens
protein binding dynein complex binding protein-membrane adaptor activity mitogen-activated protein kinase binding RNA binding Cellular component cytoplasm
Translocated_promoter_region
Protein-coding gene in the species Homo sapiens
binding mitogen-activated protein kinase kinase binding vascular endothelial growth factor receptor 2 binding protein homodimerization activity mitogen-activated
DAB2IP
Protein-coding gene in the species Homo sapiens
et al. (October 2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades". The Journal of Biological Chemistry
TRIB1
Mitogen-activated protein kinase (MAPK) networks are the pathways and signaling of MAPK, which is a type of serine/threonine-specific protein kinase.
MAPK_networks
Protein-coding gene in humans
Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene. Evolutionarily, MAPK15
MAPK15
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that
MAP3K14
Chemical compound
cytotoxicity to cells containing it. Agerafenib also inhibits phosphorylation in mitogen-activated protein kinase (an enzyme that causes certain cellular responses)
Agerafenib
Protein-coding gene in the species Homo sapiens
lymphocytes. Immune interferon (IFN-gamma; MIM 147570) is produced by mitogen- or antigen-stimulated T lymphocytes.[supplied by OMIM] The interferons
Interferon_alpha-1
Purinergic receptor
several mutants lacking the DORN1 receptors are unable to phosphorylate mitogen-activated protein kinases after ATP stimulation. DORN1 receptors may play
DORN1
Protein-coding gene in the species Homo sapiens
a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro". J. Biol. Chem
ZFP36
Class of enzymes
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
AMP-activated_protein_kinase
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
WNK3
Protein-coding gene in the species Homo sapiens
Xu J, Snyderman R (Apr 2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293
PLCB2
Protein found in humans
Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. This gene encodes a serine/threonine protein
Mitogen-activated protein kinase kinase kinase 6
Mitogen-activated_protein_kinase_kinase_kinase_6
Topics referred to by the same term
P-38 may refer to: Multisynthetase complex auxiliary component p38 p38 mitogen-activated protein kinases RPP38, ribonuclease P protein subunit p38 HMS P38 (1917)
P38
Chemical compound
chronic kidney disease and acute tubular necrosis and is a lymphocyte mitogen. Target organs include the kidneys, liver, lungs and brain. It also represents
Uranyl_nitrate
Medical condition
production of a superantigen—YpM (Yersinia pseudotuberculosis-derived mitogen). This is present in almost all strains from the Far East but only 20%
Far_East_scarlet-like_fever
Protein-coding gene in the species Homo sapiens
reference expression data Gene ontology Molecular function protein binding mitogen-activated protein kinase binding identical protein binding polyubiquitin
TNIP1
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an enzyme that in humans
MAP2K6
Protein-coding gene in the species Homo sapiens
activity peptidyl-prolyl cis-trans isomerase activity protein binding mitogen-activated protein kinase kinase binding cytoskeletal motor activity phosphoserine
PIN1
Chemical compound
muscular dystrophy (FSHD). Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression
Losmapimod
Protein-coding gene in the species Homo sapiens
Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene. The protein encoded by this gene is a member of the epidermal
Epigen
Chemical compound
needed] TPA has a specific use in cancer diagnostics as a B-cell specific mitogen in cytogenetic testing. Cells must be divided in a cytogenic test to view
12-O-Tetradecanoylphorbol-13-acetate
12-O-Tetradecanoylphorbol-13-acetate
American information scientist and health services researcher
School of Public Health Thesis Characterization of betacellulin: a novel mitogen from pancreatic beta cell tumors Academic work Institutions Weill Cornell
Rainu_Kaushal
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase kinase 3 is a protein that in humans is encoded by the MAP4K3 gene. This gene encodes a member of the mitogen-activated
MAP4K3
post-phagocytosis. Epithelial immunity is achieved predominantly through mitogen-activated protein kinase (MAPK) signaling, more specifically the p38 pathway
Candidalysin
Protein-coding gene in the species Homo sapiens
Sung HY, et al. (2004). "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades". J. Biol. Chem. 279 (41): 42703–8. doi:10
TRIB3
Mammalian protein found in Homo sapiens
named it lymphocyte-activating factor (LAF) because it was a lymphocyte mitogen. It was not until 1984 that interleukin 1 was discovered to consist of
Interleukin_1_beta
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene. The central core of each mitogen-activated
MAP3K4
MITOGEN
MITOGEN
MITOGEN
MITOGEN
Boy/Male
Indian
Trust worthy friend
Girl/Female
Indian, Sanskrit, Tamil
Lord Shiva
Female
English
Variant spelling of English Edwina, EDWENA means "rich friend."
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi
An Epithet of Ganesha
Male
English
Middle English masculine form of Anglo-Saxon Eoforhild, AVEREL means "boar battle."
Male
Norse
Diminutive form of Old Norse Agni "edge (of a sword)," EGIL means "little edge."Â
Boy/Male
Tamil
Venkatesan | வேநà¯à®•à®¾à®¤à¯‡à®¸à®¨
Venkatesh comes from the indian word which means, Lord Vishnu, Lord Krishna
Biblical
news; a month
Boy/Male
American, Australian, British, English
My Own Meadow; Hermitage Meadow
Boy/Male
American, Anglo, Australian, British, Christian, English, German
Place Name; Farmer's Settlement; From Charles Dwelling; Man
MITOGEN
MITOGEN
MITOGEN
MITOGEN
MITOGEN