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RAF KINASE

  • RAF kinase
  • RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse sarcoma virus 3611, a

    RAF kinase

    RAF kinase

    RAF_kinase

  • BRAF (gene)
  • Protein-coding gene in humans

    the protein is more formally known as serine/threonine-protein kinase B-Raf. The B-Raf protein is involved in sending signals inside cells which are involved

    BRAF (gene)

    BRAF (gene)

    BRAF_(gene)

  • MAPK/ERK pathway
  • Cell signaling pathway

    then activates the protein kinase activity of a RAF kinase. The RAF kinase phosphorylates and activates a MAPK/ERK Kinase (MEK1 or MEK2). The MEK phosphorylates

    MAPK/ERK pathway

    MAPK/ERK_pathway

  • C-Raf
  • Mammalian protein found in Homo sapiens

    RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded

    C-Raf

    C-Raf

    C-Raf

  • Mitogen-activated protein kinase
  • P38 mitogen-activated protein kinases

    A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses

    Mitogen-activated protein kinase

    Mitogen-activated_protein_kinase

  • Protein kinase
  • Enzyme that adds phosphate groups to other proteins

    protein kinases, demonstrating that the mammalian A-RAF kinase can be imported into mitochondria. This observation provided evidence that protein kinases may

    Protein kinase

    Protein kinase

    Protein_kinase

  • Raf kinase inhibitor protein
  • The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the

    Raf kinase inhibitor protein

    Raf_kinase_inhibitor_protein

  • ARAF
  • Protein-coding gene in humans

    Serine/threonine-protein kinase A-Raf, or simply A-Raf, is an enzyme that in humans is encoded by the ARAF gene. It belongs to the Raf kinase family of serine/threonine-specific

    ARAF

    ARAF

    ARAF

  • Kinase
  • Enzyme catalyzing transfer of phosphate groups onto specific substrates

    Kinases are pervasive, the human genome codes for about 500 of these enzymes. Kinases are part of the larger family of phosphotransferases. Kinases should

    Kinase

    Kinase

    Kinase

  • Extracellular signal-regulated kinases
  • Class of enzymes

    protein kinase, Raf-1, was shown to phosphorylate a "MAP kinase-kinase", thus qualifying as a "MAP kinase kinase kinase". The MAP kinase-kinase, which

    Extracellular signal-regulated kinases

    Extracellular_signal-regulated_kinases

  • Protein kinase C
  • Family of enzymes

    are, e.g., MARCKS proteins, MAP kinase, transcription factor inhibitor IκB, the vitamin D3 receptor VDR, Raf kinase, calpain, and the epidermal growth

    Protein kinase C

    Protein_kinase_C

  • RAF (disambiguation)
  • Topics referred to by the same term

    (taxonomic author abbreviation: Raf.; 1783–1840), French polymath RAF kinase, a protein family .raf, raw image format used by Fuji R.A.F. (film), a 1935 British

    RAF (disambiguation)

    RAF_(disambiguation)

  • Oncogene
  • Gene that has the potential to cause cancer

    mitogen-activated protein kinases Raf a MAP Kinase Kinase Kinase (MAPKKK), MEK a MAP Kinase Kinase (MAPKK), and ERK a MAP Kinase(MAPK), which in turn regulate

    Oncogene

    Oncogene

    Oncogene

  • HRAS
  • Protein-coding gene in humans

    GTPases. Once bound to guanosine triphosphate, H-Ras will activate a Raf kinase like c-Raf, the next step in the MAPK/ERK pathway. As its name suggests, the

    HRAS

    HRAS

    HRAS

  • Serine/threonine-specific protein kinase
  • Class of protein kinase enzymes

    A serine/threonine protein kinase (EC 2.7.11.-) is a kinase enzyme, in particular a protein kinase, that phosphorylates the OH group of the amino-acid

    Serine/threonine-specific protein kinase

    Serine/threonine-specific protein kinase

    Serine/threonine-specific_protein_kinase

  • RASopathy
  • Family of genetic conditions caused by mutations affecting Ras genes

    governs several crucial cellular. It encompasses the RAS/RAF/MEK/ERK signaling cascade. RAF kinase is a primary mediator of the MAPK pathway, responsible

    RASopathy

    RASopathy

  • Tovorafenib
  • Medication

    Ojemda, is a medication used for the treatment of glioma. It is a Type II RAF kinase inhibitor. The most common adverse reactions include rash, hair color

    Tovorafenib

    Tovorafenib

    Tovorafenib

  • Donafenib
  • Cancer medication

    systemic treatment. Donafenib is a kinase inhibitor that targets Raf kinase and various receptor tyrosine kinases. It is a deuterated derivative of sorafenib

    Donafenib

    Donafenib

    Donafenib

  • MAP2K1
  • Protein-coding gene in the species Homo sapiens

    protein kinase family that acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs)

    MAP2K1

    MAP2K1

    MAP2K1

  • MAP kinase kinase kinase
  • Class of enzymes

    Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase. Subsequently

    MAP kinase kinase kinase

    MAP_kinase_kinase_kinase

  • Antineoplastic
  • Class of drugs used to treat malignant tumors

    hormones or their antagonists that alter hormone imbalance; protein tyrosine kinase inhibitors, farnesyltransferase inhibitors, MAPK signaling pathway inhibitors

    Antineoplastic

    Antineoplastic

    Antineoplastic

  • PAQR3
  • Progestin and adipoQ receptor family member 3 (PAQR3), or Raf Kinase Trapping to Golgi apparatus (RKTG) is a protein that in humans is encoded by the PAQR3

    PAQR3

    PAQR3

    PAQR3

  • Phosphatidylethanolamine binding protein 1
  • Protein-coding gene in the species Homo sapiens

    2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20

    Phosphatidylethanolamine binding protein 1

    Phosphatidylethanolamine binding protein 1

    Phosphatidylethanolamine_binding_protein_1

  • MAPK1
  • Protein-coding gene in the species Homo sapiens

    2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20

    MAPK1

    MAPK1

    MAPK1

  • Flezurafenib
  • Pharmaceutical compound

    investigational new drug designed as a rapidly accelerated fibrosarcoma (RAF) kinase inhibitor which is being evaluated for the treatment of cancer. Developed

    Flezurafenib

    Flezurafenib

    Flezurafenib

  • Two-hybrid screening
  • Molecular biology technique

    serine/threonine kinase Raf". Cell. 74 (1): 205–214. doi:10.1016/0092-8674(93)90307-c. ISSN 0092-8674. Yuryev, Anton; Wennogle, Lawrence P. (June 1998). "The RAF family:

    Two-hybrid screening

    Two-hybrid screening

    Two-hybrid_screening

  • VEGFR-2 inhibitor
  • Class of pharmaceutical drugs

    phosphorylation), PDGFRβ (platelet-derived growth factor receptor), RAF kinase, FLT3 (Fms-like tyrosine kinase-3) and KIT (stem cell factor receptor). Sorafenib is used

    VEGFR-2 inhibitor

    VEGFR-2_inhibitor

  • MAP kinase kinase kinase kinase
  • Family of proteins

    Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. MAP4K1 (aka HPK1) MAP4K2

    MAP kinase kinase kinase kinase

    MAP_kinase_kinase_kinase_kinase

  • Anton Yuryev
  • Russian-American scientist

    interactions, including evidence for the mitochondrial import of the A-RAF kinase. Following the completion of the human genome sequencing, Yuryev shifted

    Anton Yuryev

    Anton Yuryev

    Anton_Yuryev

  • Integrin-linked kinase
  • Protein found in humans

    proliferation, and adhesion. Integrin-linked kinases (ILKs) are a subfamily of Raf-like kinases (RAF). The structure of ILK consists of three features:

    Integrin-linked kinase

    Integrin-linked kinase

    Integrin-linked_kinase

  • Sorafenib
  • Cancer treatment medicine

    Sorafenib is a protein kinase inhibitor with activity against many protein kinases, including VEGFR, PDGFR and RAF kinases. Of the RAF kinases, sorafenib is more

    Sorafenib

    Sorafenib

    Sorafenib

  • EFEMP1
  • Protein-coding gene in the species Homo sapiens

    PMC 3761217. PMID 23050525. Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    EFEMP1

    EFEMP1

    EFEMP1

  • High throughput biology
  • was initially discovered by Bayer Pharmaceuticals in 2001. By using a RAF kinase biochemical assay, 200,000 compounds were screened from medicinal chemistry

    High throughput biology

    High_throughput_biology

  • P-glycoprotein
  • Protein found in humans

    For example, miR-27a up-regulates P-gp expression by suppressing the Raf kinase inhibitor protein (RKIP); alternatively, miR-27a can also directly bind

    P-glycoprotein

    P-glycoprotein

    P-glycoprotein

  • Phosphorylation cascade
  • Signal pathway enzyme chain

    Ras-GTP now activates the Raf Kinase enzyme which will phosphorylate MEK enzymes, which in turn phosphorylate MAP/ERK kinases, which continue to phosphorylate

    Phosphorylation cascade

    Phosphorylation cascade

    Phosphorylation_cascade

  • Target peptide
  • Type of peptide chain

    interactions. During his postdoctoral research, Yuryev demonstrated that the A-RAF kinase, a signaling protein, can localize to mitochondria, providing insight

    Target peptide

    Target_peptide

  • Let-7 microRNA family
  • RNA family

    Eves EM, Newman M, Erkeland SJ, Hammond SM, et al. (February 2009). "Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving

    Let-7 microRNA family

    Let-7_microRNA_family

  • Protein kinase A
  • Family of enzymes

    In cell biology, protein kinase A (PKA) is a family of serine-threonine kinases whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA

    Protein kinase A

    Protein kinase A

    Protein_kinase_A

  • DIRAS1
  • Mammalian protein found in Homo sapiens

    members of the Ras superfamily due to amino acid substitution in the RAF kinase and Ha-RAS, critical for GTP hydrolysis. Due to these substitution, DIRAS1

    DIRAS1

    DIRAS1

    DIRAS1

  • Sigma-2 receptor
  • Protein-coding gene in the species Homo sapiens

    the regulation of signals further downstream such as PKC and RAF. Both PKC and Raf kinase up regulate transcription and cell proliferation. Ligands of

    Sigma-2 receptor

    Sigma-2 receptor

    Sigma-2_receptor

  • List of MeSH codes (D12.776.476)
  • proteins c-raf MeSH D12.776.476.450.169.500 – mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 – mitogen-activated protein kinase 3 MeSH D12

    List of MeSH codes (D12.776.476)

    List_of_MeSH_codes_(D12.776.476)

  • MTOR
  • Mammalian protein found in humans

    also known as mammalian target of rapamycin is a serine-threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival

    MTOR

    MTOR

    MTOR

  • ASK1
  • Protein found in humans

    mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion

    ASK1

    ASK1

    ASK1

  • ELK1
  • Protein-coding gene in humans

    Figure 2, Raf kinase acts upstream of MAPKs to activate them by phosphorylating and, thereby activating, MEKs, or MAPK or ERK kinases. Raf itself is activated

    ELK1

    ELK1

    ELK1

  • 60S ribosomal protein L5
  • Protein found in humans

    Boldyreff B, Issinger OG (February 1997). "A-Raf kinase is a new interacting partner of protein kinase CK2 beta subunit". FEBS Lett. 403 (2): 197–9.

    60S ribosomal protein L5

    60S ribosomal protein L5

    60S_ribosomal_protein_L5

  • TIMM44
  • Protein-coding gene in the species Homo sapiens

    homolog (yeast)". Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    TIMM44

    TIMM44

    TIMM44

  • TH1L
  • Protein-coding gene in the species Homo sapiens

    TH1L TH1-like (Drosophila)". Yuryev A, Wennogle LP (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    TH1L

    TH1L

    TH1L

  • ADCY2
  • Protein-coding gene in the species Homo sapiens

    discovered that ADCY2 can activated by a Raf kinase-mediated serine phosphorylation. In aggregate, Raf kinase associates with adenylyl cyclases and is

    ADCY2

    ADCY2

    ADCY2

  • P38 mitogen-activated protein kinases
  • Protein family

    p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines

    P38 mitogen-activated protein kinases

    P38_mitogen-activated_protein_kinases

  • CHUK
  • Protein-coding gene in humans

    factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans

    CHUK

    CHUK

    CHUK

  • RRAS
  • Protein-coding gene in the species Homo sapiens

    (r-ras) oncogene homolog". Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    RRAS

    RRAS

    RRAS

  • Paraptosis
  • Type of programmed cell death distinct from apoptosis and necrosis

    PEBP, or Raf kinase inhibitor protein (RKIP) is diminished in paraptotic cells, thus resultant down regulation of PEBP and/or other kinase inhibitors

    Paraptosis

    Paraptosis

    Paraptosis

  • Protein kinase C zeta type
  • Mammalian protein found in Homo sapiens

    Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative

    Protein kinase C zeta type

    Protein kinase C zeta type

    Protein_kinase_C_zeta_type

  • Oct-4
  • Mammalian protein found in Homo sapiens

    PMID 30904611. Lee S, Wottrich S, Bonavida B (April 2017). "Crosstalks between Raf-kinase inhibitor protein and cancer stem cell transcription factors (Oct4, KLF4

    Oct-4

    Oct-4

    Oct-4

  • CAMK
  • Enzyme type

    or CCaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes. CAMKs are activated by increases in the concentration

    CAMK

    CAMK

  • P70-S6 Kinase 1
  • Protein-coding gene in the species Homo sapiens

    Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is

    P70-S6 Kinase 1

    P70-S6 Kinase 1

    P70-S6_Kinase_1

  • AMP-activated protein kinase
  • Class of enzymes

    5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular

    AMP-activated protein kinase

    AMP-activated protein kinase

    AMP-activated_protein_kinase

  • PRPF6
  • Protein-coding gene in the species Homo sapiens

    PMID 15161931. Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    PRPF6

    PRPF6

    PRPF6

  • Julian Downward
  • English research director

    RAF kinase, which controls the mitogen-activated protein kinase pathway. Julian was first to demonstrate that phosphoinositide 3-kinase (PI 3-kinase)

    Julian Downward

    Julian Downward

    Julian_Downward

  • Protein kinase B
  • Set of three serine threonine-specific protein kinases

    Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple

    Protein kinase B

    Protein kinase B

    Protein_kinase_B

  • Receptor tyrosine kinase
  • Class of enzymes

    unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. Receptor tyrosine kinases have been shown not

    Receptor tyrosine kinase

    Receptor tyrosine kinase

    Receptor_tyrosine_kinase

  • Crosstalk (biology)
  • of which involve the cAMP-dependent protein kinase (PKA) and the inhibition of Ras-dependent signals to Raf-1. However, cAMP can also stimulate cell proliferation

    Crosstalk (biology)

    Crosstalk_(biology)

  • Deborah K. Morrison
  • American cell biologist

    Institute. She conducts research characterizing the RAS pathway and the RAF family kinases and leads efforts to design new therapeutic strategies for cancer

    Deborah K. Morrison

    Deborah K. Morrison

    Deborah_K._Morrison

  • Hsp90 inhibitor
  • Drug class

    proteosomal degradation of signaling proteins like steroid receptors, Raf kinase and Akt. Geldanamycin and radicicol also inhibit mutated protein in cancer

    Hsp90 inhibitor

    Hsp90 inhibitor

    Hsp90_inhibitor

  • Encorafenib
  • Chemical compound

    detected by an FDA-approved test. Encorafenib acts as an ATP-competitive RAF kinase inhibitor, decreasing ERK phosphorylation and down-regulation of CyclinD1

    Encorafenib

    Encorafenib

    Encorafenib

  • CCT3
  • Protein-coding gene in humans

    1016/S0168-8278(02)00412-9. PMID 12586295. Yuryev A, Wennogle LP (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    CCT3

    CCT3

    CCT3

  • YWHAB
  • Protein-coding gene in the species Homo sapiens

    Boss GR, Pilz RB (October 2000). "Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins". J. Biol. Chem. 275 (41): 31921–9. doi:10

    YWHAB

    YWHAB

    YWHAB

  • IKK2
  • Protein-coding gene in the species Homo sapiens

    Chatterjee D, et al. (November 2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation"

    IKK2

    IKK2

    IKK2

  • STUB1
  • Protein-coding gene in the species Homo sapiens

    K (Dec 2008). "X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility". Nature Cell Biology. 10 (12): 1447–55. doi:10.1038/ncb1804

    STUB1

    STUB1

    STUB1

  • Richard Marais
  • British cancer researcher

    protein kinases regulate gene expression by directly phosphorylating transcription factors. However his greatest impact has been with the RAF kinase family

    Richard Marais

    Richard Marais

    Richard_Marais

  • PAK1
  • Mammalian protein found in Homo sapiens

    protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl transferase V, B-Raf proto-oncogene, casein kinase 2-interacting protein

    PAK1

    PAK1

    PAK1

  • RRAS2
  • Protein-coding gene in the species Homo sapiens

    leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8). UNITED STATES: 895–900. doi:10

    RRAS2

    RRAS2

    RRAS2

  • Protein kinase R
  • Human protein and coding gene

    Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation

    Protein kinase R

    Protein kinase R

    Protein_kinase_R

  • YWHAQ
  • Protein-coding gene in the species Homo sapiens

    2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. 20

    YWHAQ

    YWHAQ

    YWHAQ

  • Testicular receptor 4
  • Protein-coding gene in the species Homo sapiens

    Wyche J, Kolch W, Sedivy JM (Nov 2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation"

    Testicular receptor 4

    Testicular receptor 4

    Testicular_receptor_4

  • Rho-associated protein kinase
  • Protein family

    Rho-associated protein kinase or Rho-associated coiled-coil kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine specific

    Rho-associated protein kinase

    Rho-associated protein kinase

    Rho-associated_protein_kinase

  • RHEB
  • Protein-coding gene in the species Homo sapiens

    related (ATR) 5' AMP-activated protein kinase (AMPK) RAF proto-oncogene serine/threonine-protein kinase (C-Raf) mammalian Target of Rapamycin Complex

    RHEB

    RHEB

    RHEB

  • AKT1
  • Protein-coding gene in humans

    Vojtek AB (Sep 2000). "Negative regulation of the serine/threonine kinase B-Raf by Akt". J. Biol. Chem. 275 (35): 27354–9. doi:10.1074/jbc.M004371200

    AKT1

    AKT1

    AKT1

  • MTOR inhibitors
  • Class of pharmaceutical drugs

    serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR regulates cellular

    MTOR inhibitors

    MTOR inhibitors

    MTOR_inhibitors

  • Mitogen-activated protein kinase kinase
  • Kinase enzyme

    transduction MAP kinase MAP kinase kinase kinase MAP kinase kinase kinase kinase Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction

    Mitogen-activated protein kinase kinase

    Mitogen-activated_protein_kinase_kinase

  • CSNK2B
  • Protein-coding gene in humans

    Casein kinase II subunit beta is a protein that in humans is encoded by the CSNK2B gene. It is a ubiquitous protein kinase which regulates metabolic pathways

    CSNK2B

    CSNK2B

    CSNK2B

  • TIMM50
  • Protein-coding gene in the species Homo sapiens

    PMID 14743216. S2CID 11683986. Yuryev A, Wennogle LP (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    TIMM50

    TIMM50

    TIMM50

  • Philadelphia chromosome
  • Genetic abnormality in leukemia cancer cells

    gene BCR::ABL1. The oncogenic protein with persistently enhanced tyrosine kinase (TK) activity transcribed by the BCR::ABL1 fusion gene can lead to rapid

    Philadelphia chromosome

    Philadelphia chromosome

    Philadelphia_chromosome

  • MTORC1
  • Protein complex

    kinase, the adaptor protein GRB2 binds with its SH2 domains. This recruits the GEF called Sos, which activates the Ras G protein. Ras activates Raf (MAPKKK)

    MTORC1

    MTORC1

    MTORC1

  • Proto-oncogene tyrosine-protein kinase Src
  • Mammalian protein found in humans

    Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)

    Proto-oncogene tyrosine-protein kinase Src

    Proto-oncogene tyrosine-protein kinase Src

    Proto-oncogene_tyrosine-protein_kinase_Src

  • Catrin Pritchard
  • British researcher

    (1992–1995). At DNAX she worked on intracellular signalling through RAF kinases, investigating their mechanisms of control of the MAPK pathway in normal

    Catrin Pritchard

    Catrin_Pritchard

  • Neurofibromin
  • Mammalian protein found in humans

    of targeted pharmacologic agents, such as sorafenib (VEGFR, PDGFR and RAF kinases inhibitor) and everolimus (mTORC inhibitor) for the treatment of NF1

    Neurofibromin

    Neurofibromin

    Neurofibromin

  • Cyclin-dependent kinase
  • Class of enzymes

    Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases involved in the regulation of the cell cycle. These enzymes function as

    Cyclin-dependent kinase

    Cyclin-dependent kinase

    Cyclin-dependent_kinase

  • Martin J. Lohse
  • German physician and pharmacologist

    activation of so-called ERK protein kinases (Extracellular signal-regulated kinases). Another regulatory protein, Raf kinase inhibitor protein (RKIP), was shown

    Martin J. Lohse

    Martin_J._Lohse

  • PBK (gene)
  • Protein-coding gene in the species Homo sapiens

    242603899. PMC 139241. PMID 12477932. Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis"

    PBK (gene)

    PBK (gene)

    PBK_(gene)

  • Heat shock protein 90kDa alpha (cytosolic), member A1
  • Protein-coding gene in the species Homo sapiens

    K (Dec 2008). "X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility". Nature Cell Biology. 10 (12): 1447–55. doi:10.1038/ncb1804

    Heat shock protein 90kDa alpha (cytosolic), member A1

    Heat shock protein 90kDa alpha (cytosolic), member A1

    Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1

  • Cyclin-dependent kinase 4
  • Human protein

    Cyclin-dependent kinase 4 (CDK4), also known as cell division protein kinase 4, is an enzyme that is encoded by the CDK4 gene in humans. CDK4 is a member

    Cyclin-dependent kinase 4

    Cyclin-dependent kinase 4

    Cyclin-dependent_kinase_4

  • IkappaB kinase
  • Class of enzymes

    The IκB kinase (IkappaB kinase or IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation, specifically the regulation

    IkappaB kinase

    IkappaB_kinase

  • C-Jun N-terminal kinases
  • Chemical compounds

    c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional

    C-Jun N-terminal kinases

    C-Jun N-terminal kinases

    C-Jun_N-terminal_kinases

  • Martin McMahon (biologist)
  • British cancer biologist

    oncoproteins and RAS-regulated signaling pathways mediated by RAF protein kinases and PI3'-lipid kinases. His research has significantly contributed to understanding

    Martin McMahon (biologist)

    Martin_McMahon_(biologist)

  • AKT (disambiguation)
  • Topics referred to by the same term

    Wiktionary, the free dictionary. Protein kinase B, also known as Akt, is a serine/threonine-specific protein kinase. AKT, Akt or akt may also refer to: AKT

    AKT (disambiguation)

    AKT_(disambiguation)

  • PKM2
  • Protein-coding gene in humans

    Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding

    PKM2

    PKM2

    PKM2

  • Tyrosine-protein kinase SYK
  • Enzyme

    Tyrosine-protein kinase SYK, also known as spleen tyrosine kinase, is an enzyme which in humans is encoded by the SYK gene. SYK, along with ZAP70, is a

    Tyrosine-protein kinase SYK

    Tyrosine-protein kinase SYK

    Tyrosine-protein_kinase_SYK

  • Aurora kinase A
  • Protein-coding gene in the species Homo sapiens

    Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family

    Aurora kinase A

    Aurora kinase A

    Aurora_kinase_A

  • YWHAZ
  • Protein-coding gene in the species Homo sapiens

    cell survival and interacts with many apoptotic proteins, including Raf kinases, BAX, BAD, NOXA, and caspase-2. For the most part, 14-3-3ζ negatively

    YWHAZ

    YWHAZ

    YWHAZ

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RAF KINASE

  • RAY
  • Male

    English

    RAY

    Short form of English Raymond, RAY means "wise protector."

    RAY

  • Raj
  • Boy/Male

    Sanskrit

    Raj

    King. Raja is an Indian or Malay princely title; Raj means 'rule.

    Raj

  • JÖRAN
  • Male

    Swedish

    JÖRAN

    Variant spelling of Swedish Göran, JÖRAN means "earth-worker, farmer."

    JÖRAN

  • GÖRAN
  • Male

    Swedish

    GÖRAN

    Swedish form of Greek Georgios, GÖRAN means "earth-worker, farmer."

    GÖRAN

  • Ram
  • Boy/Male

    English Teutonic Biblical Sanskrit

    Ram

    Ram.

    Ram

  • RAFA
  • Male

    Hebrew

    RAFA

    Variant spelling of Hebrew Rapha, RAFA means "feeble, flaccid, weak," i.e. "a shade" living in Hades, void of blood and animal life; therefore weak and languid like a sick person, but still able to think. 

    RAFA

  • RAV
  • Male

    Hebrew

    RAV

    (רַב) Hebrew name RAV means "great" or "teacher."

    RAV

  • RAB
  • Male

    Hebrew

    RAB

     Variant spelling of Hebrew Rav, RAB means "great" or "teacher." Compare with another form of Rab.

    RAB

  • Muni-Ram
  • Boy/Male

    Indian, Telugu

    Muni-Ram

    Lord Ram

    Muni-Ram

  • RAE
  • Male

    English

    RAE

    Variant spelling of English Ray, RAE means "wise protector." 

    RAE

  • Rau
  • Surname or Lastname

    German

    Rau

    German : nickname for a ruffian, earlier for a hairy person, from Middle High German rūch, rūhe, rouch ‘hairy’, ‘shaggy’, ‘rough’.English : from a medieval personal name, a variant of Ralph.Italian (Sicily) : from a local variant of the personal name Rao, an old form of Ra(o)ul, composed of the Germanic elements rad ‘counsel’, ‘advice’ + wolf ‘wolf’. Compare Ralph.Indian : variant of Rao.

    Rau

  • RALF
  • Male

    Scandinavian

    RALF

     Scandinavian form of Old Norse Ráðúlfr, RALF means "wise wolf." Compare with another form of Ralf.

    RALF

  • Ram Kinkar
  • Boy/Male

    Hindu

    Ram Kinkar

    Lord Ram named rock

    Ram Kinkar

  • RAB
  • Male

    Scottish

    RAB

     Pet form of Scottish Raibeart, RAB means "bright fame." Compare with another form of Rab.

    RAB

  • HAF
  • Female

    Welsh

    HAF

    Welsh name HAF means "summer."

    HAF

  • RAM
  • Male

    Hebrew

    RAM

    (רָם) Hebrew name RAM means "high." In the bible, this is the name of several characters, including a son of Hezron.

    RAM

  • RAE
  • Female

    English

    RAE

    English name, possibly derived from the vocabulary word ray, RAE means "sunbeam."

    RAE

  • RAFE
  • Male

    English

    RAFE

    Medieval form of English Ralph, RAFE means "wise wolf."

    RAFE

  • RAN
  • Female

    Japanese

    RAN

    (蘭) Japanese name RAN means "lily" or "orchid."

    RAN

  • RAJ
  • Male

    Hindi/Indian

    RAJ

    (राज) Hindi name RAJ means "king."

    RAJ

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Online names & meanings

  • Sudharshan
  • Boy/Male

    Hindu

    Sudharshan

    Lord Perumal, Good looking, Lion, Vishnus weapon

  • Sully
  • Boy/Male

    English

    Sully

    From the south meadow.

  • LEOPOLD
  • Male

    English

    LEOPOLD

    English form of French Léopold, LEOPOLD means "people-bold."

  • Umm Haraam |
  • Girl/Female

    Muslim

    Umm Haraam |

    Name of a sahabiyah ra

  • KEISHA
  • Female

    English

    KEISHA

    Modern form of English Keziah, KEISHA means "cassia," a bark similar to cinnamon.

  • Bipin
  • Boy/Male

    Hindu

    Bipin

    Forest (Vipin)

  • FERDINANDO
  • Male

    Italian

    FERDINANDO

    Italian form of Visigothic Frithnanth, FERDINANDO means "ardent for peace."

  • Kalle
  • Girl/Female

    Finnish

    Kalle

  • Mudawar
  • Boy/Male

    Arabic

    Mudawar

    Round

  • Singler
  • Surname or Lastname

    English

    Singler

    English : from Middle English sengler, syngler ‘singular’ (Old French se(i)ngler), perhaps a nickname for a solitary person.German : topographic name for a valley dweller, from a diminutive of Middle High German senke ‘valley’ + the suffix -er, denoting an inhabitant.German : habitational name for someone from Singeln near Waldshut.German : variant of Sing 1.

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Other words and meanings similar to

RAF KINASE

AI search in online dictionary sources & meanings containing RAF KINASE

RAF KINASE

  • Raw
  • superl.

    Not mixed or diluted; as, raw spirits

  • Raft
  • v. t.

    To transport on a raft, or in the form of a raft; to make into a raft; as, to raft timber.

  • Raw
  • superl.

    Not tanned; as, raw hides

  • Rat
  • n.

    One of several species of small rodents of the genus Mus and allied genera, larger than mice, that infest houses, stores, and ships, especially the Norway, or brown, rat (M. decumanus), the black rat (M. rattus), and the roof rat (M. Alexandrinus). These were introduced into America from the Old World.

  • Raw
  • superl.

    Not spun or twisted; as, raw silk or cotton

  • Raw
  • superl.

    Deprived of skin; galled; as, a raw sore.

  • Raw
  • superl.

    Not altered from its natural state; not prepared by the action of heat; as, raw sienna; specifically, not cooked; not changed by heat to a state suitable for eating; not done; as, raw meat.

  • Ray
  • n.

    A line of light or heat proceeding from a radiant or reflecting point; a single element of light or heat propagated continuously; as, a solar ray; a polarized ray.

  • Raw
  • superl.

    Not distilled; as, raw water

  • Raw
  • superl.

    Not tried; not melted and strained; as, raw tallow

  • Ray
  • n.

    One of the component elements of the total radiation from a body; any definite or limited portion of the spectrum; as, the red ray; the violet ray. See Illust. under Light.

  • Ram
  • v. t.

    To butt or strike against; to drive a ram against or through; to thrust or drive with violence; to force in; to drive together; to cram; as, to ram an enemy's vessel; to ram piles, cartridges, etc.

  • Ram
  • n.

    A hydraulic ram. See under Hydraulic.

  • Raw
  • n.

    A raw, sore, or galled place; a sensitive spot; as, to touch one on the raw.

  • Raw
  • superl.

    Disagreeably damp or cold; chilly; bleak; as, a raw wind.

  • Rap
  • v. i.

    To strike with a quick, sharp blow; to knock; as, to rap on the door.

  • Raw
  • superl.

    Hence: Unprepared for use or enjoyment; immature; unripe; unseasoned; inexperienced; unpracticed; untried; as, raw soldiers; a raw recruit.

  • Ray
  • n.

    To send forth or shoot out; to cause to shine out; as, to ray smiles.