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Search references for ASK1. Phrases containing ASK1
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Protein found in humans
Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and
ASK1
P38 mitogen-activated protein kinases
targeting upstream MAPKs, such as ASK1. Studies in animal models of inflammatory arthritis have yielded promising results, and ASK1 has recently been found to
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Class of reduction–oxidation proteins
shown by Ghosal et.al in 1999. Thioredoxin has been shown to interact with: ASK1, Collagen, type I, alpha 1, Glucocorticoid receptor, SENP1, TXNIP. NF-κB
Thioredoxin
Class of enzymes
MEKK1) MAP3K2 (aka MEKK2) MAP3K3 (aka MEKK3) MAP3K4 (aka MEKK4) MAP3K5 (aka ASK1) MAP3K6 (aka ASK2) MAP3K7 (aka MEKK7) (aka TAK1) MAP3K8 (aka TPL2 or Tpl2)
MAP_kinase_kinase_kinase
Disorders of adaptive immune system
inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation". Toxicology and Applied Pharmacology. 287 (3): 299–305. Bibcode:2015ToxAP
Autoimmune_disease
Family of enzymes
although it acts on ASK1, which is upstream of JNK. The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex
Glutathione_S-transferase
Protein found in humans
UV-radiation. ASK1 will be transported to the nucleus when UV-irradiation is used to treat the cell. It is still unknown as to whether ASK1 binds Daxx,
Death-associated_protein_6
Protein family
Dabas, Hadas; Hammarlund, Marc (2022-03-14). "Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss
CCAAT-enhancer-binding proteins
CCAAT-enhancer-binding_proteins
Indian neuroscientist
Rangarajan, Govindan; Ravindranath, Vijayalakshmi (2015). "MPTP activates ASK1–p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism
Vijayalakshmi_Ravindranath
Digital Pathology
Stress-Induced Hypothalamic Neuronal Injury in Rats via the PERK-ATF4-CHOP and IRE1-ASK1-JNK Pathways". Frontiers in Cellular Neuroscience. 13 190. doi:10.3389/fncel
Tissue_cytometry
Excessive fat buildup in the liver with other metabolic disease
agonists, peroxisome proliferator-activated receptor (PPAR) agonists, and ASK1 (apoptosis signal-regulating kinase 1) inhibitors may improve MASFLD by multiple
Metabolic dysfunction–associated steatotic liver disease
Metabolic_dysfunction–associated_steatotic_liver_disease
Protein-coding gene in the species Homo sapiens
Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, et al. (June 2002). "ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death
ERN1
Cytokine
kinase 2 (HIPK2), which then activates apoptosis signal-inducing kinase 1 (ASK1), which goes on to activate the Jun amino-terminal kinase (JNK) pathway and
Transforming growth factor beta
Transforming_growth_factor_beta
Insoluble protein aggregate with a fibrillar morphology
(January 2005). "Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation". Cell Death and Differentiation. 12 (1): 19–24. doi:10.1038/sj
Amyloid
Class of immunosuppressive drug
inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation". Toxicology and Applied Pharmacology. 287 (3): 299–305. Bibcode:2015ToxAP
TNF_inhibitor
Protein found in humans
identical proteins have been reported. TRAF6 has been shown to interact with: ASK1, CD40, FHL2, HSPB2, IKBKG, IRAK1, IRAK2, TAB1, MAP3K7IP2, MAP3K7 PPP4C, RANK
TRAF6
Enzyme
humans is encoded by the PPP5C gene. PPP5C has been shown to interact with ASK1, CRY2 GNA12. and Rac1, GRCh38: Ensembl release 89: ENSG00000011485 – Ensembl
PPP5C
Protein-coding gene in humans
one transcript has been determined. TRAF2 has been shown to interact with: ASK1, BCL10, BIRC2, Baculoviral IAP repeat-containing protein 3, CASP8AP2, CD134
TRAF2
Protein-coding gene in the species Homo sapiens
product is functionally redundant. PDCD6 has been shown to interact with ASK1, PDCD6IP, Fas receptor, ANXA11 and PEF1. GRCh38: Ensembl release 89: ENSG00000249915
PDCD6
Protein-coding gene in the species Homo sapiens
Liu W, et al. (2003). "AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3". J. Clin. Invest. 111
DAB2IP
Protein-coding gene in the species Homo sapiens
variants has not been determined. MAPK8IP3 has been shown to interact with ASK1, C-Raf, PTK2, MAPK10, Mitogen-activated protein kinase 9, MAPK8, MAP2K1,
MAPK8IP3
Protein-coding gene in the species Homo sapiens
species. The interaction between ASK1 and STRAP is characterized by specific domains, with the C-terminal domain of ASK1 and the fourth and sixth WD40 repeats
STRAP
Mammalian protein found in Homo sapiens
example, is a poor enzyme on its own, and its activity appears to be tied to ASK1/ASK2 heterodimerisation. Raf-like kinases are fully absent from fungi. But
C-Raf
Protein-coding gene in the species Homo sapiens
with craniofacial abnormalities. MAP3K7 has been shown to interact with: ASK1, CHUK, MAP2K6, TAB1, MAP3K7IP2, MAP3K7IP3, Mothers against decapentaplegic
MAP3K7
Mammalian protein found in Homo sapiens
Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, et al. (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Molecular Cell. 2 (3): 389–95
Transcription_factor_Jun
Topics referred to by the same term
ASK Riga, a Latvian basketball club FK ASK, a Latvian former football club ASK1, apoptosis signal-regulating kinase 1 Aaru Sundarimaarude Katha, a 2013 Malayalam
ASK
Series of biochemical reactions
(SAPK) pathway. Phosphorylation of apoptosis signal-regulating kinase 1 (ASK1) on Ser83 and mixed lineage kinase 3 (MLK3) on Ser674 inhibits their activity
Akt/PKB_signaling_pathway
Human protein and coding gene
fetal alcohol syndrome. Protein kinase R has been shown to interact with: ASK1, DNAJC3, ILF3, METAP2, P53, PPP1CA, PRKRA, STAT1, and TARBP2. GRCh38: Ensembl
Protein_kinase_R
Protein-coding gene in the species Homo sapiens
variants have been characterized. TRAF5 has been shown to interact with: ASK1, CD134, CD30, CD40, RANK TNFRSF13B, and TNFRSF14. GRCh38: Ensembl release
TRAF5
Protein found in humans
mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1". J. Biol. Chem. 282 (10): 7522–31. doi:10.1074/jbc.M607177200. PMID 17210579
Mitogen-activated protein kinase kinase kinase 6
Mitogen-activated_protein_kinase_kinase_kinase_6
Protein-coding gene in the species Homo sapiens
activation and apoptosis. MAP2K6 has been shown to interact with TAOK2, ASK1, MAPK14 and MAP3K7. GRCh38: Ensembl release 89: ENSG00000108984 – Ensembl
MAP2K6
proteins that are involved in spindle dynamics such as Sli15, Ase1, and Ask1, spindle elongation and chromosomal segregation are promoted, facilitating
Mitotic_exit
Protein-coding gene in the species Homo sapiens
JH, Cho JH, Yoon KW, Dreyfuss G, Choi EJ (2007). "Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein
Gem-associated_protein_5
Protein-coding gene in the species Homo sapiens
Daxx apoptotic protein and prevents the association of Daxx with Fas and Ask1. Moreover, Hsp27 phosphorylation leads to the activation of TAK1 and TAK1-p38/ERK
Hsp27
Protein-coding gene in the species Homo sapiens
in patients. HSPA1A has been shown to interact with: XIAP, Apaf-1, AIFM1, ASK1, BAG3, Casein kinase 2, FANCC, GPR37, HSF1, MSR1, PARK2, PARP1, STUB1, and
HSPA1A
Protein-coding gene in the species Homo sapiens
PMID 12702766. Song JJ, Lee YJ (Nov 2003). "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization". The Journal of Biological Chemistry
HIPK1
Protein-coding gene in the species Homo sapiens
2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"
MAP2K4
Protein-coding gene in the species Homo sapiens
apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1". Oncogene. 27 (9): 1297–305. doi:10.1038/sj.onc.1210740. PMID 17700517.
GSPT1
Protein-coding gene in humans
p53-p21-Cdk axis in carcinogenesis. CDC25A has been shown to interact with: ASK1, C-Raf, CHEK1, CCNE1, EGFR, PIM1 and YWHAB. GRCh38: Ensembl release 89: ENSG00000164045
CDC25A
Protein-coding gene in the species Homo sapiens
YJ, et al. (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth". Mol. Cell.
PPP3R1
Human protein and coding gene
IRE1α also stimulates the activation of the apoptotic-signaling kinase-1 (ASK1), which then activates the downstream kinases, Jun-N-terminal kinase (JNK)
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Protein-coding gene in the species Homo sapiens
Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (September 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell. 2 (3): 389–95
MAPK8
Protein-coding gene in the species Homo sapiens
2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"
MAPK10
Protein-coding gene in the species Homo sapiens
He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W (Jul 2003). "ASK1 associates with troponin T and induces troponin T phosphorylation and contractile
TNNT2
Protein-coding gene in the species Homo sapiens
encoded by the RB1CC1 gene. RB1CC1 has been shown to interact with PTK2B, ASK1 and PTK2. GRCh38: Ensembl release 89: ENSG00000023287 – Ensembl, May 2017
RB1CC1
proteins that are involved in spindle dynamics such as Sli15, Ase1, and Ask1, spindle elongation and chromosomal segregation are promoted, facilitating
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Protein-coding gene in the species Homo sapiens
2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade"
MAP2K7
Protein-coding gene in the species Homo sapiens
interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively
TPD52L1
Protein-coding gene in the species Homo sapiens
humans is encoded by the DUSP19 gene. DUSP19 has been shown to interact with ASK1 and MAP2K7. GRCh38: Ensembl release 89: ENSG00000162999 – Ensembl, May 2017
DUSP19
Protein-coding gene in the species Homo sapiens
affecting synaptic plasticity. GADD45B has been shown to interact with: ASK1, GADD45GIP1, MAP2K7 and MAP3K4. Gadd45 GRCh38: Ensembl release 89: ENSG00000099860
GADD45B
Protein-coding gene in the species Homo sapiens
"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10.1074/jbc.M407617200
RALBP1
Protein-coding gene in the species Homo sapiens
mixed-lineage kinase 2/3 (MLK2/3), and apoptosis signal-regulating kinase 1/2 (ASK1/2), as well as MAP2Ks, such as MKK3, 6 and 4. MAP2K mediated phosphorylation
MAPK14
ASK1
ASK1
ASK1
ASK1
Boy/Male
Indian, Kannada
God Sivan
Boy/Male
Tamil
Nishikesh | நீஷீகேஷÂ
Boy/Male
German
Small; Intelligent One
Boy/Male
Indian, Sikh
One Light; God's Light
Surname or Lastname
English
English : habitational name from a place in Suffolk called Cavenham (of which this is a reduced form), from the genitive case of an unattested Old English byname CÄfna (from cÄf ‘bold’, ‘active’) + Old English hÄm ‘homestead’.
Surname or Lastname
English
English : reduced form of Calverley.Possibly an Americanized spelling of German Kälberer (see Kalberer).
Boy/Male
Arabic Muslim Welsh
Beams of light; shafts of light.
Boy/Male
American, British, English
From the Cattle Shed on the Meadow
Boy/Male
American, British, English
Gray-haired; Son of the Gray Family; Son of Gregory
Girl/Female
Arabic, Muslim, Sindhi
Good News
ASK1
ASK1
ASK1
ASK1
ASK1